{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:12:31Z","timestamp":1783487551425,"version":"3.55.0"},"reference-count":69,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T00:00:00Z","timestamp":1449705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Nucleoside Reverse Transcriptase Inhibitors (NRTIs) have not only improved therapeutic outcomes in the treatment of HIV infection but have also led to an increase in associated metabolic complications of NRTIs. Naringin\u2019s effects in mitigating NRTI-induced complications were investigated in this study. Wistar rats, randomly allotted into seven groups (n = 7) were orally treated daily for 56 days with 100 mg\/kg zidovudine (AZT) (groups I, II III), 50 mg\/kg stavudine (d4T) (groups IV, V, VI) and 3 mL\/kg of distilled water (group VII). Additionally, rats in groups II and V were similarly treated with 50 mg\/kg naringin, while groups III and VI were treated with 45 mg\/kg vitamin E. AZT or d4T treatment significantly reduced body weight and plasma high density lipoprotein concentrations but increased liver weights, plasma triglycerides and total cholesterol compared to controls, respectively. Furthermore, AZT or d4T treatment significantly increased oxidative stress, adiposity index and expression of Bax protein, but reduced Bcl-2 protein expression compared to controls, respectively. However, either naringin or vitamin E significantly mitigated AZT- or d4T-induced weight loss, dyslipidemia, oxidative stress and hepatocyte apoptosis compared to AZT- or d4T-only treated rats. Our results suggest that naringin reverses metabolic complications associated with NRTIs by ameliorating oxidative stress and apoptosis. This implies that naringin supplements could mitigate lipodystrophy and dyslipidemia associated with NRTI therapy.<\/jats:p>","DOI":"10.3390\/nu7125540","type":"journal-article","created":{"date-parts":[[2015,12,14]],"date-time":"2015-12-14T02:57:29Z","timestamp":1450061849000},"page":"10352-10368","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Naringin Reverses Hepatocyte Apoptosis and Oxidative Stress Associated with HIV-1 Nucleotide Reverse Transcriptase Inhibitors-Induced Metabolic Complications"],"prefix":"10.3390","volume":"7","author":[{"given":"Oluwafeyisetan","family":"Adebiyi","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Discipline of Pharmaceutical Sciences, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban 4001, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olubunmi","family":"Adebiyi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Discipline of Pharmaceutical Sciences, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban 4001, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Owira","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Discipline of Pharmaceutical Sciences, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban 4001, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2015,12,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2174\/157016208784324976","article-title":"Mortality and morbidity of HIV infected patients receiving HAART: A cohort study","volume":"6","author":"Panos","year":"2008","journal-title":"Curr. HIV Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1097\/01.aids.0000196178.73174.24","article-title":"Deaths in the era of HAART: Contribution of late presentation, treatment exposure, resistance and abnormal laboratory markers","volume":"20","author":"Sabin","year":"2006","journal-title":"AIDS"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/j.1468-1293.2008.00600.x","article-title":"Trends of mortality and causes of death among HIV-infected patients in Taiwan, 1984\u20132005","volume":"9","author":"Yang","year":"2008","journal-title":"HIV Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.tiv.2005.11.007","article-title":"Cell culture models for the investigation of NRTI-induced mitochondrial toxicity. Relevance for the prediction of clinical toxicity","volume":"20","author":"Hoschele","year":"2006","journal-title":"Toxicol. Vitro"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1001\/jama.2010.1004","article-title":"Antiretroviral treatment of adult HIV infection: 2010 recommendations of the International AIDS Society-USA panel","volume":"304","author":"Thompson","year":"2010","journal-title":"JAMA"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1097\/QAD.0b013e3283578bfa","article-title":"The impact of HAART on cardiomyopathy among children and adolescents perinatally infected with HIV-1","volume":"26","author":"Patel","year":"2012","journal-title":"AIDS"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0140-6736(05)78436-1","article-title":"Short course of AZT halves HIV-1 perinatal transmission","volume":"351","author":"Morris","year":"1998","journal-title":"Lancet"},{"key":"ref_8","first-page":"198","article-title":"Current treatment strategies, complications and considerations for the use of HIV antiretroviral therapy during pregnancy","volume":"13","author":"Senise","year":"2011","journal-title":"AIDS Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1097\/QAD.0b013e32835c54b8","article-title":"Frequency of stavudine substitution due to toxicity in children receiving antiretroviral treatment in sub-Saharan Africa","volume":"27","author":"Palmer","year":"2013","journal-title":"AIDS"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Maskew, M., Westreich, D., Fox, M.P., Maotoe, T., and Sanne, I.M. (2012). Effectiveness