{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:00:56Z","timestamp":1786122056461,"version":"build-2736575974"},"reference-count":62,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Health Commission of Hubei Province Scientific Research Project","award":["WJ2019H303"],"award-info":[{"award-number":["WJ2019H303"]}]},{"award":["WJ2019H303"],"award-info":[{"award-number":["WJ2019H303"]}],"id":[{"id":"https:\/\/ror.org\/02g4yc525","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Wuhan Preventive Medicine Research Project","award":["WY19M01"],"award-info":[{"award-number":["WY19M01"]}]},{"name":"Wuhan Preventive Medicine Research Project","award":["WY22A01"],"award-info":[{"award-number":["WY22A01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Long-term exposure to fine particulate matter (PM2.5) and its components, as well as lower nutritional scores or irregular leisure-time physical activity, has been individually linked to reduced kidney function. However, the joint associations of PM2.5 component mixture combined with nutritional scores or leisure-time physical activity with estimated glomerular filtration rate (eGFR) remain underexplored, especially among subway workers. Method: This study included 8477 subway workers in Wuhan, China. PM2.5, and component data were obtained from the Tracking Air Pollution in China (TAP) dataset. Leisure-time physical activity was assessed using a self-administered questionnaire adapted from the International Physical Activity Questionnaire (IPAQ). Kidney function was evaluated by creatinine-based eGFR. Nutritional indices of Geriatric Nutritional Risk Index (GNRI) and the Prognostic Nutritional Index (PNI) were calculated. Generalized linear models were used to examine the associations of PM2.5 and each of its components or nutritional indices with lower creatinine-based eGFR. The associations of PM2.5 component mixture with creatinine-based eGFR were evaluated using WQS, QGC, and BKMR models. Joint associations of PM2.5 component mixture with nutritional indices or leisure-time physical activity were further explored. Results: Negative associations of individual PM2.5 components and their mixture with eGFR values were observed. WQS and QGC models showed that the mixture of PM2.5 components was associated with an increased risk of lower creatinine-based eGFR, and their corresponding ORs (95%CI) were 1.183 (1.106, 1.266) and 1.183 (1.083, 1.291), respectively. BKMR analysis further showed the overall effect on eGFR values in relation to a 5-percentile increase in the PM2.5 component mixture was \u22120.045 (\u22120.068, \u22120.022), compared with their levels fixed at their respective medians. Meanwhile, the probability of lower creatinine-based eGFR increased with rising quantiles of PM2.5 component mixture concentration. Notably, differential associations were observed across subgroups classified by nutritional indices or leisure-time physical activity, but no significant interaction was observed. Conclusions: Long-term exposure to residential ambient PM2.5 components or their mixture is associated with lower creatinine-based eGFR. This different association was observed among subgroups classified by nutritional indices or leisure-time physical activity, which may inform hypothesis generation for future studies.<\/jats:p>","DOI":"10.3390\/nu18152580","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T14:45:47Z","timestamp":1786027547000},"page":"2580","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Joint Associations of Residential Ambient PM2.5 Components, Nutritional Indices, and Leisure-Time Physical Activity with Lower Estimated Glomerular Filtration Rate Among Subway Workers"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1439-7067","authenticated-orcid":false,"given":"Xiaomeng","family":"Tan","sequence":"first","affiliation":[{"name":"School of Management, Zhengzhou University, Zhengzhou 450001, China"},{"name":"School of Kinesiology and Physical Education, Zhengzhou University, Zhengzhou 450001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingri","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lv","family":"Shang","sequence":"additional","affiliation":[{"name":"Wuhan Center for Disease Control and Prevention, Wuhan 430024, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Ye","sequence":"additional","affiliation":[{"name":"School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7455-1735","authenticated-orcid":false,"given":"Li","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9492-1673","authenticated-orcid":false,"given":"Zijian","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Kinesiology