{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:04:01Z","timestamp":1790327041328,"version":"4.1.0"},"reference-count":111,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Qinghai University Research Ability Enhancement Project","award":["2025KTSQ02"],"award-info":[{"award-number":["2025KTSQ02"]}],"id":[{"id":"https:\/\/ror.org\/05h33bt13","id-type":"ROR","asserted-by":"crossref"}]},{"award":["2025KTSQ02"],"award-info":[{"award-number":["2025KTSQ02"]}],"id":[{"id":"https:\/\/ror.org\/05h33bt13","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Qinghai Kunlun Talent Project","award":["QHKLYC-GDCXCY-2024-460"],"award-info":[{"award-number":["QHKLYC-GDCXCY-2024-460"]}]},{"name":"Qinghai University Undergraduate Research Training Program","award":["SRT202601"],"award-info":[{"award-number":["SRT202601"]}],"id":[{"id":"https:\/\/ror.org\/05h33bt13","id-type":"ROR","asserted-by":"crossref"}]},{"award":["SRT202601"],"award-info":[{"award-number":["SRT202601"]}],"id":[{"id":"https:\/\/ror.org\/05h33bt13","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Lycium ruthenicum Murr., commonly known as black goji berry, is a solanaceous shrub distributed in saline-alkaline desert environments of the Qinghai\u2013Tibet Plateau and other arid regions. Its growing interest as a functional food resource is closely related to a rich nutritional profile and a phytochemical pattern that differs from that of the common red goji berry (Lycium barbarum). The most distinctive feature is the abundance of anthocyanins, particularly petunidin-derived compounds, which contribute to its dark fruit color and many of its reported biological properties. This review brings together evidence on the chemical composition, nutritional value, biological activities, and food-processing applications of L. ruthenicum. Anthocyanins, polysaccharides, fatty acids, amino acids, minerals, and trace elements are discussed in relation to antioxidant, anti-aging, neuroprotective, metabolic-regulatory, and immunomodulatory effects reported in current studies. Most of these health-relevant effects are currently supported by chemical\/biochemical assays, in vitro studies, and animal models, whereas direct human evidence remains limited. Processing strategies, including drying, extraction, fermentation, encapsulation, and intelligent packaging, are considered alongside emerging genomic evidence related to stress tolerance and quality formation. The available evidence indicates that L. ruthenicum is a promising functional food and nutraceutical resource, although its bioavailability, safety, mechanisms of action, and clinical relevance still require more rigorous evaluation.<\/jats:p>","DOI":"10.3390\/nu18193160","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T08:09:02Z","timestamp":1790323742000},"page":"3160","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lycium ruthenicum as a Functional Food Resource: Chemical Composition, Nutritional Value, Health Benefits, and Biological Activities"],"prefix":"10.3390","volume":"18","author":[{"given":"Yujin","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Basic Medical Science, Qinghai University Medical College, Xining 810001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Science, Qinghai University Medical College, Xining 810001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Science, Qinghai University Medical College, Xining 810001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyi","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Science, Qinghai University Medical College, Xining 810001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Science, Qinghai University Medical College, Xining 810001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Science, Qinghai University Medical College, Xining 810001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xicheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Science, Qinghai University Medical College, Xining 810001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengzhu","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Science, Qinghai University Medical College, Xining 810001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3105-375X","authenticated-orcid":false,"given":"Ying","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Science, Qinghai University Medical College, Xining 810001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Science, Qinghai University Medical College, Xining 810001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2022-7234","authenticated-orcid":false,"given":"Youwei","family":"Du","sequence":"additional","affiliation":[{"name":"College of Plant Protection, Northwest A&F University, Yangling 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiya","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Science, Qinghai University Medical College, Xining 810001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40816-021-00328-7","article-title":"Current findings and future prospective of high-value trans Himalayan medicinal plant Lycium ruthenicum Murr: A systematic review","volume":"8","author":"Sharma","year":"2022","journal-title":"Clin. Phytosci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"uhae298","DOI":"10.1093\/hr\/uhae298","article-title":"High-quality genome of black wolfberry (Lycium ruthenicum Murr.) provides insights into the genetics of anthocyanin biosynthesis regulation","volume":"12","author":"Xu","year":"2025","journal-title":"Hortic. Res."