{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T12:04:26Z","timestamp":1790597066230,"version":"4.1.0"},"reference-count":78,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004071","name":"Khon Kaen University","doi-asserted-by":"publisher","award":["IN69047"],"award-info":[{"award-number":["IN69047"]}],"id":[{"id":"10.13039\/501100004071","id-type":"DOI","asserted-by":"publisher"}]},{"award":["IN69047"],"award-info":[{"award-number":["IN69047"]}],"id":[{"id":"https:\/\/ror.org\/03cq4gr50","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Accumulation of oxidative damage and brain inflammation plays a role in aging-associated memory impairment. D-galactose (D-gal) is a monosaccharide used to induce aging in rat models by promoting oxidative damage and neuroinflammation. Prunus domestica L. (PD) contains high levels of flavonoid compounds, which possess antioxidant, anti-inflammatory, neuroprotective and anti-aging properties. This study investigated the effects of PD fruit extract on memory, vascular-associated cell proliferation, immature neuronal cells, and survival of neurons in the dentate gyrus (DG) using a rat model of D-gal-induced aging. Methods: Forty-eight male Sprague\u2013Dawley (SD) rats, two months old, were randomly assigned to eight groups: vehicle (0.9% normal saline), D-gal (50 mg\/kg), PD (75, 100, and 150 mg\/kg), or D-gal (50 mg\/kg) co-administered with PD (75, 100 or 150 mg\/kg). Spatial memory was assessed using the novel object location (NOL) test. Hippocampal neurogenesis and vascular-associated cell proliferation in the DG were evaluated using immunofluorescence staining for the co-localization of the markers Ki-67\/rat endothelial cell antigen-1 (RECA-1) and 5-bromo-2\u2032-deoxyuridine\/neuronal nuclear protein (BrdU\/NeuN), as well as doublecortin (DCX). Results: Rats treated with D-gal alone did not show a significant preference for the novel location. Additionally, D-gal treatment reduced the numbers of Ki-67-, Ki-67\/RECA-1-, BrdU\/NeuN-, and DCX-stained cells in the hippocampus. Conversely, co-administration of PD fruit extract was associated with a significant preference for the novel location, and this treatment also attenuated the D-gal-triggered reductions in cellular markers. Conclusions: These finding suggest that PD fruit extract exerts a neuroprotective effect against D-gal-induced brain aging, potentially preserving spatial memory-related performance in rats.<\/jats:p>","DOI":"10.3390\/nu18193178","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T11:35:59Z","timestamp":1790595359000},"page":"3178","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prunus domestica L. Fruit Extract Mitigates the Depletion of Rat Hippocampal Neurogenesis and Memory Deficits Observed in a D-Galactose-Induced Aging Rat Model"],"prefix":"10.3390","volume":"18","author":[{"given":"Salinee","family":"Naewla","sequence":"first","affiliation":[{"name":"Department of Basic Medical Science, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok 10300, Thailand"},{"name":"Neurogenesis Research Group, Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"}]},{"given":"Puncharatsm","family":"Pannin","sequence":"additional","affiliation":[{"name":"Neurogenesis Research Group, Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"},{"name":"Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"}]},{"given":"Papatchaya","family":"Sintow","sequence":"additional","affiliation":[{"name":"Neurogenesis Research Group, Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"},{"name":"School of Integrative Medicine, Mae Fah Luang University, Chiang Rai 57100, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"data-curation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"}]},{"given":"Ram","family":"Prajit","sequence":"additional","affiliation":[{"name":"Neurogenesis Research Group, Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"},{"name":"Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Nataya","family":"Sritawan","sequence":"additional","affiliation":[{"name":"Neurogenesis Research Group, Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"},{"name":"Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"}]},{"given":"Apiwat","family":"Sirichoat","sequence":"additional","affiliation":[{"name":"Neurogenesis Research Group, Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"},{"name":"Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6433-0293","authenticated-orcid":false,"given":"Rawiwan","family":"Charoensup","sequence":"additional","affiliation":[{"name":"School of Integrative Medicine, Mae Fah Luang University, Chiang Rai 57100, Thailand"},{"name":"Medicinal Plant Innovation Center of Mae Fah Luang University, Mae Fah Luang University, Chiang Rai 57100, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"}]},{"given":"Peter","family":"Wigmore","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Medical School, Queen\u2019s Medical Centre, University of Nottingham, Nottingham NG7 2RD, UK"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2872-1542","authenticated-orcid":false,"given":"Jariya Umka","family":"Welbat","sequence":"additional","affiliation":[{"name":"Neurogenesis Research Group, Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"},{"name":"Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.cell.2016.07.050","article-title":"Epigenetic Mechanisms of Longevity and Aging","volume":"166","author":"Sen","year":"2016","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/nature20411","article-title":"Ageing, neurodegeneration and brain rejuvenation","volume":"539","year":"2016","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Singh, P., Barman, B., and Thakur, M.K. 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