{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:02:12Z","timestamp":1789570932630,"version":"build-2803163510"},"reference-count":42,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004035","name":"Jordan University of Science and Technology","doi-asserted-by":"publisher","award":["350\/2017"],"award-info":[{"award-number":["350\/2017"]}],"id":[{"id":"10.13039\/501100004035","id-type":"DOI","asserted-by":"publisher"}]},{"award":["350\/2017"],"award-info":[{"award-number":["350\/2017"]}],"id":[{"id":"https:\/\/ror.org\/03y8mtb59","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Introduction: Cystic fibrosis (CF) is a rare, life-limiting genetic disorder characterized by abnormally thick mucus secretions that obstruct the respiratory, gastrointestinal, and reproductive tracts. Globally, CF affects an estimated 70,000 to 100,000 individuals. This study investigated nutritional awareness and dietary management among caregivers of pediatric CF patients. Specifically, it evaluated parental nutritional knowledge, caregiving behaviors, and patients\u2019 actual nutrient intake and diet quality relative to established clinical guidelines. Methods: A cross-sectional study was conducted with a representative sample of 50 parents and their children with CF (aged 4\u201318 years) receiving specialized care at Caritas Baby Hospital in Bethlehem, Palestine. Data collection utilized a comprehensive parental questionnaire alongside a 3-day food diary completed by participants. Objective clinical status and biochemical markers were extracted directly from patients\u2019 medical records. CF-specific recommendations were used where available, and general pediatric reference values were used otherwise. Results: A significant disparity (p \u2264 0.05) was observed between patients\u2019 actual dietary intake and the recommended daily allowances for protein, carbohydrates, zinc, and calcium; however, intakes of sodium and iron did not differ significantly from guidelines. Higher patient adherence to dietary recommendations was significantly associated with superior lung function (measured via FEV1) and optimal serum albumin levels (p \u2264 0.05). Notably, 38% of the study sample were classified as underweight, and 76.9% of children with available 25(OH)D measurements (30\/39) exhibited concentrations below 30 ng\/mL. Clinical and biochemical measurements were not available for all participants. Caregiver nutritional knowledge was not significantly associated with the measured clinical or biochemical outcomes, whereas better patient dietary adherence was associated with higher FEV1% predicted and serum albumin concentrations. Conclusion: The high prevalence of underweight status and micronutrient deficiencies highlights a critical need for targeted nutritional education and clinical counseling programs. Enhancing awareness among patients and parents is essential to correct dietary deficits, optimize growth, and improve long-term health outcomes.<\/jats:p>","DOI":"10.3390\/nu18183034","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:50:27Z","timestamp":1789566627000},"page":"3034","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nutritional Status and Caregiver Knowledge in Pediatric Cystic Fibrosis Management"],"prefix":"10.3390","volume":"18","author":[{"given":"Hadil S.","family":"Subih","sequence":"first","affiliation":[{"name":"Department of Nutrition and Food Technology, Faculty of Agriculture, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nour","family":"Khamis","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Technology, Faculty of Agriculture, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0315-4032","authenticated-orcid":false,"given":"Belal S.","family":"Obeidat","sequence":"additional","affiliation":[{"name":"Department of Animal Production, Faculty of Agriculture, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Nisreen","family":"Rumman","sequence":"additional","affiliation":[{"name":"Pulmonary Clinical Medical Department, Caritas Baby Hospital (CBH), Bethlehem, Palestine"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Linda","family":"Alyahya","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Universiti Sains Malaysia, Gelugor 11800, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1177\/0884533615591604","article-title":"Nutrition management of cystic fibrosis in the 21st century","volume":"30","author":"Schindler","year":"2015","journal-title":"Nutr. Clin. Pract."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jcf.2015.09.008","article-title":"Cystic fibrosis in young children: A review of disease manifestation, progression, and response to early treatment","volume":"15","author":"Kahle","year":"2016","journal-title":"J. Cyst. Fibros."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.jcf.2016.11.002","article-title":"Environmental scan of cystic fibrosis research worldwide","volume":"16","author":"Kelly","year":"2017","journal-title":"J. Cyst. Fibros."