{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T05:27:04Z","timestamp":1786512424568,"version":"build-2736575974"},"reference-count":62,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001738","name":"Ministry of Innovation, Science and Technology","doi-asserted-by":"publisher","award":["#1001951663."],"award-info":[{"award-number":["#1001951663."]}],"id":[{"id":"10.13039\/501100001738","id-type":"DOI","asserted-by":"publisher"}]},{"award":["#1001951663."],"award-info":[{"award-number":["#1001951663."]}],"id":[{"id":"https:\/\/ror.org\/02heb2n75","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Individual responses to weight-loss diets vary widely due to genetic, metabolic, and lifestyle factors, motivating individualized approaches over \u201cone-size-fits-all\u201d advice. We aimed to evaluate long-term (12-month) weight loss, weight maintenance, and cardiometabolic outcomes of a cohort following a nutrigenetically tailored Mediterranean-style dietary program in a real-world, community setting. Methods: The retrospective data cohort included 426 Israeli adults (mean BMI 32.11 \u00b1 4.58 kg\/m2; 66.9% women) who participated in a nutrigenetic weight-loss program. Following nutrigenetic direct-to-consumer screening of 425 genetic variants, the participants received a 3-month personalized adjusted diet with remote dietitian-led follow-up by telephone, after which they transitioned to a 9-month self-monitoring and maintenance period. Blood biochemical parameters were reported from routine Health Maintenance Organization (HMO) laboratory testing. Weight\/BMI trajectories (0\u20133, 3\u20136, 6\u20139, 9\u201312 months) were evaluated using linear mixed-effects models; biomarker changes were analyzed with repeated-measures MANOVA and follow-up univariate ANOVAs. Results: Model-estimated cumulative weight loss at 12 months was 10.12 kg (11.4% of baseline) with a mean BMI reduction of 3.68 kg\/m2 (p &lt; 0.001). The steepest decline occurred during months 3\u20136 (\u22121.13 kg\/month). Triglycerides (\u221214.06 mg\/dL), total cholesterol (\u22124.68 mg\/dL), LDL cholesterol (\u22122.49 mg\/dL), fasting glucose (\u22125.14 mg\/dL), and HbA1c (\u22120.14%) improved significantly (p &lt; 0.05), while HDL cholesterol levels remained stable (+0.86 mg\/dL; p &gt; 0.05) at 12 months. Among participants with elevated baseline biochemical values, levels transitioned to normal range by 12-month follow-up for triglycerides (46.4%), total cholesterol (29.4%), LDL cholesterol (34.5%), glucose (39.6%), and HbA1c (35.5%). Conclusions: In a real-world cohort, inclusion of genetic information to personalize dietary guidance was implemented through a flexible, individually tailored program supported by an initial 3-month phase of remote dietitian-led counseling. This approach was associated with durable, clinically meaningful reductions in weight and cardiometabolic risk markers over 12 months. Randomized trials are warranted to confirm causality and evaluate cost-effectiveness.<\/jats:p>","DOI":"10.3390\/nu18162618","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T16:35:16Z","timestamp":1786379716000},"page":"2618","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nutrigenetic Tailored Diet Results in Long-Term (12 Months) Weight-Loss Compliance and Improved Cardiometabolic Outcomes in a Real-World Community-Based Setting"],"prefix":"10.3390","volume":"18","author":[{"given":"Mor","family":"Bensimhon","sequence":"first","affiliation":[{"name":"Nutrition Department, Health Science Faculty, Ariel University, Ariel 40700, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1053-9478","authenticated-orcid":false,"given":"Alice H.","family":"Lichtenstein","sequence":"additional","affiliation":[{"name":"Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5770-4277","authenticated-orcid":false,"given":"Ruth","family":"Birk","sequence":"additional","affiliation":[{"name":"Nutrition Department, Health Science Faculty, Ariel University, Ariel 40700, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Lin, X., and Li, H. 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