{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T03:41:04Z","timestamp":1788925264859,"version":"build-2803163510"},"reference-count":76,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T00:00:00Z","timestamp":1435276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015941","name":"Glendorn Foundation","doi-asserted-by":"publisher","award":["Gift"],"award-info":[{"award-number":["Gift"]}],"id":[{"id":"10.13039\/100015941","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA125243"],"award-info":[{"award-number":["CA125243"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Women who are obese at the time of breast cancer diagnosis have higher overall mortality than normal weight women and some evidence implicates adiponectin and leptin as contributing to prognostic disadvantage. While intentional weight loss is thought to improve prognosis, its impact on these adipokines is unclear. This study compared the pattern of change in plasma leptin and adiponectin in overweight-to-obese post-menopausal breast cancer survivors during weight loss. Given the controversies about what dietary pattern is most appropriate for breast cancer control and regulation of adipokine metabolism, the effect of a low fat versus a low carbohydrate pattern was evaluated using a non-randomized, controlled study design. Anthropometric data and fasted plasma were obtained monthly during the six-month weight loss intervention. While leptin was associated with fat mass, adiponectin was not, and the lack of correlation between leptin and adiponectin concentrations throughout weight loss implies independent mechanisms of regulation. The temporal pattern of change in leptin but not adiponectin was affected by magnitude of weight loss. Dietary pattern was without effect on either adipokine. Mechanisms not directly related to dietary pattern, weight loss, or fat mass appear to play dominant roles in the regulation of circulating levels of these adipokines.<\/jats:p>","DOI":"10.3390\/nu7075156","type":"journal-article","created":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T10:24:46Z","timestamp":1435314286000},"page":"5156-5176","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Impact of Weight Loss on Plasma Leptin and Adiponectin in Overweight-to-Obese Post Menopausal Breast Cancer Survivors"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3730-9322","authenticated-orcid":false,"given":"Henry","family":"Thompson","sequence":"first","affiliation":[{"name":"Cancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523-1173, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scot","family":"Sedlacek","sequence":"additional","affiliation":[{"name":"Cancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523-1173, USA"},{"name":"Rocky Mountain Cancer Centers, Denver, CO 80220, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Wolfe","sequence":"additional","affiliation":[{"name":"Colorado Biostatistics Consortium, University of Colorado, Denver, CO 80045, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devchand","family":"Paul","sequence":"additional","affiliation":[{"name":"Rocky Mountain Cancer Centers, Denver, CO 80220, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Lakoski","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Vermont, Burlington, VT 05405, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Playdon","sequence":"additional","affiliation":[{"name":"Cancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523-1173, USA"},{"name":"Department of Chronic Disease Epidemiology, Yale University, New Haven, CT 06520, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"McGinley","sequence":"additional","affiliation":[{"name":"Cancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523-1173, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawna","family":"Matthews","sequence":"additional","affiliation":[{"name":"Cancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523-1173, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2015,6,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1200\/JCO.2010.29.7614","article-title":"Effect of obesity on prognosis after early-stage breast cancer","volume":"29","author":"Ewertz","year":"2011","journal-title":"J. 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