{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:59:16Z","timestamp":1790845156296,"version":"4.1.0"},"reference-count":28,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2026-25471954"],"award-info":[{"award-number":["RS-2026-25471954"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"award":["RS-2026-25471954"],"award-info":[{"award-number":["RS-2026-25471954"]}],"id":[{"id":"https:\/\/ror.org\/013aysd81","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Whether high-sensitivity C-reactive protein (hsCRP) and vitamin D (Vit D) provide complementary prognostic information for acute ischemic stroke is unclear. We examined the separate and joint associations of serum hsCRP and Vit D levels with short-term functional outcomes after acute ischemic stroke. Methods: We retrospectively analyzed 192 patients with brain magnetic resonance imaging-confirmed acute ischemic stroke admitted to a single tertiary center. Stroke severity at admission was graded using the National Institutes of Health Stroke Scale. Physical and cognitive recovery were assessed using the Berg Balance Scale (BBS), Manual Function Test (MFT), Korean Mini-Mental State Examination (K-MMSE), and Korean version of the modified Barthel Index, while disability was graded using the modified Rankin Scale (mRS) at discharge. Results: Among 192 patients stratified into low- (&lt;1.0 mg\/L, n = 76), moderate- (1.0\u20133.0 mg\/L, n = 57), and high- (&gt;3.0 mg\/L, n = 59) hsCRP groups, serum 25-hydroxyvitamin D fell stepwise as hsCRP rose, and high hsCRP was independently associated with poorer BBS, MFT, K-MMSE, and mRS outcomes. Patients with both high hsCRP and Vit D deficiency (&lt;20 ng\/mL) formed the highest-risk group (adjusted odds ratio up to 12.54), with the risk increasing stepwise as the number of adverse markers increased. No significant multiplicative interaction was observed, whereas a significant additive interaction was found only for cognitive impairment. Conclusions: Patients with both elevated hsCRP and Vit D deficiency showed the highest odds of poor short-term outcomes. A simple count of these adverse markers may help identify patients at higher risk after acute ischemic stroke and may help define a subgroup for further evaluation in prospective intervention trials of Vit D supplementation.<\/jats:p>","DOI":"10.3390\/nu18193244","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:19:08Z","timestamp":1790842748000},"page":"3244","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Combined Association of High-Sensitivity C-Reactive Protein and Vitamin D with Short-Term Functional Outcomes in Acute Ischemic Stroke"],"prefix":"10.3390","volume":"18","author":[{"given":"Seongmin","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Physical Medicine & Rehabilitation, Kyung Hee University Hospital, College of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Yunjung","family":"Rho","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine & Rehabilitation, Kyung Hee University Hospital, College of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"}]},{"given":"Min-Su","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine & Rehabilitation, Kyung Hee University Hospital, College of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Myung Chul","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine & Rehabilitation, Kyung Hee University Hospital, College of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Ga Yang","family":"Shim","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine & Rehabilitation, Kyung Hee University Hospital, College of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Jin San","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kyung Hee University Hospital, College of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Sung Joon","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine & Rehabilitation, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul 05278, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8368-4900","authenticated-orcid":false,"given":"Yunsoo","family":"Soh","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine & Rehabilitation, Kyung Hee University Hospital, College of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Butsing, N., Thongniran, N., and Keandoungchun, J. (2025). Changes in functional outcome after a first-time stroke: Data from a longitudinal study. PLoS ONE, 20.","DOI":"10.1371\/journal.pone.0330086"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1161\/CIRCRESAHA.122.319951","article-title":"Post-stroke cognitive impairment and dementia","volume":"130","author":"Rost","year":"2022","journal-title":"Circ. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e98","DOI":"10.1161\/STR.0000000000000098","article-title":"Guidelines for adult stroke rehabilitation and recovery: A guideline for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"47","author":"Winstein","year":"2016","journal-title":"Stroke"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"341","DOI":"10.5535\/arm.21171","article-title":"A path to precision medicine: Incorporating blood-based biomarkers in stroke rehabilitation","volume":"45","author":"Oh","year":"2021","journal-title":"Ann. Rehabil. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1161\/STROKEAHA.120.029232","article-title":"Role of blood-based biomarkers in ischemic stroke prognosis: A systematic review","volume":"52","author":"Montellano","year":"2021","journal-title":"Stroke"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Kim, M.-S., Heo, M.Y., Joo, H.J., Shim, G.Y., Chon, J., Chung, S.J., Soh, Y., and Yoo, M.C. (2023). Neutrophil-to-lymphocyte ratio as a predictor of short-term functional outcomes in acute ischemic stroke patients. Int. J. Environ. Res. Public Health, 20.","DOI":"10.3390\/ijerph20020898"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1172\/JCI200318921","article-title":"C-reactive protein: A critical update","volume":"111","author":"Pepys","year":"2003","journal-title":"J. Clin. Investig."