{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T08:39:42Z","timestamp":1780562382762,"version":"3.54.1"},"reference-count":91,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T00:00:00Z","timestamp":1430956800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Metabolic bone disease is a frequent co-morbidity in newly diagnosed adults with celiac disease (CD), an autoimmune disorder triggered by the ingestion of dietary gluten. This systematic review of studies looked at the efficacy of the gluten-free diet, physical activity, nutrient supplementation, and bisphosphonates for low bone density treatment. Case control and cohort designs were identified from PubMed and other academic databases (from 1996 to 2015) that observed newly diagnosed adults with CD for at least one year after diet treatment using the dual-energy x-ray absorptiometry (DXA) scan. Only 20 out of 207 studies met the inclusion criteria. Methodological quality was assessed using the Strengthening of the Reporting of Observational Studies in Epidemiology (STROBE) statement checklist.  Gluten-free diet adherence resulted in partial recovery of bone density by one year in all studies, and full recovery by the fifth year. No treatment differences were observed between the  gluten-free diet alone and diet plus bisphosphonates in one study. For malnourished patients, supplementation with vitamin D and calcium resulted in significant improvement. Evidence for the impact of physical activity on bone density was limited. Therapeutic strategies aimed at modifying lifestyle factors throughout the lifespan should be studied.<\/jats:p>","DOI":"10.3390\/nu7053347","type":"journal-article","created":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T10:54:29Z","timestamp":1430996069000},"page":"3347-3369","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Bones of Contention: Bone Mineral Density Recovery in Celiac Disease\u2014A Systematic Review"],"prefix":"10.3390","volume":"7","author":[{"given":"Patricia","family":"Grace-Farfaglia","sequence":"first","affiliation":[{"name":"Department of Nutritional Sciences, The University of Connecticut, Waterbury, CT 06702, USA"},{"name":"Health and Wellness Promotion, Rocky Mountain University of Health Professions, Provo,  UT 84606, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2015,5,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1111\/j.1365-2036.2007.03502.x","article-title":"Increasing prevalence of coeliac disease over time","volume":"26","author":"Lohi","year":"2007","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"154","DOI":"10.4321\/S1130-01082013000300006","article-title":"Bone mineral density in adult coeliac disease: An updated review","volume":"105","author":"Lucendo","year":"2013","journal-title":"Rev. Esp. Enferm. Dig."},{"key":"ref_3","first-page":"462","article-title":"Prevalence and clinical presentation of subclinical\/silent celiac disease in adults: An analysis on a 12-year observation","volume":"48","author":"Tursi","year":"2001","journal-title":"Hepato-Gastroenterol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"173082","DOI":"10.1155\/2014\/173082","article-title":"Bone mineral density at diagnosis of celiac disease and after 1 year of gluten-free diet","volume":"2014","author":"Pantaleoni","year":"2014","journal-title":"Sci. World J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"187","DOI":"10.4321\/S1130-01082013000400002","article-title":"Does dermatitis herpetiformis result in bone loss as coeliac disease does? A cross sectional study","volume":"105","author":"Lorinczy","year":"2013","journal-title":"Rev. Esp. Enferm. Dig."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/ncpgasthep1281","article-title":"Celiac disease in the elderly","volume":"5","author":"Johnson","year":"2008","journal-title":"Nat. Clin. Pract. Gastroenterol. Hepatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.pmr.2009.12.003","article-title":"Falls, aging, and disability","volume":"21","author":"Finlayson","year":"2010","journal-title":"Phys. Med. Rehabil. Clin. N. Am."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1007\/s00198-004-1822-z","article-title":"Excess non-spine fractures in women over 50 years with celiac disease: A cross-sectional, questionnaire-based study","volume":"16","author":"Davie","year":"2005","journal-title":"Osteoporos. Int."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1007\/s00198-014-2683-8","article-title":"Celiac disease and risk of fracture in adults\u2014A review","volume":"25","author":"Hjelle","year":"2014","journal-title":"Osteoporos. Int."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1365-2036.2006.03203.x","article-title":"Coeliac disease and the risk of fractures\u2013A general population-based cohort study","volume":"25","author":"Ludvigsson","year":"2007","journal-title":"Aliment. Pharm. Ther."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/j.1753-4887.2009.00232.x","article-title":"Metabolic osteopathy in celiac disease: Importance of a gluten-free diet","volume":"67","author":"Capriles","year":"2009","journal-title":"Nutr. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"198025","DOI":"10.1155\/2012\/198025","article-title":"Bone mineralization in celiac disease","volume":"2012","author":"Larussa","year":"2012","journal-title":"Gastroenterol. Res. Pract."},{"key":"ref_13","first-page":"43","article-title":"Bone mineral density in patients with gluten-sensitivity celiac disease","volume":"82","author":"Albulova","year":"2010","journal-title":"Ter. Arkh."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jocd.2011.07.003","article-title":"Dramatic effect of vitamin d supplementation and a gluten-free diet on bone mineral density in a patient with celiac disease","volume":"15","author":"Duerksen","year":"2012","journal-title":"J. Clin. Densitometr."},{"key":"ref_15","first-page":"274","article-title":"Bone and mineral metabolism in adult celiac disease","volume":"83","author":"Caraceni","year":"1988","journal-title":"Am. J. Gastroenterol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"522","DOI":"10.3109\/07853890.2013.849383","article-title":"Appropriate nutrient supplementation in celiac disease","volume":"45","author":"Caruso","year":"2013","journal-title":"Ann. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1093\/ije\/dym018","article-title":"Tools for assessing quality and susceptibility to bias in observational studies in epidemiology: A systematic review and annotated bibliography","volume":"36","author":"Sanderson","year":"2007","journal-title":"Int. J. Epidemiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.dld.2007.09.006","article-title":"Systematic review and meta-analysis of observational studies on the prevalence of fractures in coeliac disease","volume":"40","author":"Olmos","year":"2008","journal-title":"Dig. Liver Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.cgh.2012.12.015","article-title":"Diagnosis of celiac disease in adults based on serology test results, without small-bowel biopsy","volume":"11","author":"Pagadala","year":"2013","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/ajg.2013.79","article-title":"Acg clinical guidelines: Diagnosis and management of celiac disease","volume":"108","author":"Hill","year":"2013","journal-title":"Am. J. Gastroenterol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1053\/j.gastro.2015.01.044","article-title":"Advances in diagnosis and management of celiac disease","volume":"148","author":"Kelly","year":"2015","journal-title":"Gastroenterology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/8756-3282(96)00071-3","article-title":"Influence of pattern of clinical presentation and of gluten-free diet on bone mass and metabolism in adult coeliac disease","volume":"18","author":"Corazza","year":"1996","journal-title":"Bone"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1136\/gut.38.3.322","article-title":"Reversal of osteopenia with diet in adult coeliac disease","volume":"38","author":"Valdimarsson","year":"1996","journal-title":"Gut"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1136\/gut.39.2.180","article-title":"Effect of a gluten free diet on osteopenia in adults with newly diagnosed coeliac disease","volume":"39","author":"McFarlane","year":"1996","journal-title":"Gut"},{"key":"ref_25","first-page":"992","article-title":"Effects of dietary treatment on bone mineral density in adults with celiac disease: Factors predicting response","volume":"92","author":"Ciacci","year":"1997","journal-title":"Am. J. Gastroenterol."},{"key":"ref_26","first-page":"313","article-title":"Effect of treatment on bone mass, mineral metabolism, and body composition in untreated celiac disease patients","volume":"92","author":"Mautalen","year":"1997","journal-title":"Am. J. Gastroenterol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S8756-3282(99)00171-4","article-title":"Bone recovery after a gluten-free diet: A 5-year follow-up study","volume":"25","author":"Kemppainen","year":"1999","journal-title":"Bone"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1080\/003655299750025381","article-title":"Low circulating insulin-like growth factor I in coeliac disease and its relation to bone mineral density","volume":"34","author":"Valdimarsson","year":"1999","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1046\/j.1365-2036.2000.00671.x","article-title":"The effects of 1-year gluten withdrawal on bone mass, bone metabolism and nutritional status in newly-diagnosed adult coeliac disease patients","volume":"14","author":"Grosso","year":"2000","journal-title":"Aliment. Pharmcol. Ther."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1359\/JBMR.040319","article-title":"Imbalance of osteoclastogenesis-regulating factors in patients with celiac disease","volume":"19","author":"Taranta","year":"2004","journal-title":"J. Miner. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"A213","DOI":"10.1016\/S0016-5085(08)60986-5","article-title":"S1264 the lazy celiac adults and their bone density","volume":"134","author":"Bucci","year":"2008","journal-title":"Gastroenterology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3109\/00365520903555879","article-title":"Gastrointestinal symptoms, quality of life and bone mineral density in mild enteropathic coeliac disease: A prospective clinical trial","volume":"45","author":"Kurppa","year":"2010","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"S308","DOI":"10.1016\/S0016-5085(10)61416-3","article-title":"S2044 effect of a gluten free diet on bone mineral density in patients with celiac disease","volume":"138","author":"Papamichael","year":"2010","journal-title":"Gastroenterology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.jocd.2011.06.002","article-title":"Longitudinal evaluation of bone mineral density and body composition in patients with positive celiac serology","volume":"14","author":"Duerksen","year":"2011","journal-title":"J. Clin. Densitometr."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/1471-230X-11-136","article-title":"Clinical benefit of gluten-free diet in screen-detected older celiac disease patients","volume":"11","author":"Vilppula","year":"2011","journal-title":"BMC Gastroenterol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1111\/j.1532-5415.2012.03997.x","article-title":"Celiac disease in elderly adults: Clinical, serological, and histological characteristics and the effect of a gluten-free diet","volume":"60","author":"Casella","year":"2012","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.dld.2011.12.012","article-title":"Bone mass in women with celiac disease: Role of exercise and gluten-free diet","volume":"44","author":"Passananti","year":"2012","journal-title":"Dig. Liver Dis."},{"key":"ref_38","first-page":"270","article-title":"Low bone mineral density in adult patients with coeliac disease","volume":"63","author":"Szymczak","year":"2012","journal-title":"Endokrynol. Pol."},{"key":"ref_39","first-page":"882","article-title":"Effect of zoledronic acid on bone mineral density in patients of celiac disease: A prospective, randomized, pilot study","volume":"138","author":"Kumar","year":"2013","journal-title":"Indian J. Med. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1053\/j.gastro.2014.05.003","article-title":"Benefits of a gluten-free diet for asymptomatic patients with serologic markers of celiac disease","volume":"147","author":"Kurppa","year":"2014","journal-title":"Gastroenterology"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"S174","DOI":"10.1007\/s00592-003-0058-2","article-title":"Dxa vs. qct for subclinical celiac disease patients","volume":"40","author":"Masala","year":"2003","journal-title":"Acta Diabetol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/j.bone.2012.02.639","article-title":"Effect of co-morbidities on fracture risk: Findings from the global longitudinal study of osteoporosis in women (glow)","volume":"50","author":"Dennison","year":"2012","journal-title":"Bone"},{"key":"ref_43","first-page":"S120","article-title":"P.05.6 high levels of osteoprotegerin and low levels of cooh-terminal propeptide of type I procollagen characterize the persisting bone derangement in celiac disease patients on long-term gluten-free diet","volume":"45","author":"Mengoli","year":"2013","journal-title":"Dig. Dis."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1055\/s-2006-944548","article-title":"Altered osteoprotegerin\/rankl ratio and low bone mineral density in celiac patients on long-term treatment with gluten-free diet","volume":"38","author":"Fiore","year":"2006","journal-title":"Horm. Metab. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.3748\/wjg.v17.i25.3035","article-title":"Risk of fracture in celiac disease: Gender, dietary compliance, or both?","volume":"17","author":"Sanchez","year":"2011","journal-title":"World J. Gastroenterol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"S117","DOI":"10.1016\/S1590-8658(10)60155-7","article-title":"P.41 reduced bone mineral density is frequent in treated adult coeliac disease notwithstanding complete normalization of duodenal lesions","volume":"42","author":"Larussa","year":"2010","journal-title":"Dig. Liver Dis."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1111\/j.1572-0241.2003.07379.x","article-title":"High prevalence of small intestinal bacterial overgrowth in celiac patients with persistence of gastrointestinal symptoms after gluten withdrawal","volume":"98","author":"Tursi","year":"2003","journal-title":"Am. J. Gastroenterol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.3390\/nu4081095","article-title":"Diet-induced dysbiosis of the intestinal microbiota and the effects on immunity and disease","volume":"4","author":"Brown","year":"2012","journal-title":"Nutrients"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3109\/08830185.2011.599084","article-title":"Unraveling the ties between celiac disease and intestinal microbiota","volume":"30","author":"Sanz","year":"2011","journal-title":"Int. Rev. Immunol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"135","DOI":"10.4161\/gmic.1.3.11868","article-title":"Effects of a gluten-free diet on gut microbiota and immune function in healthy adult humans","volume":"1","author":"Sanz","year":"2010","journal-title":"Gut Microb."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"S92","DOI":"10.1016\/S1590-8658(08)60242-X","article-title":"Pa.47 complications in coeliac disease under gluten-free diet","volume":"40","author":"Tursi","year":"2008","journal-title":"Dig. Liver Dis."