{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:03:56Z","timestamp":1782601436021,"version":"3.54.5"},"reference-count":55,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T00:00:00Z","timestamp":1398038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Little attention has been given to the association of plasma homocysteine (Hcy) and metabolic syndrome (MetS) in children. We have evaluated the risk of MetS with plasma Hcy in a cohort of 6 to 8 year old rural Nepalese children, born to mothers who had participated in an antenatal micronutrient supplementation trial. We assessed Hcy in plasma from a random selection of n = 1000 children and determined the relationship of elevated Hcy (&gt;12.0 \u03bcmol\/L) to MetS (defined as the presence of any three of the following: abdominal adiposity (waist circumference \u2265 85th percentile of the study population), high plasma glucose (\u226585th percentile), high systolic or diastolic blood pressure (\u226590th percentile of reference population), triglyceride \u2265 1.7 mmol\/L and high density lipoprotein &lt; 0.9 mmol\/L.) and its components. There was an increased risk of low high-density lipoproteins (HDL), [odds ratios (OR) = 1.77, 95% confidence intervals  (CI) = 1.08\u20132.88; p = 0.020], high blood pressure [OR = 1.60, 95% CI = 1.10\u20132.46;  p = 0.015] and high body mass index (BMI) [OR = 1.98, 95% CI = 1.33\u20132.96; p = 0.001] with elevated Hcy. We observed an increased risk of MetS (OR = 1.75,  95% CI = 1.06\u20132.90; p = 0.029) with elevated Hcy in age and gender-adjusted logistic regression models. High plasma Hcy is associated with increased risk of MetS and may have implications for chronic disease later in life.<\/jats:p>","DOI":"10.3390\/nu6041649","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T06:34:17Z","timestamp":1398062057000},"page":"1649-1661","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["High Plasma Homocysteine Increases Risk of Metabolic Syndrome in 6 to 8 Year Old Children in Rural Nepal"],"prefix":"10.3390","volume":"6","author":[{"given":"Mohsin","family":"Yakub","sequence":"first","affiliation":[{"name":"Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry","family":"Schulze","sequence":"additional","affiliation":[{"name":"Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subarna","family":"Khatry","sequence":"additional","affiliation":[{"name":"Nepal Nutrition Intervention Project-Sarlahi, Tripureswor, Kathmandu 45104, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Stewart","sequence":"additional","affiliation":[{"name":"Program in International and Community Nutrition, University of California, Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parul","family":"Christian","sequence":"additional","affiliation":[{"name":"Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Keith","family":"West","sequence":"additional","affiliation":[{"name":"Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2014,4,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1161\/CIRCULATIONAHA.109.192644","article-title":"Harmonizing the metabolic syndrome: A joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity","volume":"120","author":"Alberti","year":"2009","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1001\/jama.295.13.1549","article-title":"Prevalence of overweight and obesity in the United States, 1999\u20132004","volume":"295","author":"Ogden","year":"2006","journal-title":"JAMA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1089\/met.2012.0122","article-title":"The Prevalence of Metabolic Syndrome in Children: A Systematic Review of the Literature","volume":"11","author":"Friend","year":"2013","journal-title":"Metab. 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