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Lee, H.S., and Choi, C.I. (2023). Black Goji Berry (Lycium ruthenicum Murray): A Review of Its Pharmacological Activity. Nutrients, 15.","DOI":"10.3390\/nu15194181"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.pld.2025.01.001","article-title":"The chromosome-scale genome of black wolfberry (Lycium ruthenicum) provides useful genomic resources for identifying genes related to anthocyanin biosynthesis and disease resistance","volume":"47","author":"Yisilam","year":"2025","journal-title":"Plant Divers."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Yan, Y., Nisar, T., Fang, Z., Wang, L., Wang, Z., Gu, H., Wang, H., and Wang, W. (2022). Current Developments on Chemical Compositions, Biosynthesis, Color Properties and Health Benefits of Black Goji Anthocyanins: An Updated Review. Horticulturae, 8.","DOI":"10.3390\/horticulturae8111033"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1039\/D1FO04095B","article-title":"Bioactivity-guided isolation of the major anthocyanin from Lycium ruthenicum Murr. fruit and its antioxidant activity and neuroprotective effectsin vitroandin vivo","volume":"13","author":"Chen","year":"2022","journal-title":"Food Funct."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jff.2019.05.038","article-title":"Ameliorative effect of purified anthocyanin from Lycium ruthenicum on atherosclerosis in rats through synergistic modulation of the gut microbiota and NF-\u03baB\/SREBP-2 pathways","volume":"59","author":"Luo","year":"2019","journal-title":"J. Funct. Foods"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1080\/87559129.2025.2483812","article-title":"Anthocyanins in Black Wolfberry (Lycium ruthenicum Murray): Chemical Structure, Composition, Stability and Biological Activity","volume":"42","author":"Zhou","year":"2025","journal-title":"Food Rev. Int."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"108952","DOI":"10.1016\/j.foodres.2019.108952","article-title":"Effects of long-term intake of anthocyanins from Lycium ruthenicum Murray on the organism health and gut microbiota in vivo","volume":"130","author":"Peng","year":"2020","journal-title":"Food Res. Int."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Lu, Y., Kong, X., Zhang, J., Guo, C., Qu, Z., Jin, L., and Wang, H. (2021). Composition Changes in Lycium ruthenicum Fruit Dried by Different Methods. Front. Nutr., 8.","DOI":"10.3389\/fnut.2021.737521"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"131080","DOI":"10.1016\/j.foodchem.2021.131080","article-title":"Improved colorimetric analysis for subtle changes of powdered anthocyanins extracted from Lycium ruthenicum Murr","volume":"371","author":"Deng","year":"2022","journal-title":"Food Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4365","DOI":"10.1111\/1750-3841.15888","article-title":"Stabilization of Lycium ruthenicum Murr. anthocyanins by natural polyphenol extracts","volume":"86","author":"Luan","year":"2021","journal-title":"J. Food Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e39566","DOI":"10.1016\/j.heliyon.2024.e39566","article-title":"A review of Lycium ruthenicum Murray: Geographic distribution tracing, bioactive components, and functional properties","volume":"10","author":"Li","year":"2024","journal-title":"Heliyon"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"119618","DOI":"10.1016\/j.carbpol.2022.119618","article-title":"Isolation, structure and biological activity of polysaccharides from the fruits of Lycium ruthenicum Murr: A review","volume":"291","author":"Yun","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1111\/1750-3841.14328","article-title":"Fatty Acid and Phytosterol Composition, and Biological Activities of Lycium ruthenicum Murr. Seed Oil","volume":"83","author":"Zhao","year":"2018","journal-title":"J. Food Sci."