{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:49:08Z","timestamp":1791953348361,"version":"4.3.4"},"reference-count":31,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Patients with an ileostomy are at risk of developing a high-output ileostomy (HOS). An episode of HOS can lead to dehydration and acute kidney injury (AKI). Existing dietary recommendations are largely based on expert opinion. At Charit\u00e9\u2014Campus Benjamin Franklin, a new interdisciplinary nutrition concept was developed for patients following ileostomy creation. Methods: This prospective, single-centre interventional study included adult patients undergoing elective surgery with the creation of an ileostomy between July 2022 and November 2024. The primary outcome was the incidence of post-discharge HOS occurring during the follow-up period. Patients received standardized postoperative meals and individualized dietary counselling. Outcomes were compared to a historical cohort. Results: Among 103 patients (44.2% female; median age 47.5 years), HOS occurred in 13 patients (12.6%; 95% CI 6.8\u201320.4%) during follow-up and in 41 of 296 patients in the historical cohort (13.9%; 95% CI, 10.4\u201318.3%). Patients (n = 23) developing HOS during hospitalization experienced no recurrence at follow-up. Readmission was more frequent in the HOS group (53.8% vs. 21.1%, p = 0.011), particularly due to AKI (46.2% vs. 5.6%, p &lt; 0.001). Weight loss was also more common during follow-up in the group with HOS (76.9% vs. 35.6%, p = 0.005), with a median weight loss of 2 kg. Conclusions: HOS incidence was not different from that observed in the historical cohort; however, the study was not designed to establish equivalence or non-inferiority. The structured nutrition pathway was feasible to implement. Post-discharge HOS was associated with readmission, acute kidney injury, and weight loss.<\/jats:p>","DOI":"10.3390\/nu18193301","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:16:52Z","timestamp":1791472612000},"page":"3301","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prospective Evaluation of Individualized Nutrition Support on the Incidence of High-Output Ileostomy"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1637-5467","authenticated-orcid":false,"given":"Rahel M.","family":"Strobel","sequence":"first","affiliation":[{"name":"Department of General and Visceral Surgery, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin und Humboldt-Universit\u00e4t zu Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Toepfer","sequence":"additional","affiliation":[{"name":"Department for Urology, Franziskus Krankenhaus, 10787 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9482-0971","authenticated-orcid":false,"given":"Konrad","family":"Neumann","sequence":"additional","affiliation":[{"name":"Institute of Biometry and Clinical Epidemiology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin und Humboldt-Universit\u00e4t zu Berlin, 10117 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kati","family":"Engel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Infectiology and Rheumatology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin und Humboldt-Universit\u00e4t zu Berlin, 12203 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6391-9979","authenticated-orcid":false,"given":"Michael","family":"Schumann","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Infectiology and Rheumatology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin und Humboldt-Universit\u00e4t zu Berlin, 12203 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wael","family":"Rayya","sequence":"additional","affiliation":[{"name":"Department of General and Visceral Surgery, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin und Humboldt-Universit\u00e4t zu Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9189-6751","authenticated-orcid":false,"given":"Christian H. W.","family":"Schineis","sequence":"additional","affiliation":[{"name":"Department of General and Visceral Surgery, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin und Humboldt-Universit\u00e4t zu Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Beyer","sequence":"additional","affiliation":[{"name":"Department for General, Visceral and Transplantation Surgery, University Medicine Augsburg, 86156 Augsburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5474-2171","authenticated-orcid":false,"given":"Arved","family":"Weimann","sequence":"additional","affiliation":[{"name":"Department of General, Visceral, and Oncological Surgery, St. George Hospital, 04129 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes C.","family":"Lauscher","sequence":"additional","affiliation":[{"name":"Department for General, Visceral and Transplantation Surgery, University Medicine Augsburg, 86156 Augsburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00053-018-0240-1","article-title":"Stoma","volume":"40","year":"2018","journal-title":"Coloproctology"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Seifarth, C., Augustin, L.N., Lehmann, K.S., Stroux, A., Lauscher, J.C., Kreis, M.E., and Holmer, C. 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