{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T05:16:46Z","timestamp":1788239806738,"version":"build-2803163510"},"reference-count":164,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005891","name":"State Administration of Traditional Chinese Medicine of the People\u2019s Republic of China","doi-asserted-by":"crossref","award":["GZYYBRJH [2022] No. 245"],"award-info":[{"award-number":["GZYYBRJH [2022] No. 245"]}],"id":[{"id":"10.13039\/501100005891","id-type":"DOI","asserted-by":"crossref"}]},{"award":["GZYYBRJH [2022] No. 245"],"award-info":[{"award-number":["GZYYBRJH [2022] No. 245"]}],"id":[{"id":"https:\/\/ror.org\/003cpqh10","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Guizhou Provincial Science and Technology Innovation Leading Talent","award":["QKHRC-RX [2026]014"],"award-info":[{"award-number":["QKHRC-RX [2026]014"]}]},{"name":"Guizhou University of Traditional Chinese Medicine","award":["GZYZX [2024] No. 013"],"award-info":[{"award-number":["GZYZX [2024] No. 013"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Polyendocrine metabolic ovarian syndrome (PMOS), renamed from polycystic ovary syndrome (PCOS) by global consensus in May 2026, is one of the most common endocrine diseases in women of reproductive age, affecting physical and mental health. Growing evidence suggests that medicine\u2013food homology (MFH) plants and their bioactive compounds may help regulate PMOS-related metabolism and reproductive abnormalities through dietary intervention. This review summarizes their reported roles and potential mechanisms. Based on the existing literature, this review presents nine edible plant resources identified under the MFH\/dietary-use framework and 21 bioactive constituents or constituent classes, all selected for detailed synthesis from a broader eligible evidence base and with reported PMOS-related bioactivity. Across preclinical studies, these constituents appear to act through convergent, multi-target mechanisms, including anti-inflammatory and antioxidant activities to reduce systemic inflammation, as well as restoring hormone balance, correcting abnormal lipid metabolism, relieving insulin resistance and protecting ovarian function. Importantly, the evidence base remains predominantly preclinical, with few human randomized trials. Key translational barriers include insufficient standardization of preparations and doses, limited oral bioavailability of several constituents, safety and herb\u2013drug interaction concerns, and uncertain formulation feasibility for functional-food applications. By integrating evidence at the plant and compound levels, this review provides a mechanistic rationale\u2014rather than clinical proof\u2014for further investigation of dietary strategies relevant to PMOS and proposes a framework for the development and evaluation of MFH-based functional foods.<\/jats:p>","DOI":"10.3390\/nu18172837","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T04:24:03Z","timestamp":1788150243000},"page":"2837","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Medicine\u2013Food Homology Plants and Bioactive Compounds in Polyendocrine Metabolic Ovarian Syndrome: Multi-Target Mechanisms and Functional Food Potential\u2014A Review"],"prefix":"10.3390","volume":"18","author":[{"given":"Qiuni","family":"Yang","sequence":"first","affiliation":[{"name":"The Second Clinical Medical College, Guizhou University of Traditional Chinese Medicine, Guiyang 550002, China"},{"name":"Yuni Township Health Centre, Panzhou 553523, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linzuo","family":"Zou","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical College, Guizhou University of Traditional Chinese Medicine, Guiyang 550002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxue","family":"Huang","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical College, Guizhou University of Traditional Chinese Medicine, Guiyang 550002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical College, Guizhou University of Traditional Chinese Medicine, Guiyang 550002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyao","family":"He","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical College, Guizhou University of Traditional Chinese Medicine, Guiyang 550002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Cheng","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical College, Guizhou University of Traditional Chinese Medicine, Guiyang 550002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Research Center for Quality Control of Natural Medicine, Guizhou Normal University, Guiyang 550001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1016\/S0140-6736(26)00717-8","article-title":"Polyendocrine metabolic ovarian syndrome, the new name for polycystic ovary syndrome: A multistep global consensus process","volume":"407","author":"Teede","year":"2026","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.ebiom.2018.09.046","article-title":"Erythropoietin-Producing Hepatocellular A7 Triggering Ovulation Indicates a Potential Beneficial Role for Polycystic Ovary Syndrome","volume":"36","author":"Li","year":"2018","journal-title":"EBioMedicine"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1093\/humupd\/dmaf030","article-title":"Prevalence of polycystic ovary syndrome: A global and regional systematic review and meta-analysis","volume":"32","author":"Neven","year":"2026","journal-title":"Hum. 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