{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T10:03:46Z","timestamp":1789553026995,"version":"build-2803163510"},"reference-count":168,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Asparagus racemosus, popularly known as Shatavari, is a well-acclaimed medicinal herb for the rejuvenation of reproductive and cognitive health. The therapeutic potential of the herb is primarily due to its famed bioactive compound, Shatavarin IV, which is a steroidal saponin with a close structural resemblance to the female reproductive hormone estrogen. Over the last few decades, independent studies have shown that the steroidal saponins, flavonoids, alkaloids, and polyphenols from the plant can neutralize oxidative stress, arrest neuroinflammation, prevent apoptosis, regulate serotonergic and dopaminergic neurotransmission, and promote synaptic plasticity for holistic cognitive homeostasis. A critical finding in delineating the secret of a healthy brain has been its intricate linkage with a happy gut. Intestinal microbes play a significant role in modulating the synthesis of key neurotransmitters through the diverse plethora of their secreted metabolites, such as short-chain fatty acids. The gut\u2013brain axis, primarily the vagus nerve, acts as a specialized access point for these molecules into the brain. In addition, gut microbes play key roles in ensuring the optimal function of the hypothalamic\u2013pituitary\u2013adrenal axis, the central mechanism for the management and mitigation of physical and emotional stress. Fructooligosaccharide residues, found in abundance in Shatavari, serve as excellent prebiotics for the gut microbial population. This review presents an extensive analysis of the key mechanistic insights obtained thus far on the crossroads of Shatavari with the cells of the nervous system and the microbial community involved therein, including findings from our own laboratory, which could provide long-term solutions in addressing cognitive health.<\/jats:p>","DOI":"10.3390\/nu18183016","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:23:53Z","timestamp":1789496633000},"page":"3016","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unraveling the Mechanistic Insights of Asparagus Bioactives to Promote Cognitive Health: Insights from the Gut\u2013Brain Axis"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7320-150X","authenticated-orcid":false,"given":"Debayan","family":"Das","sequence":"first","affiliation":[{"name":"Department of Bioscience and Biotechnology, Indian Institute of Technology Kharagpur, Kharagpur 721302, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5446-9582","authenticated-orcid":false,"given":"Somdeb Bose","family":"Dasgupta","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Biotechnology, Indian Institute of Technology Kharagpur, Kharagpur 721302, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0075-7508","authenticated-orcid":false,"given":"Samudra Prosad","family":"Banik","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Government General Degree College, Narayangarh, Rathipur 721437, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9478-6427","authenticated-orcid":false,"given":"Debasis","family":"Bagchi","sequence":"additional","affiliation":[{"name":"Department  of Biology, College of Arts and Sciences, Adelphi University, Garden City, NY 11530, USA"},{"name":"Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"ref_1","first-page":"394","article-title":"Dietary habits, lifestyle factors and neurodegenerative diseases","volume":"15","author":"Dumbrava","year":"2019","journal-title":"Neural Regen. Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e70084","DOI":"10.1002\/jimd.70084","article-title":"Neurocognitive Impairment in Inherited Metabolic Disorders due to Intoxication and Energy Defects: A Systematic Review","volume":"48","author":"Arias","year":"2025","journal-title":"J. Inherit. Metab. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Khamidullina, Z., Marat, A., Muratbekova, S., Mustapayeva, N.M., Chingayeva, G.N., Shepetov, A.M., Ibatova, S.S., Terzic, M., and Aimagambetova, G. (2025). Postpartum Depression Epidemiology, Risk Factors, Diagnosis, and Management: An Appraisal of the Current Knowledge and Future Perspectives. J. Clin. Med., 14.","DOI":"10.3390\/jcm14072418"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s44187-025-00422-6","article-title":"New insight on dietary strategies to increase insulin sensitivity and reduce diabetes prevalence: An expert perspective and recommendation","volume":"5","author":"Nurkolis","year":"2025","journal-title":"Discov. Food"},{"key":"ref_5","first-page":"111419","article-title":"Ultra-processed diet, systemic oxidative stress, and breach of immunologic tolerance","volume":"91\u201392","year":"2021","journal-title":"Nutrition"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"104152","DOI":"10.1016\/j.numecd.2025.104152","article-title":"Association of advanced glycation end products consumption and nutritional parameters in cardiovscular rehabilitation patients","volume":"35","author":"Ladeira","year":"2025","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"109638","DOI":"10.1016\/j.celrep.2021.109638","article-title":"Long-term depression links amyloid-\u03b2 to the pathological hyperphosphorylation of tau","volume":"36","author":"Taylor","year":"2021","journal-title":"Cell Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.advnut.2023.07.006","article-title":"The Beneficial and Adverse Effects of Autophagic Response to Caloric Restriction and Fasting","volume":"14","author":"Shabkhizan","year":"2023","journal-title":"Adv. Nutr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.2174\/011570159X446831260303200516","article-title":"Molecular Mechanisms of Dopaminergic Neuron Degeneration in Parkinson\u2019s disease: A Comprehensive Review","volume":"24","author":"Abubakar","year":"2026","journal-title":"Curr. Neuropharmacol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1017\/S1092852914000480","article-title":"The role of reproductive hormones in postpartum depression","volume":"20","author":"Schiller","year":"2015","journal-title":"CNS Spectr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"5286","DOI":"10.1523\/JNEUROSCI.6394-10.2011","article-title":"Estrogen shapes dopamine-dependent cognitive processes: Implications for women\u2019s health","volume":"31","author":"Jacobs","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Zhang, C., Feng, X., Zhang, X., Chen, Y., Kong, J., and Lou, Y. (2024). Research progress on the correlation between estrogen and estrogen receptor on postmenopausal sarcopenia. