{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:12:23Z","timestamp":1792789943163,"version":"4.5.0"},"reference-count":89,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institutes of Health","award":["HL 163844"],"award-info":[{"award-number":["HL 163844"]}]},{"name":"Department of Veterans Affairs","award":["CARB-013-165"],"award-info":[{"award-number":["CARB-013-165"]}]},{"name":"Department of Veterans Affairs","award":["HL 151738"],"award-info":[{"award-number":["HL 151738"]}]},{"award":["CARB-013-165"],"award-info":[{"award-number":["CARB-013-165"]}],"id":[{"id":"https:\/\/ror.org\/05dbx6743","id-type":"ROR","asserted-by":"publisher"}]},{"award":["HL 151738"],"award-info":[{"award-number":["HL 151738"]}],"id":[{"id":"https:\/\/ror.org\/05dbx6743","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Core Facilities at Vanderbilt University","award":["DK 020593"],"award-info":[{"award-number":["DK 020593"]}],"id":[{"id":"https:\/\/ror.org\/02vm5rt34","id-type":"ROR","asserted-by":"crossref"}]},{"award":["DK 020593"],"award-info":[{"award-number":["DK 020593"]}],"id":[{"id":"https:\/\/ror.org\/02vm5rt34","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Combined high fructose and high sodium diet (FHS) is linked to elevated blood pressure (BP), heightened sympathetic activity, and cardiovascular and renal dysfunction. Total-renal denervation is effective in lowering BP in some hypertension models. Objectives: The present studies tested whether selective afferent (A-RDNx) or total-renal denervation (T-RDNx) ameliorates FHS cardiovascular and renal function. Methods: Male and female Sprague Dawley rats were fed 20% glucose and 0.4% Na chow for one week then assigned to one of four groups: 20% glucose plus 0.4% Na sham-operation (G-Sham) or 20% fructose plus 4% Na with either sham-operation (F-Sham), A-RDNx, or T-RDNx for ~21 days. Telemetric BP and heart rate, echocardiography, pulse-wave velocity (PWV), and renal function were assessed. Results: T-RDNx reduced FHS-induced high BP in both sexes. LVEF did not differ, but global longitudinal strain showed hypercontractility in male F-Sham, which normalized with A-RDNx or T-RDNx. Increased LV perivascular fibrosis in F-Sham rats of both sexes was prevented by A-RDNx or T-RDNx. T-RDNx improved elevated PWV, endothelium-independent vasodilation by myography, and aortic oxidative stress in male F-Sham aortas. High plasma renin activity in male F-Sham decreased with T-RDNx to levels similar to G-Sham rats. Serum creatinine, urine albumin:creatinine ratio, and mesangial hypercellularity in F-Sham male rats decreased with A-RDNx or T-RDNx. Renal function was unchanged in female F-Sham; T-RDNx decreased albuminuria. Conclusions: Renal-sympathetic nerves play a crucial role in elevated BP, cardiac dysfunction, vascular stiffness, and renal impairment associated with FHS diet, particularly in male rats, and implicates a complex interplay with BP, the renin-angiotensin system, and oxidative stress.<\/jats:p>","DOI":"10.3390\/nu18183067","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:50:03Z","timestamp":1789995003000},"page":"3067","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact\u00a0of\u00a0Total or Afferent Renal-Nerve Denervation on Cardiovascular and Renal Function in Sprague Dawley Rats Fed High-Fructose and High-Sodium Diet"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6979-4994","authenticated-orcid":false,"given":"Sharif Hasan","family":"Siddiqui","sequence":"first","affiliation":[{"name":"Department of Physiology, School of Medicine, Wayne State University, 540 E. Canfield, Detroit, MI 48201, USA"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8855-4291","authenticated-orcid":false,"given":"Dragana","family":"Komnenov","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, Wayne State University, 540 E. Canfield, Detroit, MI 48201, USA"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9084-840X","authenticated-orcid":false,"given":"Afoluso","family":"Olayonwa","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, Wayne State University, 540 E. Canfield, Detroit, MI 48201, USA"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Hainan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Eugene Applebaum Colledge of Pharmacy and Health Sciences, Wayne State University, 549 Mack Ave,\u00a0Detroit, MI 48201, USA"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8723-4410","authenticated-orcid":false,"given":"Jiemei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Eugene Applebaum Colledge of Pharmacy and Health Sciences, Wayne State University, 549 Mack Ave,\u00a0Detroit, MI 48201, USA"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9180-3236","authenticated-orcid":false,"given":"Charles S.","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, Wayne State University, 540 E. Canfield, Detroit, MI 48201, USA"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9980-154X","authenticated-orcid":false,"given":"Ana M.","family":"Daugherty","sequence":"additional","affiliation":[{"name":"Department of Psychology, Wayne State University, 87 Ferry St., Detroit, MI 48202, USA"},{"name":"Institute of Gerontology, Wayne State University, 87 Ferry St., Detroit, MI 48202, USA"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5886-427X","authenticated-orcid":false,"given":"Noreen F.","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, Wayne State University, 540 E. 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