{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:36:13Z","timestamp":1790775373621,"version":"4.1.0"},"reference-count":39,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T00:00:00Z","timestamp":1433376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Cancer cachexia, of which the most notable symptom is severe and rapid weight loss, is present in the majority of patients with advanced cancer. Inflammatory mediators play an important role in the development of cachexia, envisaged as a chronic inflammatory syndrome. The white adipose tissue (WAT) is one of the first compartments affected in cancer cachexia and suffers a high rate of lipolysis. It secretes several cytokines capable of directly regulating intermediate metabolism. A common pathway in the regulation of the expression of pro-inflammatory cytokines in WAT is the activation of the nuclear transcription factor kappa-B (NF-\u03baB). We have examined the gene expression of the subunits NF-\u03baBp65 and NF-\u03baBp50, as well as NF-\u03baBp65 and NF-\u03baBp50 binding, the gene expression of pro-inflammatory mediators under NF-\u03baB control (IL-1\u03b2, IL-6, INF-\u03b3, TNF-\u03b1, MCP-1), and its inhibitory protein, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (I\u03baB-\u03b1). The observational study involved 35 patients (control group, n = 12 and cancer group, n = 23, further divided into cachectic and  non-cachectic). NF-\u03baBp65 and its target genes expression (TNF-\u03b1, IL-1\u03b2, MCP-1 and  I\u03baB-\u03b1) were significantly higher in cachectic cancer patients. Moreover, NF-\u03baBp65 gene expression correlated positively with the expression of its target genes. The results strongly suggest that the NF-\u03baB pathway plays a role in the promotion of WAT inflammation during cachexia.<\/jats:p>","DOI":"10.3390\/nu7064465","type":"journal-article","created":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T11:54:59Z","timestamp":1433418899000},"page":"4465-4479","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["NF-\u03baBp65 and Expression of Its Pro-Inflammatory Target Genes Are Upregulated in the Subcutaneous Adipose Tissue of Cachectic Cancer Patients"],"prefix":"10.3390","volume":"7","author":[{"given":"Rodolfo","family":"Camargo","sequence":"first","affiliation":[{"name":"Cancer Metabolism Research Group, Institute of Biomedical Sciences, University of Sao Paulo,  Av. Prof. Lineu Prestes, 1524\u2014Cidade Universit\u00e1ria, Sao Paulo, 05508-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Riccardi","sequence":"additional","affiliation":[{"name":"Cancer Metabolism Research Group, Institute of Biomedical Sciences, University of Sao Paulo,  Av. Prof. Lineu Prestes, 1524\u2014Cidade Universit\u00e1ria, Sao Paulo, 05508-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Cancer Metabolism Research Group, Institute of Biomedical Sciences, University of Sao Paulo,  Av. Prof. Lineu Prestes, 1524\u2014Cidade Universit\u00e1ria, Sao Paulo, 05508-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Luiz","family":"Carnevali","sequence":"additional","affiliation":[{"name":"Cancer Metabolism Research Group, Institute of Biomedical Sciences, University of Sao Paulo,  Av. Prof. Lineu Prestes, 1524\u2014Cidade Universit\u00e1ria, Sao Paulo, 05508-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emidio","family":"De Matos-Neto","sequence":"additional","affiliation":[{"name":"Cancer Metabolism Research Group, Institute of Biomedical Sciences, University of Sao Paulo,  Av. Prof. Lineu Prestes, 1524\u2014Cidade Universit\u00e1ria, Sao Paulo, 05508-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Enjiu","sequence":"additional","affiliation":[{"name":"Cancer Metabolism Research Group, Institute of Biomedical Sciences, University of Sao Paulo,  Av. Prof. Lineu Prestes, 1524\u2014Cidade Universit\u00e1ria, Sao Paulo, 05508-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Neves","sequence":"additional","affiliation":[{"name":"Cancer Metabolism Research Group, Institute of Biomedical Sciences, University of Sao Paulo,  Av. Prof. Lineu Prestes, 1524\u2014Cidade Universit\u00e1ria, Sao Paulo, 05508-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Lima","sequence":"additional","affiliation":[{"name":"Cancer Metabolism Research Group, Institute of Biomedical Sciences, University of Sao Paulo,  Av. Prof. Lineu Prestes, 1524\u2014Cidade Universit\u00e1ria, Sao Paulo, 05508-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Figuer\u00eado","sequence":"additional","affiliation":[{"name":"Cancer Metabolism Research Group, Institute of Biomedical Sciences, University of Sao Paulo,  Av. Prof. Lineu Prestes, 1524\u2014Cidade Universit\u00e1ria, Sao Paulo, 05508-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo","family":"De Alc\u00e2ntara","sequence":"additional","affiliation":[{"name":"Department of Clinical Surgery, University of Sao Paulo, Av. Prof. Lineu Prestes,  2565\u2014Cidade Universit\u00e1ria, S\u00e3o Paulo, 05508-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Maximiano","sequence":"additional","affiliation":[{"name":"Department of Clinical Surgery, University of Sao Paulo, Av. Prof. Lineu Prestes,  2565\u2014Cidade Universit\u00e1ria, S\u00e3o Paulo, 05508-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Otoch","sequence":"additional","affiliation":[{"name":"Department of Clinical Surgery, University of Sao Paulo, Av. Prof. Lineu Prestes,  2565\u2014Cidade Universit\u00e1ria, S\u00e3o Paulo, 05508-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Miguel","family":"Batista","sequence":"additional","affiliation":[{"name":"Biotechnology Group, Laboratory of Adipose Tissue Biology, University of Mogi das Cruzes,  Mogi das Cruzes, Sao Paulo, 05508-100, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"P\u00fcschel","sequence":"additional","affiliation":[{"name":"Department of Nutritional Biochemistry, University of Potsdam, Potsdam, 14558, Germany,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilia","family":"Seelaender","sequence":"additional","affiliation":[{"name":"Cancer Metabolism Research Group, Institute of Biomedical Sciences, University of Sao Paulo,  Av. 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