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1494972"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Hwang, W.J., Lee, T.Y., Kim, N.S., and Kwon, J.S. (2021). The Role of Estrogen Receptors and Their Signaling across Psychiatric Disorders. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22010373"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1038\/s12276-021-00646-3","article-title":"Redefining differential roles of MAO-A in dopamine degradation and MAO-B in tonic GABA synthesis","volume":"53","author":"Cho","year":"2021","journal-title":"Exp. Mol. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41392-024-01743-1","article-title":"Microbiota-gut-brain axis and its therapeutic applications in neurodegenerative diseases","volume":"9","author":"Loh","year":"2024","journal-title":"Signal Transduct. Target Ther."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1038\/s41598-025-86858-3","article-title":"Gut-brain axis and neuropsychiatric health: Recent advances","volume":"15","author":"Doenyas","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/s41564-018-0307-3","article-title":"GABA-modulating bacteria of the human gut microbiota","volume":"4","author":"Strandwitz","year":"2019","journal-title":"Nat. Microbiol."},{"key":"ref_18","first-page":"28","article-title":"The Gut-Brain Axis: Influence of Microbiota on Mood and Mental Health","volume":"17","author":"Appleton","year":"2018","journal-title":"Integr. Med."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Hou, Y., Li, J., and Ying, S. (2023). Tryptophan Metabolism and Gut Microbiota: A Novel Regulatory Axis Integrating the Microbiome, Immunity, and Cancer. Metabolites, 13.","DOI":"10.3390\/metabo13111166"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Mithaiwala, M.N., Santana-Coelho, D., Porter, G.A., and O\u2019Connor, J.C. (2021). Neuroinflammation and the Kynurenine Pathway in CNS Disease: Molecular Mechanisms and Therapeutic Implications. Cells, 10.","DOI":"10.3390\/cells10061548"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.21474\/IJAR01\/23277","article-title":"The Gut-Microbiota-Brain Axis In Neurodegenerative Disorders: Molecular Mechanisms, Immune Interactions, And Therapeutic Opportunities","volume":"14","author":"Shukla","year":"2026","journal-title":"Int. J. Adv. Res."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Adhikary, K., Ganguly, K., Sarkar, R., Abubakar, M., Banerjee, P., and Karak, P. (2025). Phytonutrients and their neuroprotective role in brain disorders. Front. Mol. Biosci., 12.","DOI":"10.3389\/fmolb.2025.1607330"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e3806517","DOI":"10.1155\/bmri\/3806517","article-title":"Predictive Analysis of Brain-Derived Neurotrophic Factor and Apolipoprotein E SNPs in Alzheimer\u2019s Pathogenesis","volume":"2026","author":"Beliraya","year":"2026","journal-title":"BioMed Res. Int."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"100689","DOI":"10.1016\/j.focha.2024.100689","article-title":"Exploring pharmacological properties and food applications of Asparagus racemosus (Shatavari)","volume":"4","author":"Akhtar","year":"2024","journal-title":"Food Chem. Adv."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Krishnarajabhatt, H.S., and Unnikrishnan, P. (2025). Phytochemical insights and neuro-gut axis modulation of Asparagus racemosus (Shatavari) in postpartum depression: A mini review with HPTLC-based justification. Front. Nutr., 12.","DOI":"10.3389\/fnut.2025.1677952"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1080\/14786419.2015.1092148","article-title":"Asparagus racemosus: A review on its phytochemical and therapeutic potential","volume":"30","author":"Singh","year":"2016","journal-title":"Nat. Prod. Res."},{"key":"ref_27","first-page":"441","article-title":"Shatavarin IV, a bioactive constituent of Asparagus racemosus, exerts antioxidant and anti-inflammatory effects in LPS-treated cultured SH-SY5Y cells via TrkB-BDNF axis","volume":"45","author":"Das","year":"2026","journal-title":"J. Am. Nutr. Assoc."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Dieterich, W., Schink, M., and Zopf, Y. (2018). Microbiota in the Gastrointestinal Tract. Med. Sci., 6.","DOI":"10.3390\/medsci6040116"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"261","DOI":"10.14740\/gr1053w","article-title":"The Role of the Gut Barrier Function in Health and Disease","volume":"11","author":"Assimakopoulos","year":"2018","journal-title":"Gastroenterol. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3390\/nu7010045","article-title":"Understanding how commensal obligate anaerobic bacteria regulate immune functions in the large intestine","volume":"7","author":"Maier","year":"2014","journal-title":"Nutrients"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nrgastro.2017.75","article-title":"Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics","volume":"14","author":"Gibson","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"100680","DOI":"10.1016\/j.fufo.2025.100680","article-title":"Recent advances in prebiotics: Classification, mechanisms, and health applications","volume":"12","author":"Ali","year":"2025","journal-title":"Future Foods"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Collins, S., and Reid, G. (2016). Distant Site Effects of Ingested Prebiotics. Nutrients, 8.","DOI":"10.3390\/nu8090523"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.52711\/0974-360X.2023.00429","article-title":"Identification and quantification of Shatavarin IV in five different species of the genus Asparagus through a validated HPTLC method","volume":"16","author":"Champati","year":"2023","journal-title":"Res. J. Pharm. Technol."