{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:57:48Z","timestamp":1790485068834,"version":"4.1.0"},"reference-count":89,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National System of Researchers","award":["171150"],"award-info":[{"award-number":["171150"]}]},{"name":"National System of Researchers","award":["32753"],"award-info":[{"award-number":["32753"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Tartrazine (TZ) has been linked to hyperactivity in children, as well as to kidney and liver damage. Furthermore, naringenin (NG) is a flavonoid with antioxidant and anti-inflammatory properties that may mitigate the damage caused by TZ. Methods: Four independent groups were used, each consisting of seven male Wistar rats\u2014vehicle VEH (saline solution\/DMSO, 0.600 mL; IP), TZ (150 mg\/kg; IP), NG (100 mg\/kg; IP), and TZ + NG (150 mg\/kg; 100 mg\/kg; IP). For 28 days, treatments were administered every 24 h, and the behavioral effects were evaluated via the open field and Rotarod tests. At the end of the behavioral tests, biochemical and histological analyses of the liver, kidney, and intestine were performed. Results: In the open field test, TZ decreased the number of crossings and rearing behaviors, which was attenuated in NG. The number of grooming behaviors was significantly reduced by TZ, while the duration of this behavior did not significantly differ between the treatment groups. In Rotarod, the TZ group presented less coordination than the other groups. In the TZ group, all parameters included in the liver and kidney function tests showed a significant increase compared to normal levels, reflecting a pathological condition in those organs. On the other hand, groups TZ + NG were within the reference intervals. Treatment with NG reduced the damage caused by TZ. Finally, in the histological analysis, damage to liver, kidney, and intestinal tissues was observed in the TZ groups, whereas treatment with NG mitigated the cellular damage caused by TZ. Conclusions: Naringenin exhibited a protective effect as it restored liver and kidney parameters to normal levels and demonstrated a predominant preservation of the histological architecture of the liver, kidney, and intestine. In this regard, the protective effect observed could be related to the antioxidant, anti-inflammatory, and anti-apoptotic properties described for naringenin. However, further research is still needed to validate the use of naringenin as a potential candidate for improving renal and hepatic function, based on mechanistic studies.<\/jats:p>","DOI":"10.3390\/nu18193161","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T08:09:02Z","timestamp":1790323742000},"page":"3161","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tartrazine-Induced Toxicity Is Attenuated by Naringenin in Wistar Rats: A Biochemical, Histological, and Behavioral Study"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5662-2202","authenticated-orcid":false,"given":"Eduardo","family":"Rivadeneyra-Dom\u00ednguez","sequence":"first","affiliation":[{"name":"Facultad de Qu\u00edmica Farmac\u00e9utica Biol\u00f3gica, Universidad Veracruzana, Xalapa 91000, Veracruz, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"conceptualization","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5837-103X","authenticated-orcid":false,"given":"Juan Francisco","family":"Rodr\u00edguez-Landa","sequence":"additional","affiliation":[{"name":"Facultad de Qu\u00edmica Farmac\u00e9utica Biol\u00f3gica, Universidad Veracruzana, Xalapa 91000, Veracruz, Mexico"},{"name":"Laboratorio de Neurofarmacolog\u00eda, Instituto de Neuroetolog\u00eda, Universidad Veracruzana, Xalapa 911900, Veracruz, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"validation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"}]},{"given":"David J.","family":"Salazar-Camacho","sequence":"additional","affiliation":[{"name":"Facultad de Qu\u00edmica Farmac\u00e9utica Biol\u00f3gica, Universidad Veracruzana, Xalapa 91000, Veracruz, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4707-1389","authenticated-orcid":false,"given":"Isaac","family":"Zamora-Bello","sequence":"additional","affiliation":[{"name":"Facultad de Qu\u00edmica Farmac\u00e9utica Biol\u00f3gica, Universidad Veracruzana, Xalapa 