{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T04:13:46Z","timestamp":1793160826050,"version":"4.5.0"},"reference-count":158,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2015,8,13]],"date-time":"2015-08-13T00:00:00Z","timestamp":1439424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Dairy foods contain complex nutrients which interact with the host. Yet, evolution of lactase persistence has divided the human species into those that can or cannot digest lactose in adulthood. Such a ubiquitous trait has differential effects on humanity. The literature is reviewed to explore how the divide affects lactose handling by lactase non persistent persons. There are two basic differences in digesters. Firstly, maldigesters consume less dairy foods, and secondly, excess lactose is digested by colonic microflora. Lactose intolerance in maldigesters may occur with random lactose ingestion. However, lactose intolerance without maldigestion tends to detract from gaining a clear understanding of the mechanisms of symptoms formation and leads to confusion with regards to dairy food consumption. The main consequence of intolerance is withholding dairy foods. However, regular dairy food consumption by lactase non persistent people could lead to colonic adaptation by the microbiome. This process may mimic a prebiotic effect and allows lactase non persistent people to consume more dairy foods enhancing a favorable microbiome. This process then could lead to alterations in outcome of diseases in response to dairy foods in lactose maldigesters. The evidence that lactose is a selective human prebiotic is reviewed and current links between dairy foods and some diseases are discussed within this context. Colonic adaptation has not been adequately studied, especially with modern microbiological techniques.<\/jats:p>","DOI":"10.3390\/nu7085309","type":"journal-article","created":{"date-parts":[[2015,8,13]],"date-time":"2015-08-13T11:13:57Z","timestamp":1439464437000},"page":"6751-6779","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["Adaptation to Lactose in Lactase Non Persistent People: Effects on Intolerance and the Relationship between Dairy Food Consumption and Evalution of Diseases"],"prefix":"10.3390","volume":"7","author":[{"given":"Andrew","family":"Szilagyi","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Jewish General Hospital, McGill University School of Medicine; 3755, Chemin de la Cote-Ste-Catherine Rd, Rm E110, Montreal H3T 1E2, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2015,8,13]]},"reference":[{"key":"ref_1","first-page":"197","article-title":"Genetics of lactase persistence and lactose intolerance","volume":"37","author":"Swallow","year":"2003","journal-title":"Ann. Hum. Genet."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/ng1946","article-title":"Convergent adaptation of human lactase persistence in Africa and Europe","volume":"39","author":"Tishkoff","year":"2007","journal-title":"Nat. Genet."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1212S","DOI":"10.3945\/ajcn.113.073437","article-title":"Dairy products in global public health","volume":"99","author":"Prentice","year":"2014","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_4","first-page":"605","article-title":"Phylogenetic analysis of the evolution of lactose digestion in adults","volume":"69","author":"Holden","year":"1997","journal-title":"Hum. Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0140-6736(73)93267-4","article-title":"Lactose nutrition and natural selection","volume":"2","author":"Flatz","year":"1973","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1086\/421051","article-title":"Genetic signatures of strong recent positive selection at the lactase gene","volume":"74","author":"Bersaglieri","year":"2004","journal-title":"Am. J. Hum. Genet."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Lomer, M. (2014). Advanced Nutrition and Dietetics in Gastroenterology, John Wiley and Sons Ltd. [1st ed.].","DOI":"10.1002\/9781118872796"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1080\/01635580701745301","article-title":"Impact of lactose containing foods and the genetics of lactase on diseases: An analytical review of population data","volume":"60","author":"Shrier","year":"2008","journal-title":"Cancer Nutr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1093\/ajcn\/48.4.1086","article-title":"Prevalence of lactose maldigestion","volume":"48","author":"Scrimshaw","year":"1988","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1093\/ajcn\/64.2.232","article-title":"Colonic adaptation to daily lactose feeding in lactose maldigesters reduces lactose intolerance","volume":"64","author":"Hertzler","year":"1996","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"792","DOI":"10.7326\/0003-4819-152-12-201006150-00248","article-title":"National Institutes of Health Consensus Development Conference: Lactose intolerance and health","volume":"152","author":"Suchy","year":"2010","journal-title":"Ann. Intern. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/j.1365-2362.2008.01966.x","article-title":"The colonic metabolism in lactose intolerance","volume":"38","author":"He","year":"2008","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"797","DOI":"10.7326\/0003-4819-152-12-201006150-00241","article-title":"Systematic review: Effective management strategies for lactose intolerance","volume":"152","author":"Shaukat","year":"2010","journal-title":"Ann. Intern. