{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:12:22Z","timestamp":1792789942608,"version":"4.5.0"},"reference-count":45,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Foundation for the Study of Diabetes\/Boehringer Ingelheim European Research Programme","id":[{"id":"https:\/\/ror.org\/05tgz4m05","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with multiple extrahepatic complications, but its relationship with peripheral neuropathy, even without co-existing type 2 diabetes (T2D), remains poorly understood. Furthermore, to what extent addressing liver and metabolic health would be associated with improvements in small nerve fibre morphology (that mediate neuropathy) is unknown. We investigated the relationship between liver health and small nerve fibre morphology in adults with MASLD before and after diet-induced weight loss and improvements in liver health. Methods: Adults with MASLD (n = 12) and controls without MASLD or T2D (n = 16) underwent anthropometry, biochemistry, transient elastography (TE) and corneal confocal microscopy (CCM). Participants with MASLD then completed a 12-week low-calorie diet (LCD; Counterweight-Plus, ~850 kcal\/day) with repeat assessments including multi-organ magnetic resonance imaging (MRI). TE quantified hepatic steatosis (controlled attenuation parameter, CAP), while MRI measured hepatic and pancreatic fat (proton density fat fraction, PDFF) and fibroinflammation (iron-corrected T1, cT1). Neuropathy was assessed using validated questionnaires and CCM-derived corneal nerve fibre density (CNFD), branch density (CNBD) and fibre length (CNFL). The primary outcome measure was change in liver PDFF. Associations between hepatic and neuropathy measures were assessed using correlation and multivariable linear regression. Results: Compared with controls, MASLD participants had higher liver fat and metabolic dysfunction, with reduced CNFD (25.7 vs. 28.4 fibres\/mm2, p = 0.03) and CNFL (14.1 vs. 17.1 mm\/mm2, p = 0.02). In multivariable regression, TE-derived CAP was independently associated with CNFD (\u03b2 \u22120.03 (95% CI \u22120.06, \u22120.01), p &lt; 0.05), while total cholesterol was associated with CNFL (\u03b2 \u22121.54 (95% CI \u22122.81, \u22120.27), p &lt; 0.02). After LCD, participants lost 12.5 kg with reductions in metabolic syndrome components (p = 0.04) and liver fat (\u0394PDFF \u22125.0%, p = 0.03). Neuropathic symptoms improved and CNFD increased (+1.87 fibres\/mm2, p = 0.05). Reduction in liver fat correlated with increased CNFL (r = \u22120.63, p = 0.03), while change in hepatic fibroinflammation (\u0394cT1) correlated with neuropathy disability (r = 0.62, p = 0.04) and small-fibre symptom scores (r = 0.47, p = 0.05). Conclusions: These exploratory findings suggest that MASLD, even without T2D, may be associated with small nerve fibre abnormalities and neuropathic symptoms. Diet-induced weight loss improved liver, metabolic and neural health in parallel. Larger prospective confirmatory studies are required to more precisely establish this relationship both at baseline and with interventions.<\/jats:p>","DOI":"10.3390\/nu18193242","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:19:08Z","timestamp":1790842748000},"page":"3242","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Small-Nerve Fibre Pathology in Metabolic Dysfunction-Associated Steatotic Liver Disease Is Associated with Liver Fat\/Inflammation and Improves with Weight Loss"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8066-9470","authenticated-orcid":false,"given":"Alex E.","family":"Henney","sequence":"first","affiliation":[{"name":"Department of Cardiovascular and Metabolic Medicine, University of Liverpool, Liverpool L69 7ZX, UK"},{"name":"Metabolism and Nutrition Research Group, Liverpool University Hospitals NHS Foundation Trust, Liverpool L7 8YE, UK"},{"name":"Liverpool Centre for Cardiovascular Sciences, University of Liverpool, Liverpool University Hospitals NHS Foundation Trust, Liverpool L7 8YE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azlinda","family":"Hamid","sequence":"additional","affiliation":[{"name":"Metabolism and Nutrition Research Group, Liverpool University Hospitals NHS Foundation Trust, Liverpool L7 8YE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7165-6918","authenticated-orcid":false,"given":"Jamie","family":"Burgess","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Metabolic Medicine, University of Liverpool, Liverpool L69 7ZX, UK"},{"name":"Pain Research Institute, University of Liverpool, Liverpool L9 7AL, UK"},{"name":"Department of Musculoskeletal and Ageing Science, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool L69 7ZX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Riley","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Metabolic Medicine, University of Liverpool, Liverpool L69 7ZX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7887-809X","authenticated-orcid":false,"given":"Barbara","family":"Fielding","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, University of Surrey, Guildford GU2 7XH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Marshall","sequence":"additional","affiliation":[{"name":"Pain