91000, Veracruz, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5036-4086","authenticated-orcid":false,"given":"\u00d3scar","family":"Rosales-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Facultad de Qu\u00edmica Farmac\u00e9utica Biol\u00f3gica, Universidad Veracruzana, Xalapa 91000, Veracruz, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"}]},{"given":"Mar\u00eda de la Soledad","family":"Lagunes-Castro","sequence":"additional","affiliation":[{"name":"LADISER Inmunolog\u00eda y Biolog\u00eda Molecular, Facultad de Ciencias Qu\u00edmicas, Universidad Veracruzana, Orizaba 94340, Veracruz, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0838-470X","authenticated-orcid":false,"given":"Socorro","family":"Herrera-Meza","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Psicol\u00f3gicas, Universidad Veracruzana, Xalapa 91190, Veracruz, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9577-0777","authenticated-orcid":false,"given":"Jorge E.","family":"Morales-M\u00e1vil","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda de la Conducta, Instituto de Neuroetolog\u00eda, Universidad Veracruzana, Xalapa 91190, Veracruz, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2025, July 11). JECFA Chemical Evaluation: Chemical ID 3885. Available online: https:\/\/apps.who.int\/foodadditives-contaminants-jecfa-database\/Home\/Chemical\/3885."},{"key":"ref_2","first-page":"862","article-title":"Food Additives and Reactions: Antioxidants, Benzoates, Parabens, Colorings, Flavorings, Natural Protein-Based Additives","volume":"1","year":"2024","journal-title":"Encycl. Food Allergy"},{"key":"ref_3","first-page":"7","article-title":"Sustituci\u00f3n de Tartrazina por Betacaroteno en la Elaboraci\u00f3n de Bebidas No Alcoh\u00f3licas","volume":"3","author":"Restrepo","year":"2006","journal-title":"Lasallista Investig."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e38111","DOI":"10.1016\/j.heliyon.2024.e38111","article-title":"Safety of Tartrazine in the Food Industry and Potential Protective Factors","volume":"10","author":"Amchova","year":"2024","journal-title":"Heliyon"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"dos Santos, J.R., Soares, L.d.S., Soares, B.M., de Gomes Farias, M., de Oliveira, V.A., de Sousa, N.A.B., Negreiros, H.A., da Silva, F.C.C., Peron, A.P., and Pacheco, A.C.L. (2022). Cytotoxic and Mutagenic Effects of the Food Additive Tartrazine on Eukaryotic Cells. BMC Pharmacol. Toxicol., 23.","DOI":"10.1186\/s40360-022-00638-7"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"T125","DOI":"10.1111\/j.1750-3841.2011.02267.x","article-title":"Effect of Food Azo Dye Tartrazine on Learning and Memory Functions in Mice and Rats, and the Possible Mechanisms Involved","volume":"76","author":"Gao","year":"2011","journal-title":"J. Food Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"73","DOI":"10.4149\/gpb_2018039","article-title":"Protective Effect of Crocin on Food Azo Dye Tartrazine-Induced Hepatic Damage by Improving Biochemical Parameters and Oxidative Stress Biomarkers in Rats","volume":"38","author":"Velioglu","year":"2019","journal-title":"Gen. Physiol. Biophys."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1080\/02772248.2021.1942472","article-title":"Prevention of Toxic Effects of Orally Administered Tartrazine by Crocin in Wistar Rats","volume":"103","author":"Altinoz","year":"2021","journal-title":"Toxicol. Environ. Chem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.biopha.2017.11.150","article-title":"The Protective Role of Crocin in Tartrazine-Induced Nephrotoxicity in Wistar Rats","volume":"96","author":"Erdemli","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1007\/s11356-020-10578-6","article-title":"Ameliorative Effects of Crocin on Tartrazine Dye-Induced Pancreatic Adverse Effects: A Biochemical and Histological Study","volume":"28","author":"Erdemli","year":"2021","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_11","first-page":"111","article-title":"Study of the Toxic Effect of Tartrazine Dye on Some Biochemical Parameters in Male Albino Rats","volume":"4","author":"Aldaamy","year":"2020","journal-title":"Sci. J. Med. Res."},{"key":"ref_12","first-page":"469","article-title":"Toxicological and Histopathological Studies on the Effect of Tartrazine in Male Albino Rats","volume":"10","author":"Abdelgayed","year":"2016","journal-title":"Int. J. Agric. Biol. Eng."