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/j.1365-2036.2008.03889.x","article-title":"Quantifying the \u201chidden\u201d lactose in drugs used for the treatment of gastrointestinal conditions","volume":"29","author":"Eadala","year":"2009","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1111\/j.1365-2036.2008.03815.x","article-title":"Low-dose lactose in drugs neither increases breath hydrogen excretion nor causes gastrointestinal symptoms","volume":"28","author":"Montalto","year":"2008","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1136\/pgmj.2004.025551","article-title":"Systemic lactose intolerance: A new perspective on an old problem","volume":"81","author":"Matthews","year":"2005","journal-title":"Postgrad. Med. J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1111\/j.1365-2036.2011.04799.x","article-title":"Association of lactose sensitivity with inflammatory bowel disease\u2014Demonstrated by analysis of genetic polymorphism, breath gases and symptoms","volume":"34","author":"Eadala","year":"2011","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1440-1746.2009.06149.x","article-title":"Evidence-based dietary management of functional gastrointestinal symptoms: The FODMAP approach","volume":"25","author":"Gibson","year":"2010","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.cgh.2010.03.027","article-title":"Subjective perception of lactose intolerance does not always indicate lactose malabsorption","volume":"8","author":"Casellas","year":"2010","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM199507063330101","article-title":"A comparison after the consumption of milk or lactose-hydrolyzed milk by people with self-reported severe lactose intolerance","volume":"333","author":"Suarez","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1093\/ajcn\/65.5.1502","article-title":"Tolerance to the daily ingestion of two cups of milk by individuals claiming lactose intolerance","volume":"65","author":"Suarez","year":"1997","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/jn\/136.4.1107","article-title":"Lactose intolerance symptoms assessed by meta-analysis: A grain of truth that leads to exaggeration","volume":"136","author":"Savaiano","year":"2006","journal-title":"J. Nutr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.dld.2010.02.005","article-title":"Diagnosis of lactose intolerance and the \u201cnocebo\u201d effect: The role of negative expectations","volume":"42","author":"Vernia","year":"2010","journal-title":"Dig. Liver Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1136\/gut.41.5.632","article-title":"Improved clinical tolerance to chronic lactose ingestion in subjects with lactose intolerance: A placebo effect?","volume":"41","author":"Briet","year":"1997","journal-title":"Gut"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/j.1651-2227.1973.tb17080.x","article-title":"Lactose malabsorption in Ethiopian children","volume":"62","author":"Habte","year":"1973","journal-title":"Acta Paediatr.Scand."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1093\/ajcn\/32.9.1948","article-title":"Lactose intolerance in Iran","volume":"32","author":"Sadre","year":"1979","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1093\/ajcn\/58.6.879","article-title":"Adaptation of lactose maldigesters to continued milk intakes","volume":"58","author":"Johnson","year":"1993","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_28","first-page":"697","article-title":"Improved lactose digestion during pregnancy: A case of physiologic adaptation?","volume":"71","author":"Villar","year":"1988","journal-title":"Obstet. Gynecol."},{"key":"ref_29","first-page":"416","article-title":"Improved lactose handling in late phase pregnancy","volume":"74","author":"Szilagyi","year":"1996","journal-title":"Clin. Investig. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1079\/PHN2003489","article-title":"Lactose digestion in pregnant African-Americans","volume":"6","author":"Paige","year":"2003","journal-title":"Public Health Nutr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1136\/gut.23.11.968","article-title":"Lactose malabsorption in Greek adults: Correlation of small bowel transit time with the severity of lactose intolerance","volume":"23","author":"Ladas","year":"1982","journal-title":"Gut"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1139\/y96-116","article-title":"Caco-2 cell dissaccharidase activities are unaffected by gestational hormones","volume":"74","author":"Salomon","year":"1996","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_33","first-page":"846","article-title":"Lactose intolerance in hyperthyroidism: A possible unmasking effect","volume":"80","author":"Lazzara","year":"1985","journal-title":"Am. J. Gastroenterol."},{"key":"ref_34","first-page":"A44","article-title":"Influence of hypothyroidism on gastric emptying, oral cecal transit and lactose absorption","volume":"15","author":"Szilagyi","year":"1992","journal-title":"Clin. Investig. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s12020-013-0065-1","article-title":"Decrease in TSH levels after lactose restriction in Hashimoto\u2019s thyroiditis patients with lactose intolerance","volume":"46","author":"Asik","year":"2014","journal-title":"Endocrine"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1177\/014860719902300502","article-title":"The ontogeny of the small intestinal epithelium","volume":"23","author":"Lebenthal","year":"1999","journal-title":"J. Parenter. Enteral Nutr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/BF00260793","article-title":"Adaptation of intestinal hydrolases to starvation in rats: Effect of thyroid function","volume":"161","author":"Galluser","year":"1991","journal-title":"J. Comp. Physiol. B"},{"key":"ref_38","first-page":"188","article-title":"Reversible lactose malabsorption and intolerance in Graves\u2019 disease","volume":"14","author":"Szilagyi","year":"1991","journal-title":"Clin. Investig. Med."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Yaylali, O., Kirac, S., Yilmaz, M., Akin, F., Yuksel, D., Demirkan, N., and Akdag, B. (2009). Does hypothyroidism affect gastrointestinal motility?. Gastroenterol. Res. Pract., ID529802.","DOI":"10.1155\/2009\/529802"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.3748\/wjg.15.2834","article-title":"Consequences of dysthyroidism on the digestive tract and viscera","volume":"15","author":"Daher","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1046\/j.1365-2036.1996.45187000.x","article-title":"Influence of Loperamide on lactose handling and oral caecal transit time","volume":"10","author":"Szilagyi","year":"1996","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1023\/A:1010652223705","article-title":"Improved parameters of lactose maldigestion using lactulose","volume":"46","author":"Szilagyi","year":"2001","journal-title":"Dig. Dis. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Savaiano, D.A., Ritter, A.J., Klaenhammer, T.B., James, G.M., Longcore, A.T., Chandler, J.R., Walker, W.A., and Foyt, H.L. (2013). Improving lactose digestion and symptoms of lactose intolerance with a novel galacto-oligosaccharide (RP-G28): A randomized, double-blind clinical trial. Nutr. J., 12.","DOI":"10.1186\/1475-2891-12-160"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1155\/2004\/763529","article-title":"De-adapt and re-adapt with lactose but no cross-adapt to lactulose: A case of occult colonic bacterial adaptation","volume":"18","author":"Szilagyi","year":"2004","journal-title":"Can. J. Gastroenterol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1093\/jn\/125.6.1401","article-title":"Dietary modulation of the human colonic microbiota: Introducing the concept of prebiotics","volume":"125","author":"Gibson","year":"1995","journal-title":"J. Nutr."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1053\/j.gastro.2014.01.049","article-title":"Meta\u2019omic analytic techniques for studying the intestinal microbiome","volume":"146","author":"Morgan","year":"2014","journal-title":"Gastoeneterology"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1053\/j.gastro.2014.01.052","article-title":"Compositional and functional features of gastrointestinal microbiome and their effects on human health","volume":"146","author":"Hollister","year":"2014","journal-title":"Gastroenterology"},{"key":"ref_48","first-page":"26191","article-title":"Dysbiosis of the gut microbiota in disease","volume":"26","author":"Carding","year":"2015","journal-title":"Microb. Ecol. Health Dis."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1053\/j.gastro.2014.01.058","article-title":"Diet and the intestinal microbiome: Associations, functions, and implications for health and disease","volume":"146","author":"Albenberg","year":"2014","journal-title":"Gastroenterology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/nature09944","article-title":"Enterotypes of the human gut microbiome","volume":"473","author":"Arumugam","year":"2011","journal-title":"Nature"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e34938","DOI":"10.1371\/journal.pone.0034938","article-title":"A meta-analysis of probiotic efficacy for gastrointestinal diseases","volume":"7","author":"Ritchie","year":"2012","journal-title":"PLoS ONE"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1111\/j.1365-2036.2012.05104.x","article-title":"Meta-analysis: Probiotics in antibiotic-associated diarrhoea","volume":"35","author":"Videlock","year":"2012","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1155\/2009\/915847","article-title":"Prevention of Clostridium difficile infection with Saccharomyces boulardii: A systematic review","volume":"23","author":"Tung","year":"2009","journal-title":"Can. J. Gastroenterol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Hoveyda, N., Heneghan, C., Mahtani, K.R., Perera, R., Roberts, N., and Glasziou, P. (2009). A systematic review and meta-analysis: Probiotics in the treatment of irritable bowel syndrome. BMC Gastroenterol., 9.","DOI":"10.1186\/1471-230X-9-15"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/01.MIB.0000437495.30052.be","article-title":"Effect of probiotics on inducing remission and maintaining therapy in ulcerative colitis, Crohn\u2019s disease, and pouchitis: Meta-analysis of randomized controlled trials","volume":"20","author":"Shen","year":"2014","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/S1081-1206(10)60290-6","article-title":"Efficacy of probiotics in the treatment of pediatric atopic dermatitis: A meta-analysis of randomized controlled trials","volume":"101","author":"Michail","year":"2008","journal-title":"Ann. Allergy AsthmaImmunol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"772","DOI":"10.3109\/14767058.2012.755166","article-title":"Probiotics in pregnancy and maternal outcomes: A systematic review","volume":"26","author":"Lindsay","year":"2013","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0007114511003400","article-title":"Impact of maternal supplementation with probiotics during pregnancy on atopic eczema in childhood: A meta-analysis","volume":"107","author":"Doege","year":"2012","journal-title":"Br. J. Nutr."