{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:52:50Z","timestamp":1777589570409,"version":"3.51.4"},"reference-count":29,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2015,6,2]],"date-time":"2015-06-02T00:00:00Z","timestamp":1433203200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Dyslipidemia is a major risk factor for cardiovascular disease (CVD). Dietary fatty-acid composition regulates lipids and lipoprotein metabolism and may confer CVD benefit. This review updates understanding of the effect of dietary fatty-acids on human lipoprotein metabolism. In elderly participants with hyperlipidemia, high n-3 polyunsaturated fatty-acids (PUFA) consumption diminished hepatic triglyceride-rich lipoprotein (TRL) secretion and enhanced TRL to low-density lipoprotein (LDL) conversion. n-3 PUFA also decreased TRL-apoB-48 concentration by decreasing TRL-apoB-48 secretion. High n-6 PUFA intake decreased very low-density lipoprotein (VLDL) cholesterol and triglyceride concentrations by up-regulating VLDL lipolysis and uptake. In a study of healthy subjects, the intake of saturated fatty-acids with increased palmitic acid at the sn-2 position was associated with decreased postprandial lipemia. Low medium-chain triglyceride may not appreciably alter TRL metabolism. Replacing carbohydrate with monounsaturated fatty-acids increased TRL catabolism. Trans-fatty-acid decreased LDL and enhanced high-density lipoprotein catabolism. Interactions between APOE genotype and n-3 PUFA in regulating lipid responses were also described. The major advances in understanding the effect of dietary fatty-acids on lipoprotein metabolism has centered on n-3 PUFA. This knowledge emphasizes the importance of regulating lipoprotein metabolism as a mode to improve plasma lipids and potentially CVD risk. Additional studies are required to better characterize the cardiometabolic effects of other dietary fatty-acids.<\/jats:p>","DOI":"10.3390\/nu7064416","type":"journal-article","created":{"date-parts":[[2015,6,2]],"date-time":"2015-06-02T11:38:36Z","timestamp":1433245116000},"page":"4416-4425","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":109,"title":["Effect of Dietary Fatty Acids on Human Lipoprotein Metabolism: A Comprehensive Update"],"prefix":"10.3390","volume":"7","author":[{"given":"Esther","family":"Ooi","sequence":"first","affiliation":[{"name":"Metabolic Research Centre, School of Medicine and Pharmacology, University of Western Australia, Perth, 6000, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Watts","sequence":"additional","affiliation":[{"name":"Metabolic Research Centre, School of Medicine and Pharmacology, University of Western Australia, Perth, 6000, Western Australia, Australia"},{"name":"Lipid Disorders Clinic, Cardiometabolic Service, Department of Internal Medicine,  Royal Perth Hospital, 6000, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodore","family":"Ng","sequence":"additional","affiliation":[{"name":"Metabolic Research Centre, School of Medicine and Pharmacology, University of Western Australia, Perth, 6000, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Barrett","sequence":"additional","affiliation":[{"name":"Metabolic Research Centre, School of Medicine and Pharmacology, University of Western Australia, Perth, 6000, Western Australia, Australia"},{"name":"Faculty of Engineering, Computing and Mathematics, University of Western Australia,  Perth, 6000, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2015,6,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1016\/j.jand.2014.07.037","article-title":"2013 American Heart Association\/American College of Cardiology Guideline on lifestyle management to reduce cardiovascular risk: Practice opportunities for registered dietitian nutritionists","volume":"114","author":"Millen","year":"2014","journal-title":"J. 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