and Physical Education, Zhengzhou University, Zhengzhou 450001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"He","sequence":"additional","affiliation":[{"name":"Wuhan Center for Disease Control and Prevention, Wuhan 430024, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Ke, C., Liang, J., Liu, M., Liu, S., and Wang, C. (2022). Burden of chronic kidney disease and its risk-attributable burden in 137 low-and middle-income countries, 1990\u20132019: Results from the global burden of disease study 2019. BMC Nephrol., 23.","DOI":"10.1186\/s12882-021-02597-3"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1093\/ckj\/sfac218","article-title":"Temporal trends in prevalence and mortality for chronic kidney disease in China from 1990 to 2019: An analysis of the Global Burden of Disease Study 2019","volume":"16","author":"Li","year":"2023","journal-title":"Clin. Kidney J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"151336","DOI":"10.1016\/j.semnephrol.2023.151336","article-title":"Chronic Kidney Disease Burden in Low-Resource Settings: Regional Perspectives","volume":"42","author":"Ulasi","year":"2022","journal-title":"Semin. Nephrol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"151315","DOI":"10.1016\/j.semnephrol.2023.151315","article-title":"Screening for Kidney Disease in Low- and Middle-Income Countries","volume":"42","author":"Kalyesubula","year":"2022","journal-title":"Semin. Nephrol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1093\/ckj\/sfac101","article-title":"Increase in the global burden of chronic kidney disease: Might it be attributable to air pollution?","volume":"15","author":"Copur","year":"2022","journal-title":"Clin. Kidney J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e002063","DOI":"10.1136\/bmjgh-2019-002063","article-title":"The global and national burden of chronic kidney disease attributable to ambient fine particulate matter air pollution: A modelling study","volume":"5","author":"Bowe","year":"2020","journal-title":"BMJ Glob. Health"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"115803","DOI":"10.1016\/j.ecoenv.2023.115803","article-title":"Ambient ozone pollution impairs glucose homeostasis and contributes to renal function decline: Population-based evidence","volume":"269","author":"Peng","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1093\/eurheartj\/ehad091","article-title":"Ozone pollution and hospital admissions for cardiovascular events","volume":"44","author":"Jiang","year":"2023","journal-title":"Eur. Heart J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"114144","DOI":"10.1016\/j.envres.2022.114144","article-title":"Multi-pollutant air pollution and renal health in Asian children and adolescents: An 18-year longitudinal study","volume":"214","author":"Guo","year":"2022","journal-title":"Environ. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"106752","DOI":"10.1016\/j.envint.2021.106752","article-title":"Urbanization, ambient air pollution, and prevalence of chronic kidney disease: A nationwide cross-sectional study","volume":"156","author":"Liang","year":"2021","journal-title":"Environ. Int."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1053\/j.ajkd.2022.03.009","article-title":"Association of Long-term Ambient Fine Particulate Matter (PM2.5) and Incident CKD: A Prospective Cohort Study in China","volume":"80","author":"Duan","year":"2022","journal-title":"Am. J. Kidney Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"106348","DOI":"10.1016\/j.envint.2020.106348","article-title":"Association between airborne particulate matter and renal function: An analysis of 2.5 million young adults","volume":"147","author":"Li","year":"2021","journal-title":"Environ. Int."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1093\/annweh\/wxaf008","article-title":"Airborne particulate matter exposure in male sugarcane workers at risk for chronic kidney disease in Guatemala","volume":"69","author":"Adgate","year":"2025","journal-title":"Ann. Work Expo. Health"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"133570","DOI":"10.1016\/j.chemosphere.2022.133570","article-title":"Short-term exposure to fine particulate matter and its constituents may affect renal function via oxidative stress: A longitudinal panel study","volume":"293","author":"Peng","year":"2022","journal-title":"Chemosphere"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"126557","DOI":"10.1016\/j.jhazmat.2021.126557","article-title":"Short-term exposure to PM2.5 components and renal health: Findings from the Veterans Affairs Normative Aging