{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T13:29:34Z","timestamp":1787232574359,"version":"build-2736575974"},"reference-count":30,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Kidney transplantation is associated with profound metabolic and nutritional changes, particularly across different post-transplant periods. This study aimed to evaluate differences in nutritional status, dietary intake, and immunosuppressive therapy between recipients in the early and late post-transplant period. Materials and Methods: This cross-sectional pilot study presents an analysis of baseline data obtained from a prospective cohort of 38 kidney transplant recipients divided into early (\u22641 year post-transplantation; n = 15) and late (&gt;1 year post-transplantation; n = 23) post-transplant groups. Nutritional status was assessed using anthropometric and laboratory measurements, bioelectrical impedance analysis (BIA), and Nutritional Risk Screening 2002 (NRS-2002). Dietary intake was assessed using the Food Frequency Questionnaire-6 (FFQ-6) and a 3-day dietary record. Information regarding immunosuppressive therapy was obtained from medical records and verified at routine clinic visits. Results: The groups did not differ significantly with respect to sociodemographic characteristics, comorbidities, anthropometric measurements, body composition, and nutritional risk. No significant differences were observed in body weight, body mass index (BMI), body composition parameters, or most laboratory measurements. Early post-transplant recipients exhibited significantly higher non-high-density lipoprotein (non-HDL) cholesterol concentrations (153.3 \u00b1 37.5 vs. 111.1 \u00b1 50.8 mg\/dL; p = 0.040), higher tacrolimus trough concentrations (11.2 \u00b1 5.2 vs. 4.6 \u00b1 1.1 ng\/mL; p = 0.0001), and lower serum magnesium concentrations (1.64 \u00b1 0.13 vs. 1.94 \u00b1 0.15 mg\/dL; p = 0.009) than late post-transplant recipients. No statistically significant differences were observed for most assessed dietary habits, except for the more frequent addition of sugar to beverages among the early post-transplant group (p = 0.048). Qualitative assessment of 3-day dietary records showed a tendency toward more regular meals and greater dietary variety among early post-transplant recipients. This group also received significantly higher tacrolimus trough concentrations and higher prednisone-equivalent and mycophenolate doses than recipients in the late post-transplant period. Conclusions: In this pilot study, the observed differences between early and late post-transplant recipients concerned primarily immunosuppressive exposure and selected metabolic parameters, while no statistically significant differences were identified for most measures of nutritional status or dietary intake. Given the small sample size and the exploratory nature of the study, these findings should be considered preliminary and hypothesis-generating rather than confirmatory. Larger, adequately powered prospective studies are needed to validate these observations and further evaluate nutritional and metabolic changes across the post-transplant course.<\/jats:p>","DOI":"10.3390\/nu18162725","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T12:57:53Z","timestamp":1787230673000},"page":"2725","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nutritional Status, Dietary Intake and Immunosuppressive Therapy in Kidney Transplant Recipients: Differences Between Early and Late Post-Transplant Period\u2014A Cross-Sectional Pilot Study"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0830-0406","authenticated-orcid":false,"given":"Aleksandra Anna","family":"Kajdas","sequence":"first","affiliation":[{"name":"Department of Clinical Dietetics, Medical University of Warsaw, Erazma Ciolka 27, 01-445 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5265-8176","authenticated-orcid":false,"given":"Dorota","family":"Szostak-W\u0119gierek","sequence":"additional","affiliation":[{"name":"Department of Clinical Dietetics, Medical University of Warsaw, Erazma Ciolka 27, 01-445 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Krasuski","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics and Telemedicine, Medical University of Warsaw, Litewska 14\/16, 00-581 Warsaw, Poland"},{"name":"Faculty of Mathematics and Informatics Science, Warsaw