{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T12:04:53Z","timestamp":1790597093010,"version":"4.1.0"},"reference-count":31,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006544","name":"Israel Ministry of Health","doi-asserted-by":"publisher","award":["3-00000-12789"],"award-info":[{"award-number":["3-00000-12789"]}],"id":[{"id":"10.13039\/501100006544","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006544","name":"Israel Ministry of Health","doi-asserted-by":"publisher","award":["3-00000-16050"],"award-info":[{"award-number":["3-00000-16050"]}],"id":[{"id":"10.13039\/501100006544","id-type":"DOI","asserted-by":"publisher"}]},{"award":["3-00000-12789"],"award-info":[{"award-number":["3-00000-12789"]}],"id":[{"id":"https:\/\/ror.org\/016n0q862","id-type":"ROR","asserted-by":"publisher"}]},{"award":["3-00000-16050"],"award-info":[{"award-number":["3-00000-16050"]}],"id":[{"id":"https:\/\/ror.org\/016n0q862","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["2614\/19"],"award-info":[{"award-number":["2614\/19"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"award":["2614\/19"],"award-info":[{"award-number":["2614\/19"]}],"id":[{"id":"https:\/\/ror.org\/04sazxf24","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background and objective: Evidence regarding dietary intake of specific macronutrients, dietary fiber, and fatty acids in relation to cognitive performance during school age remains limited. We examined these associations among healthy Arab children in Israel. Methods: This cross-sectional analysis included 146 children aged 10\u201312 years from a prospective cohort. Dietary intake was assessed using a single 24 h dietary recall. Cognitive performance was assessed using the Arabic version of the Wechsler Intelligence Scale for Children, Fourth Edition. Full-scale intelligence quotient (FSIQ) was the primary outcome, whereas verbal comprehension (VCI), perceptual reasoning (PRI), working memory (WMI), and processing speed (PSI) indices were exploratory secondary outcomes. Multivariable linear regression models adjusted for age, sex, village, socioeconomic status, and total energy intake. Results: No statistically significant associations were found between the examined dietary exposures and FSIQ scores. Among 48 exploratory comparisons involving 12 dietary exposures and four specific cognitive domains, higher dietary fiber intake was associated with higher WMI (B = 0.430, 95% CI 0.067\u20130.794), and this association remained consistent across sensitivity analyses. Higher polyunsaturated fatty acid intake was associated with higher PRI (B = 0.312, 95% CI 0.021 to 0.604), and higher linolenic acid intake with higher PSI (B = 3.325, 95% CI 0.081 to 6.569). However, both findings were sensitive to alternative exposure specifications. In a sensitivity analysis, any calculated trans-fat intake versus zero calculated intake was associated with lower PRI (B = \u22126.290, 95% CI \u221210.766 to \u22121.814). Conclusions: We found no evidence of associations between the examined nutrient intakes and FSIQ, the primary outcome for overall intellectual functioning. Exploratory analyses identified domain-specific associations, particularly a consistent positive association between dietary fiber intake and working memory. These findings provide new evidence on nutrient intake and cognitive performance among healthy school-aged children from an underrepresented population. Given the study limitations, these associations should be interpreted cautiously and confirmed in larger prospective studies using repeated dietary assessments.<\/jats:p>","DOI":"10.3390\/nu18193186","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T11:35:59Z","timestamp":1790595359000},"page":"3186","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations Between Nutrient Intake and Cognitive Performance Across Multiple Domains in Healthy School-Aged Children"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1086-7559","authenticated-orcid":false,"given":"Khitam","family":"Muhsen","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine, School of Public Health, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6139001, 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Psychol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"4130","DOI":"10.1002\/hbm.24690","article-title":"Longitudinal associations between white matter maturation and cognitive development across early childhood","volume":"40","author":"Dai","year":"2019","journal-title":"Hum. Brain Mapp."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/nure.12102","article-title":"Nutrition and brain development in early life","volume":"72","author":"Prado","year":"2014","journal-title":"Nutr. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"614s","DOI":"10.1093\/ajcn\/85.2.614S","article-title":"Nutrition and the developing brain: Nutrient priorities and measurement","volume":"85","author":"Georgieff","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s10654-023-01012-5","article-title":"Dietary patterns, brain morphology and cognitive performance in children: Results from a prospective population-based study","volume":"38","author":"Mou","year":"2023","journal-title":"Eur. J. Epidemiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1136\/jech.2010.111955","article-title":"Are dietary patterns in childhood associated with IQ at 8 years of age? A population-based cohort study","volume":"66","author":"Northstone","year":"2012","journal-title":"J. Epidemiol. Community Health"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.clnu.2021.11.029","article-title":"Is the association between dietary patterns and cognition mediated by children\u2019s adiposity? A longitudinal approach in Generation XXI birth cohort","volume":"41","author":"Marinho","year":"2022","journal-title":"Clin. Nutr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1079\/BJN19900005","article-title":"Nutrient intakes, vitamin-mineral supplementation, and intelligence in British schoolchildren","volume":"64","author":"Nelson","year":"1990","journal-title":"Br. J. Nutr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1093\/jn\/135.8.1967","article-title":"Dietary fat intake is associated with psychosocial and cognitive functioning of school-aged children in the United States","volume":"135","author":"Zhang","year":"2005","journal-title":"J. Nutr."