},{"key":"ref_35","first-page":"681","article-title":"An Updated Insight on the Chemistry, Ethnobotany, and Health Benefits of Asparagus racemosus (Shatavari): With a Special Emphasis on Shatavarin IV","volume":"44","author":"Banerjee","year":"2025","journal-title":"J. Am. Nutr. Assoc."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"415","DOI":"10.4103\/0976-9668.160025","article-title":"Immunomodulatory potential of shatavarins produced from Asparagus racemosus tissue cultures","volume":"6","author":"Pise","year":"2015","journal-title":"J. Nat. Sci. Biol. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1080\/14786419.2018.1517123","article-title":"Asparagus racemosus (Shatavari) targeting estrogen receptor \u03b1: - An in-vitro and in-silico mechanistic study","volume":"34","author":"Sharma","year":"2020","journal-title":"Nat. Product. Res."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Chattopadhyay, R., Karmakar, S., Chakraborty, T.R., Bagchi, M., Banik, S.P., and Bagchi, D. (2026). SheVari4\u00ae, a proprietary root extract from Asparagus racemosus, ameliorates menopausal health: Insights from a randomized, double-blind, placebo controlled clinical trial. Food & Nutrition Research, 70.","DOI":"10.29219\/fnr.v70.14275"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s43440-022-00444-2","article-title":"Estrogen fluctuations during the menopausal transition are a risk factor for depressive disorders","volume":"75","author":"Turek","year":"2023","journal-title":"Pharmacol. Rep."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/nn2057","article-title":"Activation of estrogen receptor-\u03b2 regulates hippocampal synaptic plasticity and improves memory","volume":"11","author":"Liu","year":"2008","journal-title":"Nat. Neurosci."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Barth, C., Villringer, A., and Sacher, J. (2015). Sex hormones affect neurotransmitters and shape the adult female brain during hormonal transition periods. Front. Neurosci., 9.","DOI":"10.3389\/fnins.2015.00037"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e14932","DOI":"10.1016\/j.heliyon.2023.e14932","article-title":"Adaptogenic property of Asparagus racemosus: Future trends and prospects","volume":"9","author":"Singh","year":"2023","journal-title":"Heliyon"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"P\u00e9rez-Reytor, D., Puebla, C., Karahanian, E., and Garc\u00eda, K. (2021). Use of Short-Chain Fatty Acids for the Recovery of the Intestinal Epithelial Barrier Affected by Bacterial Toxins. Front. Physiol., 12.","DOI":"10.3389\/fphys.2021.650313"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Du, Y., He, C., An, Y., Huang, Y., Zhang, H., Fu, W., Wang, M., Shan, Z., Xie, J., and Yang, Y. (2024). The Role of Short Chain Fatty Acids in Inflammation and Body Health. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25137379"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e101374","DOI":"10.1136\/gpsych-2023-101374","article-title":"Gut microbiota-derived short-chain fatty acids and depression: Deep insight into biological mechanisms and potential applications","volume":"37","author":"Cheng","year":"2024","journal-title":"Gen. Psychiatr."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1016\/j.cell.2021.03.022","article-title":"SnapShot: The microbiota-gut-brain axis","volume":"184","author":"Agirman","year":"2021","journal-title":"Cell"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/s41579-020-00460-0","article-title":"The gut microbiota-brain axis in behaviour and brain disorders","volume":"19","author":"Morais","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1152\/physrev.00018.2018","article-title":"The Microbiota-Gut-Brain Axis","volume":"99","author":"Cryan","year":"2019","journal-title":"Physiol. Rev."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"105840","DOI":"10.1016\/j.phrs.2021.105840","article-title":"The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders","volume":"172","author":"Doboszewska","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"101802","DOI":"10.1016\/j.jcmgh.2026.101802","article-title":"Microbiota-Gut-Brain Axis in Neurodegenerative Diseases: The Role of Bacterial Amyloids","volume":"20","author":"Brossaud","year":"2026","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"35092","DOI":"10.1074\/jbc.M112.383737","article-title":"Promiscuous cross-seeding between bacterial amyloids promotes interspecies biofilms","volume":"287","author":"Zhou","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/s41522-026-01005-8","article-title":"Aggregation in gut: On the link between neurodegeneration and bacterial functional amyloids","volume":"12","author":"Wojciechowska","year":"2026","journal-title":"npj Biofilms Microbiomes"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e53111","DOI":"10.7554\/eLife.53111","article-title":"A gut bacterial amyloid promotes \u03b1-synuclein aggregation and motor impairment in mice","volume":"9","author":"Sampson","year":"2020","journal-title":"eLife"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2236749","DOI":"10.1080\/19490976.2023.2236749","article-title":"Gut microbial beta-glucuronidase: A vital regulator in female estrogen metabolism","volume":"15","author":"Hu","year":"2023","journal-title":"Gut Microbes"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e2300234","DOI":"10.1002\/mabi.202300234","article-title":"Curli Amyloid Fibers in Escherichia coli Biofilms: The Influence of Water Availability on their Structure and Functional Properties","volume":"24","author":"Siri","year":"2024","journal-title":"Macromol. Biosci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e05053","DOI":"10.1016\/j.heliyon.2020.e05053","article-title":"Ribosylation induced structural changes in Bovine Serum Albumin: Understanding high dietary sugar induced protein aggregation and amyloid formation","volume":"6","author":"Das","year":"2020","journal-title":"Heliyon"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"20241091","DOI":"10.1515\/med-2024-1091","article-title":"Diabetes-related