University of Technology, Koszykowa 75, 00-662 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota","family":"Miszewska-Szyszkowska","sequence":"additional","affiliation":[{"name":"Department of Transplantology, Immunology, Nephrology and Internal Diseases, Medical University of Warsaw, Nowogrodzka 59, 02-014 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4798-1497","authenticated-orcid":false,"given":"Magdalena","family":"Durlik","sequence":"additional","affiliation":[{"name":"Department of Transplantology, Immunology, Nephrology and Internal Diseases, Medical University of Warsaw, Nowogrodzka 59, 02-014 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1111\/j.1600-6143.2011.03686.x","article-title":"Systematic review: Kidney transplantation compared with dialysis in clinically relevant outcomes","volume":"11","author":"Tonelli","year":"2011","journal-title":"Am. J. Transplant."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1053\/j.jrn.2013.01.001","article-title":"Etiology of the protein-energy wasting syndrome in chronic kidney disease: A consensus statement from the International Society of Renal Nutrition and Metabolism (ISRNM)","volume":"23","author":"Carrero","year":"2013","journal-title":"J. Ren. Nutr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1097\/MNH.0b013e3282f5dbce","article-title":"Nutrition, inflammation and chronic kidney disease","volume":"17","author":"Ikizler","year":"2008","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1053\/j.ajkd.2010.01.017","article-title":"Obesity in kidney transplant recipients and candidates","volume":"56","author":"Potluri","year":"2010","journal-title":"Am. J. Kidney Dis."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"G\u00f3rska, M., and Kurnatowska, I. (2022). Nutrition Disturbances and Metabolic Complications in Kidney Transplant Recipients: Etiology, Methods of Assessment and Prevention\u2014A Review. Nutrients, 14.","DOI":"10.3390\/nu14234996"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1093\/ndt\/gfad258","article-title":"International consensus on post-transplantation diabetes mellitus","volume":"39","author":"Sharif","year":"2024","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_7","first-page":"CD003961","article-title":"Tacrolimus versus cyclosporin as primary immunosuppression for kidney transplant recipients","volume":"4","author":"Webster","year":"2005","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.2215\/CJN.13440820","article-title":"Introduction to Kidney Transplantation: Long-Term Management Challenges","volume":"16","author":"Sawinski","year":"2021","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1053\/j.ajkd.2020.05.006","article-title":"KDOQI clinical practice guideline for nutrition in CKD: 2020 update","volume":"76","author":"Ikizler","year":"2020","journal-title":"Am. J. Kidney Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.2337\/dc19-0224","article-title":"Fruit and Vegetable Intake and Risk of Posttransplantation Diabetes in Renal Transplant Recipients","volume":"42","author":"Sotomayor","year":"2019","journal-title":"Diabetes Care"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1016\/j.transproceed.2012.07.041","article-title":"Nutritional status and body composition in patients early after renal transplantation","volume":"44","author":"Netto","year":"2012","journal-title":"Transplant. Proc."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"62","DOI":"10.7182\/pit2012888","article-title":"Characterizing dietary intake and physical activity affecting weight gain in kidney transplant recipients","volume":"22","author":"Cupples","year":"2012","journal-title":"Prog. Transplant."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Nolte Fong, J.V., and Moore, L.W. (2018). Nutrition Trends in Kidney Transplant Recipients: The Importance of Dietary Monitoring and Need for Evidence-Based Recommendations. Front. Med., 5.","DOI":"10.3389\/fmed.2018.00302"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"von Elm, E., Altman, D.G., Egger, M., Pocock, S.J., G\u00f8tzsche, P.C., Vandenbroucke, J.P. (2007). The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: Guidelines for Reporting Observational Studies. PLoS Med., 4.","DOI":"10.1371\/journal.pmed.0040296"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1007\/s40620-019-00602-5","article-title":"Prevention