{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:45:23Z","timestamp":1762004723910,"version":"build-2065373602"},"reference-count":31,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T00:00:00Z","timestamp":1429833600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The effectiveness evaluation of hospital-based comprehensive birth defects intervention methods\u2019of the People\u2032s Republic of China","award":["2006BA105A01"],"award-info":[{"award-number":["2006BA105A01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>To study the associations between maternal consumption of non-staple food in the first trimester and risk of neural tube defects (NTDs) in offspring. Data collected from a hospital-based case-control study conducted between 2006 and 2008 in Shandong\/Shanxi provinces including 459 mothers with NTDs-affected births and 459 mothers without  NTDs-affected births. Logistic regression models were used to examine the associations between maternal consumption of non-staple food in the first trimester and risk of NTDs in offspring. The effects were evaluated by odds ratio (OR) and 95% confidence intervals  (95% CIs) with SAS9.1.3.software. Maternal consumption of milk, fresh fruits and nuts in the first trimester were protective factors for total NTDs. Compared with consumption frequency of \u02c21 meal\/week, the ORs for milk consumption frequency of 1\u20132, 3\u20136,  \u22657 meals\/week were 0.50 (95% CI: 0.28\u20130.88), 0.56 (0.32\u20130.99), and 0.59 (0.38\u20130.90), respectively; the ORs for fresh fruits consumption frequency of 1\u20132, 3\u20136, \u22657 meals\/week were 0.29 (95% CI: 0.12\u20130.72), 0.22 (0.09\u20130.53), and 0.32 (0.14\u20130.71), respectively; the ORs for nuts consumption frequency of 1\u20132, 3\u20136, \u22657 meals\/week were 0.60 (95% CI: 0.38\u20130.94), 0.49 (0.31\u20130.79), and 0.63 (0.36\u20131.08), respectively. Different effects of above factors on NTDs were found for subtypes of anencephaly and spina bifida. Maternal non-staple food consumption of milk, fresh fruits and nuts in the first trimester was associated with reducing NTDs risk in offspring.<\/jats:p>","DOI":"10.3390\/nu7053067","type":"journal-article","created":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T10:01:59Z","timestamp":1429869719000},"page":"3067-3077","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Maternal Consumption of Non-Staple Food in the First Trimester and Risk of Neural Tube Defects in Offspring"],"prefix":"10.3390","volume":"7","author":[{"given":"Meng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, 44 WenhuaXilu Road, Jinan 250012, Shandong, China"},{"name":"Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road,  Hangzhou 310051, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Ping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, 44 WenhuaXilu Road, Jinan 250012, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Jie","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, 44 WenhuaXilu Road, Jinan 250012, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, 44 WenhuaXilu Road, Jinan 250012, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong-Tang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, 44 WenhuaXilu Road, Jinan 250012, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2015,4,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"i110","DOI":"10.1093\/ije\/dyq028","article-title":"Folic acid to reduce neonatal mortality from neural tube disorders","volume":"39","author":"Blencowe","year":"2010","journal-title":"Int. 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