Study","volume":"420","author":"Gao","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1021\/acs.est.1c04526","article-title":"Associations of Carbonaceous Compounds and Water-Soluble Inorganic Ions in Ambient PM2.5 with Renal Function in Older Individuals: The China BAPE Study","volume":"56","author":"Fang","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clnesp.2018.02.005","article-title":"A review of the validity of malnutrition screening tools used in older adults in community and healthcare settings\u2014A MaNuEL study","volume":"24","author":"Power","year":"2018","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Bellanti, F., Lo Buglio, A., Quiete, S., and Vendemiale, G. (2022). Malnutrition in Hospitalized Old Patients: Screening and Diagnosis, Clinical Outcomes, and Management. Nutrients, 14.","DOI":"10.3390\/nu14040910"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1053\/j.jrn.2021.09.002","article-title":"Malnutrition Risk and Kidney Function and Decline in Community-Dwelling Older Adults","volume":"32","author":"Lu","year":"2022","journal-title":"J. Ren. Nutr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00467-023-06078-7","article-title":"Malnutrition and protein energy wasting are associated with severity and progression of pediatric chronic kidney disease","volume":"39","author":"Shen","year":"2024","journal-title":"Pediatr. Nephrol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"16673","DOI":"10.1038\/s41598-022-20985-z","article-title":"Association of malnutrition with renal dysfunction and clinical outcome in patients with heart failure","volume":"12","author":"Otaki","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1046\/j.1523-1755.2000.00014.x","article-title":"Relationship between nutritional status and the glomerular filtration rate: Results from the MDRD study","volume":"57","author":"Kopple","year":"2000","journal-title":"Kidney Int."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"105954","DOI":"10.1016\/j.envint.2020.105954","article-title":"Air pollution, physical activity and health: A mapping review of the evidence","volume":"147","author":"Tainio","year":"2021","journal-title":"Environ. Int."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e045919","DOI":"10.1161\/JAHA.125.045919","article-title":"Air Pollution and Incident Cardiovascular Disease: Modification by Genetic Susceptibility and the Mitigating Role of Physical Activity","volume":"15","author":"Liu","year":"2026","journal-title":"J. Am. Heart Assoc."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1093\/eurheartj\/ehab139","article-title":"Association of the combined effects of air pollution and changes in physical activity with cardiovascular disease in young adults","volume":"42","author":"Kim","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.envint.2017.11.024","article-title":"Estimated effects of air pollution and space-time-activity on cardiopulmonary outcomes in healthy adults: A repeated measures study","volume":"111","author":"Kubesch","year":"2018","journal-title":"Environ. Int."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"127012","DOI":"10.1289\/EHP7402","article-title":"Interaction between Long-Term Exposure to Fine Particulate Matter and Physical Activity, and Risk of Cardiovascular Disease and Overall Mortality in U.S. Women","volume":"128","author":"Elliott","year":"2020","journal-title":"Environ. Health Perspect."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"105819","DOI":"10.1016\/j.envint.2020.105819","article-title":"Physical activity attenuated association of air pollution with estimated 10-year atherosclerotic cardiovascular disease risk in a large rural Chinese adult population: A cross-sectional study","volume":"140","author":"Tu","year":"2020","journal-title":"Environ. Int."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.envint.2018.04.040","article-title":"Short-term effects of physical activity, air pollution and their interaction on the cardiovascular and respiratory system","volume":"117","author":"Laeremans","year":"2018","journal-title":"Environ. Int."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1093\/ajcn\/82.4.777","article-title":"Geriatric Nutritional Risk Index: A new index for evaluating at-risk elderly medical patients","volume":"82","author":"Bouillanne","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"846659","DOI":"10.3389\/fnut.2022.846659","article-title":"Association of Four Nutritional Scores with All-Cause and Cardiovascular Mortality in the General Population","volume":"9","author":"Fan","year":"2022","journal-title":"Front. Nutr."