of complications from use of conventional immunosuppressants: A critical review","volume":"32","author":"Ponticelli","year":"2019","journal-title":"J. Nephrol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1053\/j.akdh.2024.05.001","article-title":"Immunosuppression in Kidney Transplant Recipients: An Update for the General Nephrologist","volume":"31","author":"Me","year":"2024","journal-title":"Adv. Kidney Dis. Health"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0261-5614(02)00214-5","article-title":"Nutritional Risk Screening (NRS 2002): A New Method Based on an Analysis of Controlled Clinical Trials","volume":"22","author":"Kondrup","year":"2003","journal-title":"Clin. Nutr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1177\/0148607111414023","article-title":"Nutrition screening tools: An analysis of the evidence","volume":"36","author":"Skipper","year":"2012","journal-title":"JPEN J. Parenter. Enter. Nutr."},{"key":"ref_19","unstructured":"W\u0105do\u0142owska, L. (2005). Walidacja Kwestionariusza Cz\u0119stotliwo\u015bci Spo\u017cycia \u017bywno\u015bci FFQ. Ocena Powtarzalno\u015bci [Validation of Food Frequency Questionnaire FFQ. Reproducibility Assessment], Wydawnictwo Uniwersytetu Warmi\u0144sko-Mazurskiego."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Nied\u017awiedzka, E., W\u0105do\u0142owska, L., and Kowalkowska, J. (2019). Reproducibility of a non-quantitative food frequency questionnaire (62-item FFQ-6) and PCA-driven dietary pattern identification in 13\u201321-year-old females. Nutrients, 11.","DOI":"10.3390\/nu11092183"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1097\/00007890-199310000-00008","article-title":"Factors influencing weight gain after renal transplantation","volume":"56","author":"Johnson","year":"1993","journal-title":"Transplantation"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"11107","DOI":"10.3389\/ti.2023.11107","article-title":"Obesity is associated with delayed graft function in kidney transplant recipients: A paired kidney analysis","volume":"36","author":"Shi","year":"2023","journal-title":"Transpl. Int."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/jcsm.13130","article-title":"Diagnosis, prevalence, and outcomes of sarcopenia in kidney transplantation recipients: A systematic review and meta-analysis","volume":"14","author":"Zhang","year":"2023","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1016\/j.clnu.2024.08.002","article-title":"ESPEN practical guideline on clinical nutrition in hospitalized patients with acute or chronic kidney disease","volume":"43","author":"Sabatino","year":"2024","journal-title":"Clin. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Gandolfini, I., Regolisti, G., Bazzocchi, A., Maggiore, U., Palmisano, A., Piotti, G., Fiaccadori, E., and Sabatino, A. (2019). Frailty and Sarcopenia in Older Patients Receiving Kidney Transplantation. Front. Nutr., 6.","DOI":"10.3389\/fnut.2019.00169"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Soukouli, I., Karagkounis, T., Mylonas, K.S., Kalathas, T., Poulia, K.A., Kokkinos, A., and Marinaki, S. (2025). Biomarkers of sarcopenia and sarcopenic obesity in renal transplant recipients: A systematic review and evidence quality assessment. J. Clin. Med., 14.","DOI":"10.3390\/jcm14248943"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.asjsur.2025.09.040","article-title":"Prevalence and risk factors of sarcopenia in patients after kidney transplantation: An updated systematic review and meta-analysis","volume":"49","author":"Su","year":"2026","journal-title":"Asian J. Surg."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Alajous, S., and Budhiraja, P. (2024). New-Onset Diabetes Mellitus after Kidney Transplantation. J. Clin. Med., 13.","DOI":"10.20944\/preprints202402.0314.v1"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1681\/ASN.2015040391","article-title":"Hypomagnesemia and the Risk of New-Onset Diabetes Mellitus after Kidney Transplantation","volume":"27","author":"Huang","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Kajdas, A.A., Kleibert, M., Normann, A.K., Krasuski, K., Linde, D.S., and Szostak-W\u0119gierek, D. (2025). Immunosuppressive therapy and nutritional diseases of patients after kidney transplantation: A systematic review. 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