{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:04:41Z","timestamp":1790154281405,"version":"4.0.1"},"reference-count":99,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Sarcopenia is a progressive skeletal muscle disorder associated with impaired physical function and adverse outcomes in older adults. Burn injury imposes profound hypermetabolic and catabolic stress that may compromise muscle mass, strength, and physical function, particularly in individuals with reduced baseline muscle reserve. This narrative review integrates current evidence on sarcopenia and muscle dysfunction in older adults with burn injuries, addressing baseline vulnerability, burn-related muscle deterioration, diagnostic challenges, clinical implications, and therapeutic strategies. Patients may present with pre-existing sarcopenia or reduced muscle reserve, develop acute sarcopenia during or after burn-related illness, or experience worsening of pre-existing sarcopenia, potentially resulting in an acute-on-chronic trajectory. However, substantial burn-related muscle wasting, weakness, and functional impairment may occur without fulfilling diagnostic criteria for sarcopenia and represent distinct, clinically relevant manifestations of impaired muscle health. Sarcopenia assessment in burn patients is challenging and should be individualized according to clinical context and stage of recovery. Preservation and recovery of muscle health should be addressed throughout burn care through individualized nutritional support, early mobilization, and progressive exercise, with pharmacological strategies playing an adjunctive role. Prospective longitudinal studies are needed to characterize muscle-health trajectories, distinguish sarcopenia from other forms of post-burn muscle dysfunction, and determine their prognostic significance and response to interventions, including effects on functional recovery, independence, and quality of life.<\/jats:p>","DOI":"10.3390\/nu18193122","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:14:39Z","timestamp":1790151279000},"page":"3122","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sarcopenia\u00a0and Muscle Dysfunction in Older Adults with Burn Injuries: An Integrated Clinical Perspective"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4841-3480","authenticated-orcid":false,"given":"Joana","family":"Santos-Costa","sequence":"first","affiliation":[{"name":"Physical and Rehabilitation Medicine Department, Hospitais da 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Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6800-699X","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Santos-Faria","sequence":"additional","affiliation":[{"name":"Physical and Rehabilitation Medicine Department, Hospitais da Universidade de Coimbra, Unidade Local de Sa\u00fade de Coimbra,  3000-075 Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1994-3450","authenticated-orcid":false,"given":"Fl\u00e1vio","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Physical and Rehabilitation Medicine Department, Hospitais da Universidade de Coimbra, Unidade Local de Sa\u00fade de Coimbra,  3000-075 Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8454-7780","authenticated-orcid":false,"given":"Marisa","family":"Caetano","sequence":"additional","affiliation":[{"name":"Pharmacy 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Ageing"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e70122","DOI":"10.1002\/jcsm.70122","article-title":"Psychometric Properties of the SarQoL Questionnaire: A Systematic Review and Meta-Analysis","volume":"16","author":"Demonceau","year":"2025","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1007\/s12603-018-1058-9","article-title":"Muscle, Health and Costs: A Glance at Their Relationship","volume":"22","author":"Mijnarends","year":"2018","journal-title":"J. Nutr. Health Aging"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"155533","DOI":"10.1016\/j.metabol.2023.155533","article-title":"Epidemiology of Sarcopenia: Prevalence, Risk Factors, and Consequences","volume":"144","author":"Yuan","year":"2023","journal-title":"Metabolism"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.burns.2011.06.005","article-title":"Epidemiology of Burns Throughout the World. Part I: Distribution and Risk Factors","volume":"37","author":"Peck","year":"2011","journal-title":"Burns"},{"key":"ref_6","unstructured":"World Health Organization (2008). A WHO Plan for Burns\u2014Burn Prevention and Care, World Health Organization."