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1038\/ejcn.2011.105","article-title":"Vitamin D: The light side of sunshine","volume":"65","author":"Mason","year":"2011","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s00198-003-1436-x","article-title":"Effects of exercise on bone mineral density in calcium-replete postmenopausal women with and without hormone replacement therapy","volume":"14","author":"Going","year":"2003","journal-title":"Osteoporos. Int."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1007\/s40279-014-0220-8","article-title":"Efficiency of jumping exercise in improving bone mineral density among premenopausal women: A meta-analysis","volume":"44","author":"Zhao","year":"2014","journal-title":"Sports Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1097\/00042737-200012110-00005","article-title":"Role of lifestyle factors in the pathogenesis of osteopenia in adult coeliac disease: A multivariate analysis","volume":"12","author":"Veneto","year":"2000","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0169-6009(89)90085-8","article-title":"Perimenopausal bone mass and risk factors","volume":"7","author":"Elders","year":"1989","journal-title":"Bone Miner."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/8756-3282(94)00034-W","article-title":"Body composition and bone mineral density in untreated and treated patients with celiac disease","volume":"16","author":"Mazure","year":"1995","journal-title":"Bone"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1111\/j.1365-2036.2012.05001.x","article-title":"Body mass index and the risk of obesity in coeliac disease treated with the gluten-free diet","volume":"35","author":"Kabbani","year":"2012","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nrgastro.2012.64","article-title":"Celiac disease: Obesity in celiac disease","volume":"9","author":"Sonti","year":"2012","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1136\/bjsports-2013-092558.38","article-title":"The effect of physical exercise on musculo-skeletal metabolism: A systematic review of the role of rank\/rankl\/opg pathway","volume":"47","author":"Keramaris","year":"2013","journal-title":"Br. J. Sports Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"779","DOI":"10.2165\/00007256-200434120-00001","article-title":"Are cardiovascular disease and osteoporosis directly linked?","volume":"34","author":"Whitney","year":"2004","journal-title":"Sports Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.dld.2007.06.013","article-title":"l-carnitine in the treatment of fatigue in adult celiac disease patients: A pilot study","volume":"39","author":"Ciacci","year":"2007","journal-title":"Dig. Liver Dis."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.exger.2011.02.005","article-title":"Effects of resistance and aerobic exercise on physical function, bone mineral density, opg and rankl in older women","volume":"46","author":"Marques","year":"2011","journal-title":"Exp. Gerontol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1007\/s11357-011-9311-8","article-title":"Exercise effects on bone mineral density in older adults: A meta-analysis of randomized controlled trials","volume":"34","author":"Marques","year":"2012","journal-title":"Age"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Baert, V., Gorus, E., Mets, T., and Bautmans, I. (2015). Motivators and barriers for physical activity in older adults with osteoporosis. J. Geriatr. Phys. Ther.","DOI":"10.1519\/JPT.0000000000000035"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"955","DOI":"10.3748\/wjg.15.955","article-title":"Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease","volume":"15","author":"Hadithi","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1111\/j.1572-0241.2001.03616.x","article-title":"Vitamin B12 deficiency in untreated celiac disease","volume":"96","author":"Dahele","year":"2001","journal-title":"Am. J. Gastroenterol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2988","DOI":"10.1172\/JCI72606","article-title":"Vitamin B-12-dependent taurine synthesis regulates growth and bone mass","volume":"124","author":"Mottram","year":"2014","journal-title":"J. Clin. Investig."},{"key":"ref_69","first-page":"756138","article-title":"A metabolomic perspective on coeliac disease","volume":"2014","author":"Calabro","year":"2014","journal-title":"Autoimmun. Dis."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/1471-2180-11-219","article-title":"Duodenal and faecal microbiota of celiac children: Molecular, phenotype and metabolome characterization","volume":"11","author":"Ndagijimana","year":"2011","journal-title":"BMC Microbiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.jaci.2011.01.068","article-title":"Vitamin D3 targets epidermal and dermal dendritic cells for induction of distinct regulatory T cells","volume":"127","author":"Sibiryak","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.coi.2011.11.002","article-title":"Microbiota in autoimmunity and tolerance","volume":"23","author":"Atarashi","year":"2011","journal-title":"Curr. Opin. Immunol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1590\/S0004-28032014000200013","article-title":"Lower bifidobacteria counts in adult patients with celiac disease on a gluten-free diet","volume":"51","author":"Golfetto","year":"2014","journal-title":"Arquivos Gastroenterol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1177\/0884533611436116","article-title":"Effects of gut microbes on nutrient absorption and energy regulation","volume":"27","author":"Ilhan","year":"2012","journal-title":"Nutr. Clin. Pract."