and safety of 30 mg versus 40 mg stavudine regimens: A cohort study among HIV-infected adults initiating HAART in South Africa. J. Int. AIDS Soc., 15.","DOI":"10.1186\/1758-2652-15-13"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1089\/apc.2009.0191","article-title":"Prevalence and impact of body physical changes in HIV patients treated with highly active antiretroviral therapy: Results from a study on patient and physician perceptions","volume":"24","author":"Cabrero","year":"2010","journal-title":"AIDS Patient Care STDs"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.clnu.2004.03.009","article-title":"Hyperlactataemia and lactic acidosis in HIV-infected patients receiving antiretroviral therapy","volume":"24","author":"Calza","year":"2005","journal-title":"Clin. Nutr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1185\/030079908X272742","article-title":"HIV lipodystrophy and its metabolic consequences: Implications for clinical practice","volume":"24","author":"Wierzbicki","year":"2008","journal-title":"Curr. Med. Res. Opin."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1086\/655765","article-title":"Human immunodeficiency virus treatment-induced adipose tissue pathology and lipoatrophy: Prevalence and metabolic consequences","volume":"51","author":"Hammond","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nrendo.2010.199","article-title":"Lipodystrophy: Pathophysiology and advances in treatment","volume":"7","author":"Fiorenza","year":"2011","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e76850","DOI":"10.1371\/journal.pone.0076850","article-title":"Zidovudine (AZT) and hepatic lipid accumulation: Implication of inflammation, oxidative and endoplasmic reticulum stress mediators","volume":"8","author":"Banerjee","year":"2013","journal-title":"PLoS ONE"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1097\/00002030-200211080-00011","article-title":"Increased fat accumulation in the liver in HIV-infected patients with antiretroviral therapy-associated lipodystrophy","volume":"16","author":"Sutinen","year":"2002","journal-title":"AIDS"},{"key":"ref_18","unstructured":"World Health Organization (2014). March 2014 Supplement to the 2013 Consolidated Guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection\u2014Recommendations for a Public Health Approach, WHO Press."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.tips.2011.07.007","article-title":"Mitochondrial interference by anti-HIV drugs: Mechanisms beyond Pol-gamma inhibition","volume":"32","author":"Apostolova","year":"2011","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1093\/toxsci\/kfp136","article-title":"Long-Term exposure to zidovudine delays cell cycle progression, induces apoptosis, and decreases telomerase activity in human hepatocytes","volume":"111","author":"Fang","year":"2009","journal-title":"Toxicol. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1006\/abbi.1997.0168","article-title":"The human immunodeficiency virus type 1 Tat protein potentiates zidovudine-induced cellular toxicity in transgenic mice","volume":"343","author":"Prakash","year":"1997","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_22","first-page":"1","article-title":"Role of mitochondria in HIV infection and associated metabolic disorders: Focus on nonalcoholic fatty liver disease and lipodystrophy syndrome","volume":"2013","author":"Blanco","year":"2013","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1089\/aid.2009.0062","article-title":"Short communication: Oxidative stress in HIV-infected individuals: A cross-sectional study","volume":"25","author":"Wanchu","year":"2009","journal-title":"AIDS Res. Hum. Retrovir."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.tox.2006.09.005","article-title":"Preventive effect of naringin on lipid peroxides and antioxidants in isoproterenol-induced cardiotoxicity in Wistar rats: Biochemical and histopathological evidences","volume":"228","author":"Rajadurai","year":"2006","journal-title":"Toxicology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"8809","DOI":"10.1021\/jf300669s","article-title":"Citrus flavanones: What is their role in cardiovascular protection?","volume":"60","author":"Chanet","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"6185","DOI":"10.1021\/jf8006568","article-title":"Update on uses and properties of citrus flavonoids: New findings in anticancer, cardiovascular, and anti-inflammatory activity","volume":"56","author":"Castillo","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"ref_27","first-page":"20","article-title":"Hepatotoxic changes induced by prenatal administration of zidovudine in Swiss albino mice","volume":"13","author":"Nayak","year":"2013","journal-title":"Int. J. Ther. Appl."},{"key":"ref_28","first-page":"799","article-title":"Prolonged zidovudine administration induces a moderate increase in the growth and steroidogenic capacity of the rat adrenal cortex","volume":"23","author":"Tortorella","year":"2009","journal-title":"Int. J. Mol. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.physbeh.2007.06.005","article-title":"Oral administration of stavudine induces hyperalgesia without affecting activity in rats","volume":"92","author":"Weber","year":"2007","journal-title":"Physiol. Behav."