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Xu, M.L., He, Y.F., Xie, L., Qu, L.B., Xu, G.R., and Cui, C.X. (2024). Research Progress on Active Ingredients and Product Development of Lycium ruthenicum Murray. Molecules, 29.","DOI":"10.3390\/molecules29102269"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"126674","DOI":"10.1016\/j.ijbiomac.2023.126674","article-title":"Intelligent active films of sodium alginate and konjac glucomannan mixed by Lycium ruthenicum anthocyanins and tea polyphenols for milk preservation and freshness monitoring","volume":"253","author":"Wang","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"100983","DOI":"10.1016\/j.fochx.2023.100983","article-title":"Advances in embedding techniques of anthocyanins: Improving stability, bioactivity and bioavailability","volume":"20","author":"Cheng","year":"2023","journal-title":"Food Chem. X"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Ma, Y.J., Duan, H.R., Zhang, F., Li, Y., Yang, H.S., Tian, F.P., Zhou, X.H., Wang, C.M., and Ma, R. (2018). Transcriptomic analysis of Lycium ruthenicum Murr. during fruit ripening provides insight into structural and regulatory genes in the anthocyanin biosynthetic pathway. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0208627"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Li, T., Fan, Y., Qin, H., Dai, G., Li, G., Li, Y., Wang, J., Yin, Y., Chen, F., and Qin, X. (2020). Transcriptome and Flavonoids Metabolomic Analysis Identifies Regulatory Networks and Hub Genes in Black and White Fruits of Lycium ruthenicum Murray. Front. Plant Sci., 11.","DOI":"10.3389\/fpls.2020.01256"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Qin, X., Yin, Y., Zhao, J., An, W., Fan, Y., Liang, X., and Cao, Y. (2022). Metabolomic and transcriptomic analysis of Lycium chinese and L. ruthenicum under salinity stress. BMC Plant Biol., 22.","DOI":"10.1186\/s12870-021-03375-x"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e10207","DOI":"10.7717\/peerj.10207","article-title":"Identification and expression analysis of the WRKY gene family during different developmental stages in Lycium ruthenicum Murr. fruit","volume":"8","author":"Tiika","year":"2020","journal-title":"PeerJ"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1002\/fsn3.1393","article-title":"Fatty acid and mineral contents of Lycium ruthenicum Murr. and antioxidant activity against isoproterenol-induced acute myocardial ischemia in mice","volume":"8","author":"Xia","year":"2020","journal-title":"Food Sci. Nutr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"10484","DOI":"10.1080\/10408398.2023.2225192","article-title":"The health-promoting anthocyanin petanin in Lycium ruthenicum fruit: A promising natural colorant","volume":"64","author":"Zeng","year":"2024","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3140","DOI":"10.1021\/acs.jafc.8b06402","article-title":"Anthocyanins from Lycium ruthenicum Murr. Ameliorated d-Galactose-Induced Memory Impairment, Oxidative Stress, and Neuroinflammation in Adult Rats","volume":"67","author":"Chen","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1021\/jf504525w","article-title":"High-performance liquid chromatography separation of cis-trans anthocyanin isomers from wild Lycium ruthenicum Murr. employing a mixed-mode reversed-phase\/strong anion-exchange stationary phase","volume":"63","author":"Jin","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.foodchem.2017.11.030","article-title":"Comparison and multivariate statistical analysis of anthocyanin composition in Lycium ruthenicum Murray from different regions to trace geographical origins: The case of China","volume":"246","author":"Wang","year":"2018","journal-title":"Food Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.foodchem.2010.11.052","article-title":"Anthocyanins composition and antioxidant activity of wild Lycium ruthenicum Murr. from Qinghai-Tibet Plateau","volume":"126","author":"Zheng","year":"2011","journal-title":"Food Chem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.foodchem.2018.07.034","article-title":"Black goji as a potential source of natural color in a wide pH range","volume":"269","author":"Tang","year":"2018","journal-title":"Food Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1080\/01496395.2014.943770","article-title":"Isolation, Stability, and Antioxidant Activity of Anthocyanins from Lycium ruthenicum Murray and Nitraria Tangutorum Bobr of Qinghai-Tibetan Plateau","volume":"49","author":"Hu","year":"2014","journal-title":"Sep. Sci. Technol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"112208","DOI":"10.1016\/j.indcrop.2020.112208","article-title":"Variation of anthocyanin content in fruits of wild and cultivated Lycium ruthenicum","volume":"146","author":"Liu","year":"2020","journal-title":"Ind. Crops Prod."