{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T13:15:00Z","timestamp":1789823700534,"version":"4.0.1"},"reference-count":41,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2010,10,18]],"date-time":"2010-10-18T00:00:00Z","timestamp":1287360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Acne vulgaris may be improved by dietary factors that increase insulin sensitivity. We hypothesized that a low-glycemic index diet would improve facial acne severity and insulin sensitivity. Fifty-eight adolescent males (mean age \u00b1 standard deviation 16.5 \u00b1 1.0 y and body mass index 23.1 \u00b1 3.5 kg\/m2) were alternately allocated to high or low glycemic index diets. Severity of inflammatory lesions on the face, insulin sensitivity (homeostasis modeling assessment of insulin resistance), androgens and insulin-like growth factor-1 and its binding proteins were assessed at baseline and at eight weeks, a period corresponding to the school term. Forty-three subjects (n = 23 low glycemic index and n = 20 high glycemic index) completed the study. Diets differed significantly in glycemic index (mean \u00b1 standard error of the mean, low glycemic index 51 \u00b1 1 vs. high glycemic index 61 \u00b1 2, p = 0.0002), but not in macronutrient distribution or fiber content. Facial acne improved on both diets (low glycemic index \u221226 \u00b1 6%, p = 0.0004 and high glycemic index \u221216 \u00b1 7%, p = 0.01), but differences between diets did not reach significance. Change in insulin sensitivity was not different between diets (low glycemic index 0.2 \u00b1 0.1 and high glycemic index 0.1 \u00b1 0.1, p = 0.60) and did not correlate with change in acne severity (Pearson correlation r = \u22120.196, p = 0.244). Longer time frames, greater reductions in glycemic load or\/and weight loss may be necessary to detect improvements in acne among adolescent boys.<\/jats:p>","DOI":"10.3390\/nu2101060","type":"journal-article","created":{"date-parts":[[2010,10,18]],"date-time":"2010-10-18T12:19:09Z","timestamp":1287404349000},"page":"1060-1072","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Effect of the Glycemic Index of Carbohydrates on Acne vulgaris"],"prefix":"10.3390","volume":"2","author":[{"given":"Rebecca C.","family":"Reynolds","sequence":"first","affiliation":[{"name":"Human Nutrition Unit, School of Molecular Bioscience G08, The University of Sydney, NSW 2006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Concord Repatriation General Hospital, The University of Sydney, NSW 2006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James Y. J.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Concord Repatriation General Hospital, The University of Sydney, NSW 2006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona S.","family":"Atkinson","sequence":"additional","affiliation":[{"name":"Human Nutrition Unit, School of Molecular Bioscience G08, The University of Sydney, NSW 2006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karola S.","family":"Stockmann","sequence":"additional","affiliation":[{"name":"Human Nutrition Unit, School of Molecular Bioscience G08, The University of Sydney, NSW 2006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Petocz","sequence":"additional","affiliation":[{"name":"Department of Statistics, Macquarie University, NSW 2109, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6797-8754","authenticated-orcid":false,"given":"Jennie C.","family":"Brand-Miller","sequence":"additional","affiliation":[{"name":"Human Nutrition Unit, School of Molecular Bioscience G08, The University of Sydney, NSW 2006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2010,10,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.sder.2005.04.002","article-title":"Implications for the role of diet in acne","volume":"24","author":"Cordain","year":"2005","journal-title":"Semin. 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