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Cheng, Z., He, S., Hu, C., Wang, L., Zhang, L., Tao, Y., Sun, L., and Chen, Z. (2026). Analysis of the correlation and predictive performance of GNRI, CONUT, and PNI with MAFLD in Chinese adult physical examination population. Front. Nutr., 13.","DOI":"10.3389\/fnut.2026.1726212"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Liu, J., Wang, P., Shang, L., Ye, F., Liu, L., and He, Z. (2024). Adverse Associations of Long-Term Exposure to PM2.5 and Its Components with Platelet Traits among Subway Shift-Workers without Air Purifier Use. Toxics, 12.","DOI":"10.3390\/toxics12080529"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1249\/MSS.0b013e31821ece12","article-title":"2011 Compendium of Physical Activities: A second update of codes and MET values","volume":"43","author":"Ainsworth","year":"2011","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/j.socscimed.2009.01.035","article-title":"Why have physical activity levels declined among Chinese adults? Findings from the 1991\u20132006 China Health and Nutrition Surveys","volume":"68","author":"Ng","year":"2009","journal-title":"Soc. Sci. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"105459","DOI":"10.1016\/j.envint.2020.105459","article-title":"Long-term exposure to ambient air pollution attenuated the association of physical activity with metabolic syndrome in rural Chinese adults: A cross-sectional study","volume":"136","author":"Hou","year":"2020","journal-title":"Environ. Int."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"16517","DOI":"10.1021\/acs.est.2c06510","article-title":"Tracking Daily Concentrations of PM2.5 Chemical Composition in China since 2000","volume":"56","author":"Liu","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"9187","DOI":"10.5194\/acp-17-9187-2017","article-title":"Chemical composition of ambient PM2.5 over China and relationship to precursor emissions during 2005\u20132012","volume":"17","author":"Geng","year":"2017","journal-title":"Atmos. Chem. Phys."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"111","DOI":"10.2337\/dc22-1585","article-title":"Long-term Exposure to Ambient PM2.5 and Its Components Associated with Diabetes: Evidence From a Large Population-Based Cohort From China","volume":"46","author":"Li","year":"2023","journal-title":"Diabetes Care"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1681\/ASN.2006040368","article-title":"Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease","volume":"17","author":"Ma","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"113851","DOI":"10.1016\/j.ecoenv.2022.113851","article-title":"Associations between long-term exposure to ambient air pollution and renal function in Southwest China: The China Multi-Ethnic Cohort (CMEC) study","volume":"242","author":"Li","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1136\/bjsports-2019-100989","article-title":"Habitual physical activity, renal function and chronic kidney disease: A cohort study of nearly 200 000 adults","volume":"54","author":"Guo","year":"2020","journal-title":"Br. J. Sports Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"122841","DOI":"10.1016\/j.envres.2025.122841","article-title":"Association between ambient air pollution and renal function indicators: A comprehensive systematic review and meta-analysis","volume":"286","author":"Li","year":"2025","journal-title":"Environ. Res."},{"key":"ref_44","first-page":"36","article-title":"Association of long-term exposure to ambient PM2.5 with renal function","volume":"14","author":"Xie","year":"2024","journal-title":"J. Environ. Hyg."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"121607","DOI":"10.1016\/j.envres.2025.121607","article-title":"Associations of long-term exposure to PM2.5 and its constituents with children renal function: A national retrospective study in China","volume":"278","author":"Yu","year":"2025","journal-title":"Environ. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"109325","DOI":"10.1016\/j.envint.2025.109325","article-title":"Are metals in exhaled breath condensate and urine associated with oxidative\/nitrosative stress and metabolism-related biomarkers? Results from 303 randomly selected Parisian subway workers","volume":"196","author":"Sauvain","year":"2025","journal-title":"Environ. Int."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"113837","DOI":"10.1016\/j.ijheh.2021.113837","article-title":"Particle and metal exposure in Parisian subway: Relationship between exposure biomarkers in air, exhaled breath condensate, and urine","volume":"237","author":"Hemmendinger","year":"2021","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"163181","DOI":"10.1016\/j.scitotenv.2023.163181","article-title":"Inhalation of subway fine particles induces murine extrapulmonary organs damage","volume":"878","author":"Wang","year":"2023","journal-title":"Sci. Total Environ."