{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:54:30Z","timestamp":1787072070867,"version":"build-2736575974"},"reference-count":46,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Introduction: Lifestyle interventions are a fundamental component of type 2 diabetes mellitus management; however, evidence from real-world clinical settings regarding multicomponent interventions that simultaneously evaluate behavioral, metabolic, and anthropometric outcomes remains limited. Objective: To evaluate the effect of a multicomponent lifestyle intervention program on dietary habits, biochemical parameters, physical activity, and anthropometric indicators in adults with type 2 diabetes mellitus in the Peruvian Amazon. Methods: A quasi-experimental study with a non-randomized control group and pre\u2013post assessments was conducted among 144 adults with type 2 diabetes mellitus (72 in the intervention group and 72 in the control group) receiving care at a hospital in the Peruvian Amazon. The three-month intervention included nutrition education sessions, practical workshops, group-based physical activity sessions involving traditional dance and Zumba, home visits, and follow-up through telephone calls and WhatsApp. Dietary habits, fasting blood glucose (FBG), glycated hemoglobin (HbA1c), lipid profile, physical activity (PA), body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR) were assessed. Intervention effects were estimated using linear mixed-effects regression models adjusted for age, sex, and disease duration. Results: Compared with the control group, participants receiving the intervention experienced greater improvements in dietary habits (\u03b2 = 17.85; 95% CI: 16.80 to 18.89; p &lt; 0.001), together with greater reductions in FBG (\u03b2 = \u221284.23 mg\/dL; 95% CI: \u2212100.45 to \u221268.01; p &lt; 0.001) and HbA1c (\u03b2 = \u22122.32 percentage points; 95% CI: \u22122.74 to \u22121.90; p &lt; 0.001). Greater reductions were also observed in triglycerides (\u03b2 = \u221253.68 mg\/dL), total cholesterol (\u03b2 = \u221231.73 mg\/dL), BMI (\u03b2 = \u22121.67 kg\/m2), WC (\u03b2 = \u22125.31 cm), and WHtR (\u03b2 = \u22120.034) (all p &lt; file0.001). PA increased to a greater extent among participants receiving the intervention (\u03b2 = 3015.40 MET-min\/week; 95% CI: 2769.81 to 3260.99; p &lt; 0.001), whereas no significant between-group difference in change was observed for serum creatinine (p = 0.075). Conclusions: Participation in a three-month multicomponent lifestyle intervention was associated with greater improvements in dietary habits, physical activity, glycemic control, lipid profile, and anthropometric indicators compared with usual care among adults with type 2 diabetes mellitus in the Peruvian Amazon.<\/jats:p>","DOI":"10.3390\/nu18162699","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:12:11Z","timestamp":1787069531000},"page":"2699","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of a Multicomponent Lifestyle Intervention on Behavioral and Cardiometabolic Outcomes in Adults with Type 2 Diabetes Mellitus in the Peruvian Amazon"],"prefix":"10.3390","volume":"18","author":[{"given":"M\u00f3nica Yenji","family":"Chia S\u00e1nchez","sequence":"first","affiliation":[{"name":"Departamento de Ciencia y Tecnolog\u00eda de Alimentos, Facultad de Industrias Alimentarias, Universidad Nacional de la Amazon\u00eda Peruana, Iquitos 16001, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5228-4370","authenticated-orcid":false,"given":"Alexander Javier","family":"Iman Torres","sequence":"additional","affiliation":[{"name":"Departamento de Ciencia y Tecnolog\u00eda de Alimentos, Facultad de Industrias Alimentarias, Universidad Nacional de la Amazon\u00eda Peruana, Iquitos 16001, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7047-9964","authenticated-orcid":false,"given":"Wilson","family":"Guerra Sangama","sequence":"additional","affiliation":[{"name":"Departamento de Ingenier\u00eda de Alimentos, Facultad de Industrias Alimentarias, Universidad Nacional de la Amazon\u00eda Peruana, Iquitos 16001, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Antonio","family":"Li Loo Kung","sequence":"additional","affiliation":[{"name":"Departamento de Ingenier\u00eda de Alimentos, Facultad de Industrias Alimentarias, Universidad Nacional de la Amazon\u00eda Peruana, Iquitos 16001, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susy Karina","family":"D\u00e1vila Panduro","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Sociales, Facultad de Ciencias de la Educaci\u00f3n y Humanidades, Universidad Nacional de la Amazon\u00eda Peruana, Iquitos 16000, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Huaman Gutierrez","sequence":"additional","affiliation":[{"name":"Carrera de Nutrici\u00f3n Humana, Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima 15001, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7239-960X","authenticated-orcid":false,"given":"Antonio","family":"Castillo-Paredes","sequence":"additional","affiliation":[{"name":"Grupo AFySE, Investigaci\u00f3n en Actividad F\u00edsica y Salud Escolar, Escuela de Pedagog\u00eda en Educaci\u00f3n F\u00edsica, Facultad de Educaci\u00f3n, Universidad de Las Am\u00e9ricas, Santiago 8370040, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0774-606X","authenticated-orcid":false,"given":"Jose Jairo","family":"Narrea Vargas","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Nutrici\u00f3n, Metabolismo y Ejercicio, Carrera de Nutrici\u00f3n y Diet\u00e9tica, Facultad de Ciencias de la Salud, Universidad Cient\u00edfica del Sur, Lima 15067, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00508-022-02122-y","article-title":"Diabetes Mellitus\u2014Definition, Classification, Diagnosis, Screening and Prevention (Update 2023)","volume":"135","author":"Harreiter","year":"2023","journal-title":"Wien. 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