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Razmpoosh, E., Javadi, M., Ejtahed, H.S., and Mirmiran, P. (2015). Probiotics as beneficial agents on the management of diabetes mellitus: A systematic review. Diabetes Metab. Res. Rev.","DOI":"10.1002\/dmrr.2665"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1177\/0884533612440289","article-title":"Beneficial effects oflong-term consumption of a probiotic combination of Lactobacillus casei Shirota and Bifidobacteriumbreve Yakult may persist after suspension of therapy in lactose-intolerant patients","volume":"27","author":"Almeida","year":"2012","journal-title":"Nutr. Clin. Pract."},{"key":"ref_61","first-page":"113","article-title":"Adaptation to lactose intolerance is not achieved by long term ingestion of a multi species containing probiotic","volume":"1","author":"Malolepszy","year":"2006","journal-title":"Int. J. ProbioticsPrebiotics."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1111\/j.1365-2036.2006.03042.x","article-title":"Review Article: Prebiotics in the gastrointestinal tract","volume":"24","author":"Macfarlane","year":"2006","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1053\/j.gastro.2014.03.001","article-title":"The intestinal metabolome: An intersection between microbiota and host","volume":"146","author":"Ursell","year":"2014","journal-title":"Gastroenterology"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"McNulty, N.P., Yatsunenko, T., Hsiao, A., Faith, J.J., Muegge, B.D., Goodman, A.L., Henrissat, B., Oozeer, R., Cools-Portier, S., and Gobert, G. (2011). The impact of a consortium of fermented milk strains on the gut microbiome of gnotobiotic mice and monozygotic twins. Sci. Transl. Med., 3.","DOI":"10.1126\/scitranslmed.3002701"},{"key":"ref_65","first-page":"686","article-title":"Bifidobacterial species differentially affect expression of cell surface markers and cytokines of dendritic cells harvested from cord blood","volume":"11","author":"Young","year":"2004","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"14691","DOI":"10.1073\/pnas.1005963107","article-title":"Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa","volume":"107","author":"Cavalieri","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.3390\/nu5041417","article-title":"Fiber and prebiotics: Mechanisms and health benefits","volume":"5","author":"Slavin","year":"2013","journal-title":"Nutrients"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1365-2036.2007.03562.x","article-title":"Review article: The role of butyrate on colonic function","volume":"27","author":"Hamer","year":"2008","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/MOG.0000000000000151","article-title":"Prebiotics, probiotics, synbiotics and the immune system: Experimental data and clinical evidence","volume":"31","author":"Frei","year":"2015","journal-title":"Curr. Opin. Gastroenterol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/sj.ejcn.1601829","article-title":"Lactulose ingestion increases faecal bifidobacterial counts: A randomised double-blind study in healthy humans","volume":"58","author":"Bouhnik","year":"2004","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1128\/AEM.01488-08","article-title":"In vitro analysis of fermentation of prebiotic inulin-type fructans by bifidobacterium species reveals four different phenotypes","volume":"75","author":"Falony","year":"2009","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1128\/AEM.02649-08","article-title":"Coculture fermentations of bifidobacterium species and bacteroides thetaiotaomicron reveal a mechanistic insight into the prebiotic effect of inulin-type fructans","volume":"75","author":"Falony","year":"2009","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"5810","DOI":"10.1128\/AEM.70.10.5810-5817.2004","article-title":"Lactate\u2014Utilizing bacteria, isolated from human feces, that produce butyrate as a major fermentation product","volume":"70","author":"Duncan","year":"2004","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1256S","DOI":"10.3945\/ajcn.113.073056","article-title":"Dairy products, yogurts, and bone health","volume":"99","author":"Rizzoli","year":"2014","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1097\/INF.0b013e3182620e52","article-title":"The role of prebiotics in prevention and treatment of childhood infectious diseases","volume":"31","author":"Weichert","year":"2012","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1038\/ajg.2014.202","article-title":"Efficacy of prebiotics, probiotics and synbiotics in irritable bowel syndrome and chronic idiopathic constipation: Systematic review and meta-analysis","volume":"109","author":"Ford","year":"2014","journal-title":"Am. J. Gastroenterol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1017\/S000711450779894X","article-title":"The effects of regular consumption of short-chainfructo-oligosaccharides on digestive comfort of subjects with minor functional bowel disorders","volume":"99","author":"Paineau","year":"2008","journal-title":"Br. J. Nutr."