{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T16:42:53Z","timestamp":1785516173702,"version":"3.56.0"},"reference-count":12,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2012,9,4]],"date-time":"2012-09-04T00:00:00Z","timestamp":1346716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Vitamin D3 has been called the \u201csunshine\u201d vitamin since the formation of vitamin D is mediated by exposure to sunlight. Vitamin D3 is linked to many health benefits, however serum levels of vitamin D3 have been decreasing over the last few decades and the lower levels of vitamin D3 may have consequences on normal physiology. We investigated the association between serum 25-hydroxyvitamin D (25(OH)D) levels and stratum corneum conductance as well as the effect of topical application of cholecalciferol (vitamin D3) on dry skin. Eighty three subjects were recruited and blood serum levels and skin conductance measurements were taken after a one week washout. A correlation was observed between vitamin D levels and skin moisture content, individuals with lower levels of vitamin D had lower average skin moisture. Subsequently, a 3-week split leg, randomized, vehicle controlled clinical study was conducted on a subset of 61 of the above individuals who were identified with non-sufficient vitamin D serum levels. Topical supplementation with cholecalciferol significantly increased measurements of skin moisturization and resulted in improvements in subjective clinical grading of dry skin. Taken together our finding suggest a relationship between serum vitamin D3 (25(OH)D) levels and hydration of the stratum corneum and further demonstrate the skin moisture benefit from topical application of vitamin D3.<\/jats:p>","DOI":"10.3390\/nu4091213","type":"journal-article","created":{"date-parts":[[2012,9,4]],"date-time":"2012-09-04T11:09:45Z","timestamp":1346756985000},"page":"1213-1218","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Assessing the Relationship between Vitamin D3 and Stratum Corneum Hydration for the Treatment of Xerotic Skin"],"prefix":"10.3390","volume":"4","author":[{"given":"Meghan","family":"Russell","sequence":"first","affiliation":[{"name":"Johnson and Johnson Skin Research Center, CPPW, Johnson & Johnson Consumer Companies, Inc., Skillman, NJ 08558, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2012,9,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D deficiency","volume":"357","author":"Holick","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Holick, M.F. (2010). The Vitamin D Solution A 3-Step Stategy to Cure Our Most Common Health Problem, Hudson Street Press.","DOI":"10.1007\/978-1-60327-303-9_1"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/BF02505289","article-title":"Regulation of keratinocyte proliferation and differentiation by all-trans-retinoic acid, 9-cis-retinoic acid and 1,25-dihydroxy vitamin D3","volume":"288","author":"Gibbs","year":"1996","journal-title":"Arch. Dermatol. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1111\/j.1365-2133.2010.10147.x","article-title":"Correlation between serum 25-hydroxyvitamin D levels and severity of atopic dermatitis in children","volume":"164","author":"Peroni","year":"2011","journal-title":"Br. J. Dermatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1038\/jid.2009.402","article-title":"Association of prediagnostic serum vitamin D levels with the development of basal cell carcinoma","volume":"130","author":"Asgari","year":"2010","journal-title":"J. Invest. Dermatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1600-0846.1997.tb00174.x","article-title":"EEMCO guidance for the assessment of stratum corneum hydration: Electrical methods","volume":"3","author":"Berardesca","year":"1997","journal-title":"Skin Res. Technol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.abb.2006.12.017","article-title":"Factors that influence the cutaneous synthesis and dietary sources of vitamin D","volume":"460","author":"Chen","year":"2007","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"558S","DOI":"10.1093\/ajcn\/88.2.558S","article-title":"Assessing the vitamin D status of the US population","volume":"88","author":"Yetley","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1001\/archinternmed.2008.604","article-title":"Demographic differences and trends of vitamin D insufficiency in the US population, 1988\u20132004","volume":"169","author":"Ginde","year":"2009","journal-title":"Arch. Intern. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1093\/ajcn\/67.6.1232","article-title":"Seasonal changes in plasma 25-hydroxyvitamin D concentrations of young American black and white women","volume":"67","author":"Harris","year":"1998","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Leyden, J.J., and Rawlings, A.V. (2002). Skin Moisturization (Cosmetic Science and Technology), Marcel Dekker, Inc.","DOI":"10.3109\/9780203908235"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0190-9622(97)70320-7","article-title":"Biologic effects of topical calcipotriol (MC 903) treatment in psoriatic skin","volume":"36","author":"Reichrath","year":"1997","journal-title":"J. Am. Acad. Dermatol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/4\/9\/1213\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:52:09Z","timestamp":1760219529000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/4\/9\/1213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,4]]},"references-count":12,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2012,9]]}},"alternative-id":["nu4091213"],"URL":"https:\/\/doi.org\/10.3390\/nu4091213","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,4]]}}}