{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T10:03:35Z","timestamp":1784714615606,"version":"3.55.0"},"reference-count":71,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Zhejiang Province Science and Technology Commissioner Team Project"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Dihydromyricetin (DHM) is a food-derived flavonoid enriched in vine tea and has been reported to possess antioxidant and metabolism-regulating properties. This study was designed to characterize the multi-level nutritional responses to dietary DHM supplementation, with emphasis on hepatic redox\u2013inflammatory status, jejunal barrier-related phenotypes, cecal microbiota remodeling, hepatic metabolomic alterations, and homocysteine (Hcy) metabolism-related markers in mice. Methods: Forty-eight healthy mice were assigned to a basal-diet control group or diets containing 50, 100, or 200 mg\/kg DHM for 4 weeks. Growth performance, serum biochemistry, antioxidant parameters, hepatic antioxidant-related expression, hepatic inflammatory cytokines, jejunal morphology and tight junction proteins, cecal 16S rRNA profiles, hepatic metabolomics, and Hcy metabolism-related markers were assessed. Results: Dietary DHM improved serum and hepatic antioxidant status, as reflected by increased T-AOC and GSH-Px activity and decreased MDA concentrations (p &lt; 0.05). DHM also modulated the hepatic cytokine profile, with decreased TNF-\u03b1 concentration (p &lt; 0.05) and increased IL-10 concentration (p &lt; 0.01). DHM increased hepatic Nrf2 protein abundance, HO-1 protein abundance, and Gclc mRNA expression (p &lt; 0.05). DHM also improved jejunal villus architecture, as indicated by increased villus height, decreased crypt depth, and an increased villus height-to-crypt depth ratio (p &lt; 0.05). Jejunal Occludin and ZO-1 protein expression were increased in the DHM-treated groups (p &lt; 0.05). Cecal microbiota analysis showed increased richness and diversity indices and altered microbial community structure. Hepatic metabolomics revealed changes involving vitamin B6 metabolism, purine metabolism, the pentose phosphate pathway, and \u03b1-linolenic acid metabolism. Serum Hcy levels decreased (p &lt; 0.05), accompanied by increased hepatic BHMT and MTHFR protein abundance (p &lt; 0.01). Conclusions: Dietary DHM supplementation improved hepatic redox status and supported a less pro-inflammatory cytokine profile in mice, accompanied by enhanced jejunal barrier-related phenotypes, cecal microbiota remodeling, hepatic metabolic alterations, and Hcy metabolism-related responses. These findings provide a multi-level nutritional evaluation of DHM and suggest its potential relevance for supporting intestinal barrier integrity and hepatic metabolic homeostasis under basal physiological conditions.<\/jats:p>","DOI":"10.3390\/nu18142390","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T09:20:39Z","timestamp":1784712039000},"page":"2390","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dietary Dihydromyricetin Supplementation Enhances Antioxidant Capacity and Modulates Jejunal Barrier Function, Cecal Microbiota, and Hepatic Metabolism in Mice"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4159-8447","authenticated-orcid":false,"given":"Wenjiao","family":"Liang","sequence":"first","affiliation":[{"name":"Key Laboratory of Animal Nutrition and Feed Science in East China, Ministry of Agriculture, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lishiyuan","family":"Tang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Nutrition and Feed Science in East China, Ministry of Agriculture, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghui","family":"Fan","sequence":"additional","affiliation":[{"name":"Hangzhou Academy of Agricultural Sciences, Hangzhou 310004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Nutrition and Feed Science in East China, Ministry of Agriculture, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Nutrition and Feed Science in East China, Ministry of Agriculture, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8699-1885","authenticated-orcid":false,"given":"Lichun","family":"Qian","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Nutrition and Feed Science in East China, Ministry of Agriculture, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"ref_1","first-page":"12","article-title":"Flavonoid Natural Sources and Their Importance in the Human Diet","volume":"5","year":"2011","journal-title":"Potravin. 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