{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:02:22Z","timestamp":1790240542788,"version":"4.1.0"},"reference-count":39,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Nut consumption reduces risks of cardiovascular disease, respiratory disease and depression. However, its association with dementia and Alzheimer\u2019s disease (AD) remains unclear. Methods: A population-based case\u2013control study was conducted in China, including 466 participants aged 52\u2013100 years (233 with dementia). Data on socio-demographic characteristics, lifestyle factors, comorbidities, and dietary intake over the past two years were collected through structured face-to-face interviews. Nut consumption was categorised as non-consumption or &lt;monthly, \u2265monthly but &lt;weekly, \u2265weekly but &lt;daily, daily, and \u2265twice daily. Multiple adjusted logistic regression models were employed to examine the association of nut consumption with dementia and AD. Results: Of the 466 participants, 59.0% reported consuming nuts at non-consumption or &lt;monthly, 22.5% monthly, 11.8% weekly, 6.0% daily, and 0.6% \u2265 twice daily. Compared with non-consumption or &lt;monthly consumption, the age-adjusted odds ratio (OR) for dementia was 0.31 (95% CI 0.18\u20130.52) for monthly intake, 0.52 (0.28\u20130.97) for weekly intake, and 0.32 (0.14\u20130.72) for daily or higher intake. After further adjustment for gender, education, family income, marital status, smoking, stroke, chronic bronchitis, depression, and other dietary intakes, OR was 0.27 (0.13\u20130.55) for monthly intake and 0.47 (0.23\u20130.99) for \u2265weekly intake. Among 133 participants with AD, similar associations were observed, with a fully adjusted OR of 0.34 (0.17\u20130.69) for \u2265monthly nut consumption. Conclusions: Higher nut consumption was associated with reduced risks of dementia and AD. Increasing nut intake may represent a potential strategy for dementia and AD prevention. However, large-scale cohort and interventional studies are needed to further clarify the association and determine the magnitude of the effect.<\/jats:p>","DOI":"10.3390\/nu18193143","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:06:37Z","timestamp":1790237197000},"page":"3143","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Nut Consumption with Dementia and Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3033-8753","authenticated-orcid":false,"given":"Ruoling","family":"Chen","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Sciences, University of Wolverhampton, Wolverhampton WV1 1DT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Glenn, A.J., Aune, D., Freisling, H., Mohammadifard, N., Kendall, C.W.C., Salas-Salvado, J., Jenkins, D.J.A., Hu, F.B., and Sievenpiper, J.L. (2023). Nuts and Cardiovascular Disease Outcomes: A Review of the Evidence and Future Directions. Nutrients, 15.","DOI":"10.3390\/nu15040911"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1093\/advances\/nmac077","article-title":"Consumption of Nuts and Seeds and Health Outcomes Including Cardiovascular Disease, Diabetes and Metabolic Disease, Cancer, and Mortality: An Umbrella Review","volume":"13","author":"Balakrishna","year":"2022","journal-title":"Adv. Nutr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1093\/nutrit\/nuac022","article-title":"Does the evidence support a relationship between higher levels of nut consumption, lower risk of depression, and better mood state in the general population? A systematic review","volume":"80","author":"Mesas","year":"2022","journal-title":"Nutr. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1001\/archinte.165.17.2019","article-title":"Depression in older people in rural China","volume":"165","author":"Chen","year":"2005","journal-title":"Arch. Intern. Med."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Igbinigie, P.O., Chen, R., Tang, J., Dregan, A., Yin, J., Acharya, D., Nadim, R., Chen, A., Bai, Z., and Amirabdollahian, F. (2024). Association between Egg Consumption and Dementia in Chinese Adults. Nutrients, 16.","DOI":"10.3390\/nu16193340"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"115048","DOI":"10.1016\/j.envres.2022.115048","article-title":"Association of air pollution with dementia: A systematic review with meta-analysis including new cohort data from China","volume":"223","author":"Tang","year":"2023","journal-title":"Environ. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1017\/S136898001800037X","article-title":"Association between fish consumption and risk of dementia: A new study from China and a systematic literature review and meta-analysis","volume":"21","author":"Bakre","year":"2018","journal-title":"Public Health Nutr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1097\/EDE.0b013e318294a065","article-title":"Mediterranean diet and cognitive function in older age","volume":"24","author":"Samieri","year":"2013","journal-title":"Epidemiology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1017\/S0007114511001024","article-title":"Fruit and vegetable intake and cognitive decline in middle-aged men and women: The Doetinchem Cohort Study","volume":"106","author":"Nooyens","year":"2011","journal-title":"Br. J. Nutr."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Li, F., Jiang, W., Wang, J., Zhang, T., Gu, X., Zhai, Y., Wu, M., Xu, L., and Lin, J. (2022). Beneficial Effects of Nut Consumption on Cognitive Function Among Elderly: Findings From a 6-Year Cohort Study. Front. Aging Neurosci., 14.","DOI":"10.3389\/fnagi.2022.816443"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.ajcnut.2023.05.032","article-title":"Higher versus lower nut consumption and changes in cognitive performance over two years in a population at risk of cognitive decline: A cohort study","volume":"118","author":"Ni","year":"2023","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1093\/advances\/nmaa153","article-title":"Nut Consumption for Cognitive Performance: A Systematic Review","volume":"12","author":"Theodore","year":"2021","journal-title":"Adv. Nutr."},{"key":"ref_13","first-page":"1721","article-title":"Nut consumption is associated with a lower risk of all-cause dementia in adults: A community-based cohort study from the UK Biobank","volume":"47","author":"Beneit","year":"2025","journal-title":"Geroscience"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1080\/09637486.2021.1880554","article-title":"Nut and legume consumption and human health: An umbrella review of observational studies","volume":"72","author":"Martini","year":"2021","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1093\/advances\/nmac028","article-title":"Perspective: Is it Time to Expand Research on \u201cNuts\u201d to Include \u201cSeeds\u201d? Justifications and Key Considerations","volume":"13","author":"George","year":"2022","journal-title":"Adv. Nutr."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Ros, E., Singh, A., and O\u2019Keefe, J.H. (2021). Nuts: Natural Pleiotropic Nutraceuticals. Nutrients, 13.","DOI":"10.3390\/nu13093269"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.ajcnut.2023.12.010","article-title":"Mixed nut consumption improves brain insulin sensitivity: A randomized, single-blinded, controlled, crossover trial in older adults with overweight or obesity","volume":"119","author":"Nijssen","year":"2024","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.clnu.2023.05.025","article-title":"Longer-term mixed nut consumption improves brain vascular function and memory: A randomized, controlled crossover trial in older adults","volume":"42","author":"Nijssen","year":"2023","journal-title":"Clin. Nutr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.phrs.2017.12.003","article-title":"Almond, hazelnut and walnut, three nuts for neuroprotection in Alzheimer\u2019s disease: A neuropharmacological review of their bioactive constituents","volume":"129","author":"Gorji","year":"2018","journal-title":"Pharmacol. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e016863","DOI":"10.1136\/bmjopen-2017-016863","article-title":"The effect of nut consumption on markers of inflammation and endothelial function: A systematic review and meta-analysis of randomised controlled trials","volume":"7","author":"Neale","year":"2017","journal-title":"BMJ Open"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Kim, Y., Keogh, J.B., and Clifton, P.M. (2019). Does Nut Consumption Reduce Mortality and\/or Risk of Cardiometabolic Disease? An Updated Review Based on Meta-Analyses. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph16244957"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"534","DOI":"10.2174\/1570159X14666160614091311","article-title":"Functional and Structural Benefits Induced by Omega-3 Polyunsaturated Fatty Acids During Aging","volume":"15","author":"Cutuli","year":"2017","journal-title":"Curr. Neuropharmacol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"5073","DOI":"10.1021\/jf0702693","article-title":"Anti-inflammatory effect of alpha-linolenic acid and its mode of action through the inhibition of nitric oxide production and inducible nitric oxide synthase gene expression via NF-kappaB and mitogen-activated protein kinase pathways","volume":"55","author":"Ren","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1017\/S095442241100014X","article-title":"Tree nut phytochemicals: Composition, antioxidant capacity, bioactivity, impact factors. A systematic review of almonds, Brazils, cashews, hazelnuts, macadamias, pecans, pine nuts, pistachios and walnuts","volume":"24","author":"Bolling","year":"2011","journal-title":"Nutr. Res. Rev."