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1111\/j.1365-2036.2008.03911.x","article-title":"Clinical trial: The effects of a trans-galacto-oligosaccharide prebiotic on faecal microbiota and symptoms in irritable bowel syndrome","volume":"29","author":"Silk","year":"2009","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_79","first-page":"473","article-title":"Systematic review of randomized controlled trials of probiotics, prebiotics and synbiotics in inflammatory bowel disease","volume":"7","author":"Ghouri","year":"2014","journal-title":"Clin. Exp. Gastroenterol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"181","DOI":"10.4161\/gmic.23919","article-title":"Potential of probiotics, prebiotics and synbiotics for management of colorectal cancer","volume":"4","author":"Raman","year":"2013","journal-title":"Gut Microbes"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1111\/j.1753-4887.2012.00495.x","article-title":"Effector prebiotics on biomarkers of colorectal cancer in humans: A systematic review","volume":"70","author":"Clark","year":"2012","journal-title":"Nutr. Rev."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/BF02053502","article-title":"Antioxidant vitamins or lactulose for the prevention of the recurrence of colorectal adenomas","volume":"36","author":"Roncucci","year":"1993","journal-title":"Dis. Colon Rectum"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.clp.2012.12.002","article-title":"Therapeutic use of prebiotics, probiotics and postbiotics to prevent necrotizing enterocolitis: What is the current evidence?","volume":"40","author":"Patel","year":"2013","journal-title":"Clin. Perinatol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1007\/BF01308043","article-title":"Treatment of chronic portal-systemic encephalopathy with lactose in lactase-deficient patients","volume":"25","author":"Uribe","year":"1980","journal-title":"Dig. Dis. Sci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1007\/BF01296659","article-title":"Lactitol, a second-generation disaccharide for treatment of chronic portal-systemic encephalopathy. A double-blind, crossover, randomized clinical trial","volume":"32","author":"Uribe","year":"1987","journal-title":"Dig. Dis. Sci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1159\/000346083","article-title":"Lactulose is highly potential in prophylaxis of hepatic encephalopathy in patients with cirrhosis and upper gastrointestinal bleeding: Results of a controlled randomized trial","volume":"87","author":"Wen","year":"2013","journal-title":"Digestion"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1017\/S0007114513003607","article-title":"Metabolic benefits of dietary prebiotics in human subjects: A systematic review of randomized controlled trials","volume":"111","author":"Kellow","year":"2014","journal-title":"Br. J. Nutr."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Osborn, D.A., and Sinn, J.K. (2013). Prebiotics in infants for prevention of allergy. Cochrane Database Syst. Rev.","DOI":"10.1002\/14651858.CD006474.pub3"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.jaad.2014.04.050","article-title":"Probiotics and prebiotics in dermatology","volume":"71","author":"Yim","year":"2014","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1136\/bmj.323.7318.936","article-title":"Lactulose may help prevent urinary tract infections","volume":"323","author":"Battle","year":"2001","journal-title":"Br. Med. J."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.clnu.2010.04.002","article-title":"Effect of butyrate enemas on inflammation and antioxidant status in the colonic mucosa of patients with ulcerative colitis in remission","volume":"29","author":"Hamer","year":"2010","journal-title":"Clin. Nutr."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1007\/BF02049697","article-title":"Treatment of diversion colitis by short-chain fatty acids. Prospective and double-blind study","volume":"34","author":"Guillemot","year":"1991","journal-title":"Dis. Colon Rectum"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1093\/jn\/127.8.1489","article-title":"In vitro lactose fermentation by human colonic bacteria is modified by lactobacillus acidophilus supplementation","volume":"1237","author":"Jiang","year":"1997","journal-title":"J. Nutr."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1023\/A:1018895524114","article-title":"Modification of colonic fermentation by bifidobacteria and pH in vitro (Impact on lactose metabolism, short-chain fatty acid, and lactate production)","volume":"42","author":"Jiang","year":"1997","journal-title":"Dig. Dis. Sci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1080\/00365521.1997.11720718","article-title":"In vitro and in vivo lactose and lactulose effects on colonic fermentation and portal-systemic encephalopathy parameters","volume":"32","author":"Maran","year":"1997","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1155\/2004\/350732","article-title":"Redefining lactose as a conditional prebiotic","volume":"18","author":"Szilagyi","year":"2004","journal-title":"Can. J. Gastroenterol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/S0016-5085(72)80080-5","article-title":"Lactase in man: A nonadaptable