{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T04:58:31Z","timestamp":1785560311066,"version":"3.56.0"},"reference-count":223,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004916","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Amazonas","doi-asserted-by":"crossref","award":["01.02.016301.00489\/2026-09. TO 261\/2026"],"award-info":[{"award-number":["01.02.016301.00489\/2026-09. TO 261\/2026"]}],"id":[{"id":"10.13039\/501100004916","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Dietary patterns increasingly influence research on neurodegenerative diseases, with attention shifting from isolated nutrients to integrative nutritional models. The Amazonian Diet, a biodiversity-based dietary pattern rich in native fruits, seeds, freshwater fish, and cassava-derived foods, is naturally enriched in bioactive compounds including polyphenols, anthocyanins, carotenoids, methylxanthines, selenium, vitamins, and unsaturated fatty acids. This review aimed to investigate the potential relevance of key foods derived from the Amazonian Diet to Parkinson\u2019s disease (PD) by integrating compositional nutritional analysis, multivariate analytical approaches, and mechanistic evidence synthesis. In Stage 1, the composition of 36 Amazonian foods was analyzed using TBCA and FAO data, followed by hierarchical clustering analysis (Ward\u2019s linkage, Euclidean distance). Distinct compositional patterns were identified, highlighting foods with high bioactive diversity, relevant lipid composition, and dietary fiber. In Stage 2, an integrative literature review (PubMed\/MEDLINE, SciELO) of in vitro, in vivo, observational, and clinical studies suggested that a\u00e7a\u00ed berry, guaran\u00e1, cocoa\/cacao, camu-camu, and Brazil nuts contain nutrients and bioactive compounds that intersect with biological pathways implicated in PD, including oxidative stress, mitochondrial dysfunction, and neuroinflammation. However, this review does not evaluate the effects of the Amazonian Diet on PD incidence, progression, symptoms, levodopa response, or biomarkers.<\/jats:p>","DOI":"10.3390\/nu18152472","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T08:09:42Z","timestamp":1785398982000},"page":"2472","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Potential Relevance of Amazonian Diet Components in Parkinson\u2019s Disease: An Integrative Review with Multivariate Analysis"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1722-6933","authenticated-orcid":false,"given":"Maria Fernanda","family":"Manica-Cattani","sequence":"first","affiliation":[{"name":"Centro Universit\u00e1rio da Serra Ga\u00facha (FSG), Caxias do Sul 95020-371, RS, Brazil"},{"name":"Centro de Ensino, Pesquisa e Desenvolvimento Tecnol\u00f3gico GERONTEC, Funda\u00e7\u00e3o Universidade Aberta da Terceira Idade, FUnATI, Manaus 69029-040, AM, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana Beatrice M\u00e2nica","family":"da Cruz","sequence":"additional","affiliation":[{"name":"Centro de Ensino, Pesquisa e Desenvolvimento Tecnol\u00f3gico GERONTEC, Funda\u00e7\u00e3o Universidade Aberta da Terceira Idade, FUnATI, Manaus 69029-040, AM, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Imunologia B\u00e1sica e Aplicada, Universidade Federal do Amazonas, Manaus 69080-900, AM, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Gerontologia, Universidade Federal de Santa Maria, Santa Maria 97105-900, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Euler Esteves","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Centro de Ensino, Pesquisa e Desenvolvimento Tecnol\u00f3gico GERONTEC, Funda\u00e7\u00e3o Universidade Aberta da Terceira Idade, FUnATI, Manaus 69029-040, AM, 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