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Kim, Y., Keogh, J.B., and Clifton, P.M. (2017). Benefits of Nut Consumption on Insulin Resistance and Cardiovascular Risk Factors: Multiple Potential Mechanisms of Actions. Nutrients, 9.","DOI":"10.3390\/nu9111271"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1080\/07315724.2018.1561341","article-title":"Relationship Between Nut Consumption and Metabolic Syndrome: A Meta-Analysis of Observational Studies","volume":"38","author":"Zhang","year":"2019","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s11883-010-0132-5","article-title":"Nuts and berries for heart health","volume":"12","author":"Ros","year":"2010","journal-title":"Curr. Atheroscler. Rep."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1192\/bjp.bp.107.044974","article-title":"Severity of depression and risk for subsequent dementia: Cohort studies in China and the UK","volume":"193","author":"Chen","year":"2008","journal-title":"Br. J. Psychiatry"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1080\/07315724.2002.10719221","article-title":"Effect on body weight of a free 76 Kilojoule (320 calorie) daily supplement of almonds for six months","volume":"21","author":"Fraser","year":"2002","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1079\/BJN20041223","article-title":"Long-term almond supplementation without advice on food replacement induces favourable nutrient modifications to the habitual diets of free-living individuals","volume":"92","author":"Sabate","year":"2004","journal-title":"Br. J. Nutr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/ajcn\/nqz328","article-title":"Effect of a 2-year diet intervention with walnuts on cognitive decline. The Walnuts And Healthy Aging (WAHA) study: A randomized controlled trial","volume":"111","author":"Rajaram","year":"2020","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1017\/S0007114517001957","article-title":"Favourable nutrient intake and displacement with long-term walnut supplementation among elderly: Results of a randomised trial","volume":"118","author":"Bitok","year":"2017","journal-title":"Br. J. Nutr."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Sun, Y., Jiang, C.Q., Cheng, K.K., Zhang, W.S., Leung, G.M., Lam, T.H., and Schooling, C.M. (2015). Nut Consumption and Cardiovascular Risk in Older Chinese: The Guangzhou Biobank Cohort Study. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0137178"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s12603-018-1122-5","article-title":"A Prospective Association of Nut Consumption with Cognitive Function in Chinese Adults aged 55+\u2014China Health and Nutrition Survey","volume":"23","author":"Li","year":"2019","journal-title":"J. Nutr. Health Aging"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.clnu.2025.10.020","article-title":"Longer-term skin-roasted peanut consumption improves brain vascular function and memory: A randomized, single-blind, controlled crossover trial in healthy older adults","volume":"55","author":"Kerkhof","year":"2025","journal-title":"Clin. Nutr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"5556","DOI":"10.1016\/j.clnu.2021.09.020","article-title":"Consumption of peanut products improves memory and stress response in healthy adults from the ARISTOTLE study: A 6-month randomized controlled trial","volume":"40","author":"Castellvi","year":"2021","journal-title":"Clin. Nutr."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Chauhan, A., and Chauhan, V. (2020). Beneficial Effects of Walnuts on Cognition and Brain Health. Nutrients, 12.","DOI":"10.3390\/nu12020550"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1039\/D4FO04832F","article-title":"The impact of a walnut-rich breakfast on cognitive performance and brain activity throughout the day in healthy young adults: A crossover intervention trial","volume":"16","author":"Bell","year":"2025","journal-title":"Food Funct."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"112318","DOI":"10.1016\/j.envres.2021.112318","article-title":"Impact of air pollution exposure on the risk of Alzheimer\u2019s disease in China: A community-based cohort study","volume":"205","author":"He","year":"2021","journal-title":"Environ. Res."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/19\/3143\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:16:23Z","timestamp":1790237783000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/19\/3143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,24]]},"references-count":39,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["nu18193143"],"URL":"https:\/\/doi.org\/10.3390\/nu18193143","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,24]]}}}