{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T06:58:50Z","timestamp":1785135530966,"version":"3.55.0"},"reference-count":39,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Cheers Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: This decentralized, real-world observational cohort study assessed whether Cheers Restore (Houston, TX, USA), a commercially available dietary supplement, is associated with improved next-day subjective well-being (energy, mental clarity, physical well-being, and sleep quality) following alcohol consumption in healthy adults. A secondary aim evaluated the feasibility of integrating consumer wearables into future controlled studies. Methods: Ninety adults (56% female; mean age 44.4 years) were enrolled via the Alethios digital research platform and contributed 2958 morning surveys across three self-selected behavioral conditions: Alcohol-Only (reference), Cheers Restore, and Non-Drinking Baseline. Four subjective outcomes (energy, mental clarity, physical well-being, sleep quality rating; 1\u201310 scale) were modeled using linear mixed-effects models with random intercepts for participant and centered drink count as a covariate. Results: Cheers Restore use was associated with statistically significant improvements across all four subjective outcomes relative to alcohol-only nights: mental clarity (\u03b2 = 0.356, 95% CI 0.214\u20130.499, p &lt; 0.001), physical well-being (\u03b2 = 0.335, 95% CI 0.189\u20130.482, p &lt; 0.001), energy (\u03b2 = 0.270, 95% CI 0.133\u20130.407, p &lt; 0.001), and sleep quality rating (\u03b2 = 0.263, 95% CI 0.096\u20130.430, p = 0.002). Standardized effect sizes were small (Cohen\u2019s d = 0.20\u20130.32). Paired Alcohol Use Disorders Identification Test\u2013Consumption (AUDIT-C) analysis confirmed stable consumption with no evidence of increased alcohol consumption over the short, self-reported follow-up. Conclusions: In this observational cohort, Cheers Restore use was associated with consistent improvements in next-day subjective well-being. These findings warrant a randomized, placebo-controlled trial to establish causality. ClinicalTrials.gov: NCT07069608, registered 16 July 2025.<\/jats:p>","DOI":"10.3390\/nu18152424","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T05:49:27Z","timestamp":1785131367000},"page":"2424","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Decentralized Assessment of a Dihydromyricetin- and L-Cysteine-Based Multi-Ingredient Dietary Supplement on Post-Alcohol Recovery: An Observational Cohort Study"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5742-4667","authenticated-orcid":false,"given":"Sujin","family":"Song","sequence":"first","affiliation":[{"name":"Clinical Excellence Research Center, Stanford University, Stanford, CA 94303, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3136-3109","authenticated-orcid":false,"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Clinical Excellence Research Center, Stanford University, Stanford, CA 94303, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Atwood","sequence":"additional","affiliation":[{"name":"Atwood-Sciences, Denver, CO 81658, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2044-7865","authenticated-orcid":false,"given":"Nirav R.","family":"Shah","sequence":"additional","affiliation":[{"name":"Clinical Excellence Research Center, Stanford University, Stanford, CA 94303, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza A.","family":"Jarral","sequence":"additional","affiliation":[{"name":"Clinical Excellence Research Center, Stanford University, Stanford, CA 94303, USA"},{"name":"CareHQ, Auckland 1010, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"102030","DOI":"10.1016\/j.smrv.2024.102030","article-title":"The Effect of Alcohol on Subsequent Sleep in Healthy Adults: A Systematic Review and Meta-Analysis","volume":"80","author":"Gardiner","year":"2025","journal-title":"Sleep Med. 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