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/FJC.0b013e31823827a4","article-title":"Naringin ameliorates atherogenic dyslipidemia but not hyperglycemia in rats with type 1 diabetes","volume":"59","author":"Xulu","year":"2012","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"292","DOI":"10.4103\/0976-3147.118784","article-title":"Effects of \u03b1-tocopherol and ascorbic acid in the severity and management of traumatic brain injury in albino rats","volume":"4","author":"Ishaq","year":"2013","journal-title":"J. Neurosci. Rural Pract."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"715S","DOI":"10.1093\/ajcn\/57.5.715S","article-title":"Lipid peroxidation: Its mechanism, measurement, and significance","volume":"57","author":"Halliwell","year":"1993","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A dye binding assay for protein","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1097\/01.aids.0000174451.78497.8f","article-title":"Substitution of nevirapine or efavirenz for protease inhibitor versus lipid-lowering therapy for the management of dyslipidaemia","volume":"19","author":"Calza","year":"2005","journal-title":"AIDS"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Kinpara, S., Kijiyama, M., Takamori, A., Hasegawa, A., Sasada, A., Masuda, T., Tanaka, Y., Utsunomiya, A., and Kannagi, M. (2013). Interferon-\u03b1 (IFN-\u03b1) suppresses HTLV-1 gene expression and cell cycling, while IFN-\u03b1 combined with zidovudin induces p53 signaling and apoptosis in HTLV-1-infected cells. Retrovirology, 10.","DOI":"10.1186\/1742-4690-10-52"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1177\/135965350701200303","article-title":"Normalization of fat accrual in lipoatrophic, HIV-infected children switched from stavudine to tenofovir and from protease inhibitor to efavirenz","volume":"12","author":"Vigano","year":"2007","journal-title":"Antiviral Ther."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1093\/toxsci\/kfq213","article-title":"Antiretrovirals induce endothelial dysfunction via an oxidant-dependent pathway and promote neointimal hyperplasia","volume":"117","author":"Jiang","year":"2010","journal-title":"Toxicol. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"M117","DOI":"10.1177\/135965350501002S13","article-title":"Uridine in the prevention and treatment of NRTI-related mitochondrial toxicity","volume":"10","author":"Walker","year":"2005","journal-title":"Antiviral Ther."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/art.23235","article-title":"Uridine supplementation antagonizes zidovudine-induced mitochondrial myopathy and hyperlactatemia in mice","volume":"58","author":"Lebrecht","year":"2008","journal-title":"Arthritis Rheum."},{"key":"ref_40","first-page":"1","article-title":"Achieving the balance between ROS and antioxidants: When to use the synthetic antioxidants","volume":"2013","author":"Borut","year":"2013","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1055\/s-0034-1368351","article-title":"Preclinical evidence for the pharmacological actions of Naringin: A review","volume":"80","author":"Bharti","year":"2014","journal-title":"Planta Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/bcpt.12153","article-title":"Naringin inhibits ROS-activated MAPK pathway in high glucose-induced injuries in H9c2 cardiac cells","volume":"114","author":"Chen","year":"2014","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1002\/ptr.3724","article-title":"Preventive effects of hesperidin, glucosyl hesperidin and naringin on hypertension and cerebral thrombosis in stroke-prone spontaneously hypertensive rats","volume":"29","author":"Ikemura","year":"2012","journal-title":"Phytother. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1477-7827-9-32","article-title":"Diet-induced obesity in rats leads to a decrease in sperm motility","volume":"9","author":"Fernandez","year":"2011","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/1476-511X-9-132","article-title":"A novel genetically-obese rat model with elevated 11beta-hydroxysteroid dehydrogenase type 1 activity in subcutaneous adipose tissue","volume":"9","author":"Prasad","year":"2010","journal-title":"Lipids Health Dis."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1001\/jama.2014.8722","article-title":"Antiretroviral treatment of adult HIV infection: 2014 recommendations of the International Antiviral Society-USA Panel","volume":"312","author":"Aberg","year":"2014","journal-title":"JAMA"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"118","DOI":"10.4103\/0973-7847.70902","article-title":"Free radicals, antioxidants and functional foods: Impact on human health","volume":"4","author":"Lobo","year":"2010","journal-title":"Pharmacog. Rev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"L870","DOI":"10.1152\/ajplung.00098.2012","article-title":"Decreases in manganese superoxide dismutase expression and activity contribute to oxidative stress in persistent pulmonary hypertension of the newborn","volume":"303","author":"Afolayan","year":"2012","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_49","first-page":"72","article-title":"Glutathione peroxidase activity in obese and nonobese diabetic patients and role of hyperglycemia in oxidative stress","volume":"2","author":"Goyal","year":"2011","journal-title":"J. Midlife Health"},{"key":"ref_50","first-page":"26","article-title":"Reactive oxygen species, oxidative damage, and antioxidative defense mechanism in plants under stressful conditions","volume":"2012","author":"Sharma","year":"2012","journal-title":"J. Bot."