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1136\/gutjnl-2013-306541","article-title":"Exercise and associated dietary extremes impact on gut microbial diversity","volume":"63","author":"Clarke","year":"2014","journal-title":"Gut"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"A394","DOI":"10.1016\/S0016-5085(01)81956-9","article-title":"Parenteral vitamin D in newly diagnosed coeliac disese\u2014Prelimineary analysis of double blind placebo controlled study","volume":"120","author":"Fickling","year":"2001","journal-title":"Gastroenterology"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1046\/j.1365-2036.2002.01283.x","article-title":"Evidence of poor vitamin status in coeliac patients on a gluten-free diet for 10 years","volume":"16","author":"Hallert","year":"2002","journal-title":"Aliment. Pharmacolo. Ther."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"3975","DOI":"10.3390\/nu5103975","article-title":"Vitamin and mineral deficiencies are highly prevalent in newly diagnosed celiac disease patients","volume":"5","author":"Wierdsma","year":"2013","journal-title":"Nutrients"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Riley, R.D., Lambert, P.C., and Abo-Zaid, G. (2010). Meta-analysis of individual participant data: Rationale, conduct, and reporting. Res. Methods Rep., 340.","DOI":"10.1136\/bmj.c221"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.gtc.2009.06.005","article-title":"Celiac disease in the elderly","volume":"38","author":"Rashtak","year":"2009","journal-title":"Gastroenterol. Clin. N. Am."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.nut.2013.05.027","article-title":"Pathologic bone alterations in celiac disease: Etiology, epidemiology, and treatment","volume":"30","year":"2014","journal-title":"Nutrition"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jpeds.2008.03.003","article-title":"Bone metabolism in celiac disease","volume":"153","author":"Zanchi","year":"2008","journal-title":"J. Pediatr."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1089\/jmf.2014.0025","article-title":"Functional and metabolic disorders in celiac disease: New implications for nutritional treatment","volume":"17","author":"Farnetti","year":"2014","journal-title":"J. Med. Food"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"927","DOI":"10.3109\/00365521.2012.688217","article-title":"Bone mineral density directly correlates with duodenal marsh stage in newly diagnosed adult celiac patients","volume":"47","author":"Tenias","year":"2012","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s00198-004-1641-2","article-title":"Calcium absorption and bone mineral density in celiacs after long term treatment with gluten-free diet and adequate calcium intake","volume":"16","author":"Pazianas","year":"2005","journal-title":"Osteoporos. Int."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/S0899-9007(01)00709-2","article-title":"Vitamin K and bone health","volume":"17","author":"Weber","year":"2001","journal-title":"Nutrition"},{"key":"ref_87","first-page":"51","article-title":"Bone mineral density in adult celiac patients and the effect of gluten-free diet from childhood","volume":"85","author":"Molteni","year":"1990","journal-title":"Am. J. Gastroenterol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1097\/MCG.0b013e31816a8c9b","article-title":"Psychological correlates of gluten-free diet adherence in adults with celiac disease","volume":"43","author":"Leffler","year":"2009","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S0002-8223(03)00005-1","article-title":"Motivational interviewing and dietary behavior change","volume":"103","author":"Thorpe","year":"2003","journal-title":"J. Am. Diet. Assoc."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"354151","DOI":"10.1155\/2012\/354151","article-title":"Combination of micronutrients for bone (comb) study: Bone density after micronutrient intervention","volume":"2012","author":"Genuis","year":"2012","journal-title":"J. Environ. Public Health"},{"key":"ref_91","first-page":"14","article-title":"Celiac & gluten intolerance: A wellness perspective","volume":"1","year":"2014","journal-title":"J. Nutr. Health Food Eng."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/7\/5\/3347\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T20:45:57Z","timestamp":1760215557000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/7\/5\/3347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,7]]},"references-count":91,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,5]]}},"alternative-id":["nu7053347"],"URL":"https:\/\/doi.org\/10.3390\/nu7053347","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,7]]}}}