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"111955","DOI":"10.1016\/j.injury.2024.111955","article-title":"The Global, Regional, and National Burden of Burns: An Analysis of Injury by Fire, Heat, and Hot Substances in the Global Burden of Disease Study 2019","volume":"56","author":"Yin","year":"2025","journal-title":"Injury"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"R188","DOI":"10.1186\/cc9300","article-title":"Severe Burn Injury in Europe: A Systematic Review of the Incidence, Etiology, Morbidity, and Mortality","volume":"14","author":"Brusselaers","year":"2010","journal-title":"Crit. Care"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.burns.2016.08.013","article-title":"Recent Trends in Burn Epidemiology Worldwide: A Systematic Review","volume":"43","author":"Smolle","year":"2017","journal-title":"Burns"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1093\/jbcr\/iraa040","article-title":"Relationship between Patient Characteristics and Number of Procedures as Well as Length of Stay for Patients Surviving Severe Burn Injuries: Analysis of the American Burn Association National Burn Repository","volume":"41","author":"Kruger","year":"2020","journal-title":"J. Burn Care Res."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Lee, N., Bae, Y., Jang, S., Lee, D.W., and Lee, S.W. (2025). Global, Regional, and National Burden of Burn Injury by Total Body Surface Area (TBSA) Involvement from 1990 to 2021, with Projections of Prevalence to 2050. Healthcare, 13.","DOI":"10.3390\/healthcare13162077"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41572-020-0145-5","article-title":"Burn Injury","volume":"6","author":"Jeschke","year":"2020","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s41038-018-0118-z","article-title":"Epidemiologic and Clinical Characteristics of Severe Burn Patients: Results of a Retrospective Multicenter Study in China, 2011\u20132015","volume":"6","author":"Tian","year":"2018","journal-title":"Burns Trauma"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1097\/TA.0b013e3181c453b3","article-title":"Simplified Estimates of the Probability of Death After Burn Injuries: Extending and Updating the Baux Score","volume":"68","author":"Osler","year":"2010","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1056\/NEJMra1807442","article-title":"Management of Burns","volume":"380","author":"Greenhalgh","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_16","first-page":"171","article-title":"Aging and the Pathogenic Response to Burn","volume":"3","author":"Rani","year":"2011","journal-title":"Aging Dis."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Chen, Q., Wang, R., Guo, L., Li, P., Deng, K., Xiao, H., and Xu, X. (2025). Global Trends in Thermal Burn Burden, 1990-2021: A Comprehensive Analysis for the Global Burden of Disease Study 2021. Front. Public Health, 13.","DOI":"10.3389\/fpubh.2025.1631138"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.burns.2011.03.006","article-title":"Burns Are More Aggressive in the Elderly: Proportion of Deep Burn Area\/Total Burn Area Might Have a Role in Mortality","volume":"37","author":"Albornoz","year":"2011","journal-title":"Burns"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/BCR.0b013e3181921efc","article-title":"Epidemiology and Outcomes of Older Adults with Burn Injury: An Analysis of the National Burn Repository","volume":"30","author":"Pham","year":"2009","journal-title":"J. Burn Care Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/jbcr\/irz163","article-title":"State of the Science Burn Research: Burns in the Elderly","volume":"41","author":"Jeschke","year":"2020","journal-title":"J. Burn Care Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1097\/BCR.0b013e31818ba1ab","article-title":"Risk Factors for Fires and Burns in Homebound, Urban Elderly","volume":"29","author":"Ehrlich","year":"2008","journal-title":"J. Burn Care Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1016\/j.biocel.2005.05.009","article-title":"Post Burn Muscle Wasting and the Effects of Treatments","volume":"37","author":"Pereira","year":"2005","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e625","DOI":"10.1097\/BCR.0000000000000535","article-title":"Burn Care of the Elderly","volume":"38","author":"Jeschke","year":"2017","journal-title":"J. Burn Care Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/BCR.0000000000000190","article-title":"Frailty Score on Admission Predicts Outcomes in Elderly Burn Injury","volume":"36","author":"Romanowski","year":"2015","journal-title":"J. Burn Care Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.burns.2012.03.002","article-title":"The Use of a Frailty Scoring System for Burns in the Elderly","volume":"39","author":"Masud","year":"2013","journal-title":"Burns"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Hanna-Deschamps, E., Herrmann, F.R., Chirouzes, D., Claudepierre Buratti, L., Luthy, C., Frangos, E., Pautex, S., Genton, L., Zekry, D., and