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Methods: Biochemical parameters (cholesterol, HDL, LDL, triglycerides, creatinine, blood urea nitrogen, AST, ALT, and albumin) from all groups of experimental rats were analyzed. Histopathological analysis was also performed on the kidney, liver, and pancreatic tissues. Results: The results showed that administration of ME (1.84 mg total phenolics from ME\/kg BW) was able to prevent serum biochemical changes that are indicators of metabolic disorders and organ tissue damage due to hyperglycemia. ME significantly reduced LDL (31.85%), creatinine (13.78%), AST (58.97%), and ALT (60.04%) levels in hyperglycemic rats. ME also showed promising performance in protecting the kidney and liver from damage due to hyperglycemia. Conclusions: The findings in this study emphasize the potential of ME to be used as a therapeutic agent and functional ingredient.<\/jats:p>","DOI":"10.3390\/nu18162686","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T08:08:41Z","timestamp":1787040521000},"page":"2686","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum Biochemistry and Histopathological Profiles of Normoglycemic and Streptozotozin-Induced Hyperglycemic Rats Treated with Mace Water Extract from Myristica fragrans Houtt"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7455-8638","authenticated-orcid":false,"family":"Hasbullah","sequence":"first","affiliation":[{"name":"Faculty of Agriculture, Khairun University, Ternate 97719, North Maluku, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7908-7879","authenticated-orcid":false,"given":"Fitriya","family":"Dewi","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and Biomedical Science, IPB University, Bogor 16680, West Java, Indonesia"},{"name":"Primate Research Center, IPB University, Bogor 16680, West Java, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didah","family":"Faridah","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology, Faculty of Agricultural Technology, IPB University, IPB Dramaga Campus, Bogor 16680, West Java, Indonesia"},{"name":"Southeast Asian Food and Agricultural Science and Technology (SEAFAST) Center, IPB University, IPB Dramaga Campus, Bogor 16680, West Java, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9087-4160","authenticated-orcid":false,"given":"Dias","family":"Indrasti","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology, Faculty of Agricultural Technology, IPB University, IPB Dramaga Campus, Bogor 16680, West Java, Indonesia"},{"name":"Southeast Asian Food and Agricultural Science and Technology (SEAFAST) Center, IPB University, IPB Dramaga Campus, Bogor 16680, West Java, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9528-4932","authenticated-orcid":false,"given":"Silvia","family":"Prabandari","sequence":"additional","affiliation":[{"name":"Primate Research Center, IPB University, Bogor 16680, West Java, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0065-6283","authenticated-orcid":false,"given":"Nuri","family":"Andarwulan","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology, Faculty of Agricultural Technology, IPB University, IPB Dramaga Campus, Bogor 16680, West Java, Indonesia"},{"name":"Southeast Asian Food and Agricultural Science and Technology (SEAFAST) Center, IPB University, IPB Dramaga Campus, Bogor 16680, West Java, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8143-2918","authenticated-orcid":false,"given":"Dominika","family":"\u015arednicka-Tober","sequence":"additional","affiliation":[{"name":"Department of Functional and Organic Food, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences, Nowoursynowska 159c, 02-776 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"American Diabetes Association (2010). 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