enzyme","volume":"62","author":"Gilat","year":"1972","journal-title":"Gastroenterology"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1093\/ajcn\/22.5.638","article-title":"Lactase deficiency in Thailand : Effects of prolonged lactose feeding","volume":"22","author":"Keusch","year":"1969","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/S0016-5085(76)80311-3","article-title":"Quantitative measurement of lactose absorption","volume":"70","author":"Bond","year":"1976","journal-title":"Gastroenterology"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1023\/A:1018822103911","article-title":"Fecal hydrogen production and consumption measurements. Response to daily lactose ingestion by lactose maldigesters","volume":"42","author":"Hertzler","year":"1997","journal-title":"Dig. Dis. Sci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1271\/bbb.60022","article-title":"Effects of lactose on colon microbial community structure and function in a four-stage semi-continuous culture system","volume":"70","author":"Makivuokko","year":"2006","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"5192","DOI":"10.1021\/jf050276w","article-title":"Influence of disaccharide structure on prebiotic selectivity in vitro","volume":"53","author":"Sanz","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1017\/S0007114513002274","article-title":"Dietary supplementation with lactose or artificial sweetener enhances swine gut lactobacillus population abundance","volume":"111","author":"Daly","year":"2014","journal-title":"Br. J. Nutr."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1017\/S0007114512005557","article-title":"Lactose absorption and colonic fermentation after host metabolism in rats","volume":"110","author":"Alexandre","year":"2013","journal-title":"Br. J. Nutr."},{"key":"ref_105","first-page":"73","article-title":"Influence of lactose on faecal microflora in lactose maldigesters","volume":"6","author":"Ito","year":"1993","journal-title":"Microb. Ecol. Health Dis."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1155\/2010\/649312","article-title":"Differential impact of lactose\/lactase phenotype on colonic microflora","volume":"24","author":"Szilagyi","year":"2010","journal-title":"Can. J. Gastroenterol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1046\/j.1472-765X.2003.01398.x","article-title":"Development of a quantitative tool for the comparison of the prebiotic effect of dietary oligosaccharides","volume":"37","author":"Palframan","year":"2003","journal-title":"Lett. Appl. Microbiol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3177\/jnsv.51.51","article-title":"Maximum permissive dose of lactose and lactitol for transitory diarrhea, and utilizable capacity for lactose in Japanese female adults","volume":"51","author":"Oku","year":"2005","journal-title":"J. Nutr. Sci. Viaminol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0002-8223(96)00074-0","article-title":"How much lactose is low lactose?","volume":"96","author":"Hertzler","year":"1996","journal-title":"J. Am. Diet. Assoc."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/jn\/129.1.113","article-title":"Short-chain fructo-oligosaccharide administration dose-dependently increases fecal bifidobacteria in healthy humans","volume":"129","author":"Bouhnik","year":"1999","journal-title":"J. Nutr."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.nut.2013.10.011","article-title":"Milk nutritional composition and its role in human health","volume":"30","author":"Pereira","year":"2014","journal-title":"Nutrition"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1001\/archinternmed.2008.578","article-title":"Dairy Food, Calcium, and Risk of Cancer in the NIH-AARP Diet and Health Study","volume":"169","author":"Park","year":"2009","journal-title":"Arch. Intern. Med."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1093\/jnci\/djh185","article-title":"Dairy foods, calcium, and colorectal cancer: A pooled analysis of 10 cohort studies","volume":"96","author":"Cho","year":"2004","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/annonc\/mdr269","article-title":"Dairy products and colorectal cancer risk: A systematic review and meta-analysis of cohort studies","volume":"23","author":"Aune","year":"2012","journal-title":"Ann. Oncol."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Weingarten, M.A., Zalmanovici Trestioreanu, A., and Yaphe, J. (2008). Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps. Cochrane Database Syst. Rev., 23.","DOI":"10.1002\/14651858.CD003548.pub4"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Chandler, P.D., Buring, J.E., Manson, J.E., Giovannucci, E.L., Moorthy, M.V., Zhang, S., Lee, I.M., and Lin, J.H. (2015). Circulating Vitamin D Levels and Risk of Colorectal Cancer in Women. Cancer Prev. Res.","DOI":"10.1158\/1940-6207.CAPR-14-0470"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jsbmb.2015.01.010","article-title":"Effects of supplemental vitamin D and calcium on normal colon tissue and circulating biomarkers of risk for colorectal neoplasms","volume":"148","author":"Bostick","year":"2015","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1207\/s15327914nc5502_4","article-title":"The effect of lactose maldigestion on the relationship between dairy food intake and colorectal cancer: A systematic review","volume":"55","author":"Szilagyi","year":"2006","journal-title":"Nutr. Cancer"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"e101728","DOI":"10.1371\/journal.pone.0101728","article-title":"Association between dairy intake and gastric cancer: A meta-analysis of observational studies","volume":"9","author":"Tian","year":"2014","journal-title":"PLoS ONE"},{"key":"ref_120","first-page":"875","article-title":"Epidemiologic characteristics and multiple risk factors of stomach cancer in Taiwan","volume":"10","author":"Lee","year":"1990","journal-title":"Anticancer Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.annepidem.2010.02.002","article-title":"Dietary patterns and risk of stomach cancer mortality: The Japan collaborative cohort study","volume":"20","author":"Pham","year":"2010","journal-title":"Ann. Epidemiol."