{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T04:16:00Z","timestamp":1788236160348,"version":"build-2803163510"},"reference-count":96,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Diabetes mellitus is a pervasive global health crisis, with type 2 diabetes (T2D) representing the majority of cases. While conventional pharmacological therapies exist, suboptimal efficacy, adverse effects, and inadequate glycemic control in a substantial proportion of patients highlight the need for complementary strategies. There is growing scientific and clinical interest in plant-based functional foods, including Ribes nigrum L. (blackcurrant), which is rich in bioactive phytochemicals such as anthocyanins, flavonols, and phenolic acids. This review evaluates the antidiabetic and metabolic regulatory potential of blackcurrant, focusing on its multi-target mechanisms of action. Available experimental evidence suggests that blackcurrants may influence glucose metabolism through several mechanisms, including inhibition of carbohydrate-digesting enzymes (\u03b1-amylase and \u03b1-glucosidase), modulation of intestinal glucose transporters (SGLT1 and GLUT2), and potential modulation of insulin sensitivity involving AMPK signaling and GLUT4 translocation. In addition, blackcurrant constituents may stimulate glucagon-like peptide-1 (GLP-1) secretion, modulate gut microbiota composition, and exert antioxidant and anti-inflammatory effects that counteract key drivers of insulin resistance and \u03b2-cell dysfunction. Supporting human studies indicate that blackcurrant consumption has been associated with attenuation of postprandial glycemic and insulinemic responses and modest improvements in cardiometabolic biomarkers, although findings remain limited by study size, duration, and formulation heterogeneity. Overall, Ribes nigrum represents a promising dietary adjunct for the prevention and management of T2D through multi-target metabolic regulation.<\/jats:p>","DOI":"10.3390\/nu18172852","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:19:26Z","timestamp":1788232766000},"page":"2852","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Nutraceutical Potential of Blackcurrant (Ribes nigrum) for Glycemic Control and Metabolic Health: Mechanistic and Translational Insights"],"prefix":"10.3390","volume":"18","author":[{"given":"Piotr","family":"Religa","sequence":"first","affiliation":[{"name":"Department of Medicine, Karolinska Institute, Visionsgatan 18, 171 76 Solna, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8845-5867","authenticated-orcid":false,"given":"Magdalena D.","family":"Pieczynska-Kovacs","sequence":"additional","affiliation":[{"name":"Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, 36a Postepu, 05-552 Jastrzebiec, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzena","family":"\u0141azarczyk","sequence":"additional","affiliation":[{"name":"Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, 36a Postepu, 05-552 Jastrzebiec, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8057-0385","authenticated-orcid":false,"given":"Bhupinder","family":"Kapoor","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Lovely Professional University, Phagwara 144411, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajan","family":"Logesh","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Bengaluru 560054, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4476-5860","authenticated-orcid":false,"given":"Smith B.","family":"Babiaka","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, University of Buea, Buea P.O. Box 63, Cameroon"},{"name":"Department of Microbial Bioactive Compounds, Interfaculty Institute for Microbiology and Infection Medicine, University of T\u00fcbingen, 72074 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1321-2235","authenticated-orcid":false,"given":"Piotr","family":"Pozna\u0144ski","sequence":"additional","affiliation":[{"name":"Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, 36a Postepu, 05-552 Jastrzebiec, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4186-4900","authenticated-orcid":false,"given":"Michel-Edwar","family":"Mickael","sequence":"additional","affiliation":[{"name":"Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, 36a Postepu, 05-552 Jastrzebiec, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Lagoa","sequence":"additional","affiliation":[{"name":"Associate Laboratory in Chemical Engineering, School of Technology and Management, Polytechnic Institute of Leiria, 2411-901 Leiria, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariusz","family":"Sacharczuk","sequence":"additional","affiliation":[{"name":"Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, 36a Postepu, 05-552 Jastrzebiec, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim F.","family":"Rehan","sequence":"additional","affiliation":[{"name":"Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, 36a Postepu, 05-552 Jastrzebiec, Poland"},{"name":"Department of Pathobiochemistry, Faculty of Pharmacy, Meijo University, Tempaku-ku, Nagoya-shi 468-8503, Aichi, Japan"},{"name":"Department of Animal Behavior and Husbandry, Faculty of Veterinary Medicine, Menoufia University, Shebin Alkom 32511, Menoufia, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa","family":"Elnagar","sequence":"additional","affiliation":[{"name":"Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, 36a Postepu, 05-552 Jastrzebiec, Poland"},{"name":"Department of Pathobiochemistry, Faculty of Pharmacy, Meijo University, Tempaku-ku, Nagoya-shi 468-8503, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Petra","family":"Cherciu","sequence":"additional","affiliation":[{"name":"St. Luke Chronic Diseases Hospital, \u0218oseaua Berceni 12, 041915 Bucure\u0219ti, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5546-9891","authenticated-orcid":false,"given":"Artur","family":"J\u00f3\u017awik","sequence":"additional","affiliation":[{"name":"Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, 36a Postepu, 05-552 Jastrzebiec, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2545-0967","authenticated-orcid":false,"given":"Atanas G.","family":"Atanasov","sequence":"additional","affiliation":[{"name":"Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, 36a Postepu, 05-552 Jastrzebiec, Poland"},{"name":"Patient Safety & Digital Health (PaDiH) Group, Danube Private University, 3500 Krems-Stein, Austria"},{"name":"Department of Biochemistry, Saveetha Institute of Medical and Technical Sciences, Saveetha Medical College and Hospital, Chennai 600077, Tamil Nadu, India"},{"name":"Ludwig Boltzmann Institute Digital Health and Patient Safety, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaroslaw Olav","family":"Horba\u0144czuk","sequence":"additional","affiliation":[{"name":"Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, 36a Postepu, 05-552 Jastrzebiec, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrendo.2017.151","article-title":"Global Aetiology and Epidemiology of Type 2 Diabetes Mellitus and Its Complications","volume":"14","author":"Zheng","year":"2018","journal-title":"Nat. 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