{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:00:11Z","timestamp":1787029211547,"version":"build-2736575974"},"reference-count":46,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2015,7,15]],"date-time":"2015-07-15T00:00:00Z","timestamp":1436918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>In recent years, a number of studies have investigated complementary medical approaches to the treatment of hypertension using dietary supplements. Rice bran protein hydrolysates extracted from rice is a rich source of bioactive peptides. The present study aimed to investigate the vasorelaxation and antihypertensive effects of peptides-derived from rice bran protein hydrolysates (RBP) in a rat model of two kidney-one clip (2K-1C) renovascular hypertension. 2K-1C hypertension was induced in male Sprague-Dawley rats by placing a silver clip around the left renal artery, whereas sham-operated rats were served as controls. 2K-1C and sham-operated rats were intragastrically administered with RBP (50 mg kg\u22121 or 100 mg kg\u22121) or distilled water continuously for six weeks. We observed that RBP augmented endothelium-dependent vasorelaxation in all animals. Administration of RBP to 2K-1C rats significantly reduced blood pressure and decreased peripheral vascular resistance compared to the sham operated controls (p &lt; 0.05). Restoration of normal endothelial function and blood pressure was associated with reduced plasma angiotensin converting enzyme (ACE), decreased superoxide formation, reduced plasma malondialdehyde and increased plasma nitrate\/nitrite (p &lt; 0.05). Up-regulation of eNOS protein and down-regulation of p47phox protein were found in 2K-1C hypertensive rats-treated with RBP. Our results suggest that RBP possesses antihypertensive  properties which are mainly due to the inhibition of ACE, and its vasodilatory and  antioxidant activity.<\/jats:p>","DOI":"10.3390\/nu7075252","type":"journal-article","created":{"date-parts":[[2015,7,15]],"date-time":"2015-07-15T10:33:16Z","timestamp":1436956396000},"page":"5783-5799","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Peptides-Derived from Thai Rice Bran Improves Endothelial Function in 2K-1C Renovascular Hypertensive Rats"],"prefix":"10.3390","volume":"7","author":[{"given":"Orachorn","family":"Boonla","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Upa","family":"Kukongviriyapan","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poungrat","family":"Pakdeechote","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veerapol","family":"Kukongviriyapan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patchareewan","family":"Pannangpetch","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supawan","family":"Thawornchinsombut","sequence":"additional","affiliation":[{"name":"Department of Food Technology, Faculty of Technology, Khon Kaen University,  Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2015,7,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1001\/jama.2013.184182","article-title":"Prevalence, awareness, treatment, and control of hypertension in rural and urban communities in high-, middle-, and low-income countries","volume":"310","author":"Chow","year":"2013","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"S170","DOI":"10.2337\/dc08-s247","article-title":"NADPH oxidases, reactive oxygen species, and hypertension: Clinical implications and therapeutic possibilities","volume":"31","author":"Paravicini","year":"2008","journal-title":"Diabetes Care"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1136\/hrt.2003.029389","article-title":"Free radicals and redox signalling in cardiovascular disease","volume":"90","author":"Shah","year":"2004","journal-title":"Heart"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.semnephrol.2004.04.008","article-title":"Nitric oxide, angiotensin II, and hypertension","volume":"24","author":"Zhou","year":"2004","journal-title":"Semin. 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