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1681\/ASN.2017030253","article-title":"Particulate Matter Air Pollution and the Risk of Incident CKD and Progression to ESRD","volume":"29","author":"Bowe","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"110867","DOI":"10.1016\/j.envres.2021.110867","article-title":"Ambient air pollution exposure and risk of chronic kidney disease: A systematic review of the literature and meta-analysis","volume":"195","author":"Ye","year":"2021","journal-title":"Environ. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.kint.2024.04.021","article-title":"Environmental pollution to kidney disease: An updated review of current knowledge and future directions","volume":"106","author":"Lao","year":"2024","journal-title":"Kidney Int."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"101545","DOI":"10.1016\/j.redox.2020.101545","article-title":"Oxidative stress pathways of air pollution mediated toxicity: Recent insights","volume":"34","author":"Gangwar","year":"2020","journal-title":"Redox Biol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"111028","DOI":"10.1016\/j.cbi.2024.111028","article-title":"Mild hyperhomocysteinemia alters oxidative stress profile via Nrf2, inflammation and cholinesterases in cardiovascular system of aged male rats","volume":"396","author":"Prauchner","year":"2024","journal-title":"Chem. Biol. Interact."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1053\/j.jrn.2025.12.006","article-title":"Protein-Energy Wasting Among Patients with Nondialysis Chronic Kidney Disease: Comparing ISRNM and GLIM Criteria with Malnutrition Inflammation Score","volume":"36","author":"Lin","year":"2026","journal-title":"J. Ren. Nutr."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3920\/BM2018.0060","article-title":"Probiotic Bifidobacterium lactis, anti-oxidant vitamin E\/C and anti-inflammatory dha attenuate lung inflammation due to PM2.5 exposure in mice","volume":"10","author":"Panebianco","year":"2019","journal-title":"Benef. Microbes"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"115492","DOI":"10.1016\/j.ecoenv.2023.115492","article-title":"Long-term air pollution exposure, habitual physical activity, and incident chronic kidney disease","volume":"265","author":"Li","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"113791","DOI":"10.1016\/j.ijheh.2021.113791","article-title":"Combined effects of chronic PM2.5 exposure and habitual exercise on renal function and chronic kidney disease: A longitudinal cohort study","volume":"236","author":"Zeng","year":"2021","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1515\/jtim-2026-0027","article-title":"Exercise may serve as a potential preventive strategy for mitochondria influencing the occurrence of heart failure with preserved ejection fraction","volume":"14","author":"Zheng","year":"2026","journal-title":"J. Transl. Int. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"140721","DOI":"10.1016\/j.jhazmat.2025.140721","article-title":"Microplastics bound to fine particulate matter in subway air: A pathway for toxic metal transport to enhanced carcinogenicity in human lungs","volume":"501","author":"Roy","year":"2026","journal-title":"J. Hazard. Mater."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"105188","DOI":"10.1016\/j.envint.2019.105188","article-title":"PM2.5 on the London Underground","volume":"134","author":"Smith","year":"2020","journal-title":"Environ. Int."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.jhazmat.2019.05.091","article-title":"Effect of platform subway depth on the presence of Airborne PM2.5, metals, and toxic organic species","volume":"377","year":"2019","journal-title":"J. Hazard. Mater."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1177\/0748233717693547","article-title":"Investigation of air pollution of Shanghai subway stations in ventilation seasons in terms of PM2.5 and PM10","volume":"33","author":"Guo","year":"2017","journal-title":"Toxicol. Ind. Health"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/15\/2580\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T08:14:05Z","timestamp":1786090445000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/15\/2580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,6]]},"references-count":62,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["nu18152580"],"URL":"https:\/\/doi.org\/10.3390\/nu18152580","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,6]]}}}