{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T09:01:28Z","timestamp":1785315688292,"version":"3.55.0"},"reference-count":58,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key Laboratory for Research on Autoimmune Diseases of Higher Education Schools in Guizhou Province","award":["Qianjiaoji[2023]016"],"award-info":[{"award-number":["Qianjiaoji[2023]016"]}]},{"name":"Guizhou Provincial Graduate Research Fund","award":["2025YJSKYJJ268"],"award-info":[{"award-number":["2025YJSKYJJ268"]}]},{"name":"Guizhou Provincial Basic Research Program","award":["\u9ed4\u79d1\u5408\u57fa\u7840 MS[2025]551"],"award-info":[{"award-number":["\u9ed4\u79d1\u5408\u57fa\u7840 MS[2025]551"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Major depressive disorder (MDD) is a highly prevalent and disabling psychiatric condition for which current therapies remain inadequate. Probiotics acting on the microbiota\u2013gut\u2013brain axis are a promising preventive strategy, but their benefits are strain-specific. Here we examined whether Lacticaseibacillus paracasei LP36 alleviates lipopolysaccharide (LPS)-induced depression-like behavior in mice, and we characterized its metabolic actions using serum untargeted metabolomics. Methods: Sixty male C57BL\/6J mice were randomized into eight groups (58 completed the study and were analyzed) and received saline or LP36 (1 \u00d7 108, 1 \u00d7 109, or 1 \u00d7 1010 colony-forming units (CFU)\/mL) by gavage for 28 days, with LPS (0.5 mg\/kg, i.p.) or saline given during the last 10 days. Results: LP36 pretreatment alleviated LPS-induced depression-like behavior in the sucrose preference, forced swimming, and tail suspension tests. Of 2867 annotated serum metabolites, 404 differed between the LPS and control groups, and 601 between the LP36 (1010)-treated and LPS groups. Among 180 shared differential metabolites, 172 (95.6%) changed in opposite directions, indicating that LP36 mainly reverses LPS-induced metabolic perturbations. KEGG enrichment localized these effects to lipid-related pathways, with lower relative signal intensities of polyunsaturated fatty acids and sphingolipids under LPS and higher relative signal intensities after LP36. In addition, the relative signal intensities of several microbiota-derived metabolites, including indoles, kynurenines, and secondary bile acids, shifted toward control-group values after LP36 intervention, which might reflect a contribution of the gut microbiota. Conclusions: LP36 is thus a candidate psychobiotic that may alleviate depression by reshaping gut microbiota-related metabolism and the associated lipid remodeling.<\/jats:p>","DOI":"10.3390\/nu18152468","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T08:16:52Z","timestamp":1785313012000},"page":"2468","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lacticaseibacillus paracasei LP36 Alleviates Lipopolysaccharide-Induced Depression-like Behavior in Mice: A Serum Metabolomics Study"],"prefix":"10.3390","volume":"18","author":[{"given":"Qiuyue","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Histology and Embryology, School of Basic Medical Sciences, Guizhou Medical University, Gui\u2019an New District, Guiyang 561113, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7046-0449","authenticated-orcid":false,"given":"Zhiyu","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Humanities, Guizhou Medical University, Gui\u2019an New District, Guiyang 561113, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, School of Basic Medical Sciences, Guizhou Medical University, Gui\u2019an New District, Guiyang 561113, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5342-5668","authenticated-orcid":false,"given":"Fei","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Quality and Safety of Agro-Products, Institute of Agro-Product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenbi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, School of Basic Medical Sciences, Guizhou Medical University, Gui\u2019an New District, Guiyang 561113, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, School of Basic Medical Sciences, Guizhou Medical University, Gui\u2019an New District, Guiyang 561113, China"},{"name":"Key Laboratory for Research on Autoimmune Diseases of Higher Education Schools in Guizhou Province, Guiyang 561113, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, School of Basic Medical Sciences, Guizhou Medical University, Gui\u2019an New District, Guiyang 561113, China"},{"name":"Key Laboratory for Research on Autoimmune Diseases of Higher Education Schools in Guizhou Province, Guiyang 561113, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, School of Basic Medical Sciences, Guizhou Medical University, Gui\u2019an New District, Guiyang 561113, China"},{"name":"Key Laboratory for Research on Autoimmune Diseases of Higher Education Schools in Guizhou Province, Guiyang 561113, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baijuan","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, School of Basic Medical Sciences, Guizhou Medical University, Gui\u2019an New District, Guiyang 561113, China"},{"name":"Key Laboratory for Research on Autoimmune Diseases of Higher Education Schools in Guizhou Province, Guiyang 561113, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifen","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition and Feed Sciences, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, School of Basic Medical Sciences, Guizhou Medical University, Gui\u2019an New District, Guiyang 561113, China"},{"name":"Key Laboratory for Research on Autoimmune Diseases of Higher Education Schools in Guizhou Province, Guiyang 561113, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"GBD 2019 Mental Disorders Collaborators (2022). 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