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1021\/acs.jafc.6b00035","article-title":"Characterization of Polyphenols from Lycium ruthenicum Fruit by UPLC-Q-TOF\/MS(E) and Their Antioxidant Activity in Caco-2 Cells","volume":"64","author":"Wu","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1007\/s12161-018-1191-4","article-title":"Green Approach for Sample Preparation and Determination of Anthocyanins from Lycium ruthenicum Murr. Using a \u03b2-Cyclodextrin-Based Extraction Method Coupled with UPLC-DAD Analysis","volume":"11","author":"Zhang","year":"2018","journal-title":"Food Anal. Methods"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1002\/jsfa.9459","article-title":"Green extraction of mulberry anthocyanin with improved stability using beta-cyclodextrin","volume":"99","author":"Xie","year":"2019","journal-title":"J. Sci. Food Agric."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Duan, W., Zhang, Z., Zhu, J., Zhang, D., Qian, D., Teng, F., Zhao, Y., Chen, F., Li, R., and Yang, J. (2022). Comparative Analysis of the Phenolic Profile of Lycium barbarum L. Fruits from Different Regions in China. Molecules, 27.","DOI":"10.3390\/molecules27185842"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"116240","DOI":"10.1016\/j.indcrop.2023.116240","article-title":"Salt stress affects the fruit quality of Lycium ruthenicum Murr","volume":"193","author":"Wang","year":"2023","journal-title":"Ind. Crops Prod."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"114502","DOI":"10.1016\/j.indcrop.2021.114502","article-title":"Spatio transcriptome uncover novel insight into the Lycium ruthenicum seedling tolerant to salt stress","volume":"177","author":"Mo","year":"2022","journal-title":"Ind. Crops Prod."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.foodchem.2018.06.132","article-title":"Rapid qualitative and quantitative analyses of eighteen phenolic compounds from Lycium ruthenicum Murray by UPLC-Q-Orbitrap MS and their antioxidant activity","volume":"269","author":"Zhang","year":"2018","journal-title":"Food Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"112692","DOI":"10.1016\/j.indcrop.2020.112692","article-title":"Phytochemical profiles, nutritional constituents and antioxidant activity of black wolfberry (Lycium ruthenicum Murr.)","volume":"154","author":"Liu","year":"2020","journal-title":"Ind. Crops Prod."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e2000033","DOI":"10.1002\/cbdv.202000033","article-title":"A Comparative Study on Polyphenolic Composition of Berries from the Tibetan Plateau by UPLC-Q-Orbitrap MS System","volume":"17","author":"Jia","year":"2020","journal-title":"Chem. Biodivers."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.foodchem.2017.08.105","article-title":"Simultaneous optimization of the ultrasound-assisted extraction for phenolic compounds content and antioxidant activity of Lycium ruthenicum Murr. fruit using response surface methodology","volume":"242","author":"Chen","year":"2018","journal-title":"Food Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"7968","DOI":"10.1021\/acs.jafc.2c02375","article-title":"Polyphenolic Glycosides from the Fruits Extract of Lycium ruthenicum Murr and Their Monoamine Oxidase B Inhibitory and Neuroprotective Activities","volume":"70","author":"Hu","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/nph.19602","article-title":"Major quality regulation network of flavonoid synthesis governing the bioactivity of black wolfberry","volume":"242","author":"Du","year":"2024","journal-title":"New Phytol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1080\/14786419.2018.1452014","article-title":"Structural features of an acidic polysaccharide with the potential of promoting osteoblast differentiation from Lycium ruthenicum Murr","volume":"34","author":"Wang","year":"2018","journal-title":"Nat. Prod. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"7445","DOI":"10.1002\/fsn3.3677","article-title":"A comprehensive review of goji berry processing and utilization","volume":"11","author":"Yu","year":"2023","journal-title":"Food Sci. Nutr."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Liu, B., Ma, J., Li, T., Li, P., Yan, D., Zhu, J., and Zhang, X. (2024). Advances in the Preparation, Structure and Bioactivity of Polysaccharides from Lycium ruthenicum Murr.: A Review. Foods, 13.","DOI":"10.3390\/foods13131995"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.ijbiomac.2020.04.122","article-title":"Lycium ruthenicum Murr polysaccharide protects cortical neurons against oxygen-glucose deprivation\/reperfusion in neonatal hypoxic-ischemic encephalopathy","volume":"158","author":"Deng","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"118172","DOI":"10.1016\/j.carbpol.2021.118172","article-title":"The structure elucidation of novel arabinogalactan LRP1-S2 against pancreatic cancer cells growth in vitro and in vivo","volume":"267","author":"He","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.carres.2012.10.013","article-title":"Isolation and structural characterization of a polysaccharide LRP4-A from Lycium ruthenicum Murr","volume":"365","author":"Lv","year":"2013","journal-title":"Carbohydr. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.carbpol.2012.04.067","article-title":"Isolation and structural characterization of the polysaccharide LRGP1 from Lycium ruthenicum","volume":"90","author":"Peng","year":"2012","journal-title":"Carbohydr. Polym."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"9424","DOI":"10.1021\/jf302619c","article-title":"Structural characterization of an arabinogalactan-protein from the fruits of Lycium ruthenicum","volume":"60","author":"Peng","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ijbiomac.2013.11.030","article-title":"Characterization of an immunologically active pectin from the fruits of Lycium ruthenicum","volume":"64","author":"Peng","year":"2014","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"115104","DOI":"10.1016\/j.carbpol.2019.115104","article-title":"Isolation and structural characterization of a pectin from Lycium ruthenicum Murr and its anti-pancreatic ductal adenocarcinoma cell activity","volume":"223","author":"Zhang","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1007\/s10600-016-1737-x","article-title":"Fatty Acid Composition of Lycium ruthenicum Collected from the Qinghai-Tibetan Plateau","volume":"52","author":"Chi","year":"2016","journal-title":"Chem. Nat. Compd."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/ptr.7312","article-title":"Biological and pharmacological effects and nutritional impact of phytosterols: A comprehensive review","volume":"36","author":"Barghchi","year":"2022","journal-title":"Phytother. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1021\/acs.jproteome.8b00349","article-title":"Interspecies Developmental Differences in Metabonomic Phenotypes of Lycium ruthenicum and L. barbarum Fruits","volume":"17","author":"Wang","year":"2018","journal-title":"J. Proteome Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1111\/pbi.14278","article-title":"Metabolite-based genome-wide association studies enable the dissection of the genetic bases of flavonoids, betaine and spermidine in wolfberry (Lycium)","volume":"22","author":"Zhao","year":"2024","journal-title":"Plant Biotechnol. J."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.foodchem.2017.08.026","article-title":"Lycium ruthenicum studies: Molecular biology, Phytochemistry and pharmacology","volume":"240","author":"Wang","year":"2018","journal-title":"Food Chem."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Xie, Z., Luo, Y., Zhang, C., An, W., Zhou, J., Jin, C., Zhang, Y., and Zhao, J. (2023). Integrated Metabolome and Transcriptome during Fruit Development Reveal Metabolic Differences and Molecular Basis between Lycium barbarum and Lycium ruthenicum. Metabolites, 13.","DOI":"10.3390\/metabo13060680"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e13112","DOI":"10.1111\/jfbc.13112","article-title":"Profiles and neuroprotective effects of Lycium ruthenicum polyphenols against oxidative stress-induced cytotoxicity in PC12 cells","volume":"44","author":"Gao","year":"2020","journal-title":"J. Food Biochem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1002\/fsn3.1445","article-title":"Lycium ruthenicum Murr. alleviates nonalcoholic fatty liver in mice","volume":"8","author":"Lu","year":"2020","journal-title":"Food Sci. Nutr."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"138686","DOI":"10.1016\/j.jhazmat.2025.138686","article-title":"Overexpression of anthocyanin activator LrAN2 improving black goji berry (Lycium ruthenicum) tolerant to cadmium stress","volume":"494","author":"Ai","year":"2025","journal-title":"J. Hazard. Mater."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Liu, Y., Zeng, S., Sun, W., Wu, M., Hu, W., Shen, X., and Wang, Y. (2014). Comparative analysis of carotenoid accumulation in two goji (Lycium barbarum L. and L. ruthenicum Murr.) fruits. BMC Plant Biol., 14.","DOI":"10.1186\/s12870-014-0269-4"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Jurikova, T., Tinakova, S.M., Ziarovska, J., Szekeres, L., Mlcek, J., Fatrcova-Sramkova, K., Knazicka, Z., and Skrovankova, S. (2025). Polyphenolic Spectrum of Goji Berries and Their Health-Promoting Activity. Foods, 14.","DOI":"10.3390\/foods14081387"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jff.2017.01.015","article-title":"Isolation, antioxidant property and protective effect on PC12 cell of the main anthocyanin in fruit of Lycium ruthenicum Murray","volume":"30","author":"Tang","year":"2017","journal-title":"J. Funct. Foods"},{"key":"ref_66","first-page":"1","article-title":"Comparative study of polyphenols quantification, total phenolic content, and antioxidant activities of the fruits of three plants of the family of Solanaceae: Lycium ruthenicum, Lycium barbarum, and Lycium chinense","volume":"5","author":"Nea","year":"2022","journal-title":"Investig. Med. Chem. Pharmacol."