},{"key":"ref_122","first-page":"193","article-title":"Meta-analysis of the relationship between dairy product consumption and gastric cancer","volume":"43","author":"Huang","year":"2009","journal-title":"Zhonghua Yu Fang Yi Xue Za Zhi"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1080\/01635581.2015.1019634","article-title":"Dairy consumption and gastric cancer risk: A meta-analysisof epidemiological studies","volume":"67","author":"Guo","year":"2015","journal-title":"Nutr. Cancer"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1080\/01635581.2012.725502","article-title":"Dietary patterns and risk of pancreatic cancer in a large population-based case-control study in the San Francisco Bay Area","volume":"65","author":"Chan","year":"2013","journal-title":"Nutr. Cancer"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.urology.2011.09.002","article-title":"Milk and dairy consumption and risk of bladder cancer: A meta-analysis","volume":"78","author":"Li","year":"2011","journal-title":"Urology"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1080\/01635581.2011.614716","article-title":"Milk consumption and bladder cancer risk: A meta-analysis of published epidemiological studies","volume":"63","author":"Mao","year":"2011","journal-title":"Nutr. Cancer"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1093\/aje\/kwp399","article-title":"Dairy intake and the risk of bladder cancer in the Netherlands Cohort Study on Diet and Cancer","volume":"171","author":"Keszei","year":"2010","journal-title":"Am. J. Epidemiol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1111\/j.1464-410X.2011.10749.x","article-title":"Probiotics, dendritic cells and bladder cancer","volume":"109","author":"Feyisetan","year":"2012","journal-title":"BJU Int."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/ijc.21305","article-title":"Milk, milk products and lactose intake and ovarian cancer risk: A meta-analysis of epidemiological studies","volume":"118","author":"Larsson","year":"2006","journal-title":"Int. J. Cancer"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3945\/ajcn.113.067157","article-title":"Dairy products, calcium, and prostate cancer risk: A systematic review and meta-analysis of cohort studies","volume":"101","author":"Aune","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1002\/ijc.27836","article-title":"Genetic variation in the lactase gene, dairy product intake and risk for prostate cancer in the European prospective investigation into cancer and nutrition","volume":"132","author":"Travis","year":"2013","journal-title":"Int. J. Cancer"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1002\/ijc.11327","article-title":"Canadian Cancer Registries Epidemiology Research Group. Dietary risk factors for testicular carcinoma","volume":"106","author":"Garner","year":"2003","journal-title":"Int. J. Cancer"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1093\/oxfordjournals.aje.a115423","article-title":"Lactase persistence and milk consumption as determinants of ovarian cancer risk","volume":"130","author":"Cramer","year":"1989","journal-title":"Am. J. Epidemiol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0140-6736(89)90313-9","article-title":"Galactose consumption and metabolism in relation to the risk of ovarian cancer","volume":"2","author":"Cramer","year":"1989","journal-title":"Lancet"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"454","DOI":"10.3109\/0284186X.2011.636754","article-title":"Use of dairy products, lactose, and calcium and risk of ovarian cancer\u2014Results from a Danish case-controlstudy","volume":"51","author":"Faber","year":"2012","journal-title":"Acta Oncol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1158\/1055-9965.EPI-05-0484","article-title":"Dairy products and ovarian cancer: A pooled analysis of 12 cohort studies","volume":"15","author":"Genkinger","year":"2006","journal-title":"Cancer Epidemiol. Biomarker. Prev."