{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T21:49:25Z","timestamp":1770414565269,"version":"3.49.0"},"reference-count":60,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2012,9,7]],"date-time":"2012-09-07T00:00:00Z","timestamp":1346976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>New Zealand has one of the highest incidence rates of Crohn\u2019s Disease (CD), whilst the serum selenium status of New Zealanders is amongst the lowest in the world. A prospective case-control study in Auckland, New Zealand considered serum selenium as a potential CD risk factor. Serum selenium levels were significantly lower in CD patients compared to controls (101.8 \u00b1 1.02 vs. 111.1 \u00b1 1.01 ng\/mL) (p = 5.91 \u00d7 10\u22128). Recent detailed studies in the United Kingdom have suggested an optimal serum level around 122 ng\/mL, making the average CD patient in New Zealand selenium deficient. Of the 29 single nucleotide polymorphisms (SNPs) tested, 13 were found to significantly interact with serum selenium on CD. After adjustment for multiple testing, a significant interaction with serum selenium on CD was found for three SNPs, namely rs17529609 and rs7901303 in the gene SEPHS1, and rs1553153 in the gene SEPSECS. These three SNPs have not been reported elsewhere as being significantly associated with selenium or CD. It is unclear as to whether lower selenium levels are a cause or an effect of the disease.<\/jats:p>","DOI":"10.3390\/nu4091247","type":"journal-article","created":{"date-parts":[[2012,9,7]],"date-time":"2012-09-07T11:21:14Z","timestamp":1347016874000},"page":"1247-1259","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Selenium, Selenoprotein Genes and Crohn\u2019s Disease in a Case-Control Population from Auckland, New Zealand"],"prefix":"10.3390","volume":"4","author":[{"given":"Liljana","family":"Gentschew","sequence":"first","affiliation":[{"name":"Discipline of Nutrition, FM&HS, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4935-7708","authenticated-orcid":false,"given":"Karen S.","family":"Bishop","sequence":"additional","affiliation":[{"name":"Auckland Cancer Society Research Center, FM&HS, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dug Yeo","family":"Han","sequence":"additional","affiliation":[{"name":"Discipline of Nutrition, FM&HS, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand"},{"name":"Nutrigenomics New Zealand, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angharad R.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Nutrigenomics New Zealand, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan G.","family":"Fraser","sequence":"additional","affiliation":[{"name":"Nutrigenomics New Zealand, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand"},{"name":"Department of Medicine, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen Jiun","family":"Lam","sequence":"additional","affiliation":[{"name":"Discipline of Nutrition, FM&HS, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand"},{"name":"Nutrigenomics New Zealand, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nishi","family":"Karunasinghe","sequence":"additional","affiliation":[{"name":"Auckland Cancer Society Research Center, FM&HS, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bobbi","family":"Campbell","sequence":"additional","affiliation":[{"name":"Discipline of Nutrition, FM&HS, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0107-4741","authenticated-orcid":false,"given":"Lynnette R.","family":"Ferguson","sequence":"additional","affiliation":[{"name":"Discipline of Nutrition, FM&HS, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand"},{"name":"Auckland Cancer Society Research Center, FM&HS, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand"},{"name":"Nutrigenomics New Zealand, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2012,9,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1053\/j.gastro.2011.02.046","article-title":"Recent insights into the genetics of inflammatory bowel disease","volume":"140","author":"Cho","year":"2011","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.mrfmmm.2009.09.002","article-title":"Environmental factors in the development of chronic inflammation: A case-control study on risk factors for Crohn\u2019s disease within New Zealand","volume":"690","author":"Han","year":"2010","journal-title":"Mutat. 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