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Gao, H., Xue, Y., Wu, L., Huo, J., Pang, Y., Chen, J., and Gao, Q. (2022). Protective Effect of Lycium ruthenicum Polyphenols on Oxidative Stress against Acrylamide Induced Liver Injury in Rats. Molecules, 27.","DOI":"10.3390\/molecules27134100"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Xia, N., Ding, Z., Dong, M., Li, S., Liu, J., Xue, H., Wang, Z., Lu, J., and Chen, X. (2024). Protective Effects of Lycium ruthenicum Murray against Acute Alcoholic Liver Disease in Mice via the Nrf2\/HO-1\/NF-kappaB Signaling Pathway. Pharmaceuticals, 17.","DOI":"10.3390\/ph17040497"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Chen, S., Wang, H., and Hu, N. (2022). Long-Term Dietary Lycium ruthenicum Murr. Anthocyanins Intake Alleviated Oxidative Stress-Mediated Aging-Related Liver Injury and Abnormal Amino Acid Metabolism. Foods, 11.","DOI":"10.3390\/foods11213377"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Dong, M., Lu, J., Xue, H., Lou, Y., Li, S., Liu, T., Ding, Z., and Chen, X. (2024). Anthocyanins from Lycium ruthenicum Murray Mitigate Cadmium-Induced Oxidative Stress and Testicular Toxicity by Activating the Keap1\/Nrf2 Signaling Pathway. Pharmaceuticals, 17.","DOI":"10.3390\/ph17030322"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"113775","DOI":"10.1016\/j.phytochem.2023.113775","article-title":"Polyphenolic glycosides with unusual four-membered ring possessing anti-Parkinson\u2019s disease potential from black wolfberry","volume":"213","author":"Hu","year":"2023","journal-title":"Phytochemistry"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Cui, B., Liu, L., Shi, T., Yin, M., Feng, X., and Shan, Y. (2023). The Ethanolic Extract of Lycium ruthenicum Ameliorates Age-Related Physiological Damage in Mice. Molecules, 28.","DOI":"10.3390\/molecules28227615"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"140837","DOI":"10.1016\/j.foodchem.2024.140837","article-title":"Hypoglycaemic activity of the anthocyanin enriched fraction of Lycium ruthenicum Murr. Fruits and its ingredient identification UPLC-triple-TOF-MS\/MS\u2014triple-TOF-MS\/MS","volume":"461","author":"Ren","year":"2024","journal-title":"Food Chem."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"3855","DOI":"10.1039\/D0FO02936J","article-title":"Anthocyanins from the fruits of Lycium ruthenicum Murray improve high-fat diet-induced insulin resistance by ameliorating inflammation and oxidative stress in mice","volume":"12","author":"Tian","year":"2021","journal-title":"Food Funct."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"100949","DOI":"10.1016\/j.fbio.2021.100949","article-title":"Lycium ruthenicum Murray anthocyanins effectively inhibit \u03b1-glucosidase activity and alleviate insulin resistance","volume":"41","author":"Wang","year":"2021","journal-title":"Food Biosci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1097\/CM9.0000000000000185","article-title":"Protective effect of supplementation with Lycium ruthenicum Murray extract from exhaustive exercise-induced cardiac injury in rats","volume":"132","author":"Hou","year":"2019","journal-title":"Chin. Med. J."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.freeradbiomed.2019.04.005","article-title":"Gut microbiota modulation and anti-inflammatory properties of anthocyanins from the fruits of Lycium ruthenicum Murray in dextran sodium sulfate-induced colitis in mice","volume":"136","author":"Peng","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"9250233","DOI":"10.26599\/FSHW.2024.9250233","article-title":"Higher polyphenol content and bioactivities of freeze-dried Lycium ruthenicum fruit and its impact on gut microbiota modulation","volume":"14","author":"Huang","year":"2025","journal-title":"Food Sci. Hum. Wellness"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"e2000745","DOI":"10.1002\/mnfr.202000745","article-title":"Lycium ruthenicum Anthocyanins Attenuate High-Fat Diet-Induced Colonic Barrier Dysfunction and Inflammation in Mice by Modulating the Gut Microbiota","volume":"65","author":"Tian","year":"2021","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Verediano, T.A., Stampini Duarte Martino, H., Dias Paes, M.C., and Tako, E. (2021). Effects of Anthocyanin on Intestinal Health: A Systematic Review. Nutrients, 13.","DOI":"10.3390\/nu13041331"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Kurskaya, O., Prokopyeva, E., Bi, H., Sobolev, I., Murashkina, T., Shestopalov, A., Wei, L., and Sharshov, K. (2022). Anti-Influenza Activity of Medicinal Material Extracts from Qinghai-Tibet Plateau. Viruses, 14.","DOI":"10.3390\/v14020360"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1039\/D0FO02382E","article-title":"The main anthocyanin monomer of Lycium ruthenicum Murray induces apoptosis through the ROS\/PTEN\/PI3K\/Akt\/caspase 3 signaling pathway in prostate cancer DU-145 cells","volume":"12","author":"Li","year":"2021","journal-title":"Food Funct."