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1017\/S1368980014000068","article-title":"Dietary patterns and cognitive ability among 12- to 13 year-old adolescents in Selangor, Malaysia","volume":"18","author":"Nurliyana","year":"2015","journal-title":"Public Health Nutr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.3945\/ajcn.113.079624","article-title":"Dietary lipids are differentially associated with hippocampal-dependent relational memory in prepubescent children","volume":"99","author":"Baym","year":"2014","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3945\/jn.114.198457","article-title":"Dietary fiber is positively associated with cognitive control among prepubertal children","volume":"145","author":"Khan","year":"2015","journal-title":"J. Nutr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.appet.2015.04.012","article-title":"The relation of saturated fats and dietary cholesterol to childhood cognitive flexibility","volume":"93","author":"Khan","year":"2015","journal-title":"Appetite"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s10654-012-9715-5","article-title":"Dietary patterns at 6, 15 and 24 months of age are associated with IQ at 8 years of age","volume":"27","author":"Smithers","year":"2012","journal-title":"Eur. J. Epidemiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1111\/j.1469-7610.2008.02029.x","article-title":"Dietary patterns in infancy and cognitive and neuropsychological function in childhood","volume":"50","author":"Gale","year":"2009","journal-title":"J. Child. Psychol. Psychiatry"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1007\/s00394-021-02522-2","article-title":"Trends in the adherence to the Mediterranean diet in Israeli adolescents: Results from two national health and nutrition surveys, 2003 and 2016","volume":"60","author":"Peng","year":"2021","journal-title":"Eur. J. Nutr."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.pedneo.2022.06.015","article-title":"Associations of early-life exposures and socioeconomic status with cognitive development at preadolescence","volume":"64","author":"Akawi","year":"2023","journal-title":"Pediatr. Neonatol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Muhsen, K., Na\u2019amnih, W., Goldsmith, R., Maya, M., Zeidan, N., Kassem, E., and Ornoy, A. (2021). Associations of feeding practices in early life and dietary intake at school age with obesity in 10- to 12-year-old Arab children. Nutrients, 13.","DOI":"10.3390\/nu13062106"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Kassem, E., Na\u2019amnih, W., Shapira, M., Ornoy, A., and Muhsen, K. (2022). Comparison between school-age children with and without obesity in nutritional and inflammation biomarkers. J. Clin. Med., 11.","DOI":"10.3390\/jcm11236973"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Lapidot, Y., Reshef, L., Goldsmith, R., Na\u2019amnih, W., Kassem, E., Ornoy, A., Gophna, U., and Muhsen, K. (2021). The associations between diet and socioeconomic disparities and the intestinal microbiome in preadolescence. Nutrients, 13.","DOI":"10.3390\/nu13082645"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1093\/tropej\/fmr068","article-title":"Incidence, age of acquisition and risk factors of Helicobacter pylori infection among Israeli Arab infants","volume":"58","author":"Muhsen","year":"2012","journal-title":"J. Trop. Pediatr."},{"key":"ref_22","unstructured":"Israel Central Bureau of Statistics (2021). Characterization and Classification of Geographical Units by the Socioeconomic Level of the Population 2017."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1080\/09297040590951587","article-title":"Test review: Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV)","volume":"11","author":"Baron","year":"2005","journal-title":"Child Neuropsychol."},{"key":"ref_24","unstructured":"Hakeam, S., Ibrahim, R., Yeshel, Y., Rotsheld, L., and Bernstein, D. (2015). Arabic Version of Wechsler Intelligence Tests for Children (WISC-IVARB), PsychTech Ltd."},{"key":"ref_25","first-page":"219","article-title":"Psychometric properties of the Wechsler Abbreviated Scale of Intelligence (WASI) with an Arab sample of school students","volume":"9","author":"Sartawi","year":"2011","journal-title":"Individ. Differ. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/j.ridd.2014.02.003","article-title":"Socioeconomic status, child enrichment factors, and cognitive performance among preschool-age children: Results from the Follow-Up of Growth and Development Experiences study","volume":"35","author":"Christensen","year":"2014","journal-title":"Res. Dev. Disabil."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/obr.12139","article-title":"Associations between predictors of children\u2019s dietary intake and socioeconomic position: A systematic review of the literature","volume":"15","author":"Zarnowiecki","year":"2014","journal-title":"Obes. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"660","DOI":"10.2471\/BLT.07.043497","article-title":"Development of a WHO growth reference for school-aged children and adolescents","volume":"85","author":"Onyango","year":"2007","journal-title":"Bull. World Health Organ."},{"key":"ref_29","unstructured":"WHO (2026, August 11). Growth Reference Data for 5\u201319 Years. Available online: https:\/\/www.who.int\/tools\/growth-reference-data-for-5to19-years."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: A practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. Ser. B (Methodol.)"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1146\/annurev-psych-113011-143750","article-title":"Executive functions","volume":"64","author":"Diamond","year":"2013","journal-title":"Annu. Rev. Psychol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/19\/3186\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T11:51:11Z","timestamp":1790596271000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/19\/3186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,26]]},"references-count":31,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["nu18193186"],"URL":"https:\/\/doi.org\/10.3390\/nu18193186","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,26]]}}}