{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:53:07Z","timestamp":1790257987356,"version":"4.1.0"},"reference-count":48,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2014,9,23]],"date-time":"2014-09-23T00:00:00Z","timestamp":1411430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The aim of this paper was to conduct a systematic review of body fat distribution before and after partial and complete weight restoration in individuals with anorexia nervosa. Literature searches, study selection, method development and quality appraisal were performed independently by two authors, and data was synthesized using a narrative approach. Twenty studies met the inclusion criteria and were consequently analyzed. The review had five main findings. First, during anorexia nervosa adolescent females lose more central body fat, while adult females more peripheral fat. Second, partial weight restoration leads to greater fat mass deposition in the trunk region than other body regions in adolescent females. Third, after short-term weight restoration, whether partial or complete, adults show a central adiposity phenotype with respect to healthy age-matched controls. Fourth, central fat distribution is associated with increased insulin resistance, but does not adversely affect eating disorder psychopathology or cause psychological distress in female adults. Fifth, the abnormal central fat distribution seems to normalize after long-term maintenance of complete weight restoration, indicating that preferential central distribution of body fat is a transitory phenomenon. However, a discrepancy in the findings has been noted, especially between adolescents and adults; besides age and gender, these appear to be related  to differences in the methodology and time of body composition assessments.  The PROSPERO Registry\u2014Anorexia Nervosa and Body Fat Distribution: A Systematic Review (CRD42014008738).<\/jats:p>","DOI":"10.3390\/nu6093895","type":"journal-article","created":{"date-parts":[[2014,9,23]],"date-time":"2014-09-23T10:20:41Z","timestamp":1411467641000},"page":"3895-3912","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Anorexia Nervosa and Body Fat Distribution:  A Systematic Review"],"prefix":"10.3390","volume":"6","author":[{"given":"Marwan","family":"El Ghoch","sequence":"first","affiliation":[{"name":"Department of Eating and Weight Disorders, Villa Garda Hospital, Via Montebaldo, 89,  37016 Garda (Vr), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4028-1877","authenticated-orcid":false,"given":"Simona","family":"Calugi","sequence":"additional","affiliation":[{"name":"Department of Eating and Weight Disorders, Villa Garda Hospital, Via Montebaldo, 89,  37016 Garda (Vr), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Lamburghini","sequence":"additional","affiliation":[{"name":"Department of Eating and Weight Disorders, Villa Garda Hospital, Via Montebaldo, 89,  37016 Garda (Vr), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Dalle Grave","sequence":"additional","affiliation":[{"name":"Department of Eating and Weight Disorders, Villa Garda Hospital, Via Montebaldo, 89,  37016 Garda (Vr), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2014,9,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0193-953X(05)70232-X","article-title":"The consequences and costs of the eating disorders","volume":"24","author":"Agras","year":"2001","journal-title":"Psychiatr. 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