{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:03:48Z","timestamp":1791929028844,"version":"4.3.4"},"reference-count":80,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T00:00:00Z","timestamp":1384992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Diet, particularly vitamin deficiency, is associated with the risk of birth defects. The aim of this review paper is to show the characteristics of common and severe  neural-tube defects together with congenital heart defects (CHD) as vitamin deficiencies play a role in their origin. The findings of the Hungarian intervention (randomized double-blind and cohort controlled) trials indicated that periconceptional folic acid (FA)-containing multivitamin supplementation prevented the major proportion (about 90%) of neural-tube defects (NTD) as well as a certain proportion (about 40%) of congenital heart defects. Finally the benefits and drawbacks of three main practical applications of folic acid\/multivitamin treatment such as (i) dietary intake; (ii) periconceptional supplementation; and (iii) flour fortification are discussed. The conclusion arrived at is indeed confirmation of Benjamin Franklin\u2019s statement: \u201cAn ounce of prevention is better than a pound of care\u201d.<\/jats:p>","DOI":"10.3390\/nu5114760","type":"journal-article","created":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T15:46:34Z","timestamp":1385048794000},"page":"4760-4775","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":293,"title":["Folate Deficiency and Folic Acid Supplementation:  The Prevention of Neural-Tube Defects and  Congenital Heart Defects"],"prefix":"10.3390","volume":"5","author":[{"given":"Andrew","family":"Czeizel","sequence":"first","affiliation":[{"name":"Foundation for the Community Control of Hereditary Diseases, Torokvesz lejto 32,  Budapest 1026, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istvan","family":"Dud\u00e1s","sequence":"additional","affiliation":[{"name":"Foundation for the Community Control of Hereditary Diseases, Torokvesz lejto 32,  Budapest 1026, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila","family":"Vereczkey","sequence":"additional","affiliation":[{"name":"Versys Clinics, Human Reproduction Institute, Madarasz utca 47-49, Budapest 1138, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferenc","family":"B\u00e1nhidy","sequence":"additional","affiliation":[{"name":"Second Department of Obstetrics and Gynecology, School of Medicine, Semmelweis University, Ulloi ut 78\/a, Budapest 1082, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2013,11,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/oxfordjournals.jhered.a103720","article-title":"Pigs born without eyeballs","volume":"24","author":"Hale","year":"1932","journal-title":"J. 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