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"6513","DOI":"10.1039\/D1FO01105G","article-title":"Goji berry (Lycium spp.) extracts exhibit antiproliferative activity via modulating cell cycle arrest, cell apoptosis, and the p53 signaling pathway","volume":"12","author":"Xiong","year":"2021","journal-title":"Food Funct."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Bi, Y., Liu, X., Liu, Y., Wang, M., Shan, Y., Yin, Y., Meng, X., Sun, F., Li, H., and Li, Z. (2023). Molecular and biochemical investigations of the anti-fatigue effects of tea polyphenols and fruit extracts of Lycium ruthenicum Murr. on mice with exercise-induced fatigue. Front. Mol. Biosci., 10.","DOI":"10.3389\/fmolb.2023.1223411"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"e242703","DOI":"10.1590\/fst.242703","article-title":"Anti-fatigue activities of anthocyanins from Lycium ruthenicum Murry","volume":"42","author":"Zhang","year":"2022","journal-title":"Food Sci. Technol."},{"key":"ref_86","first-page":"876","article-title":"Nutritional value of Lycium ruthenicum Murr. and its relieving resistance to exercise-induced fatigue","volume":"21","author":"Xing","year":"2019","journal-title":"Prog. Nutr."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"106415","DOI":"10.1016\/j.fbio.2025.106415","article-title":"Lycium ruthenicum anthocyanins alleviate acrylamide-induced neurotoxicity in SH-SY5Y cells by mitigating ferroptosis via the Nrf2\/GPX4 signaling pathway","volume":"68","author":"Luo","year":"2025","journal-title":"Food Biosci."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Thiruvengadam, M., Venkidasamy, B., Subramanian, U., Samynathan, R., Ali Shariati, M., Rebezov, M., Girish, S., Thangavel, S., Dhanapal, A.R., and Fedoseeva, N. (2021). Bioactive Compounds in Oxidative Stress-Mediated Diseases: Targeting the NRF2\/ARE Signaling Pathway and Epigenetic Regulation. Antioxidants, 10.","DOI":"10.3390\/antiox10121859"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"105104","DOI":"10.1016\/j.jff.2022.105104","article-title":"The major anthocyanin of Lycium ruthenicum Murr. relieves cognitive deficits, oxidative stress, neuroinflammation, and hippocampal metabolome alterations in aging rats","volume":"94","author":"Chen","year":"2022","journal-title":"J. Funct. Foods"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Liang, J., Ga, Z., Wu, J., Wang, Y., Dongzhu, N., Qieyang, R., Li, P., and Huaqian, S. (2025). Lycium ruthenicum Murray Anthocyanins Alleviate Aging Through SIRT1\/P53 Signaling Pathway. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26104510"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1007\/s00709-025-02075-9","article-title":"The effect of anthocyanin extract from Lycium ruthenicum Murray on intestinal barrier function in Bamei ternary pigs","volume":"262","author":"Wang","year":"2025","journal-title":"Protoplasma"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"143700","DOI":"10.1016\/j.ijbiomac.2025.143700","article-title":"Anti-colitis comparison of polysaccharides and anthocyanins extracted from black wolfberry based on microbiomics, immunofluorescence and multi-cytokines profile analysis","volume":"310","author":"Qiu","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"4947","DOI":"10.1039\/C5AY00612K","article-title":"Characterization of anthocyanins in wild Lycium ruthenicum Murray by HPLC-DAD\/QTOF-MS\/MS","volume":"7","author":"Jin","year":"2015","journal-title":"Anal. Methods"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Gao, Q., Song, Y., Liang, Y., Li, Y., Chang, Y., Ma, R., Cao, X., and Wang, S. (2022). Dynamics of Physicochemical Properties, Functional Compounds and Antioxidant Capacity during Spontaneous Fermentation of Lycium ruthenicum Murr. (Qinghai-Tibet Plateau) Natural Vinegar. Foods, 11.","DOI":"10.3390\/foods11091344"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Kamonsuwan, K., Balmori, V., Marnpae, M., Chusak, C., Thilavech, T., Charoensiddhi, S., Smid, S., and Adisakwattana, S. (2024). Black Goji Berry (Lycium ruthenicum) Juice Fermented with Lactobacillus rhamnosus GG Enhances Inhibitory Activity against Dipeptidyl Peptidase-IV and Key Steps of Lipid Digestion and Absorption. Antioxidants, 13.","DOI":"10.3390\/antiox13060740"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1080\/10408398.2022.2104806","article-title":"Probiotics in anthocyanin-rich fruit beverages: Research and development for novel synbiotic products","volume":"64","author":"Fuenmayor","year":"2024","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"146336","DOI":"10.1016\/j.foodchem.2025.146336","article-title":"Mechanism-driven stabilization of anthocyanins: Comparative copigmentation and encapsulation for food applications","volume":"495","author":"Yang","year":"2025","journal-title":"Food Chem."