{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:32:57Z","timestamp":1760243577892,"version":"build-2065373602"},"reference-count":108,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2013,9,26]],"date-time":"2013-09-26T00:00:00Z","timestamp":1380153600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The medicinal use of cocoa has a long history dating back almost five hundred years when Hern\u00e1n Cort\u00e9s\u2019s first experienced the drink in Mesoamerica. Doctors in Europe recommended the beverage to patients in the 1700s, and later American physicians followed suit and prescribed the drink in early America\u2014ca. 1800s. This article  delineates the historic trajectory of cocoa consumption, the linkage between cocoa\u2019s  bioactive-mechanistic properties, paying special attention to nitric oxides role in vasodilation of the arteries, to the current indicators purporting the benefits of cocoa and cardiovascular health.<\/jats:p>","DOI":"10.3390\/nu5103854","type":"journal-article","created":{"date-parts":[[2013,9,26]],"date-time":"2013-09-26T12:48:59Z","timestamp":1380199739000},"page":"3854-3870","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Cocoa and Heart Health: A Historical Review of the Science"],"prefix":"10.3390","volume":"5","author":[{"given":"Deanna","family":"Pucciarelli","sequence":"first","affiliation":[{"name":"Department of Family and Consumer Sciences, Ball State University, Muncie, IN 47304, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2013,9,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2057S","DOI":"10.1093\/jn\/130.8.2057S","article-title":"Food of the gods: Cure for humanity? 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