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/s10552-014-0381-7","article-title":"Dairy food and nutrient intake in different life periods in relation to risk of ovarian cancer","volume":"25","author":"Merritt","year":"2014","journal-title":"Cancer Causes Control"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1002\/ijc.27701","article-title":"Dairy foods and nutrients in relation to risk of ovarian cancer and major histological subtypes","volume":"132","author":"Merritt","year":"2013","journal-title":"Int. J. Cancer"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1210\/endo.132.5.7682937","article-title":"Vitamin D and prostate cancer: 1,25 dihydroxyvitamin D3 receptors and actions in human prostate cancer cell lines","volume":"132","author":"Skowronski","year":"1993","journal-title":"Endocrinology"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1080\/00365520701676831","article-title":"Lactose intolerance in prostate cancer patients: Incidence and associated factors","volume":"43","author":"Agarwal","year":"2008","journal-title":"Scand. J. Gastroeneterol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/bjc.1996.417","article-title":"Adolescent milk, dairy product and fruit consumption and testicular cancer","volume":"74","author":"Davies","year":"1998","journal-title":"Br. J. Cancer"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1158\/1055-9965.EPI-06-0372","article-title":"Adolescent milk fat and galactose consumption and testicular cell cancer","volume":"15","author":"Stang","year":"2006","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.mehy.2005.06.026","article-title":"The possible role of female sex hormones in milk from pregnant cows in the development of breast, ovarian and corpus uteri cancers","volume":"65","author":"Ganmaa","year":"2005","journal-title":"Med. Hypotheses"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"602","DOI":"10.3945\/ajcn.2008.27173","article-title":"Meat, eggs, dairy products, and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort","volume":"90","author":"Pala","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s10549-011-1467-5","article-title":"Dairy consumption and risk of breast cancer: A meta-analysis of prospective cohort studies","volume":"127","author":"Dong","year":"2011","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1002\/ijc.2910580505","article-title":"A case-control study of diet and lung cancer in Kerala, south India","volume":"58","author":"Sankaranarayanan","year":"1994","journal-title":"Int. J. Cancer"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/bjc.2014.544","article-title":"Lactose intolerance and risk of lung, breast and ovarian cancers: Aetiological clues from a population-based study in Sweden","volume":"112","author":"Ji","year":"2015","journal-title":"Br. J. Cancer"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1111\/j.1440-1746.2008.05681.x","article-title":"Is there a link between food and intestinal microbes and the occurrence of Crohn\u2019s disease an ulcerative colitis","volume":"23","author":"Asakura","year":"2008","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1177\/026010609901300203","article-title":"The relationship between habits of food consumption and reported reactions to food in people with inflammatory bowel disease\u2014Testing the limits","volume":"13","author":"Joachim","year":"1999","journal-title":"Nutr. Health"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1038\/ajg.2010.192","article-title":"Animal protein intake and risk of inflammatory bowel disease: The E3N prospective study","volume":"105","author":"Jantchou","year":"2010","journal-title":"Am. J. Gastroenterol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1093\/aje\/kwk067","article-title":"A case-control study of drinking water and dairy products in Crohn\u2019s disease\u2014Further investigation of the possible role of Mycobacterium avium paratuberculosis","volume":"165","author":"Abubakar","year":"2007","journal-title":"Am. J. Epidemiol."},{"key":"ref_152","first-page":"1148","article-title":"Increased prevalence of lactose malabsorption in Crohn\u2019s disease patients at low risk for lactose malabsorption based on ethnic origin","volume":"92","author":"Mishkin","year":"1997","journal-title":"Am. J. Gastroenterol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1023\/A:1021034028295","article-title":"Diminished efficacy of colonic adaptation to lactulose occurs in patients with inflammatory bowel disease in remission","volume":"47","author":"Szilagyi","year":"2002","journal-title":"Dig. Dis. Sci."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.nutres.2014.07.014","article-title":"Whole-fat dairy food intake is inversely associated with obesity prevalence: Findings from the Observation of Cardiovascular Risk Factors in Luxembourg study","volume":"34","author":"Crichton","year":"2014","journal-title":"Nutr. Res."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"O\u2019Sullivan, T.A., Bremner, A.P., Bremer, H.K., Seares, M.E., Beilin, L.J., Mori, T.A., Lyons-Wall, P., Devine, A., and Oddy, W.H. (2014). Dairy product consumption, dietary nutrient and energy density and associations with obesity in Australian adolescents. J. Hum. Nutr. Diet.","DOI":"10.1111\/jhn.12264"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.metabol.2014.02.009","article-title":"Associations between dairy foods, diabetes, and metabolic health: Potential mechanisms and future directions","volume":"63","author":"Hirahatake","year":"2014","journal-title":"Metabolism"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1080\/10408398.2011.587039","article-title":"Investigation of the putative associations between dairy consumption and incidence of type 1 and type 2 diabetes","volume":"54","author":"Lacroix","year":"2014","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.3945\/ajcn.113.059030","article-title":"Dairy products and the risk of type 2 diabetes: A systematic review and dose-response meta-analysis of cohort studies","volume":"98","author":"Aune","year":"2013","journal-title":"Am. J. Clin. 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