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.fbp.2025.06.001","article-title":"Anthocyanins stability theory\u2014Evidence summary on the effects of microencapsulation","volume":"153","author":"Feitosa","year":"2025","journal-title":"Food Bioprod. Process."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"109092","DOI":"10.1016\/j.foodres.2020.109092","article-title":"Anthocyanins: New techniques and challenges in microencapsulation","volume":"133","author":"Tarone","year":"2020","journal-title":"Food Res. Int."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"100238","DOI":"10.1016\/j.cpb.2022.100238","article-title":"Copigmentation and stabilization of anthocyanins using organic molecules and encapsulation techniques","volume":"29","author":"Demirci","year":"2022","journal-title":"Curr. Plant Biol."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Xu, F., Tang, C., Chen, D., Yong, H., Kan, J., and Liu, J. (2026). Recent advances in the development of intelligent packaging materials using black wolfberry (Lycium ruthenicum Murr.) anthocyanins. J. Future Foods.","DOI":"10.1016\/j.jfutfo.2026.02.018"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"109808","DOI":"10.1016\/j.meatsci.2025.109808","article-title":"Antioxidant pH-sensitive films incorporating CMC\/SA\/starch, anthocyanins, and tea polyphenols for monitoring freshness of pork","volume":"225","author":"Tan","year":"2025","journal-title":"Meat Sci."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"143560","DOI":"10.1016\/j.foodchem.2025.143560","article-title":"Synergistically engineered starch-based composite films: Multifunctional platforms integrating quaternary ammonium chitosan and anthocyanins for intelligent food monitoring and sustainable packaging","volume":"478","author":"Xie","year":"2025","journal-title":"Food Chem."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1007\/s00449-021-02605-8","article-title":"Anthocyanin extract from Lycium ruthenicum enhanced production of biomass and polysaccharides during submerged fermentation of Agaricus bitorquis (Quel.) Sacc. Chaidam","volume":"44","author":"Wu","year":"2021","journal-title":"Bioprocess Biosyst. Eng."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1080\/23802359.2019.1638324","article-title":"The complete chloroplast genome sequence of Lycium ruthenicum (Solanaceae), a traditional medicinal plant in China","volume":"4","author":"Wang","year":"2019","journal-title":"Mitochondrial DNA B Resour."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Guo, J., Wang, J., Peng, C., Liu, H., and Shang, J. (2025). Integrated Metabolomic and Transcriptomic Analyses of Anthocyanin Synthesis During Fruit Development in Lycium ruthenicum Murr. Biology, 14.","DOI":"10.3390\/biology14111614"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1080\/23802359.2018.1450681","article-title":"Characterization of the complete chloroplast genome of Lycium ruthenicum (Solanaceae)","volume":"3","author":"Yisilam","year":"2018","journal-title":"Mitochondrial DNA B Resour."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"100464","DOI":"10.1016\/j.genrep.2019.100464","article-title":"Complete chloroplast genome and comparative analysis of three Lycium (Solanaceae) species with medicinal and edible properties","volume":"17","author":"Cui","year":"2019","journal-title":"Gene Rep."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Yisilam, G., Wang, C.X., Xia, M.Q., Comes, H.P., Li, P., Li, J., and Tian, X.M. (2022). Phylogeography and Population Genetics Analyses Reveal Evolutionary History of the Desert Resource Plant Lycium ruthenicum (Solanaceae). Front. Plant Sci., 13.","DOI":"10.3389\/fpls.2022.915526"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1093\/plphys\/kiae122","article-title":"Anthocyanin biosynthesis in goji berry is inactivated by deletion in a bHLH transcription factor LrLAN1b promoter","volume":"195","author":"Li","year":"2024","journal-title":"Plant Physiol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/ppl.12669","article-title":"Isolation and characterization of a salt stress-responsive betaine aldehyde dehydrogenase in Lycium ruthenicum Murr","volume":"163","author":"Liu","year":"2018","journal-title":"Physiol. Plant."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/19\/3160\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T08:19:11Z","timestamp":1790324351000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/19\/3160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,25]]},"references-count":111,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["nu18193160"],"URL":"https:\/\/doi.org\/10.3390\/nu18193160","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,25]]}}}