cognitive impairment: Mechanisms, symptoms, and treatments","volume":"20","author":"Yu","year":"2025","journal-title":"Open Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1080\/15376516.2025.2567419","article-title":"Potential of Fenfuro\u00ae, a novel, standardized Trigonella foenum-graecum (Fenugreek) seed extract, in ameliorating glycation-mediated amyloidogenesis","volume":"36","author":"Saha","year":"2026","journal-title":"Toxicol. Mech. Methods"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"14112","DOI":"10.1038\/s41598-020-70986-z","article-title":"Bifidobacterium adolescentis as a key member of the human gut microbiota in the production of GABA","volume":"10","author":"Duranti","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s11739-023-03374-w","article-title":"Gut microbiota, intestinal permeability, and systemic inflammation: A narrative review","volume":"19","author":"Petito","year":"2024","journal-title":"Intern. Emerg. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"7493","DOI":"10.3390\/ijms16047493","article-title":"Impacts of Gut Bacteria on Human Health and Diseases","volume":"16","author":"Zhang","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"938","DOI":"10.4103\/NRR.NRR-D-24-01265","article-title":"Short-chain fatty acids mediate enteric and central nervous system homeostasis in Parkinson\u2019s disease: Innovative therapies and their translation","volume":"21","author":"Pang","year":"2025","journal-title":"Neural Regen. Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/1751-7915.12254","article-title":"Overexpression and optimization of glutamate decarboxylase in Lactobacillus plantarum Taj-Apis362 for high gamma-aminobutyric acid production","volume":"8","author":"Tajabadi","year":"2015","journal-title":"Microb. Biotechnol."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Aja, E., Zeng, A., Gray, W., Connelley, K., Chaganti, A., and Jacobs, J.P. (2025). Health Effects and Therapeutic Potential of the Gut Microbe Akkermansia muciniphila. Nutrients, 17.","DOI":"10.3390\/nu17030562"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"100928","DOI":"10.1016\/j.nmni.2021.100928","article-title":"The importance of Faecalibacterium prausnitzii in human health and diseases","volume":"43","author":"Parsaei","year":"2021","journal-title":"New Microbes New Infect."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1590\/S1517-83822013000100028","article-title":"Submerged fermentation of Lactobacillus rhamnosus YS9 for \u03b3-aminobutyric acid (GABA) production","volume":"44","author":"Lin","year":"2013","journal-title":"Braz. J. Microbiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3390\/cimb46010015","article-title":"Biosynthesis of Gamma-Aminobutyric Acid (GABA) by Lactiplantibacillus plantarum in Fermented Food Production","volume":"46","author":"Iorizzo","year":"2024","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Dargenio, V.N., Cristofori, F., Brindicci, V.F., Schettini, F., Dargenio, C., Castellaneta, S.P., Iannone, A., and Francavilla, R. (2024). Impact of Bifidobacterium longum Subspecies infantis on Pediatric Gut Health and Nutrition: Current Evidence and Future Directions. Nutrients, 16.","DOI":"10.3390\/nu16203510"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"29217","DOI":"10.1038\/s41598-024-80635-4","article-title":"Small intestinal derived Prevotella histicola simulates biologic as a therapeutic agent","volume":"14","author":"Balakrishnan","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1038\/s41467-018-05470-4","article-title":"Microbial tryptophan catabolites in health and disease","volume":"9","author":"Roager","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"107379","DOI":"10.1016\/j.jff.2026.107379","article-title":"Nutritional and bioactive properties of Pereskia aculeata Miller: Potential in nutrigenomics and functional food development","volume":"144","author":"Mercer","year":"2026","journal-title":"J. Funct. Foods"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"114424","DOI":"10.1016\/j.isci.2025.114424","article-title":"Commensal human gut microbes produce species specific neuroactive compounds","volume":"29","author":"Tingler","year":"2026","journal-title":"iScience"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Stanimirov, B., \u0110ani\u0107, M., Pavlovi\u0107, N., Zaklan, D., Lazarevi\u0107, S., Mikov, M., and Stankov, K. (2025). Gut\u2013Brain Axis and Bile Acid Signaling: Linking Microbial Metabolism to Brain Function and Metabolic Regulation. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms262412167"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Rehman, M.U., Ghazanfar, S., Haq, R.U., Ullah, S., Khan, S., Wu, J., Ahmad, W., and Tipu, M.K. (2022). Probiotics (Bacillus clausii and Lactobacillus fermentum NMCC-14) Ameliorate Stress Behavior in Mice by Increasing Monoamine Levels and mRNA Expression of Dopamine Receptors (D1 and D2) and Synaptophysin. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.915595"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Feng, S., Meng, C., Hao, Z., and Liu, H. (2022). Bacillus licheniformis Reshapes the Gut Microbiota to Alleviate the Subhealth. Nutrients, 14.","DOI":"10.3390\/nu14081642"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"128317","DOI":"10.1016\/j.micres.2025.128317","article-title":"Akkermansia muciniphila: A key player in gut microbiota-based disease modulation","volume":"301","author":"Shaheen","year":"2025","journal-title":"Microbiol. Res."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Otaru, N., Ye, K., Mujezinovic, D., Berchtold, L., Constancias, F., Cornejo, F.A., Krzystek, A., de Wouters, T., Braegger, C., and Lacroix, C. (2021). GABA Production by Human Intestinal Bacteroides spp.: Prevalence, Regulation, and Role in Acid Stress Tolerance. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.656895"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.bbrc.2022.09.006","article-title":"GRID2 aberration leads to disturbance in neuroactive ligand-receptor interactions via changes to the species richness and composition of gut microbes","volume":"631","author":"Huang","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.gtc.2016.09.007","article-title":"The Microbiome-Gut-Brain Axis in Health and Disease","volume":"46","author":"Dinan","year":"2017","journal-title":"Gastroenterol. Clin. N. Am."