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1002\/ppul.26366","article-title":"Clinical characteristics and outcomes of cystic fibrosis in Palestine: Cross sectional study","volume":"58","author":"Salah","year":"2023","journal-title":"Pediatr. Pulmonol."},{"key":"ref_5","unstructured":"Savant, A., Lyman, B., Bojanowski, C., and Upadia, J. (2024). Cystic Fibrosis. GeneReviews\u00ae, University of Washington."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1016\/j.jpeds.2016.09.065","article-title":"Diagnosis of cystic fibrosis in screened populations","volume":"181","author":"Farrell","year":"2017","journal-title":"J. Pediatr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/jftr.12070","article-title":"Parent-to-child transition in managing cystic fibrosis: A research synthesis","volume":"7","author":"Leeman","year":"2015","journal-title":"J. Fam. Theory Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.clnu.2012.04.012","article-title":"Use of body mass index percentile to identify fat-free mass depletion in children with cystic fibrosis","volume":"31","author":"Engelen","year":"2012","journal-title":"Clin. Nutr."},{"key":"ref_9","unstructured":"Cystic Fibrosis Foundation (2026). Understanding Changes in Life Expectancy, Cystic Fibrosis Foundation."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1016\/j.jpeds.2016.09.064","article-title":"Diagnosis of cystic fibrosis: Consensus guidelines from the Cystic Fibrosis Foundation","volume":"181S","author":"Farrell","year":"2017","journal-title":"J. Pediatr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.jand.2020.03.015","article-title":"Academy of Nutrition and Dietetics Evidence Analysis Center Academy of Nutrition and Dietetics: 2020 Cystic Fibrosis Evidence Analysis Center Evidence-Based Nutrition Practice Guideline","volume":"121","author":"McDonald","year":"2020","journal-title":"J. Acad. Nutr. Diet."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Struyvenberg, M.R., Martin, C.R., and Freedman, S.D. (2017). Practical guide to exocrine pancreatic insufficiency\u2013breaking the myths. BMC Med., 15.","DOI":"10.1186\/s12916-017-0783-y"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1177\/0884533613507086","article-title":"Malnutrition in cystic fibrosis: A review","volume":"6","author":"Culhane","year":"2013","journal-title":"Nutr. Clin. Pract."},{"key":"ref_14","first-page":"515","article-title":"Protein is an important but undervalued macronutrient in the nutritional care of patients with cystic fibrosis","volume":"17","author":"Engelen","year":"2014","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.clnu.2023.12.017","article-title":"ESPEN-ESPGHAN-ECFS guideline on nutrition care for cystic fibrosis","volume":"43","author":"Wilschanski","year":"2024","journal-title":"Clin. Nutr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.clnu.2016.03.004","article-title":"ESPEN-ESPGHAN-ECFS guidelines on nutrition care for infants, children, and adults with cystic fibrosis","volume":"35","author":"Turck","year":"2016","journal-title":"Clin. Nutr."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jcf.2005.05.015","article-title":"Mealtime behaviors in families of infants and toddlers with cystic fibrosis","volume":"4","author":"Powers","year":"2005","journal-title":"J. Cyst. Fibros."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1177\/1367493518768448","article-title":"Transition from pediatric to adult healthcare for young people with cystic fibrosis: Parents\u2019 information needs","volume":"22","author":"Coyne","year":"2018","journal-title":"J. Child Health Care"},{"key":"ref_19","first-page":"117","article-title":"Strategies to optimize treatment adherence in adolescent patients with cystic fibrosis","volume":"7","author":"Bishay","year":"2016","journal-title":"Adolesc. Health Med. Ther."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/S0022-3476(98)70024-1","article-title":"Growth status in children with cystic fibrosis based on the National Cystic Fibrosis Patient Registry data: Evaluation of various criteria used to identify malnutrition","volume":"132","author":"Lai","year":"1998","journal-title":"J. Pediatr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ccm.2015.11.009","article-title":"Nutritional issues in cystic fibrosis","volume":"37","author":"Solomon","year":"2016","journal-title":"Clin. Chest Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/S0002-8223(97)00235-6","article-title":"Relationship of nutritional status to length of stay, hospital costs, and discharge status of patients hospitalized in the medicine service","volume":"97","author":"Chima","year":"1997","journal-title":"J. Am. Diet. Assoc."