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"20","DOI":"10.18639\/RABM.2016.02.284474","article-title":"Toxicity Induced after Subchronic Administration of the Synthetic Food Dye Tartrazine in Adult Rats: Role of Oxidative Stress","volume":"2","author":"Jrad","year":"2016","journal-title":"Recent Adv. Biol. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"108239","DOI":"10.1016\/j.jfca.2025.108239","article-title":"Elevated Health Risks for Children and Adolescents: Quantification of Artificial Sweeteners and Synthetic Dyes in Powdered Beverages Reveals Regulatory Gaps","volume":"148","author":"Refai","year":"2025","journal-title":"J. Food Compos. Anal."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/j.fct.2010.03.028","article-title":"Immunological Studies on Amaranth, Sunset Yellow and Curcumin as Food Colouring Agents in Albino Rats","volume":"48","author":"Hashem","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S1383-5718(02)00128-6","article-title":"The Comet Assay with 8 Mouse Organs: Results with 39 Currently Used Food Additives","volume":"519","author":"Sasaki","year":"2002","journal-title":"Mutat. Res."},{"key":"ref_17","first-page":"13","article-title":"Effects of Some Synthetic Coloring Additives on DNA Damage and Chromosomal Aberrations of Rats","volume":"13","author":"Hassan","year":"2010","journal-title":"Arab J. Biotechnol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e3041","DOI":"10.7717\/peerj.3041","article-title":"Tartrazine Induces Structural and Functional Aberrations and Genotoxic Effects In Vivo","volume":"5","author":"Khayyat","year":"2017","journal-title":"PeerJ"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Visternicu, M., S\u0103vuc\u0103, A., Rarinca, V., Burlui, V., Plavan, G., Ionescu, C., Ciobica, A., Balmus, I.M., Albert, C., and Hogas, M. (2025). Toxicological Effects of Tartrazine Exposure: A Review of In Vitro and Animal Studies with Human Health Implications. Toxics, 13.","DOI":"10.20944\/preprints202508.0270.v1"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"34","DOI":"10.6000\/1927-5951.2011.01.01.07","article-title":"Investigations of In Vitro Digestibility of Proteins Bound to Food Colors","volume":"1","author":"Saeed","year":"2011","journal-title":"J. Pharm. Nutr. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00003-012-0782-z","article-title":"Oxidative Effect of Tartrazine (CAS No. 1934-21-0) and New Coccin (CAS No. 2611-82-7) Azo Dyes on CHO Cells","volume":"7","author":"Demirkol","year":"2012","journal-title":"J. Verbrauch. Lebensm."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Albasher, G., Maashi, N., Alfarraj, S., Almeer, R., Albrahim, T., Alotibi, F., Bin-Jumah, M., and Mahmoud, A.M. (2020). Perinatal Exposure to Tartrazine Triggers Oxidative Stress and Neurobehavioral Alterations in Mice Offspring. Antioxidants, 9.","DOI":"10.3390\/antiox9010053"},{"key":"ref_23","first-page":"341","article-title":"Synthetic Food Dyes Cause Testicular Damage via Up-Regulation of Pro-Inflammatory Cytokines and Down-Regulation of FSH-R and TESK-1 Gene Expression","volume":"25","author":"Wopara","year":"2021","journal-title":"JBRA Assist. Reprod."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1128\/MCB.24.7.2593-2604.2004","article-title":"Molecular Mechanism of Suppression of Testicular Steroidogenesis by Pro-Inflammatory Cytokine Tumor Necrosis Factor Alpha","volume":"24","author":"Hong","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Singh, A., Kukreti, R., Saso, L., and Kukreti, S. (2022). Mechanistic Insight into Oxidative Stress-Triggered Signaling Pathways and Type 2 Diabetes. Molecules, 27.","DOI":"10.3390\/molecules27030950"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1556\/2060.103.2016.3.6","article-title":"Food Additives: Sodium Benzoate, Potassium Sorbate, Azorubine, and Tartrazine Modify the Expression of NF\u03baB, GADD45\u03b1, and MAPK8 Genes","volume":"103","author":"Raposa","year":"2016","journal-title":"Physiol. Int."