{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T10:22:16Z","timestamp":1789122136474,"version":"build-2803163510"},"reference-count":48,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFF1100300"],"award-info":[{"award-number":["2022YFF1100300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Yunnan Key Laboratory for Integrative Conservation of Plant Species with Extremely Small Populations, Kunming Institute of Botany, Chinese Academy of Sciences"},{"id":[{"id":"https:\/\/ror.org\/034t30j35","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Cinnamomum chago (C. chago) B.S.Sun et H.L.Zhao, a rare tree species endemic to Yunnan Province of China, produces fruit kernels that are rich in fatty oils (CCKF); however, the potential health benefits of CCKF have not been previously reported. Method: We characterized the chemical composition of CCKF and evaluated its therapeutic potential in a rat model of loperamide-induced functional constipation (FC). Results: CCKF contained an abundance of dodecanoic acid, accounting for 70.18%. CCKF alleviated constipation by increasing fecal pellet output and moisture content, enhancing small intestinal propulsion rate, and ameliorating colonic pathological damage. Additionally, CCKF modulated gastrointestinal hormone levels and enhanced the expression of ZO-1 and Occludin. Furthermore, CCKF increased gut microbial diversity, altered the Bacillota\/Bacteroidota ratio, enriched potentially beneficial bacteria (including Kineothrix, Roseburia, Lacrimispora, and Lawsonibacter), and reduced Segatella abundance. CCKF may affect Arginine and proline metabolism, Biosynthesis of amino acids, D-Amino acid metabolism, etc. Conclusion: The present results provide a scientific basis for the potential application of CCKF as a functional food to alleviate functional constipation.<\/jats:p>","DOI":"10.3390\/nu18182979","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T09:09:40Z","timestamp":1789117780000},"page":"2979","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Kernel Fatty Oils of Cinnamomum chago Alleviate Functional Constipation by Improving Gut Microbiota and Intestinal Barrier Function"],"prefix":"10.3390","volume":"18","author":[{"given":"Senye","family":"Wang","sequence":"first","affiliation":[{"name":"National R & D Center for Edible Fungus Processing Technology, Henan University, Kaifeng 475004, China"},{"name":"College of Agriculture, Henan University, Kaifeng 475004, 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Agric. Food Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1093\/gastro\/goab035","article-title":"Role of gut microbiota in functional constipation","volume":"9","author":"Zhang","year":"2021","journal-title":"Gastroenterol. Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3389\/fmed.2019.00019","article-title":"Gut Microbiota and Chronic Constipation: A Review and Update","volume":"6","author":"Ohkusa","year":"2019","journal-title":"Front. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"106711","DOI":"10.1016\/j.fbio.2025.106711","article-title":"Licorice water extract improves constipation by repairing the intestinal barrier and regulating the gut microbiota: A potential alternative treatment strategy","volume":"68","author":"Sun","year":"2025","journal-title":"Food Biosci."},{"key":"ref_5","first-page":"93","article-title":"A new species of Cinnamomum from Yunnan","volume":"13","author":"Sun","year":"1991","journal-title":"J. Yunnan Univ."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"9420018","DOI":"10.26599\/FMH.2024.9420018","article-title":"Perspectives in Food & Medicine Homology","volume":"1","author":"Cong","year":"2024","journal-title":"Food Med. Homol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"9420057","DOI":"10.26599\/FMH.2025.9420057","article-title":"Overview of research on the application of medicine food homologous bioactive ingredients to functional constipation","volume":"2","author":"Yu","year":"2025","journal-title":"Food Med. Homol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3389\/fnut.2019.00157","article-title":"Plant-Based Fat, Dietary Patterns Rich in Vegetable Fat and Gut Microbiota Modulation","volume":"6","author":"Muralidharan","year":"2019","journal-title":"Front. Nutr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3154","DOI":"10.1080\/10408398.2015.1096763","article-title":"Prebiotic nut compounds and human microbiota","volume":"57","author":"Onge","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3390\/nu18020319","article-title":"The Effects of Chinese Dwarf Cherry (Cerasus humilis) Kernel Oil on Defecation and the Gut Microbiota in Constipated Mice","volume":"18","author":"Gao","year":"2026","journal-title":"Nutrients"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e2300615","DOI":"10.1002\/mnfr.202300615","article-title":"Torreya grandis Kernel Oil Alleviates Loperamide-Induced Slow Transit Constipation via Up-Regulating the Colonic Expressions of Occludin\/Claudin-1\/ZO-1 and 5-HT3R\/5-HT4R in BALB\/c Mice","volume":"68","author":"Wang","year":"2024","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Li, H.L., Feng, X.M., Zhong, F.L., and Luo, X.G. (2026). Live and Heat-Inactivated Ameliorate Loperamide-Induced Constipation in Mice via Modulating Gut Microbiota, Short-Chain Fatty Acids and Gastrointestinal Function. Nutrients, 18.","DOI":"10.3390\/nu18111658"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"118256","DOI":"10.1016\/j.foodres.2025.118256","article-title":"Ameliorative effects of Atractylodes macrocephala insoluble dietary fiber on loperamide-induced functional constipation in rats","volume":"227","author":"Wang","year":"2026","journal-title":"Food Res. Int."