{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T11:24:59Z","timestamp":1773746699376,"version":"3.50.1"},"reference-count":38,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T00:00:00Z","timestamp":1423008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Non-alcoholic fatty liver disease, including non-alcoholic steatohepatitis (NASH), appears to be increasingly common worldwide. The aim of the study was to investigate the effects of 6-gingerol ((S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone), a bioactive ingredient of plants belonging to the Zingiberaceae family, on experimental models of NASH. In HepG2 cells, 6-gingerol (100 \u03bcmol\/L) treatment inhibited free fatty acids mixture (0.33 mmol\/L palmitate and 0.66 mmol\/L oleate)-induced triglyceride and inflammatory marker accumulations. Male C57BL\/6 mice were fed with a methionine and choline-deficient (MCD) diet to induce steatohepatitis. After four weeks of MCD diet feeding, the mice were dosed orally with 6-gingerol (25, 50 or 100 mg\/kg\/day) once  daily for another four weeks. 6-Gingerol (100 mg\/kg\/day) attenuated liver steatosis and necro-inflammation in MCD diet-fed mice. The expressions of inflammatory cytokine genes, including those for monocyte chemoattractant protein-1, tumor necrosis factor-\u03b1, and interleukin-6, and nuclear transcription factor (NF-\u03baB), which were increased in the livers of MCD diet-fed mice, were attenuated by 6-gingerol. 6-Gingerol possesses a repressive property on hepatic steatosis, which is associated with induction of peroxisome  proliferator-activated receptor \u03b1. Our study demonstrated the protective role of 6-gingerol in ameliorating nutritional steatohepatitis. The effect was mediated through regulating key genes related to lipid metabolism and inflammation.<\/jats:p>","DOI":"10.3390\/nu7020999","type":"journal-article","created":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T08:25:00Z","timestamp":1423038300000},"page":"999-1020","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["6-Gingerol Protects against Nutritional Steatohepatitis  by Regulating Key Genes Related to Inflammation and  Lipid Metabolism"],"prefix":"10.3390","volume":"7","author":[{"given":"Thing-Fong","family":"Tzeng","sequence":"first","affiliation":[{"name":"Department of Pharmacy & Graduate Institute of Pharmaceutical Technology, Tajen University, Yanpu Township, 90741 Pingtung County, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shorong-Shii","family":"Liou","sequence":"additional","affiliation":[{"name":"Department of Pharmacy & Graduate Institute of Pharmaceutical Technology, Tajen University, Yanpu Township, 90741 Pingtung County, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy & Graduate Institute of Pharmaceutical Technology, Tajen University, Yanpu Township, 90741 Pingtung County, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I-Min","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy & Graduate Institute of Pharmaceutical Technology, Tajen University, Yanpu Township, 90741 Pingtung County, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2015,2,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S99","DOI":"10.1002\/hep.20973","article-title":"Nonalcoholic fatty liver disease: From steatosis to cirrhosis","volume":"43","author":"Farrell","year":"2006","journal-title":"Hepatology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/S0016-5085(98)70599-2","article-title":"Steatohepatitis: A tale of two \u201chits\u201d?","volume":"114","author":"Day","year":"1998","journal-title":"Gastroenterology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4539","DOI":"10.3748\/wjg.v13.i34.4539","article-title":"Pathogenesis and management issues for non-alcoholic fatty liver disease","volume":"13","author":"Duvnjak","year":"2007","journal-title":"World J. 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