{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T08:31:56Z","timestamp":1786437116672,"version":"build-2736575974"},"reference-count":31,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Nutrisens Spain","award":["DON24\/0015"],"award-info":[{"award-number":["DON24\/0015"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: This study evaluated whether phase angle (PhA) was associated more strongly with nutritional and functional vulnerability than with postoperative morbidity. Methods: This cohort included 207 adults undergoing colorectal cancer surgery. Primary outcomes were malnutrition defined according to the Global Leadership Initiative on Malnutrition (GLIM) criteria, low handgrip strength and impaired Short Physical Performance Battery (SPPB) scores; postoperative complications, readmissions and length of stay were exploratory outcomes. PhA was measured by 50 kHz bioelectrical impedance vector analysis. Analyses estimated areas under the curve (AUCs) with 95% confidence intervals and Youden cut-offs; models adjusted for age, sex and body mass index. Results: PhA was lower in participants with nutritional vulnerability than in those without it (4.57 \u00b1 0.62\u00b0 vs. 5.20 \u00b1 0.69\u00b0; p &lt; 0.001). Discrimination was excellent for handgrip strength &lt;10th percentile (AUC 0.803) and acceptable for SPPB &lt; 10 (AUC 0.785), SPPB \u2264 6 (AUC 0.761) and GLIM-defined malnutrition (AUC 0.728) but showed no discrimination for any postoperative complication (AUC 0.507). After adjustment, PhA \u2264 4.7\u00b0 remained associated with GLIM-defined malnutrition, handgrip strength &lt; 10th percentile and SPPB &lt; 10 but not with any postoperative complication. Conclusions: PhA was more strongly associated with nutritional and functional vulnerability than with postoperative morbidity. Thresholds require external validation; PhA may complement, not replace, GLIM, body composition, handgrip strength and SPPB.<\/jats:p>","DOI":"10.3390\/nu18162619","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T08:09:36Z","timestamp":1786435776000},"page":"2619","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preoperative Phase Angle as a Marker of Nutritional and Functional Vulnerability in Patients Undergoing Colorectal Cancer Surgery: A Prospective Observational Cohort Study"],"prefix":"10.3390","volume":"18","author":[{"given":"David","family":"S\u00e1nchez-Relinque","sequence":"first","affiliation":[{"name":"Unit of General and Digestive Surgery, Punta de Europa University Hospital, 11207 Algeciras, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0404-4863","authenticated-orcid":false,"given":"Alejandro","family":"Garc\u00eda-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Biomedical Research and Innovation Institute of C\u00e1diz (INiBICA), Puerta del Mar University Hospital, 11009 C\u00e1diz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Eugenia","family":"Valenzuela-Mateos","sequence":"additional","affiliation":[{"name":"Unit of General and Digestive Surgery, Punta de Europa University Hospital, 11207 Algeciras, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jara","family":"D\u00edaz-Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Department of Didactics of Physical, Plastic and Musical Education, University of C\u00e1diz, 11519 Puerto Real, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6590-8922","authenticated-orcid":false,"given":"\u00c1lvaro","family":"Zambrano-Rico","sequence":"additional","affiliation":[{"name":"Department of Nursing and Physiotherapy, University of C\u00e1diz, 11009 C\u00e1diz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1598-7728","authenticated-orcid":false,"given":"Mar\u00eda Jos\u00e9 M.","family":"Alf\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Physiology, Institute of Nutrition and Food Technology Jos\u00e9 Mataix, University of Granada, 18071 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"S\u00e1nchez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Unit of General and Digestive Surgery, Punta de Europa University Hospital, 11207 Algeciras, Spain"},{"name":"Biomedical Research and Innovation Institute of C\u00e1diz (INiBICA), Puerta del Mar University Hospital, 11009 C\u00e1diz, Spain"},{"name":"Department of Nursing and Physiotherapy, University of C\u00e1diz, 11009 C\u00e1diz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"109397","DOI":"10.1016\/j.surg.2025.109397","article-title":"Guidelines for perioperative care in elective colorectal surgery: Enhanced Recovery After Surgery (ERAS) Society recommendations 2025","volume":"184","author":"Gustafsson","year":"2025","journal-title":"Surgery"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1001\/jamasurg.2023.0198","article-title":"Effect of multimodal prehabilitation on reducing postoperative complications and enhancing functional capacity following colorectal cancer surgery: The PREHAB randomized clinical trial","volume":"158","author":"Molenaar","year":"2023","journal-title":"JAMA Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4745","DOI":"10.1016\/j.clnu.2021.03.031","article-title":"ESPEN practical guideline: Clinical nutrition in surgery","volume":"40","author":"Weimann","year":"2021","journal-title":"Clin. 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