{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:00:22Z","timestamp":1787029222131,"version":"build-2736575974"},"reference-count":157,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T00:00:00Z","timestamp":1369785600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The elderly chronic kidney disease (CKD) population is growing. Both  aging and CKD can disrupt calcium (Ca2+) homeostasis and cause alterations of multiple Ca2+-regulatory mechanisms, including parathyroid hormone, vitamin D, fibroblast growth factor-23\/Klotho, calcium-sensing receptor and Ca2+-phosphate product. These alterations can be deleterious to bone mineral metabolism and soft tissue health, leading to metabolic bone disease and vascular calcification and aging, termed CKD-mineral and bone disorder (MBD). CKD-MBD is associated with morbid clinical outcomes, including fracture, cardiovascular events and all-cause mortality. In this paper, we comprehensively review Ca2+ regulation and bone mineral metabolism, with a special emphasis on elderly CKD patients. We also present the current treatment-guidelines and management options  for CKD-MBD.<\/jats:p>","DOI":"10.3390\/nu5061913","type":"journal-article","created":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T11:59:57Z","timestamp":1369828797000},"page":"1913-1936","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Calcium Regulation and Bone Mineral Metabolism in Elderly Patients with Chronic Kidney Disease"],"prefix":"10.3390","volume":"5","author":[{"given":"Vickram","family":"Tejwani","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Mayo Clinic College of Medicine, Rochester,  MN 55905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Qian","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Mayo Clinic College of Medicine, Rochester,  MN 55905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2013,5,29]]},"reference":[{"key":"ref_1","unstructured":"(2011). 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