{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T11:14:44Z","timestamp":1784805284306,"version":"3.55.0"},"reference-count":50,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2015,7,7]],"date-time":"2015-07-07T00:00:00Z","timestamp":1436227200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Type 2 diabetes is a metabolic disorder caused by abnormal carbohydrate metabolism, and closely associated with abnormal lipid metabolism and hepato-renal dysfunction. This study investigated the anti-diabetic and hepato-renal protective properties of ziyuglycoside I (ZG01) derivative on type 2 diabetes. ZG01 was isolated from roots of Sanguisorba officinalis and chemically modified by deglycosylation and esterification to obtained ziyuglycoside II methyl ester (ZG02-ME). Here, we showed that ZG02-ME has stronger anti-diabetic activity than the original compound (ZG01) through decreasing blood glucose, glycated hemoglobin (HbA1c), and insulin levels in a mouse model of type 2 diabetes (db\/db mice). We further found that ZG02-ME treatment effectively ameliorated serum insulin, leptin and C-peptide levels, which are key metabolic hormones, in db\/db mice. In addition, we showed that elevated basal blood lipid levels were decreased by ZG02-ME treatment in db\/db mice. Furthermore, treatment of ZG02-ME significantly decreased serum AST, ALT, BUN, creatinine, and liver lipid peroxidation in db\/db mice. These results demonstrated that compared to ZG01, chemically modified ZG02-ME possess improved anti-diabetic properties, and has hepato-renal protective activities in type 2 diabetes.<\/jats:p>","DOI":"10.3390\/nu7075232","type":"journal-article","created":{"date-parts":[[2015,7,8]],"date-time":"2015-07-08T10:10:02Z","timestamp":1436350202000},"page":"5469-5483","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Anti-Diabetic and Hepato-Renal Protective Effects of Ziyuglycoside II Methyl Ester in Type 2 Diabetic Mice"],"prefix":"10.3390","volume":"7","author":[{"given":"Dong","family":"Son","sequence":"first","affiliation":[{"name":"College of Pharmacy & Medical Research Center, Chungbuk National University, Cheongju, Chungbuk 361-951, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seock","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Laboratory Science, College of Natural Science, Daejeon University, Daejeon 300-716, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung-Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Korean Medicine, Daejeon University, Daejeon 300-716, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Un","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biomedical Laboratory Science, College of Natural Science, Daejeon University, Daejeon 300-716, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Korean Medicine, Daejeon University, Daejeon 300-716, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2015,7,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"American Diabetes Association (2009). 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