Graf, C.E. (2026). Sarcopenia in Hospitalized Older Adults: A Cross-Sectional Study Comparing Diagnostic Thresholds and Handgrip Strength Measurement Tools. Geriatrics, 11.","DOI":"10.3390\/geriatrics11010007"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/jbcr\/iraa149","article-title":"Computed Tomography Measurements of Sarcopenia Predict Length of Stay in Older Burn Patients","volume":"42","author":"Romanowski","year":"2021","journal-title":"J. Burn Care Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1093\/jbcr\/irab032.057","article-title":"53 Frailty Is Not Only a Phenomenon of Elderly Burn Patients","volume":"42","author":"Romanowski","year":"2021","journal-title":"J. Burn Care Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/jcsm.12783","article-title":"Global Prevalence of Sarcopenia and Severe Sarcopenia: A Systematic Review and Meta-Analysis","volume":"13","author":"Balntzi","year":"2022","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e041879","DOI":"10.1136\/bmjopen-2020-041879","article-title":"Prevalence of Sarcopenia in Older Chinese Adults: A Systematic Review and Meta-Analysis","volume":"11","author":"Xin","year":"2021","journal-title":"BMJ Open"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/ageing\/afy106","article-title":"The Prevalence of Sarcopenia in Community-Dwelling Older Adults, an Exploration of Differences Between Studies and Within Definitions: A Systematic Review and Meta-Analyses","volume":"48","author":"Mayhew","year":"2019","journal-title":"Age Ageing"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s40520-017-0866-9","article-title":"Quality of Life in Sarcopenia Measured with the SarQoL\u00ae: Impact of the Use of Different Diagnosis Definitions","volume":"30","author":"Beaudart","year":"2018","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1177\/1460408618773514","article-title":"The Prevalence of Comorbidities among Acute Burn Patients","volume":"21","author":"Salehi","year":"2019","journal-title":"Trauma"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"227","DOI":"10.47482\/acmr.1091483","article-title":"Elderly Burns; Our Clinical Experiences","volume":"3","author":"Akin","year":"2022","journal-title":"Arch. Curr. Med. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.clnu.2024.01.028","article-title":"Sarcopenia and Poor Nutritional Status in Older Adults","volume":"43","author":"Calcaterra","year":"2024","journal-title":"Clin. Nutr."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Chew, S.T.H., Tey, S.L., Yalawar, M., Liu, Z., Baggs, G., How, C.H., Cheong, M., Chow, W.L., Low, Y.L., and Huynh, D.T.T. (2022). Prevalence and Associated Factors of Sarcopenia in Community-Dwelling Older Adults at Risk of Malnutrition. BMC Geriatr., 22.","DOI":"10.1186\/s12877-022-03704-1"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"100428","DOI":"10.1016\/j.advnut.2025.100428","article-title":"Prognostic and Associative Significance of Malnutrition in Sarcopenia: A Systematic Review and Meta-Analysis","volume":"16","author":"Prokopidis","year":"2025","journal-title":"Adv. Nutr."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.jamda.2020.03.006","article-title":"Frailty, Sarcopenia, and Malnutrition Frequently (Co-)Occur in Hospitalized Older Adults: A Systematic Review and Meta-Analysis","volume":"21","author":"Luiking","year":"2020","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"nzac007","DOI":"10.1093\/cdn\/nzac007","article-title":"The Association between Malnutrition and Physical Performance in Older Adults: A Systematic Review and Meta-Analysis of Observational Studies","volume":"6","author":"Kramer","year":"2022","journal-title":"Curr. Dev. Nutr."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Norman, K., Ha\u00df, U., and Pirlich, M. (2021). Malnutrition in Older Adults-Recent Advances and Remaining Challenges. Nutrients, 13.","DOI":"10.3390\/nu13082764"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.arr.2013.07.003","article-title":"Skeletal Muscle Atrophy during Short-Term Disuse: Implications for Age-Related Sarcopenia","volume":"12","author":"Wall","year":"2013","journal-title":"Ageing Res. Rev."},{"key":"ref_42","first-page":"103","article-title":"The Effect of Comorbidities and Complications on the Mortality of Burned Patients","volume":"30","author":"Barros","year":"2017","journal-title":"Ann. Burns Fire Disasters"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/jcsm.12411","article-title":"Sarcopenia and Its Association with Falls and Fractures in Older Adults: A Systematic Review and Meta-Analysis","volume":"10","author":"Yeung","year":"2019","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s00268-014-2785-7","article-title":"Sarcopenia and Frailty in Elderly Trauma Patients","volume":"39","author":"Fairchild","year":"2015","journal-title":"World J. Surg."