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"103326","DOI":"10.1016\/j.fochx.2025.103326","article-title":"Development and characterization of high-performance macadamia oil-based oleogel emulsions","volume":"32","author":"Gao","year":"2025","journal-title":"Food Chem. X"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3892\/ijmm.2025.5619","article-title":"Piezo knockdown reduces 5-hydroxytryptamine release from enterochromaffin cells and exacerbates intestinal dyskinesia in mice with functional constipation","volume":"56","author":"Yan","year":"2025","journal-title":"Int. J. Mol. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3390\/foods15010095","article-title":"Barley Leaves Improves Loperamide-Induced Constipation via Gut Barrier and Microbiota Modulation in Mice","volume":"15","author":"Xu","year":"2025","journal-title":"Foods"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"9420008","DOI":"10.26599\/FMH.2024.9420008","article-title":"Artemisia argyi polysaccharide alleviates intestinal inflammation and intestinal flora dysbiosis in lipopolysaccharide-treated mice","volume":"1","author":"Ning","year":"2024","journal-title":"Food Med. Homol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"5037","DOI":"10.1039\/D1FO04151G","article-title":"Bifidobacterium longum relieves constipation by regulating the intestinal barrier of mice","volume":"13","author":"Wang","year":"2022","journal-title":"Food Funct."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"5702","DOI":"10.1039\/D2FO03574J","article-title":"Gut indigenous Ruminococcus gnavus alleviates constipation and stress-related behaviors in mice with loperamide-induced constipation","volume":"14","author":"Li","year":"2023","journal-title":"Food Funct."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"9420077","DOI":"10.26599\/FMH.2025.9420077","article-title":"Potential of Dendrobium officinale oligosaccharides to alleviate chronic colitis by modulating inflammation and gut microbiota","volume":"2","author":"Shi","year":"2025","journal-title":"Food Med. Homol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1039\/D4FO04660A","article-title":"Bifidobacterium longum subsp. longum relieves loperamide hydrochloride-induced constipation in mice by enhancing bile acid dissociation","volume":"16","author":"Zhang","year":"2025","journal-title":"Food Funct."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3993","DOI":"10.1039\/D2FO00008C","article-title":"Microbiome-metabolomics deciphers the effects of Cistanche deserticola polysaccharides on aged constipated rats","volume":"13","author":"Liu","year":"2022","journal-title":"Food Funct."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Wu, Y., Li, Q., Liu, J., Liu, Y., Xu, Y., Zhang, R., Yu, Y., Wang, Y., and Yang, C. (2021). Integrating Serum Metabolome and Gut Microbiome to Evaluate the Benefits of Lauric Acid on Lipopolysaccharide- Challenged Broilers. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.759323"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"109739","DOI":"10.1016\/j.fsi.2024.109739","article-title":"Dietary lauric acid promoted antioxidant and immune capacity by improving intestinal structure and microbial population of swimming crab (Portunus trituberculatus)","volume":"151","author":"Zhan","year":"2024","journal-title":"Fish Shellfish Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/1348-0421.13187","article-title":"Gut Microbiota and Metabolite Profiles Associated With Functional Constipation Severity","volume":"69","author":"Wang","year":"2025","journal-title":"Microbiol. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"110273","DOI":"10.1016\/j.foodres.2021.110273","article-title":"The different effects of Chinese Herb Solid Drink and lactulose on gut microbiota in rats with slow transit constipation induced by compound diphenoxylate","volume":"143","author":"Deng","year":"2021","journal-title":"Food Res. Int."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"105218","DOI":"10.1016\/j.fbio.2024.105218","article-title":"Safflower dietary fiber alleviates functional constipation in rats via regulating gut microbiota and metabolism","volume":"62","author":"Wang","year":"2024","journal-title":"Food Biosci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"9420048","DOI":"10.26599\/FMH.2025.9420048","article-title":"Total Glycosides of Cistanche deserticola attenuates DSS-induced inflammatory bowel disease by regulating intestinal environmental homeostasis","volume":"2","author":"Zhang","year":"2025","journal-title":"Food Med. Homol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/s41420-025-02762-9","article-title":"Segatella exacerbates chronic heart failure via TLR4\/NF-kappaB pathway and therapeutic potential of low-carbohydrate diet","volume":"11","author":"Abudouwayiti","year":"2025","journal-title":"Cell Death Discov."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e00738-24","DOI":"10.1128\/mra.00738-24","article-title":"A whole-genome metagenomic approach to explore the gut microbiome of inflammatory bowel disease patients in Bangladesh","volume":"14","author":"Siam","year":"2025","journal-title":"Microbiol. Resour. Announc."