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10725-010-9526-1","article-title":"Manganese-excess induces oxidative stress, lowers the pool of antioxidants and elevates activities of key antioxidative enzymes in rice seedlings","volume":"64","author":"Srivastava","year":"2011","journal-title":"Plant Growth Regul."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00709-010-0210-0","article-title":"Arsenite treatment induces oxidative stress, upregulates antioxidant system, and causes phytochelatin synthesis in rice seedlings","volume":"248","author":"Mishra","year":"2011","journal-title":"Protoplasma"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1016\/S0024-3205(01)01363-7","article-title":"Antioxidative activity of naringin and lovastatin in high cholesterol-fed rabbits","volume":"69","author":"Jeon","year":"2001","journal-title":"Life Sci."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Bakheet, S.A., and Attia, S.M. (2011). Evaluation of chromosomal instability in diabetic rats treated with naringin. Oxid. Med. Cell. Longev., 2011.","DOI":"10.1155\/2011\/365292"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Cristina, D.C., del Rosario, R.M., Rosa, A.C., and Veronica, O.A. (2013). On the performance of trimetazidine and vitamin E as pharmacoprotection agents in cyclosporin A-induced toxicity. ISRN Pharmacol., 2013.","DOI":"10.1155\/2013\/605640"},{"key":"ref_56","first-page":"140","article-title":"Mitochondrial toxicity of nucleoside analogue reverse transcriptase inhibitors: Lactic acidosis, risk factors and therapeutic options","volume":"1","author":"Brinkmann","year":"1999","journal-title":"AIDS Rev."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1097\/00002030-200411050-00004","article-title":"The HIV-1 nucleoside reverse transcriptase inhibitors stavudine and zidovudine alter adipocyte functions in vitro","volume":"18","author":"Caron","year":"2004","journal-title":"AIDS"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3349\/ymj.2000.41.2.195","article-title":"Early ultrastructural changes of apoptosis induced by fumonisin B1 in rat liver","volume":"41","year":"2000","journal-title":"Yonsei Med. J."},{"key":"ref_59","first-page":"123","article-title":"Increased Bax\/Bcl-2 ratio up-regulates caspase-3 and increases apoptosis in the thymus of patients with myasthenia gravis","volume":"21","author":"Salakou","year":"2007","journal-title":"Vivo"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s004419900057","article-title":"Ultrastructural and biochemical observations on the early changes in apoptotic epithelial cells of the rat prostate induced by castration","volume":"298","author":"Kwong","year":"1999","journal-title":"Cell Tissue Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00418-007-0356-9","article-title":"Morphological and cytochemical determination of cell death by apoptosis","volume":"129","author":"Taatjes","year":"2008","journal-title":"Histochem. Cell Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"38954","DOI":"10.1074\/jbc.M203842200","article-title":"Oxidative stress-mediated apoptosis: The anticancer effect of the sesquiterpene lactone parthenolide","volume":"277","author":"Wen","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Shamas-Din, A., Kale, J., Leber, B., and Andrews, D.W. (2013). Mechanisms of action of Bcl-2 family proteins. Cold Spring Harb. Perspect. Biol., 5.","DOI":"10.1101\/cshperspect.a008714"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.cbi.2014.05.012","article-title":"Naringin, a flavanone glycoside, promotes angiogenesis and inhibits endothelial apoptosis through modulation of inflammatory and growth factor expression in diabetic foot ulcer in rats","volume":"219","author":"Kandhare","year":"2014","journal-title":"Chem. Biol. Interact."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"7271","DOI":"10.1158\/1078-0432.CCR-07-1595","article-title":"The roles of therapy-induced autophagy and necrosis in cancer treatment","volume":"13","author":"Amaravadi","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/1054-8807(92)90042-M","article-title":"Dilated cardiomyopathy in a zidovudine-treated AIDS patient","volume":"1","author":"Kwan","year":"1992","journal-title":"Cardiovasc. Pathol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/0046-8177(91)90112-3","article-title":"Ultrastructural characteristics and DNA immunocytochemistry in human immunodeficiency virus and zidovudine-associated myopathies","volume":"22","author":"Pezeshkpour","year":"1992","journal-title":"Hum. Pathol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.2337\/db14-0812","article-title":"Mitochondria-associated endoplasmic reticulum membranes in insulin signaling","volume":"63","author":"Rutter","year":"2014","journal-title":"Diabetes"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1172\/JCI79273","article-title":"Calcium release channel RyR2 regulates insulin release and glucose homeostasis","volume":"125","author":"Santulli","year":"2015","journal-title":"J. Clin. Investig."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/7\/12\/5540\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T20:53:47Z","timestamp":1760216027000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/7\/12\/5540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,10]]},"references-count":69,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2015,12]]}},"alternative-id":["nu7125540"],"URL":"https:\/\/doi.org\/10.3390\/nu7125540","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,10]]}}}