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1161\/01.CIR.100.13.1481","article-title":"Assessment of cardiovascular risk by use of multiple-risk-factor assessment equations: A statement for healthcare professionals from the American Heart Association and the American College of Cardiology","volume":"100","author":"Grundy","year":"1999","journal-title":"Circulation"},{"key":"ref_9","first-page":"204","article-title":"C-reactive protein: How has JUPITER impacted clinical practice?","volume":"9","author":"Verma","year":"2009","journal-title":"Ochsner J."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Chen, L., Wang, M., Yang, C., Wang, Y., and Hou, B. (2023). The role of high-sensitivity C-reactive protein serum levels in the prognosis for patients with stroke: A meta-analysis. Front. Neurol., 14.","DOI":"10.3389\/fneur.2023.1199814"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"104054","DOI":"10.1016\/j.ebiom.2022.104054","article-title":"Association between high-sensitivity C-reactive protein, functional disability, and stroke recurrence in patients with acute ischaemic stroke: A mediation analysis","volume":"80","author":"Gu","year":"2022","journal-title":"eBioMedicine"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Choi, B.-H., and Shin, S. (2025). Association Between Serum High Sensitivity C-Reactive Protein Levels and Low Muscle Strength Among Korean Adults. Nutrients, 17.","DOI":"10.3390\/nu17162698"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1038\/s41598-024-52381-0","article-title":"Initial stroke severity and discharge outcome in patients with muscle mass deficit","volume":"14","author":"Han","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1038\/s41430-020-0558-y","article-title":"Vitamin D deficiency 2.0: An update on the current status worldwide","volume":"74","author":"Amrein","year":"2020","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Lee, G.Y., Park, C.Y., and Han, S.N. (2026). Vitamin D-mediated immunoregulation in degenerative diseases: Insights into cardiovascular, neurodegenerative and musculoskeletal disorders. Nutrients, 18.","DOI":"10.3390\/nu18040629"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"19450","DOI":"10.1074\/jbc.M113.467670","article-title":"Vitamin D receptor inhibits nuclear factor \u03baB activation by interacting with I\u03baB kinase \u03b2 protein","volume":"288","author":"Chen","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_17","first-page":"370","article-title":"Vitamin D and CRP are associated in hospitalized inflammatory bowel disease (IBD) patients in Shanghai","volume":"33","author":"Song","year":"2024","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s11011-016-9939-2","article-title":"Vitamin D deficiency is associated with acute ischemic stroke, C-reactive protein, and short-term outcome","volume":"32","author":"Alfieri","year":"2017","journal-title":"Metab. Brain Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1093\/ije\/dyac087","article-title":"Vitamin D deficiency and C-reactive protein: A bidirectional Mendelian randomization study","volume":"52","author":"Zhou","year":"2023","journal-title":"Int. J. Epidemiol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Kim, M.-S., Lee, J.S., Chung, S.J., and Soh, Y. (2023). Association between vitamin D and short-term functional outcomes in acute ischemic stroke. Nutrients, 15.","DOI":"10.3390\/nu15234957"},{"key":"ref_21","unstructured":"Singh, B., Goyal, A., and Patel, B.C. (2025). C-reactive protein: Clinical relevance and interpretation. StatPearls [Internet], StatPearls Publishing."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"103","DOI":"10.5535\/arm.240029","article-title":"Outcome measurement in balance problems: Berg balance scale","volume":"48","author":"Joa","year":"2024","journal-title":"Ann. Rehabil. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/PHM.0b013e3181951133","article-title":"Reliability and validity of the Manual Function Test in patients with stroke","volume":"88","author":"Miyamoto","year":"2009","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"281","DOI":"10.5535\/arm.230040","article-title":"Performance of activities of daily living in typically developing children in Korea: Normative value of K-MBI","volume":"48","author":"Yoon","year":"2024","journal-title":"Ann. Rehabil. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"17907","DOI":"10.1038\/s41598-022-22840-7","article-title":"The impact of self-reported sensory impairment on cognitive function using the Korean longitudinal study of aging survey data","volume":"12","author":"Joo","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Lee, S.Y., Kim, D.Y., Sohn, M.K., Lee, J., Lee, S.-G., Shin, Y.-I., Kim, S.-Y., Oh, G.-J., Lee, Y.H., and Lee, Y.-S. (2020). Determining the cut-off score for the Modified Barthel Index and the Modified Rankin Scale for assessment of functional independence and residual disability after stroke. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0226324"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.12786\/bn.2024.17.e13","article-title":"Is the Korean mini-mental state examination (K-MMSE) useful in evaluating the cognitive function of brain injury patients?: Through correlation analysis with computerized neurocognitive test (CNT)","volume":"17","author":"Han","year":"2024","journal-title":"Brain Neurorehabilit."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1161\/01.STR.0000177872.87960.61","article-title":"Optimizing cutoff scores for the Barthel index and the modified Rankin scale for defining outcome in acute stroke trials","volume":"36","author":"Uyttenboogaart","year":"2005","journal-title":"Stroke"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/19\/3244\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:30:19Z","timestamp":1790843419000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/19\/3244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":28,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["nu18193244"],"URL":"https:\/\/doi.org\/10.3390\/nu18193244","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]}}}