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/s41575-019-0157-3","article-title":"The role of short-chain fatty acids in microbiota-gut-brain communication","volume":"16","author":"Dalile","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s10571-026-01746-2","article-title":"The role of serotonin in brain development: From molecular pathways to neurodevelopmental risk","volume":"46","author":"Chan","year":"2026","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jad.2007.05.031","article-title":"No association between a TPH2 promoter polymorphism and mood disorders or monoamine turnover","volume":"106","author":"Mann","year":"2008","journal-title":"J. Affect. Disord."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"108730","DOI":"10.1016\/j.fbio.2026.108730","article-title":"Efficient biosynthesis of serotonin and melatonin through combinatorial metabolic engineering in Escherichia coli","volume":"79","author":"Wan","year":"2026","journal-title":"Food Biosci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1146\/annurev.med.60.042307.110802","article-title":"The Expanded Biology of Serotonin","volume":"60","author":"Berger","year":"2009","journal-title":"Annu. Rev. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1053\/j.gastro.2006.11.002","article-title":"The Serotonin Signaling System: From Basic Understanding To Drug Development for Functional GI Disorders","volume":"132","author":"Gershon","year":"2007","journal-title":"Gastroenterology"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.cell.2015.02.047","article-title":"Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis","volume":"161","author":"Yano","year":"2015","journal-title":"Cell"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"100668","DOI":"10.1016\/j.microb.2026.100668","article-title":"Serotonin and the gut microbiome: Pathways, functions, and health implications","volume":"10","author":"Abubaker","year":"2026","journal-title":"Microbe"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Bazzari, A.H., and Bazzari, F.H. (2022). BDNF therapeutic mechanisms in neuropsychiatric disorders. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23158417"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1093\/advances\/nmz127","article-title":"Tryptophan Metabolism: A Link Between the Gut Microbiota and Brain","volume":"11","author":"Gao","year":"2020","journal-title":"Adv. Nutr."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/mp.2012.77","article-title":"The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner","volume":"18","author":"Clarke","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Xia, H.-H., and Huang, J.-Z. (2026). Tryptophan metabolism at the crossroads of the neuro-immuno-microbial axis: Implications for precision medicine in chronic diseases. Front. Cell. Infect. Microbiol., 15.","DOI":"10.3389\/fcimb.2025.1707850"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"e37114","DOI":"10.1097\/MD.0000000000037114","article-title":"The correlation between gut microbiota and both neurotransmitters and mental disorders: A narrative review","volume":"103","author":"Mhanna","year":"2024","journal-title":"Medicine"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Roth, W., Zadeh, K., Vekariya, R., Ge, Y., and Mohamadzadeh, M. (2021). Tryptophan metabolism and gut-brain homeostasis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22062973"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jpsychires.2008.03.009","article-title":"The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat","volume":"43","author":"Desbonnet","year":"2008","journal-title":"J. Psychiatr. Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1096\/fj.12-223339","article-title":"Lactobacillus johnsonii inhibits indoleamine 2,3-dioxygenase and alters tryptophan metabolite levels in BioBreeding rats","volume":"27","author":"Valladares","year":"2013","journal-title":"FASEB J."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1002\/fsn3.3826","article-title":"Exploring the serotonin-probiotics-gut health axis: A review of current evidence and potential mechanisms","volume":"12","author":"Akram","year":"2024","journal-title":"Food Sci. Nutr."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"150218","DOI":"10.1016\/j.bbrc.2024.150218","article-title":"GABAergic implications in anxiety and related disorders","volume":"724","author":"Arora","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"e40665","DOI":"10.1016\/j.heliyon.2024.e40665","article-title":"GABA and its receptors\u2019 mechanisms in the treatment of insomnia","volume":"10","author":"Zhu","year":"2024","journal-title":"Heliyon"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"561213","DOI":"10.2147\/IJWH.S561213","article-title":"Effects of Shatavari (Asparagus racemosus) Root Extract on Sexual Wellness in Women: Findings from a Prospective, Randomized, Double-Blind, Three-Arm, Parallel-Group, Placebo-Controlled Study","volume":"18","author":"Ademola","year":"2026","journal-title":"Int. J. Womens Health"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"105831","DOI":"10.1016\/j.neuint.2024.105831","article-title":"Monoamine oxidase and neurodegeneration: Mechanisms, inhibitors and natural compounds for therapeutic intervention","volume":"179","author":"Banerjee","year":"2024","journal-title":"Neurochem. Int."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jhip.2026.02.004","article-title":"Gut\u2013brain axis in neurological disorders: Mechanistic links and regulatory role of Chinese herbal medicines","volume":"7","author":"Sharma","year":"2026","journal-title":"J. Holist. Integr. Pharm."