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Beyond circadian regulation, it is indispensable for diverse critical physiological processes, including organ function modulation, metabolism, immune responses, and neural activity and transcriptional regulation. Many phytochemicals have been confirmed to regulate CNS function and systemic metabolism via REV-ERB and its downstream cascades. In this review, the regulatory potential of REV-ERB in CNS homeostasis and function is summarized. The roles of various phytochemicals in this regulatory pathway are examined, with a particular emphasis on their capacity to modulate neurological health. This work could enhance our understanding of REV-ERB-mediated neuroprotective and metabolic actions of phytochemicals, and provide a scientific basis for circadian-guided functional food design and the application of phytochemicals in preventing neurodegenerative diseases.<\/jats:p>","DOI":"10.3390\/nu18183071","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:50:03Z","timestamp":1789995003000},"page":"3071","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["REV-ERB-Mediated Regulation of Neural Functional Mechanisms by Phytochemicals in the Circadian System"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4944-8585","authenticated-orcid":false,"given":"Ming-Ying","family":"Pan","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1099-9454","authenticated-orcid":false,"given":"Jiang-Bao","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Run","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Food Science, Rutgers University, New Brunswick, NJ 08901, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7158-0423","authenticated-orcid":false,"given":"Mu-Wen","family":"Lu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7924-9356","authenticated-orcid":false,"given":"Jun-Qing","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Gomatou, G., Karachaliou, A., Veloudiou, O.-Z., Karvela, A., Syrigos, N., and Kotteas, E. 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