{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T08:46:04Z","timestamp":1785833164067,"version":"3.56.0"},"reference-count":55,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Xizang Academy of Agricultural and Animal Husbandry Sciences Whole-Village Demonstration Project on Improving Dietary Nutrition and Health of Tibetan Residents","award":["18080291"],"award-info":[{"award-number":["18080291"]}]},{"name":"Xizang Academy of Agricultural and Animal Husbandry Sciences Whole-Village Demonstration Project on Improving Dietary Nutrition and Health of Tibetan Residents","award":["18080308"],"award-info":[{"award-number":["18080308"]}]},{"name":"Xizang Autonomous Region Financial Special Project","award":["XZCZ-SS-2024"],"award-info":[{"award-number":["XZCZ-SS-2024"]}]},{"name":"Xizang Autonomous Region Financial Special Project","award":["XZCZ-SS-2025"],"award-info":[{"award-number":["XZCZ-SS-2025"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Dietary assessment tools specifically developed and validated for high-altitude Tibetan agricultural and pastoral populations facing unique nutritional challenges remain limited. To address this gap, we developed a digital Tibetan Food Frequency Questionnaire (T-FFQ) with region-specific modules to capture dietary heterogeneity across the agricultural and pastoral communities of Qinghai-Tibetan Plateau (QTP). Its offline-capable architecture based on a web application enables real-time field data capture and storage in resource-limited high-altitude settings. Methods: A total of 200 Tibetan residents from agricultural and pastoral communities (n = 100 per group; elevation range: 3650\u20134900 m) were enrolled to validate the T-FFQ. Participants were asked to complete a full-length FFQ (Full-FFQ), three nonconsecutive 24-h dietary recalls (24HDRs), and two administrations of the region-specific T-FFQ approximately 2 weeks apart. Results: Reproducibility analysis revealed intraclass correlation coefficients (ICCs) of 0.279\u20130.935 for nutrients and 0.146\u20130.924 for food groups in the agricultural area, and 0.401\u20130.944 for nutrients and 0.378\u20130.990 for food groups in the pastoral area. Relative validity against the participant-specific mean of three 24HDRs showed energy-adjusted correlation coefficients ranging from 0.096 to 0.948 in the agricultural region and from \u22120.019 to 0.789 in the pastoral region. Across 42 estimable nutrient and food-group variables, the mean proportion of participants classified into the same or adjacent quartiles was 82.3%, and the mean extreme misclassification rate was 3.9%. The T-FFQ showed comparatively stronger performance for macronutrients, sodium, vitamin E, and several commonly consumed dietary components, supporting its use for population-level dietary ranking and stratification. Conclusions: The T-FFQ is a practical, semi-quantitative, and culturally adapted tool for ranking habitual intakes of commonly consumed foods and selected nutrients at the population level in high-altitude Tibetan agricultural and pastoral communities.<\/jats:p>","DOI":"10.3390\/nu18152530","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T08:02:19Z","timestamp":1785830539000},"page":"2530","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Modular Digital FFQ for Tibetan Highlanders in Agricultural and Pastoral Communities: Development and Rigorous Multi-Method Validation"],"prefix":"10.3390","volume":"18","author":[{"given":"Zhuoning","family":"Tang","sequence":"first","affiliation":[{"name":"Key Laboratory of Eco-Environment and Population Health of Xizang Autonomous Region, Xizang University, Lhasa 850000, China"},{"name":"Institute of Nutrition, Fudan University, Shanghai 200032, China"},{"name":"China Key Laboratory of Public Health Safety, MOE, School of Public Health, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Eco-Environment and Population Health of Xizang Autonomous Region, Xizang University, Lhasa 850000, China"},{"name":"Institute of Nutrition, Fudan University, Shanghai 200032, China"},{"name":"China Key Laboratory of Public Health Safety, MOE, School of Public Health, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Eco-Environment and Population Health of Xizang Autonomous Region, Xizang University, Lhasa 850000, China"},{"name":"Institute of Nutrition, Fudan University, Shanghai 200032, China"},{"name":"China Key Laboratory of Public Health Safety, MOE, School of Public Health, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunsang","family":"Yangchen","sequence":"additional","affiliation":[{"name":"College of Medicine, Xizang University, Lhasa 850000, China"},{"name":"Key Laboratory of Public Health Safety & Policy Research, Xizang University, Lhasa 850000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyu","family":"Fang","sequence":"additional","affiliation":[{"name":"Institute of Nutrition, Fudan University, Shanghai 200032, China"},{"name":"China Key Laboratory of Public Health Safety, MOE, School of Public Health, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangting","family":"Hu","sequence":"additional","affiliation":[{"name":"Institute of Nutrition, Fudan University, Shanghai 200032, China"},{"name":"China Key Laboratory of Public Health Safety, MOE, School of Public Health, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yining","family":"Luo","sequence":"additional","affiliation":[{"name":"Institute of Nutrition, Fudan University, Shanghai 200032, China"},{"name":"China Key Laboratory of Public Health Safety, MOE, School of Public Health, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhu","family":"Tang","sequence":"additional","affiliation":[{"name":"Institute of Nutrition, Fudan University, Shanghai 200032, China"},{"name":"China Key Laboratory of Public Health Safety, MOE, School of Public Health, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[{"name":"Xizang Academy of Agriculture and Animal Husbandry Sciences, Lhasa 850000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Xizang Academy of Agriculture and Animal Husbandry Sciences, Lhasa 850000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Xizang Academy of Agriculture and Animal Husbandry Sciences, Lhasa 850000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Eco-Environment and Population Health of Xizang Autonomous Region, Xizang University, Lhasa 850000, China"},{"name":"Institute of Nutrition, Fudan University, Shanghai 200032, China"},{"name":"China Key Laboratory of Public Health Safety, MOE, School of Public Health, Fudan University, Shanghai 200032, China"},{"name":"College of Medicine, Xizang University, Lhasa 850000, China"},{"name":"Key Laboratory 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