Research Institute, University of Liverpool, Liverpool L9 7AL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khansa","family":"Makawi","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine, Hamad Medical Corporation, Doha P.O. Box 3050, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdel-Naser","family":"Elzouki","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine, Hamad Medical Corporation, Doha P.O. Box 3050, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Einas","family":"Elgassim","sequence":"additional","affiliation":[{"name":"Department of Medicine, Weill Cornell Medicine-Qatar, Qatar Foundation, Doha P.O. Box 34110, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8324-9666","authenticated-orcid":false,"given":"Graham J.","family":"Kemp","sequence":"additional","affiliation":[{"name":"Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool L69 7ZX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7188-8903","authenticated-orcid":false,"given":"Rayaz A.","family":"Malik","sequence":"additional","affiliation":[{"name":"Division of Research, Weill Cornell Medicine, Doha P.O. Box 24144, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3190-1122","authenticated-orcid":false,"given":"Uazman","family":"Alam","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Metabolic Medicine, University of Liverpool, Liverpool L69 7ZX, UK"},{"name":"Metabolism and Nutrition Research Group, Liverpool University Hospitals NHS Foundation Trust, Liverpool L7 8YE, UK"},{"name":"Liverpool Centre for Cardiovascular Sciences, University of Liverpool, Liverpool University Hospitals NHS Foundation Trust, Liverpool L7 8YE, UK"},{"name":"Centre for Musculoskeletal Research, Faculty of Biology Medicine and Health, The University of Manchester, Manchester M13 9PL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6128-0822","authenticated-orcid":false,"given":"Daniel J.","family":"Cuthbertson","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Metabolic Medicine, University of Liverpool, Liverpool L69 7ZX, UK"},{"name":"Metabolism and Nutrition Research Group, Liverpool University Hospitals NHS Foundation Trust, Liverpool L7 8YE, UK"},{"name":"Liverpool Centre for Cardiovascular Sciences, University of Liverpool, Liverpool University Hospitals NHS Foundation Trust, Liverpool L7 8YE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.3350\/cmh.2024.0431","article-title":"Epidemiology of metabolic dysfunction-associated steatotic liver disease","volume":"31","author":"Younossi","year":"2025","journal-title":"Clin. Mol. Hepatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.2337\/dci24-0094","article-title":"Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in People With Diabetes: The Need for Screening and Early Intervention. A Consensus Report of the American Diabetes Association","volume":"48","author":"Cusi","year":"2025","journal-title":"Diabetes Care"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1111\/liv.16086","article-title":"Metabolic syndrome traits differentially and cumulatively influence micro- and macrovascular disease risk in patients with MASLD","volume":"44","author":"Henney","year":"2024","journal-title":"Liver Int."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"156306","DOI":"10.1016\/j.metabol.2025.156306","article-title":"Impact of metabolic dysfunction severity in steatotic liver disease and its interaction with liver fibrosis on all-cause mortality and multiple hepatic and extra-hepatic outcomes","volume":"170","author":"Cuthbertson","year":"2025","journal-title":"Metabolism"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Deravi, N., Firouzabadi, F.D., Moosaie, F., Asadigandomani, H., Bafrani, M.A., Yoosefi, N., Poopak, A., Firouzabadi, M.D., Poudineh, M., and Rabizadeh, S. (2023). Non-alcoholic fatty liver disease and incidence of microvascular complications of diabetes in patients with type 2 diabetes: A prospective cohort study. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1147458"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"104271","DOI":"10.1016\/j.numecd.2025.104271","article-title":"Association of metabolic dysfunction-associated fatty liver disease with microvascular complications in adults with prediabetes","volume":"36","author":"Xie","year":"2026","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"101087","DOI":"10.1016\/j.aohep.2023.101087","article-title":"Type 2 diabetes complications are associated with liver fibrosis independent of hemoglobin A1c","volume":"28","author":"Trivedi","year":"2023","journal-title":"Ann. Hepatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"5304","DOI":"10.1038\/s41598-023-32115-4","article-title":"Association between nonalcoholic fatty liver disease and peripheral neuropathy in US population, a cross-sectional study","volume":"13","author":"Gu","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1111\/jdi.13562","article-title":"Liver fibrosis is independently associated with diabetic peripheral neuropathy in type 2 diabetes mellitus","volume":"12","author":"Huang","year":"2021","journal-title":"J. Diabetes Investig."