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Sad\u017eak, A., Mravljak, J., Maltar-Strme\u010dki, N., Arsov, Z., Baranovi\u0107, G., Erceg, I., Kriechbaum, M., Strasser, V., P\u0159ibyl, J., and \u0160egota, S. (2020). The Structural Integrity of the Model Lipid Membrane during Induced Lipid Peroxidation: The Role of Flavonols in the Inhibition of Lipid Peroxidation. Antioxidants, 9.","DOI":"10.3390\/antiox9050430"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Mandelker, L. (2011). Oxidative Stress, Free Radicals, and Cellular Damage. Studies in Veterinary Medicine, Humana Press.","DOI":"10.1007\/978-1-61779-071-3_1"},{"key":"ref_29","first-page":"1021","article-title":"Study on Toxic Effect of Tartrazine Pigment on Oxidative Stress in Male Albino Rats","volume":"21","author":"Aldaamy","year":"2021","journal-title":"Biochem. Cell Arch."},{"key":"ref_30","first-page":"635","article-title":"Curcumin Protects against Tartrazine-Mediated Oxidative Stress and Hepatotoxicity in Male Rats","volume":"21","author":"Habila","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.lfs.2018.07.017","article-title":"Combating Oxidative Stress Disorders with Citrus Flavonoid: Naringenin","volume":"208","author":"Zaidun","year":"2018","journal-title":"Life Sci."},{"key":"ref_32","first-page":"795","article-title":"Protective Effects of Naringenin against CCl4-Induced Acute Liver Injury in Mice","volume":"39","author":"Wang","year":"2014","journal-title":"J. Toxicol. Sci."},{"key":"ref_33","first-page":"579","article-title":"Analysis of Activity and Motor Coordination in Rats Undergoing Stereotactic Surgery and Implantation of a Cannula into the Dorsal Hippocampus","volume":"32","year":"2017","journal-title":"Neurologia"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Rivadeneyra-Dom\u00ednguez, E., P\u00e9rez-P\u00e9rez, J.E., V\u00e1zquez-Luna, A., D\u00edaz-Sobac, R., and Rodr\u00edguez-Landa, J.F. (2020). Effects of Cassava Juice (Manihot esculenta Crantz) on Renal and Hepatic Function and Motor Impairments in Male Rats. Toxins, 12.","DOI":"10.3390\/toxins12110708"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1017\/S0962728600029596","article-title":"The 3Rs: Past, Present, and Future","volume":"14","author":"Russell","year":"2005","journal-title":"Anim. Welf."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Arafah, A., Rehman, M.U., Mir, T.M., Wali, A.F., Ali, R., Qamar, W., Khan, R., Ahmad, A., Aga, S.S., and Alqahtani, S. (2020). Multi-Therapeutic Potential of Naringenin (4\u2032,5,7-Trihydroxyflavonone): Experimental Evidence and Mechanisms. Plants, 9.","DOI":"10.3390\/plants9121784"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.etap.2014.07.015","article-title":"Protective Effect of Naringenin against Gentamicin-Induced Nephrotoxicity in Rats","volume":"38","author":"Fouad","year":"2014","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1016\/j.lfs.2004.11.005","article-title":"Naringenin Attenuates Cisplatin Nephrotoxicity in Rats","volume":"76","author":"Badary","year":"2005","journal-title":"Life Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1080\/01480545.2018.1512612","article-title":"Potential Protective Effects of Naringenin against Vancomycin-Induced Nephrotoxicity via Reduction of Apoptotic and Oxidative Stress Markers in Rats","volume":"43","author":"Uckun","year":"2020","journal-title":"Drug Chem. Toxicol."},{"key":"ref_40","first-page":"471","article-title":"Naringenin Abrogates Cisplatin-Induced Nephrotoxicity through Nuclear Factor-\u03baB and Apoptosis Inhibition in Mice","volume":"16","author":"Sultana","year":"2013","journal-title":"J. Med. Food"},{"key":"ref_41","first-page":"1008","article-title":"Protective Effect of Naringenin on Gentamicin-Induced Nephrotoxicity in Rats through the Suppression of Oxidative Stress and Inflammation","volume":"32","author":"Jamuna","year":"2016","journal-title":"Toxicol. Ind. Health"},{"key":"ref_42","first-page":"48","article-title":"Protective Effects of Naringenin against Nephrotoxicity in Rats","volume":"7","author":"Waly","year":"2018","journal-title":"Oxid. Antioxid. Med. Sci."},{"key":"ref_43","first-page":"13","article-title":"Gentamicin-Induced Nephrotoxicity: Possible Use of Naringenin for Therapeutic Intervention","volume":"7","author":"Shah","year":"2015","journal-title":"Int. J. Pharm. Pharm. Sci."},{"key":"ref_44","unstructured":"Matayoshi-Rodr\u00edguez, S.D. (2017). Efecto de la Tartrazina Sobre el Tejido Cerebral y Funci\u00f3n Cognitiva en Ratas de Segunda Generaci\u00f3n. [Bachelor\u2019s Thesis, Universidad Nacional Mayor de San Marcos]. Available online: https:\/\/cybertesis.unmsm.edu.pe\/handle\/20.500.12672\/6151."