{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:24:24Z","timestamp":1785435864103,"version":"3.56.0"},"reference-count":131,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ildong Bioscience, Co., Ltd."},{"DOI":"10.13039\/501100014189","name":"Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry","doi-asserted-by":"publisher","award":["RS-2025-02216704"],"award-info":[{"award-number":["RS-2025-02216704"]}],"id":[{"id":"10.13039\/501100014189","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hanwoomul-Phagi Basic Research Program through the National Research Foundation of Korea (NRF) grant"},{"id":[{"id":"https:\/\/ror.org\/013aysd81","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"Korean government","doi-asserted-by":"publisher","award":["202400352752"],"award-info":[{"award-number":["202400352752"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Functional bowel disorders (FBDs) are chronic gastrointestinal conditions that substantially impair quality of life. This randomized, double-blind, placebo-controlled trial investigated the effects of Heyndrickxia coagulans IDCC 1201 (COA 1201) in adults with FBD. Methods: Participants received COA 1201 or a placebo for 8 weeks, with outcomes assessed using the irritable bowel syndrome (IBS) Symptom Severity Score (IBS-SSS), IBS Quality of Life (IBS-QOL), and bowel activity measures. And Fecal microbiome and metabolomics were measured by 16S rRNA gene sequencing gas chromatography-mass spectrometry, respectively. Results: Both groups showed improvement from baseline, but COA 1201 produced greater symptom relief, particularly in abdominal bloating, post-defecation discomfort, and the body image domain of IBS-QOL. Fecal microbiome profiling revealed modest changes in global diversity, yet taxa linked to saccharolytic activity and short-chain fatty acid production\u2014including Ruminococcus bromii, Agathobacter rectalis, and Bifidobacterium\u2014were enriched in participants receiving COA 1201, whereas Clostridium leptum increased in those receiving a placebo. Untargeted metabolomics demonstrated distinct metabolic signatures between groups, confirmed by supervised partial least squares discriminant analysis. Exploratory metabolites were identified using variable importance in projection scores (&gt;1.5), statistical significance (p &lt; 0.05), and absolute log2 fold change (&gt;1). Alanine and proline emerged as time-dependent metabolites, while tryptophan, lactic acid, and phytosphingosine were specifically associated with COA 1201 treatment. Conclusions: Collectively, these findings suggest that COA 1201 alleviates FBD symptoms by modulating the gut microbiome and metabolome.<\/jats:p>","DOI":"10.3390\/nu18152466","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T08:16:52Z","timestamp":1785313012000},"page":"2466","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Heyndrickxia coagulans IDCC 1201 Alters Gut Microbiome and Metabolome in Patients with Functional Bowel Disorders"],"prefix":"10.3390","volume":"18","author":[{"given":"Hyeon Ji","family":"Jeon","sequence":"first","affiliation":[{"name":"School of Food Science and Biotechnology, Kyungpook National University, Daegu 41566, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0375-7175","authenticated-orcid":false,"given":"Jin Seok","family":"Moon","sequence":"additional","affiliation":[{"name":"ILDONG Bioscience Co., Ltd., 17 Poseunggongdan-ro, Poseung-eup, Pyeongtaek-si 17957, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Min","family":"Jeong","sequence":"additional","affiliation":[{"name":"School of Food Science and Biotechnology, Kyungpook National University, Daegu 41566, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2788-1157","authenticated-orcid":false,"given":"Won Yeong","family":"Bang","sequence":"additional","affiliation":[{"name":"ILDONG Bioscience Co., Ltd., 17 Poseunggongdan-ro, Poseung-eup, Pyeongtaek-si 17957, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayoung","family":"Kim","sequence":"additional","affiliation":[{"name":"ILDONG Bioscience Co., Ltd., 17 Poseunggongdan-ro, Poseung-eup, Pyeongtaek-si 17957, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donggyu","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Microbiology, College of Medicine, Inha University, Incheon 22212, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhye","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Microbiology, College of Medicine, Inha University, Incheon 22212, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3836-729X","authenticated-orcid":false,"given":"Jungwoo","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Microbiology, College of Medicine, Dongguk University, 123 Dongdae-ro, Gyeongju 38066, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jongbeom","family":"Shin","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Inha University Hospital, Inha University School of Medicine, Incheon 22212, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0781-3608","authenticated-orcid":false,"given":"Young Hoon","family":"Jung","sequence":"additional","affiliation":[{"name":"School of Food Science and Biotechnology, Kyungpook National University, Daegu 41566, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1159\/000488773","article-title":"Dysbiosis in Functional Bowel Disorders","volume":"72","author":"Enck","year":"2018","journal-title":"Ann. 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