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"24372","DOI":"10.1038\/s41598-021-03870-z","article-title":"Liver fibrosis indices are related to diabetic peripheral neuropathy in individuals with type 2 diabetes","volume":"11","author":"Kim","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1113\/JP277994","article-title":"Liver sympathetic denervation reverses obesity-induced hepatic steatosis","volume":"597","author":"Hurr","year":"2019","journal-title":"J. Physiol."},{"key":"ref_12","unstructured":"FDA (2024). FDA Approves First Treatment for Patients with Liver Scarring Due to Fatty Liver Disease."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"97","DOI":"10.17476\/jmbs.2025.14.2.97","article-title":"Cost-Effectiveness of Obesity Treatments: Glucagon-Like Peptide-1 Receptor Agonists, Endoscopic Sleeve Gastroplasty, and Metabolic\/Bariatric Surgery","volume":"14","author":"Huh","year":"2025","journal-title":"J. Metab. Bariatr. Surg."},{"key":"ref_14","unstructured":"European Association for the Study of the Liver (EASL), European Association for the Study of Diabetes (EASD), and European Association for the Study of Obesity (EASO) (2024). EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). J. Hepatol., 81, 492\u2013542."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1053\/j.gastro.2015.04.005","article-title":"Weight Loss Through Lifestyle Modification Significantly Reduces Features of Nonalcoholic Steatohepatitis","volume":"149","author":"Friedman","year":"2015","journal-title":"Gastroenterology"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Dobbie, L.J., Burgess, J., Hamid, A., Nevitt, S.J., Hydes, T.J., Alam, U., and Cuthbertson, D.J. (2024). Effect of a Low-Calorie Dietary Intervention on Liver Health and Body Weight in Adults with Metabolic-Dysfunction Associated Steatotic Liver Disease (MASLD) and Overweight\/Obesity: A Systematic Review and Meta-Analysis. Nutrients, 16.","DOI":"10.3390\/nu16071030"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S2213-8587(19)30076-2","article-title":"Understanding the mechanisms of reversal of type 2 diabetes","volume":"7","author":"Taylor","year":"2019","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1007\/s11695-020-05052-8","article-title":"Improvements in Diabetic Neuropathy and Nephropathy After Bariatric Surgery: A Prospective Cohort Study","volume":"31","author":"Adam","year":"2021","journal-title":"Obes. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/s41366-020-00727-9","article-title":"Bariatric surgery leads to an improvement in small nerve fibre damage in subjects with obesity","volume":"45","author":"Azmi","year":"2021","journal-title":"Int. J. Obes."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/j.jhep.2023.06.003","article-title":"A multisociety Delphi consensus statement on new fatty liver disease nomenclature","volume":"79","author":"Lazarus","year":"2023","journal-title":"J. Hepatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.2337\/db23-0926","article-title":"Quantitative Imaging Reveals Steatosis and Fibroinflammation in Multiple Organs in People With Type 2 Diabetes: A Real-World Study","volume":"73","author":"Diamond","year":"2024","journal-title":"Diabetes"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"838","DOI":"10.2337\/dc14-2311","article-title":"Normative values for corneal nerve morphology assessed using corneal confocal microscopy: A multinational normative data set","volume":"38","author":"Tavakoli","year":"2015","journal-title":"Diabetes Care"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/liv.14669","article-title":"Prognostic accuracy of FIB-4, NAFLD fibrosis score and APRI for NAFLD-related events: A systematic review","volume":"41","author":"Lee","year":"2021","journal-title":"Liver Int."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1167\/iovs.62.1.20","article-title":"Corneal Keratocyte Density and Corneal Nerves Are Reduced in Patients With Severe Obesity and Improve After Bariatric Surgery","volume":"62","author":"Iqbal","year":"2021","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1002\/oby.23246","article-title":"Dietary weight loss in people with severe obesity stabilizes neuropathy and improves symptomatology","volume":"29","author":"Callaghan","year":"2021","journal-title":"Obesity"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1007\/s00125-019-4897-y","article-title":"Early nerve fibre regeneration in individuals with type 1 diabetes after simultaneous pancreas and kidney transplantation","volume":"62","author":"Azmi","year":"2019","journal-title":"Diabetologia"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1111\/liv.15947","article-title":"Exercise improves surrogate measures of liver histological response in metabolic dysfunction-associated steatotic liver disease","volume":"44","author":"Cuthbertson","year":"2024","journal-title":"Liver Int."