},{"key":"ref_45","first-page":"435","article-title":"Mitigation of toxic effects caused by tartrazine in wistar rats through oral administration of melon seed oil","volume":"56","author":"Ahmad","year":"2019","journal-title":"Pak. J. Agric. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Balta, I., Sevastre, B., Mire\u015fan, V., Taulescu, M., Raducu, C., Longodor, A.L., Marchi\u015f, Z., Mari\u015f, C.S., and Coroian, A. (2019). Protective effect of blackthorn fruits (Prunus spinosa) against tartrazine toxicity development in albino Wistar rats. BMC Chem., 13.","DOI":"10.1186\/s13065-019-0610-y"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Rivadeneyra-Dom\u00ednguez, E., Zamora-Bello, I., Ju\u00e1rez-Zaragoza, E.R., Rosales-S\u00e1nchez, \u00d3., Guill\u00e9n-Ruiz, G., and Rodr\u00edguez-Landa, J.F. (2025). Resveratrol reverses cassava (Manihot esculenta Crantz) juice-induced motor impairment in the Wistar rat. BMC Complement. Med. Ther., 25.","DOI":"10.1186\/s12906-025-04934-7"},{"key":"ref_48","first-page":"49","article-title":"Estudio Toxicol\u00f3gico y Farmacol\u00f3gico de los Extractos Hidroalcoh\u00f3licos de Algunas Especies de Smilax de Centroam\u00e9rica","volume":"8","author":"Villalobos","year":"2008","journal-title":"Rev. Fitoter."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.toxrep.2018.11.006","article-title":"Alterations of blood chemistry, hepatic and renal function, and blood cytometry in acrylamide-treated rats","volume":"5","year":"2018","journal-title":"Toxicol. Rep."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e06378","DOI":"10.1016\/j.heliyon.2021.e06378","article-title":"Anxiogenic and memory impairment effect of food color exposure: Upregulation of oxido-neuroinflammatory markers and acetyl-cholinestrase activity in the prefrontal cortex and hippocampus","volume":"7","author":"Wopara","year":"2021","journal-title":"Heliyon"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.fct.2013.06.004","article-title":"Neurotoxic Effect of Linamarin in Rats Associated with Cassava (Manihot esculenta Crantz) Consumption","volume":"59","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"9096404","DOI":"10.1155\/2019\/9096404","article-title":"High-Dose Aspirin Reverses Tartrazine-Induced Cell Growth Dysregulation Independent of p53 Signaling and Antioxidant Mechanisms in Rat Brain","volume":"2019","author":"Alsalman","year":"2019","journal-title":"BioMed Res. Int."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1111\/j.1471-4159.2005.03456.x","article-title":"Emerging evidence for a similar role of glutamate receptors in the nervous and immune systems","volume":"95","author":"Boldyrev","year":"2005","journal-title":"J. Neurochem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"301","DOI":"10.55782\/ane-2006-1619","article-title":"Excitotoxic neuronal injury in chronic homocysteine neurotoxicity studied in vitro: The role of NMDA and group I metabotropic glutamate receptors","volume":"66","author":"Zieminska","year":"2006","journal-title":"Acta Neurobiol. Exp."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.tiv.2008.12.005","article-title":"Naringenin-Induced Apoptosis Is Attenuated by Bcl-2 but Restored by the Small Molecule Bcl-2 Inhibitor, HA14-1, in Human Leukemia U937 Cells","volume":"23","author":"Jin","year":"2009","journal-title":"Toxicol. In Vitro"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Manchope, M.F., Calixto-Campos, C., Coelho-Silva, L., Zarpelon, A.C., Pinho-Ribeiro, F.A., and Georgetti, S.R. (2016). Naringenin Inhibits Superoxide Anion-Induced Inflammatory Pain: Role of Oxidative Stress, Cytokines, Nrf2 and the NO-cGMP-PKG-KATP Channel Signaling Pathway. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0153015"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4103\/tcmj.tcmj_103_18","article-title":"Antinociceptive and Anti-Inflammatory Effects of the Citrus Flavanone Naringenin","volume":"31","author":"Chung","year":"2019","journal-title":"Tzu-Chi Med. J."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.fct.2018.02.011","article-title":"Tartrazine-Induced Neurobiochemical Alterations in Rat Brain Sub-Regions","volume":"113","author":"Bhatt","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"ref_59","unstructured":"Zimmerman, H.J. (1999). Hepatotoxicity: The Adverse Effects of Drugs and Other Chemicals on the Liver, Lippincott Williams & Wilkins. [2nd ed.]