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Bertollo, A.G., Santos, C.F., Bagatini, M.D., and Ign\u00e1cio, Z.M. (2025). Hypothalamus-pituitary-adrenal and gut-brain axes in biological interaction pathway of the depression. Front. Neurosci., 19.","DOI":"10.3389\/fnins.2025.1541075"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Tang, X., Ran, L., and Li, W. (2026). Decreased hippocampal neurogenesis and post-stroke depression. Front. Psychiatry, 17.","DOI":"10.3389\/fpsyt.2026.1761408"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.amjmed.2025.05.044","article-title":"An Integrative Approach to HPA Axis Dysfunction: From Recognition to Recovery","volume":"138","author":"Ring","year":"2025","journal-title":"Am. J. Med."},{"key":"ref_105","first-page":"e67595","article-title":"Hypothalamic-Pituitary-Adrenal (HPA) Axis: Unveiling the Potential Mechanisms Involved in Stress-Induced Alzheimer\u2019s Disease and Depression","volume":"16","author":"P","year":"2024","journal-title":"Cureus"},{"key":"ref_106","first-page":"102501","article-title":"Unlocking nature\u2019s potential: The power of adaptogens in enhancing modern health and wellness","volume":"24","author":"Malekijahan","year":"2025","journal-title":"J. Agric. Food Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s43094-025-00857-9","article-title":"From gut to brain: Exploring the impact of microbiota, dysbiosis, and neuroinflammation in neurodegenerative disorders","volume":"11","author":"Paul","year":"2025","journal-title":"Future J. Pharm. Sci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"EBC20253055","DOI":"10.1042\/EBC20253055","article-title":"Dysbiosis and the gut-brain axis impairment in the pathophysiology of Alzheimer\u2019s disease and related dementias: Is \u2018pathobiome\u2019 an etiological element?","volume":"69","author":"Park","year":"2025","journal-title":"Essays Biochem."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1007\/s00394-023-03310-w","article-title":"Shatavari supplementation in postmenopausal women alters the skeletal muscle proteome and pathways involved in training adaptation","volume":"63","author":"Jackman","year":"2024","journal-title":"Eur. J. Nutr."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Huang, J., Huang, Z.-T., Sun, X.-C., Chen, T.-T., and Wu, X.-T. (2024). Mental health status and related factors influencing healthcare workers during the COVID-19 pandemic: A systematic review and meta-analysis. PLoS ONE, 19.","DOI":"10.1371\/journal.pone.0289454"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nn.4476","article-title":"Interactions between the microbiota, immune and nervous systems in health and disease","volume":"20","author":"Fung","year":"2017","journal-title":"Nat. Neurosci."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"215","DOI":"10.4103\/0973-7847.70921","article-title":"Chemical constituents of Asparagus","volume":"4","author":"Negi","year":"2010","journal-title":"Pharmacogn. Rev."},{"key":"ref_113","unstructured":"BenchChem Technical Support Team (2026, September 08). Shatavarin IV: A Comprehensive Technical Guide on Its Antioxidant and Free Radical Scavenging Properties. BenchChem, Available online: https:\/\/www.benchchem.com\/product\/B1216113\/docs."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Witzel, K., and Matros, A. (2020). Fructans Are Differentially Distributed in Root Tissues of Asparagus. Cells, 9.","DOI":"10.3390\/cells9091943"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"101790","DOI":"10.1016\/j.fbio.2022.101790","article-title":"The inhibition mechanisms between asparagus polyphenols after hydrothermal treatment and tyrosinase: A circular dichroism spectrum, fluorescence, and molecular docking study","volume":"48","author":"Yu","year":"2022","journal-title":"Food Biosci."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"e70268","DOI":"10.1002\/mco2.70268","article-title":"Oxidative Stress: Signaling Pathways, Biological Functions, and Disease","volume":"6","author":"Liu","year":"2025","journal-title":"MedComm (2020)"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"11","DOI":"10.53964\/id.2025011","article-title":"Therapeutic potential of Shatavari (Asparagus racemosus) for psychological stress-mediated women\u2019s reproductive health disorders","volume":"2","author":"Pandey","year":"2025","journal-title":"Innov. Discov."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Shih, R.-H., Wang, C.-Y., and Yang, C.-M. (2015). NF-kappaB signaling pathways in neurological inflammation: A mini review. Front. Mol. Neurosci., 8.","DOI":"10.3389\/fnmol.2015.00077"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.7150\/ijbs.90982","article-title":"Polyphenols Targeting NF-\u03baB Pathway in Neurological Disorders: What We Know So Far?","volume":"20","author":"Mamun","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"e16635","DOI":"10.7717\/peerj.16635","article-title":"New insights into the role of GSK-3\u03b2 in the brain: From neurodegenerative disease to tumorigenesis","volume":"11","author":"Lai","year":"2023","journal-title":"PeerJ"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"9132","DOI":"10.1021\/acsomega.4c09072","article-title":"Development and optimization of piracetam and shatavarin IV-loaded nanoemulsion for Alzheimer\u2019s disease therapy: In silico and experimental analysis","volume":"10","author":"Nadeem","year":"2025","journal-title":"ACS Omega"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3897\/pharmacia.72.e167365","article-title":"Oxidative stress as a key factor in the pathophysiology of neurodegenerative diseases: Molecular mechanisms and protection pathways\u2014Review","volume":"72","author":"Karatchobanov","year":"2025","journal-title":"Pharmacia"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Chen, W.-T., and Dodson, M. (2023). The untapped potential of targeting NRF2 in neurodegenerative disease. Front. Aging, 4.","DOI":"10.3389\/fragi.2023.1270838"},{"key":"ref_124","first-page":"348","article-title":"Antioxidant enzyme activity of Shatavarin- IV in Drosophila melanogaster under Oxidative stress","volume":"13","author":"Ashadevi","year":"2022","journal-title":"J. Adv. Sci. Res."