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/S0140-6736(16)31469-6","article-title":"The Metabolic Stress Response to Burn Trauma: Current Understanding and Therapies","volume":"388","author":"Porter","year":"2016","journal-title":"Lancet"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1097\/SLA.0b013e3181856241","article-title":"Pathophysiologic Response to Severe Burn Injury","volume":"248","author":"Jeschke","year":"2008","journal-title":"Ann. Surg."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"E453","DOI":"10.1152\/ajpendo.00204.2007","article-title":"Regulation of Muscle Protein Synthesis during Sepsis and Inflammation","volume":"293","author":"Lang","year":"2007","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/01.shk.0000223120.26394.7d","article-title":"Cytokine Expression Profile Over Time in Severely Burned Pediatric Patients","volume":"26","author":"Finnerty","year":"2006","journal-title":"Shock"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1002\/jpen.2238","article-title":"Skeletal Muscle Wasting after a Severe Burn Is a Consequence of Cachexia and Sarcopenia","volume":"45","author":"Song","year":"2021","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Jeschke, M.G., Kamolz, L.-P., and Shahrokhi, S. (2021). Rehabilitation and Therapy of the Burn Patient. Burn Care and Treatment: A Practical Guide, Springer International Publishing.","DOI":"10.1007\/978-3-030-39193-5"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.pmr.2011.02.001","article-title":"Positioning, Splinting, and Contracture Management","volume":"22","author":"Dewey","year":"2011","journal-title":"Phys. Med. Rehabil. Clin. N. Am."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"6049","DOI":"10.1113\/jphysiol.2008.160333","article-title":"Immobilization Induces Anabolic Resistance in Human Myofibrillar Protein Synthesis with Low and High Dose Amino Acid Infusion","volume":"586","author":"Glover","year":"2008","journal-title":"J. Physiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"E137","DOI":"10.1152\/ajpendo.00227.2015","article-title":"Short-Term Muscle Disuse Lowers Myofibrillar Protein Synthesis Rates and Induces Anabolic Resistance to Protein Ingestion","volume":"310","author":"Wall","year":"2016","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_54","first-page":"34","article-title":"Protecting Muscle Mass and Function in Older Adults During Bed Rest","volume":"13","author":"English","year":"2010","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1681\/ASN.2006010083","article-title":"Protein Degradation by the Ubiquitin-Proteasome Pathway in Normal and Disease States","volume":"17","author":"Lecker","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1001\/jama.297.16.1772-b","article-title":"Effect of 10 Days of Bed Rest on Skeletal Muscle in Healthy Older Adults","volume":"297","author":"Kortebein","year":"2007","journal-title":"JAMA"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1093\/gerona\/63.10.1076","article-title":"Functional Impact of 10 Days of Bed Rest in Healthy Older Adults","volume":"63A","author":"Kortebein","year":"2008","journal-title":"J. Gerontol."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Di Girolamo, F.G., Fiotti, N., Milanovi\u0107, Z., Situlin, R., Mearelli, F., Vinci, P., \u0160imuni\u010d, B., Pi\u0161ot, R., Narici, M., and Biolo, G. (2021). The Aging Muscle in Experimental Bed Rest: A Systematic Review and Meta-Analysis. Front. Nutr., 8.","DOI":"10.3389\/fnut.2021.633987"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1152\/ajpendo.00603.2011","article-title":"Bed Rest Impairs Skeletal Muscle Amino Acid Transporter Expression, MTORC1 Signaling, and Protein Synthesis in Response to Essential Amino Acids in Older Adults","volume":"302","author":"Drummond","year":"2012","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1186\/s13054-015-0993-7","article-title":"Clinical Review: Intensive Care Unit Acquired Weakness","volume":"19","author":"Hermans","year":"2015","journal-title":"Crit. Care"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"S299","DOI":"10.1097\/CCM.0b013e3181b6ef67","article-title":"A Framework for Diagnosing and Classifying Intensive Care Unit-Acquired Weakness","volume":"37","author":"Stevens","year":"2009","journal-title":"Crit. Care Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1677\/JOE-07-0606","article-title":"Mechanisms of Glucocorticoid-Induced Myopathy","volume":"197","author":"Schakman","year":"2008","journal-title":"J. Endocrinol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1743-7075-8-68","article-title":"Skeletal Muscle Protein Metabolism in the Elderly: Interventions to Counteract the \u201cAnabolic Resistance\u201d of Ageing","volume":"8","author":"Breen","year":"2011","journal-title":"Nutr. Metab."