."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3109\/03602532.2011.602688","article-title":"Oxidant Stress, Mitochondria, and Cell Death Mechanisms in Drug-Induced Liver Injury: Lessons Learned from Acetaminophen Hepatotoxicity","volume":"44","author":"Jaeschke","year":"2012","journal-title":"Drug Metab. Rev."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"90892","DOI":"10.1007\/s11356-023-28454-4","article-title":"Naringin and Naringenin Counteract Taxol-Induced Liver Injury in Wistar Rats via Suppression of Oxidative Stress, Apoptosis and Inflammation","volume":"30","author":"Khaled","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1002\/tox.24164","article-title":"Effects of Naringenin on Oxidative Damage and Apoptosis in Liver and Kidney in Rats Subjected to Chronic Mercury Chloride","volume":"39","author":"Yaman","year":"2024","journal-title":"Environ. Toxicol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.toxrep.2017.12.022","article-title":"Nigella sativa Oil Protects against Tartrazine Toxicity in Male Rats","volume":"5","author":"Zamazami","year":"2018","journal-title":"Toxicol. Rep."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4314\/dujopas.v8i1b.12","article-title":"Sub-Acute Toxicity Study on Tartrazine in Male Albino Rats","volume":"8","author":"Usman","year":"2022","journal-title":"Dutse J. Pure Appl. Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1002\/fsn3.2790","article-title":"Evaluation of Nano-Curcumin Effects against Tartrazine-Induced Abnormalities in Liver and Kidney Histology and Other Biochemical Parameters","volume":"10","author":"Wabaidur","year":"2022","journal-title":"Food Sci. Nutr."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"51","DOI":"10.9734\/jamps\/2020\/v22i630179","article-title":"Assessment of Atherogenic Indices and Markers of Cardiac Injury in Albino Rats Orally Administered with Tartrazine Azo Dye","volume":"22","author":"Iroh","year":"2020","journal-title":"J. Adv. Med. Pharm. Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.intimp.2018.08.002","article-title":"Comparative Haemato-Immunotoxic Impacts of Long-Term Exposure to Tartrazine and Chlorophyll in Rats","volume":"63","author":"Hashem","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"ref_68","first-page":"892","article-title":"Naringenin Ameliorates Paracetamol-Induced Hepatotoxicity in Mice through Antioxidative Stress and Inhibition of Inflammatory Cytokines","volume":"23","author":"Alam","year":"2020","journal-title":"Iran. J. Basic Med. Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.etp.2009.03.010","article-title":"Cadmium-Induced Hepatotoxicity in Rats and the Protective Effect of Naringenin","volume":"62","author":"Renugadevi","year":"2010","journal-title":"Exp. Toxicol. Pathol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s12011-011-9268-6","article-title":"Protective Effect of Naringenin against Lead-Induced Oxidative Stress in Rats","volume":"146","author":"Wang","year":"2012","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"568","DOI":"10.3109\/15376516.2012.707255","article-title":"Anti-Inflammatory Role of Naringenin in Rats with Ethanol-Induced Liver Injury","volume":"22","author":"Jayaraman","year":"2012","journal-title":"Toxicol. Mech. Methods"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1017\/S0954422410000338","article-title":"Garlic in Health and Disease","volume":"24","author":"Rana","year":"2011","journal-title":"Nutr. Res. Rev."},{"key":"ref_73","unstructured":"Wu, J., Kuncio, G.S., and Zern, M.A. (1998). Liver Growth Repair: From Basic Science to Clinical Practice, Chapman and Hall."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jtcme.2019.01.001","article-title":"Naringenin Mitigates Antituberculosis Drugs-Induced Hepatic and Renal Injury in Rats","volume":"10","author":"Sahu","year":"2020","journal-title":"J. Tradit. Complement. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"564","DOI":"10.12991\/marupj.319304","article-title":"Tartrazine-Induced Changes in Physiological and Biochemical Parameters in Swiss Albino Mice, Mus musculus","volume":"21","author":"Arefin","year":"2017","journal-title":"Marmara Pharm. J."