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1136\/thorax.57.7.596","article-title":"Relationship between nutritional status and lung function in cystic fibrosis: Cross sectional and longitudinal analyses from the German CF quality assurance (CFQA) project","volume":"57","author":"Steinkamp","year":"2002","journal-title":"Thorax"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1111\/crj.12920","article-title":"Is an FEV1 of 80% predicted a normal spirometry in cystic fibrosis children and adults","volume":"12","author":"Ner","year":"2018","journal-title":"Clin. Respir. J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1183\/09031936.00166412","article-title":"Factors associated with FEV1 decline in cystic fibrosis: Analysis of the ECFS patient registry","volume":"43","author":"Kerem","year":"2014","journal-title":"Eur. Respir. J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0031-3955(16)36620-2","article-title":"Laboratory tests and nutritional assessment: Protein-energy status","volume":"36","author":"Benjamin","year":"1989","journal-title":"Pediatr. Clin. N. Am."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.jpeds.2008.04.058","article-title":"Current treatment recommendations for correcting vitamin D deficiency in pediatric patients with cystic fibrosis are inadequate","volume":"153","author":"Green","year":"2008","journal-title":"J. Pediatr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1177\/0884533614562839","article-title":"Prevalence of inadequate vitamin d status and associated factors in children with cystic fibrosis","volume":"30","author":"Norton","year":"2015","journal-title":"Nutr. Clin. Pract."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1093\/ajcn\/75.6.1005","article-title":"Abnormal lipid concentrations in cystic fibrosis","volume":"75","author":"Figueroa","year":"2002","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_30","first-page":"4","article-title":"Nutritional management of cystic fibrosis\u2013an update for the 21st century","volume":"26","author":"Collins","year":"2018","journal-title":"Pediatr. Respir. Rev."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1002\/ppul.23307","article-title":"A five-year retrospective analysis of adherence in cystic fibrosis","volume":"50","author":"Shakkottai","year":"2015","journal-title":"Pediatr. Pulmonol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7762\/cnr.2015.4.1.1","article-title":"The role of calcium in human aging","volume":"4","author":"Beto","year":"2015","journal-title":"Clin. Nutr. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1111\/j.1651-2227.2003.tb00601.x","article-title":"Decreased bone mineral density in normal-growing patients with cystic fibrosis","volume":"92","author":"Gronowitz","year":"2003","journal-title":"Acta Paediatr."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"168S","DOI":"10.1080\/07315724.2001.10719029","article-title":"The importance of meeting calcium needs with foods","volume":"20","author":"Miller","year":"2001","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.jcf.2010.04.008","article-title":"Guidelines on the early management of infants diagnosed with cystic fibrosis following newborn screening","volume":"9","author":"Mayell","year":"2010","journal-title":"J. Cyst. Fibros."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.jcf.2009.08.006","article-title":"Evaluation of salt supplementation in CF infants","volume":"8","author":"Coates","year":"2009","journal-title":"J. Cyst. Fibros."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/ppul.22857","article-title":"Iron deficiency occurs frequently in children with cystic fibrosis","volume":"49","author":"Uijterschout","year":"2014","journal-title":"Pediatr. Pulmonol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1136\/archdischild-2011-301527","article-title":"The natural history and predictors of persistent problem behaviours in cystic fibrosis: A multicentre, prospective study","volume":"97","author":"Sheehan","year":"2012","journal-title":"Arch. Dis. Child."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1093\/jpepsy\/19.6.751","article-title":"Modifying problematic mealtime interactions of children with cystic fibrosis and their parents via behavioral parent training","volume":"19","author":"Stark","year":"1994","journal-title":"J. Pediatr. Psychol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S0022-3999(99)00065-3","article-title":"Psychosocial predictors of adherence to nutritional recommendations and growth outcomes in children with cystic fibrosis","volume":"47","author":"Anthony","year":"1999","journal-title":"J. Psychosom. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jcf.2006.03.002","article-title":"A multi-method assessment of treatment adherence for children with cystic fibrosis","volume":"5","author":"Modi","year":"2006","journal-title":"J. Cyst. Fibros."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.jcf.2012.11.014","article-title":"Self-efficacy: Empowering parents of children with cystic fibrosis","volume":"12","author":"McDonald","year":"2013","journal-title":"J. Cyst. Fibros."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/18\/3034\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:02:53Z","timestamp":1789567373000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/18\/3034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,16]]},"references-count":42,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["nu18183034"],"URL":"https:\/\/doi.org\/10.3390\/nu18183034","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,16]]}}}