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2217\/fmb-2016-0130","article-title":"Roseburia spp.: A marker of health?","volume":"12","author":"Smida","year":"2017","journal-title":"Future Microbiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"uqac006","DOI":"10.1093\/femsml\/uqac006","article-title":"Human milk oligosaccharides induce acute yet reversible compositional changes in the gut microbiota of conventional mice linked to a reduction of butyrate levels","volume":"3","author":"Holst","year":"2022","journal-title":"Microlife"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"8846","DOI":"10.1039\/D5FO03604F","article-title":"Docynia delavayi (Franch.) Schneid polyphenols alleviate dextran sulfate sodium-induced colitis by regulating the gut microbiota","volume":"16","author":"Zhang","year":"2025","journal-title":"Food Funct."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1099\/ijsem.0.001643","article-title":"Kineothrix alysoides, gen. nov., sp. nov., a saccharolytic butyrate-producer within the family Lachnospiraceae","volume":"67","author":"Haas","year":"2017","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"14668","DOI":"10.1038\/s41598-023-41160-y","article-title":"Gut commensal Kineothrix alysoides mitigates liver dysfunction by restoring lipid metabolism and gut microbial balance","volume":"13","author":"Choi","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e70037","DOI":"10.1002\/cam4.70037","article-title":"Gut Roseburia is a protective marker for peritoneal metastasis of gastric cancer","volume":"13","author":"Yu","year":"2024","journal-title":"Cancer Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1186\/s12866-025-04344-2","article-title":"Oral and fecal microbiome alterations in pancreatic cancer: Insights into potential diagnostic biomarkers","volume":"25","author":"Tavanaeian","year":"2025","journal-title":"BMC Microbiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s42003-025-07493-2","article-title":"Lipid metabolism and microbial regulation analyses provide insights into the energy-saving strategies of hibernating snakes","volume":"8","author":"Wei","year":"2025","journal-title":"Commun. Biol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Dempsey, E., and Corr, S.C. (2022). Lactobacillus spp. for Gastrointestinal Health: Current and Future Perspectives. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.840245"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3502","DOI":"10.1038\/s41467-024-47594-w","article-title":"The gut commensal Blautia maintains colonic mucus function under low-fiber consumption through secretion of short-chain fatty acids","volume":"15","author":"Holmberg","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"108088","DOI":"10.1016\/j.fbio.2025.108088","article-title":"Emerging roles of lactic acid bacteria in health management: Insights from fermented foods to microbiota","volume":"75","author":"Shi","year":"2026","journal-title":"Food Biosci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"5721","DOI":"10.3390\/ijms20225721","article-title":"The Constipation-Relieving Property of d-Tagatose by Modulating the Composition of Gut Microbiota","volume":"20","author":"Liang","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.biopha.2017.11.119","article-title":"Enteromorpha and polysaccharides from enteromorpha ameliorate loperamide-induced constipation in mice","volume":"96","author":"Ren","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"E1273","DOI":"10.1073\/pnas.1621400114","article-title":"Creatine maintains intestinal homeostasis and protects against colitis","volume":"114","author":"Turer","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.3390\/nu13051429","article-title":"Creatine Supplementation for Patients with Inflammatory Bowel Diseases: A Scientific Rationale for a Clinical Trial","volume":"13","author":"Wallimann","year":"2021","journal-title":"Nutrients"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e0016","DOI":"10.1097\/IN9.0000000000000016","article-title":"Revisiting the \u201cstarved gut\u201d hypothesis in inflammatory bowel disease","volume":"5","author":"Colgan","year":"2023","journal-title":"Immunometabolism"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"4365","DOI":"10.1172\/JCI89885","article-title":"S-sulfocysteine\/NMDA receptor-dependent signaling underlies neurodegeneration in molybdenum cofactor deficiency","volume":"127","author":"Kumar","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"149679","DOI":"10.1016\/j.ijbiomac.2025.149679","article-title":"The gut-liver axis mediates the protective effect of Cinnamomum chago polysaccharide against acute liver injury: Insights from integrated microbiome and metabolomics analysis","volume":"338","author":"Li","year":"2026","journal-title":"Int. J. Biol. Macromol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/18\/2979\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T09:18:25Z","timestamp":1789118305000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/18\/2979"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,11]]},"references-count":48,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["nu18182979"],"URL":"https:\/\/doi.org\/10.3390\/nu18182979","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,11]]}}}