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.3748\/wjg.v24.i16.1679","article-title":"Beneficial Effects of Naringenin in Liver Diseases: Molecular Mechanisms","volume":"24","author":"Muriel","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/ki.2010.337","article-title":"New Insights into the Mechanism of Aminoglycoside Nephrotoxicity: An Integrative Point of View","volume":"79","author":"Vicente","year":"2011","journal-title":"Kidney Int."},{"key":"ref_78","first-page":"43","article-title":"Biomarkers of Drug-Induced Liver Injury","volume":"85","author":"McGill","year":"2019","journal-title":"Adv. Pharmacol."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Ammar, N.M., Hassan, H.A., Abdallah, H.M.I., Afifi, S.M., Elgamal, A.M., Farrag, A.R.H., El-Gendy, A.E.-N.G., Farag, M.A., and Elshamy, A.I. (2022). Protective Effects of Naringenin from Citrus sinensis (Var. Valencia) Peels against CCl4-Induced Hepatic and Renal Injuries in Rats Assessed by Metabolomics, Histological and Biochemical Analyses. Nutrients, 14.","DOI":"10.3390\/nu14040841"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"60","DOI":"10.21608\/zjfm.2020.44386.1064","article-title":"Toxic Effects of Food Azo Dye Tartrazine on the Brain of Young Male Albino Rats: Role of Oxidative Stress","volume":"19","author":"Hosieny","year":"2020","journal-title":"Zagazig J. Forensic Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"e08454","DOI":"10.1016\/j.heliyon.2021.e08454","article-title":"Involvement of Striatal Oxido-Inflammatory, Nitrosative and Decreased Cholinergic Activity in Neurobehavioral Alteration in Adult Rat Model with Oral Co-Exposure to Erythrosine and Tartrazine","volume":"7","author":"Wopara","year":"2021","journal-title":"Heliyon"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"112180","DOI":"10.1016\/j.biopha.2021.112180","article-title":"Nephroprotective Effect of Naringin in Methotrexate-Induced Renal Toxicity in Male Rats","volume":"143","author":"Elsawy","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s41936-022-00313-7","article-title":"The Protective Effect of Naringenin against Pyrazinamide-Induced Hepatotoxicity in Male Wistar Rats","volume":"83","author":"Ali","year":"2022","journal-title":"J. Basic Appl. Zool."},{"key":"ref_84","unstructured":"Himri, I., Bellahcen, S., Souna, F., Belmakki, F., Aziz, M., Bnouham, M., and Aziz, K. (2011). A 90-Day Oral Toxicity Study of Tartrazine, a Synthetic Food Dye, in Wistar Rats. Int. J. Pharm. Pharm. Sci., 159\u2013169."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Yan, X., Lin, T., Zhu, Q., Zhang, Y., Song, Z., and Pan, X. (2023). Naringenin Protects against Acute Pancreatitis-Associated Intestinal Injury by Inhibiting NLRP3 Inflammasome Activation via AhR Signaling. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1090261"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Eanes, L.A., Eldeeb, M., Storholt, D., and Patel, Y.M. (2025). Naringenin Impairs Mitochondrial Function via ROS to Induce Apoptosis in Tamoxifen-Resistant MCF-7 Breast Cancer Cells. PLoS ONE, 20.","DOI":"10.1371\/journal.pone.0320020"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1016\/j.fct.2008.09.056","article-title":"Naringenin Induces Apoptosis through Downregulation of Akt and Caspase-3 Activation in Human Leukemia THP-1 Cells","volume":"46","author":"Park","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Ahamad, M.S., Siddiqui, S., Jafri, A., Ahmad, S., Afzal, M., and Arshad, M. (2014). Induction of Apoptosis and Antiproliferative Activity of Naringenin in Human Epidermoid Carcinoma Cell through ROS Generation and Cell Cycle Arrest. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0110003"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.3892\/ijo.2014.2617","article-title":"Naringin Inhibits Growth and Induces Apoptosis by a Mechanism Dependent on Reduced Activation of the NF-\u03baB\/COX-2\/Caspase-1 Pathway in HeLa Cervical Cancer Cells","volume":"45","author":"Zeng","year":"2014","journal-title":"Int. J. Oncol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/19\/3161\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:15:18Z","timestamp":1790482518000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/19\/3161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,25]]},"references-count":89,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["nu18193161"],"URL":"https:\/\/doi.org\/10.3390\/nu18193161","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,25]]}}}