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e001420","DOI":"10.1136\/bmjdrc-2020-001420","article-title":"Effect of treatment with exenatide and pioglitazone or basal-bolus insulin on diabetic neuropathy: A substudy of the Qatar Study","volume":"8","author":"Ponirakis","year":"2020","journal-title":"BMJ Open Diabetes Res. Care"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e70011","DOI":"10.1111\/jns.70011","article-title":"Dapagliflozin for Small Nerve Fibre Regeneration in Diabetic Peripheral Neuropathy: A Randomised Controlled Study (DINE)","volume":"30","author":"Adhikari","year":"2025","journal-title":"J. Peripher. Nerv. Syst."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1210\/clinem\/dgac244","article-title":"Bariatric Surgery-induced High-density Lipoprotein Functionality Enhancement Is Associated With Reduced Inflammation","volume":"107","author":"Adam","year":"2022","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"12573","DOI":"10.1038\/s41598-021-90346-9","article-title":"The role of abnormalities of lipoproteins and HDL functionality in small fibre dysfunction in people with severe obesity","volume":"11","author":"Azmi","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jhep.2017.11.014","article-title":"Lipotoxicity and the gut-liver axis in NASH pathogenesis","volume":"68","author":"Marra","year":"2018","journal-title":"J. Hepatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1002\/hep.23719","article-title":"Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites","volume":"52","year":"2010","journal-title":"Hepatology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.2147\/DMSO.S247571","article-title":"Progressive Loss of Corneal Nerve Fibers and Sensitivity in Rats Modeling Obesity and Type 2 Diabetes Is Reversible with Omega-3 Fatty Acid Intervention: Supporting Cornea Analyses as a Marker for Peripheral Neuropathy and Treatment","volume":"13","author":"Coppey","year":"2020","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.2040-1124.2010.00070.x","article-title":"Mechanism of diabetic neuropathy: Where are we now. and where to go?","volume":"2","author":"Yagihashi","year":"2011","journal-title":"J. Diabetes Investig."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Burgess, J., Frank, B., Marshall, A., Khalil, R.S., Ponirakis, G., Petropoulos, I.N., Cuthbertson, D.J., Malik, R.A., and Alam, U. (2021). Early Detection of Diabetic Peripheral Neuropathy: A Focus on Small Nerve Fibres. Diagnostics, 11.","DOI":"10.3390\/diagnostics11020165"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.jdiacomp.2013.04.003","article-title":"Obesity and hyperlipidemia are risk factors for early diabetic neuropathy","volume":"27","author":"Smith","year":"2013","journal-title":"J. Diabetes Complicat."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"119186","DOI":"10.1016\/j.atherosclerosis.2025.119186","article-title":"Small nerve fibre damage and cardiac autonomic dysfunction in patients with hypertriglyceridaemia","volume":"405","author":"Bashir","year":"2025","journal-title":"Atherosclerosis"},{"key":"ref_39","first-page":"1119","article-title":"Neurodegeneration in familial chylomicronemia syndrome","volume":"19","author":"Bashir","year":"2025","journal-title":"J. Clin. Lipidol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.jacl.2022.04.006","article-title":"Corneal confocal microscopy identifies small nerve fibre damage in patients with hypertriglyceridemia","volume":"16","author":"Ferdousi","year":"2022","journal-title":"J. Clin. Lipidol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e70025","DOI":"10.1111\/jns.70025","article-title":"Differential Effects of Visceral and Subcutaneous Adiposity on Peripheral Neuropathy","volume":"30","author":"Ponirakis","year":"2025","journal-title":"J. Peripher. Nerv. Syst."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1038\/s41598-020-60422-7","article-title":"Corneal confocal microscopy detects small nerve fibre damage in patients with painful diabetic neuropathy","volume":"10","author":"Kalteniece","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Angarita-Rodr\u00edguez, A., Matiz-Gonz\u00e1lez, J.M., Pinz\u00f3n, A., Aristizabal, A.F., Ram\u00edrez, D., Barreto, G.E., and Gonz\u00e1lez, J. (2024). Enzymatic Metabolic Switches of Astrocyte Response to Lipotoxicity as Potential Therapeutic Targets for Nervous System Diseases. Pharmaceuticals, 17.","DOI":"10.3390\/ph17050648"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1038\/s41440-023-01287-x","article-title":"Multi-organ denervation: A novel approach to combat cardiometabolic disease","volume":"46","author":"Kiuchi","year":"2023","journal-title":"Hypertens. Res."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Hwang, J., Okada, J., Liu, L., Pessin, J.E., Schwartz, G.J., and Jo, Y.-H. (2024). The development of hepatic steatosis depends on the presence of liver-innervating parasympathetic cholinergic neurons in mice fed a high-fat diet. PLoS Biol., 22.","DOI":"10.1371\/journal.pbio.3002865"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/19\/3242\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:29:57Z","timestamp":1790843397000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/19\/3242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":45,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["nu18193242"],"URL":"https:\/\/doi.org\/10.3390\/nu18193242","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]}}}