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"136294","DOI":"10.1016\/j.neulet.2021.136294","article-title":"Neuromodulatory potential of Asparagus racemosus and its bioactive molecule Shatavarin IV by enhancing synaptic acetylcholine level and nAChR activity","volume":"764","author":"Trivedi","year":"2021","journal-title":"Neurosci. Lett."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1080\/10715762.2017.1395419","article-title":"Shatavarin IV elicits lifespan extension and alleviates Parkinsonism in Caenorhabditis elegans","volume":"51","author":"Smita","year":"2017","journal-title":"Free Radic. Res."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s12017-025-08857-x","article-title":"Unlocking Alzheimer\u2019s Disease: The Role of BDNF Signaling in Neuropathology and Treatment","volume":"27","author":"Alqahtani","year":"2025","journal-title":"Neuromolecular Med."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Hassamal, S. (2023). Chronic stress, neuroinflammation, and depression: An overview of pathophysiological mechanisms and emerging anti-inflammatories. Front. Psychiatry, 14.","DOI":"10.3389\/fpsyt.2023.1130989"},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Beknazarova, A., Kuvaeva, V., Baltin, M., Mutig, K., and Bobylev, A. (2026). BDNF\/TrkB signaling in the brain\u2013kidney axis under functional stress. Biology, 15.","DOI":"10.3390\/biology15090696"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Kraus, V., Birkov\u00e1, A., Majern\u00edkov\u00e1, M., and \u010ci\u017em\u00e1rov\u00e1, B. (2026). Exploring the Health Effects of Phytoestrogens. Metabolites, 16.","DOI":"10.3390\/metabo16060410"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0960-0760(03)00360-1","article-title":"Sources of estrogen and their importance","volume":"86","author":"Simpson","year":"2003","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/s41574-023-00822-7","article-title":"The G protein-coupled oestrogen receptor GPER in health and disease: An update","volume":"19","author":"Prossnitz","year":"2023","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.yfrne.2006.09.004","article-title":"Estrogen and brain-derived neurotrophic factor (BDNF) in hippocampus: Complexity of steroid hormone-growth factor interactions in the adult CNS","volume":"27","author":"Scharfman","year":"2006","journal-title":"Front. Neuroendocrinol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1146\/annurev-clinpsy-050718-095557","article-title":"Estrogen, Stress, and Depression: Cognitive and Biological Interactions","volume":"15","author":"Albert","year":"2019","journal-title":"Annu. Rev. Clin. Psychol."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Mhatre, Y., Jadhav, P., Malik, A., Srivathsan, M., and Langade, D. (2026). Efficacy and safety of Shatavari root extract in women with Polycystic Ovarian Syndrome: A randomized, double-blind, placebo-controlled trial. Front. Endocrinol., 17.","DOI":"10.3389\/fendo.2026.1769773"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/bs.ctdb.2016.12.005","article-title":"Estrogen Hormone Biology","volume":"125","author":"Hamilton","year":"2017","journal-title":"Curr. Top. Dev. Biol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"332","DOI":"10.4088\/JCP.v62n0504","article-title":"Estrogen deficiency in severe postpartum depression: Successful treatment with sublingual physiologic 17beta-estradiol: A preliminary study","volume":"62","author":"Ahokas","year":"2001","journal-title":"J. Clin. Psychiatry"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s40203-023-00169-x","article-title":"A network pharmacology approach to explore pharmacological mechanisms of Asparagus racemosus for ameliorative effect in epilepsy and comorbid progressive memory dysfunction","volume":"11","author":"Kaur","year":"2023","journal-title":"In Silico Pharmacol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s11064-025-04440-9","article-title":"Exploration of Asparagus racemosus Willd for Alzheimer\u2019s disease through integrated metabolomics and network pharmacology analyses targeting BACE1 protein","volume":"50","author":"Shaji","year":"2025","journal-title":"Neurochem. Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"775","DOI":"10.6026\/973206300200775","article-title":"Molecular docking analysis of shatavarins with female hormonal receptors","volume":"20","author":"Arora","year":"2024","journal-title":"Bioinformation"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1021\/acs.jcim.3c00018","article-title":"Investigation of anti-Alzheimer\u2019s mechanisms of sarsasapogenin derivatives by network-based combining structure-based methods","volume":"63","author":"Zhou","year":"2023","journal-title":"J. Chem. Inf. Model."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.neulet.2011.07.051","article-title":"Asparagus racemosus competitively inhibits in vitro the acetylcholine and monoamine metabolizing enzymes","volume":"503","author":"Meena","year":"2011","journal-title":"Neurosci. Lett."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"108529","DOI":"10.1016\/j.steroids.2019.108529","article-title":"Sarsasapogenin: A steroidal saponin from Asparagus racemosus as multi target directed ligand in Alzheimer\u2019s disease","volume":"153","author":"Kashyap","year":"2020","journal-title":"Steroids"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.5897\/JMPR12.497","article-title":"Neuroprotective response of the hippocampus region of the brain to Withania somnifera and Asparagus racemosus root extract: An in vitro study","volume":"7","author":"Bhatnagar","year":"2013","journal-title":"J. Med. Plants Res."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.pbb.2008.07.010","article-title":"Antidepressant activity of Asparagus racemosus in rodent models","volume":"91","author":"Singh","year":"2009","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1179\/1476830513Y.0000000053","article-title":"Asparagus racemosus modulates the hypothalamic\u2013pituitary\u2013adrenal axis and brain monoaminergic systems in rats","volume":"16","author":"Krishnamurthy","year":"2013","journal-title":"Nutr. Neurosci."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s10571-014-0035-z","article-title":"Asparagus racemosus attenuates anxiety-like behavior in experimental animal models","volume":"34","author":"Garabadu","year":"2014","journal-title":"Cell Mol. Neurobiol."