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1016\/S0140-6736(19)31138-9","article-title":"Sarcopenia","volume":"393","author":"Sayer","year":"2019","journal-title":"Lancet"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1007\/s12603-018-1139-9","article-title":"International Clinical Practice Guidelines for Sarcopenia (ICFSR): Screening, Diagnosis and Management","volume":"22","author":"Dent","year":"2018","journal-title":"J. Nutr. Health Aging"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.21873\/invivo.12595","article-title":"Screening Tools for Sarcopenia","volume":"35","author":"Nishikawa","year":"2021","journal-title":"In Vivo"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/jcsm.12871","article-title":"Validation of a Proxy-Reported SARC-F Questionnaire for Current and Retrospective Screening of Sarcopenia-Related Functional Impairments","volume":"13","author":"Maurus","year":"2022","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1093\/jbcr\/iry010","article-title":"Grip and Muscle Strength Dynamometry in Acute Burn Injury: Evaluation of an Updated Assessment Protocol","volume":"39","author":"Gittings","year":"2018","journal-title":"J. Burn Care Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jbcr\/irac008","article-title":"Clinical Practice Guideline: Early Mobilization and Rehabilitation of Critically Ill Burn Patients","volume":"44","author":"Cartotto","year":"2023","journal-title":"J. Burn Care Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1177\/0148607109336601","article-title":"Measurement of Body Composition in Burned Children: Is There a Gold Standard?","volume":"34","author":"Branski","year":"2010","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0305-4179(98)00016-3","article-title":"Non-Invasive Assessment of Intercompartmental Fluid Shifts in Burn Victims","volume":"24","author":"Zdolsek","year":"1998","journal-title":"Burns"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/jpen.2748","article-title":"Recognizing Malnutrition in Adults with Critical Illness: Guidance Statements from the Global Leadership Initiative on Malnutrition","volume":"49","author":"Compher","year":"2025","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1093\/jbcr\/iraa071","article-title":"Bioimpedance Spectroscopy Is a Valid and Reliable Measure of Edema Following Hand Burn Injury (Part 1\u2014Method Validation)","volume":"41","author":"Edwick","year":"2020","journal-title":"J. Burn Care Res."},{"key":"ref_74","first-page":"125","article-title":"Assessment of Skeletal Muscle Mass in Critically Ill Patients: Considerations for the Utility of Computed Tomography Imaging and Ultrasonography","volume":"19","author":"Paris","year":"2016","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s41999-020-00433-9","article-title":"Application of Ultrasound for Muscle Assessment in Sarcopenia: 2020 SARCUS Update","volume":"12","author":"Perkisas","year":"2021","journal-title":"Eur. Geriatr. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"jrm00305","DOI":"10.2340\/jrm.v54.1064","article-title":"Comparison of Six-Minute Walk Test and Modified Bruce Treadmill Test in Paediatric Patients with Severe Burns: A Cross-Over Study","volume":"54","author":"Palackic","year":"2022","journal-title":"J. Rehabil. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1002\/jcsm.13083","article-title":"D3-Creatine Dilution for Skeletal Muscle Mass Measurement: Historical Development and Current Status","volume":"13","author":"McCarthy","year":"2022","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1152\/japplphysiol.00045.2014","article-title":"Total Body Skeletal Muscle Mass: Estimation by Creatine (Methyl-d 3 ) Dilution in Humans","volume":"116","author":"Clark","year":"2014","journal-title":"J. Appl. Physiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"E29451","DOI":"10.1097\/MD.0000000000029451","article-title":"Neuromuscular Electrical Stimulation in the Intensive Care Unit Prevents Muscle Atrophy in Critically Ill Older Patients: A Retrospective Cohort Study","volume":"101","author":"Nonoyama","year":"2022","journal-title":"Medicine"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"afad236","DOI":"10.1093\/ageing\/afad236","article-title":"The Effects of Neuromuscular Electrical Stimulation on Hospitalised Adults: Systematic Review and Meta-Analysis of Randomised Controlled Trials","volume":"52","author":"Alqurashi","year":"2023","journal-title":"Age Ageing"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"afac003","DOI":"10.1093\/ageing\/afac003","article-title":"Resistance Exercise as a Treatment for Sarcopenia: Prescription and Delivery","volume":"51","author":"Hurst","year":"2022","journal-title":"Age Ageing"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1002\/jcsm.13225","article-title":"Exercise for Sarcopenia in Older People: A Systematic Review and Network Meta-Analysis","volume":"14","author":"Shen","year":"2023","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Wang, H., Huang, Y., and Zhao, Y. (2022). Efficacy of Exercise on Muscle Function and Physical Performance in Older Adults with Sarcopenia: An Updated Systematic Review and Meta-Analysis. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19138212"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1249\/JES.0000000000000029","article-title":"The Role of Exercise in the Rehabilitation of Patients with Severe Burns","volume":"43","author":"Porter","year":"2015","journal-title":"Exerc. Sport Sci. Rev."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1007\/s40279-021-01528-4","article-title":"Rehabilitative Exercise Training for Burn Injury","volume":"51","author":"Palackic","year":"2021","journal-title":"Sports Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.burns.2017.08.009","article-title":"Resistance Training for Rehabilitation After Burn Injury: A Systematic Literature Review & Meta-Analysis","volume":"44","author":"Gittings","year":"2018","journal-title":"Burns"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.burns.2020.03.015","article-title":"The Efficacy of Resistance Training in Addition to Usual Care for Adults with Acute Burn Injury: A Randomised Controlled Trial","volume":"47","author":"Gittings","year":"2021","journal-title":"Burns"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"537","DOI":"10.3390\/ebj4040035","article-title":"Nutrition Considerations for Burn Patients: Optimizing Recovery and Healing","volume":"4","author":"Shields","year":"2023","journal-title":"Eur. Burn J."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.clnu.2013.02.012","article-title":"ESPEN Endorsed Recommendations: Nutritional Therapy in Major Burns","volume":"32","author":"Rousseau","year":"2013","journal-title":"Clin. Nutr."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.clnu.2018.05.024","article-title":"ESPEN Guideline on Clinical Nutrition and Hydration in Geriatrics","volume":"38","author":"Volkert","year":"2019","journal-title":"Clin. Nutr."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.burns.2018.03.009","article-title":"Anabolic and Anticatabolic Agents Used In Burn Care: What Is Known and What Is Yet To Be Learned","volume":"46","author":"Gus","year":"2020","journal-title":"Burns"},{"key":"ref_92","first-page":"e57167","article-title":"The Use of Oxandrolone in the Management of Severe Burns: A Multi-Service Survey of Burns Centres and Units Across the United Kingdom","volume":"16","author":"Feathers","year":"2024","journal-title":"Cureus"},{"key":"ref_93","first-page":"176","article-title":"Burns: Where Are We Standing With Propranolol, Oxandrolone, Recombinant Human Growth Hormone, And The New Incretin Analogs?","volume":"14","author":"Gauglitz","year":"2011","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1080\/08998280.2021.2002110","article-title":"Application of Beta-Blockers in Burn Management","volume":"35","author":"Kopel","year":"2022","journal-title":"Bayl. Univ. Med. Cent. Proc."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1097\/BCR.0b013e31818481ce","article-title":"Insulin Resistance Postburn: Underlying Mechanisms and Current Therapeutic Strategies","volume":"29","author":"Gauglitz","year":"2008","journal-title":"J. Burn Care Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"E2020836","DOI":"10.1001\/jamanetworkopen.2020.20836","article-title":"Bimagrumab vs Optimized Standard of Care for Treatment of Sarcopenia in Community-Dwelling Older Adults: A Randomized Clinical Trial","volume":"3","author":"Rooks","year":"2020","journal-title":"JAMA Netw. Open"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.burns.2013.03.018","article-title":"The Impact of Severe Burns on Skeletal Muscle Mitochondrial Function","volume":"39","author":"Porter","year":"2013","journal-title":"Burns"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"C58","DOI":"10.1152\/ajpcell.00106.2021","article-title":"Burn-Induced Hypermetabolism and Skeletal Muscle Dysfunction","volume":"321","author":"Knuth","year":"2021","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Beaudart, C., Zaaria, M., Pasleau, F., Reginster, J.Y., and Bruy\u00e8re, O. (2017). Health Outcomes of Sarcopenia: A Systematic Review and Meta-Analysis. 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