},{"key":"ref_148","first-page":"S171","article-title":"Antidepressant effect of roots of Asparagus racemosus on diabetes-induced depression in rats","volume":"40","author":"Bhapkar","year":"2008","journal-title":"Indian J. Pharmacol."},{"key":"ref_149","first-page":"419","article-title":"Antistress activity of ethanolic extract of Asparagus racemosus Willd roots in mice","volume":"50","author":"Joshi","year":"2012","journal-title":"Indian J. Exp. Biol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"67","DOI":"10.5214\/ans.0972.7531.2005.120401","article-title":"Antioxidant effects of Asparagus racemosus Wild and Withania somnifera Dunal in rat brain","volume":"12","author":"Vimal","year":"2005","journal-title":"Ann. Neurosci."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bandc.2010.05.009","article-title":"Asparagus racemosus enhances memory and protects against amnesia in rodent models","volume":"74","author":"Ojha","year":"2010","journal-title":"Brain Cogn."},{"key":"ref_152","first-page":"20","article-title":"In vivo investigation of antiamnesic effect of Asparagus racemosus root extract in scopolamine induced amnesic mice","volume":"3","author":"Jagdish","year":"2015","journal-title":"Int. J. Herb. Med."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"391","DOI":"10.5530\/ajbls.2021.10.52","article-title":"Neuroprotective efficacy of Asparagus racemosus root extract on hippocampal neurons in a scopolamine mouse model of Alzheimer\u2019s disease","volume":"10","author":"Jagdish","year":"2021","journal-title":"Asian J. Biol. Life Sci."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.jep.2018.07.014","article-title":"Neuroprotective effect of Asparagus racemosus root extract via the enhancement of brain-derived neurotrophic factor and estrogen receptor in ovariectomized rats","volume":"225","author":"Lalert","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"ref_155","first-page":"18","article-title":"Neuroprotective effects of the Asparagus racemosus root extract on ovariectomized rats","volume":"26","author":"Lalert","year":"2013","journal-title":"J. Physiol. BioMed Sci."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"57","DOI":"10.5214\/ans.0972.7531.2007.140302","article-title":"Neuroprotective effects of Asparagus racemosus Linn root extract: An experimental and clinical evidence","volume":"14","author":"Saxena","year":"2007","journal-title":"Ann. Neurosci."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.yebeh.2016.01.025","article-title":"Ameliorative effect of Asparagus racemosus root extract against pentylenetetrazol-induced kindling and associated depression and memory deficit","volume":"57","author":"Pahwa","year":"2016","journal-title":"Epilepsy Behav."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1007\/s11064-021-03455-2","article-title":"Anticonvulsant effect of Asparagus racemosus Willd. in a mouse model of catamenial epilepsy","volume":"47","author":"Pahwa","year":"2022","journal-title":"Neurochem. Res."},{"key":"ref_159","first-page":"64","article-title":"An experimental evaluation of anticonvulsant activity of Asparagus racemosus","volume":"11","author":"Amberkar","year":"2011","journal-title":"Int. J. Pharm. Sci. Rev. Res."},{"key":"ref_160","first-page":"157","article-title":"Antiepileptic effect of Asparagus racemosus root extracts","volume":"10","author":"Jalalpure","year":"2009","journal-title":"J. Trop. Med. Plants"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"97","DOI":"10.5530\/rjps.2015.3.3","article-title":"Phytochemical investigation and antiepileptic activity of Asparagus racemosus (Wild) root extracts in rodents","volume":"5","author":"Shastry","year":"2015","journal-title":"RGUHS J. Pharm. Sci."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3923\/jpt.2011.49.61","article-title":"Cerebroprotective effect of root extract of Asparagus racemosus Willd. in global cerebral ischemia in rats","volume":"6","author":"Nandagopal","year":"2011","journal-title":"J. Pharmacol. Toxicol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"569","DOI":"10.5530\/ijpi.2020.4.99","article-title":"Antiparkinsonian and antioxidant effects of hydroalcoholic extract of Camellia sinensis, Asparagus racemosus, Mucuna pruriens and their combination","volume":"10","author":"Giri","year":"2020","journal-title":"Int. J. Pharm. Investig."},{"key":"ref_164","first-page":"102381","article-title":"Neuroprotective potential of polyherbal formulation: Evidence from preliminary in-vitro and in-vivo studies","volume":"45","author":"Rathod","year":"2026","journal-title":"Biochem. Biophys. Rep."},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Erten, F., Er, B., Ozmen, R., Tokmak, M., Gokdere, E., Orhan, C., Morde, A.A., Padigaru, M., and Sahin, K. (2025). Effects of integrated extracts of Trigonella foenum-graecum and Asparagus racemosus on hot flash-like symptoms in ovariectomized rats. Antioxidants, 14.","DOI":"10.3390\/antiox14030355"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.2147\/IJWH.S544267","article-title":"Efficacy and safety of Shatavari (Asparagus racemosus) root extract for perimenopause: Randomized, double-blind, placebo-controlled study","volume":"17","author":"Mahajan","year":"2025","journal-title":"Int. J. Womens Health"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1080\/19390211.2026.2689348","article-title":"Efficacy and safety of Shatavari root extract in managing peri-menopausal symptoms: A randomized, double-blind, placebo-controlled clinical trial","volume":"23","author":"Surampalli","year":"2026","journal-title":"J. Diet. Suppl."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1654503","DOI":"10.3389\/frph.2025.1654503","article-title":"Efficacy and safety of Shatavari root extract (Asparagus racemosus) for menopausal symptoms: A randomized, double-blind, three-arm, placebo-controlled study","volume":"7","author":"Ademola","year":"2025","journal-title":"Front. Reproduct. 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