{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:18:49Z","timestamp":1768565929104,"version":"3.49.0"},"reference-count":55,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2016,3,3]],"date-time":"2016-03-03T00:00:00Z","timestamp":1456963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Oral uptake of lycopene has been shown to be beneficial for preventing myocardial ischemia-reperfusion (I\/R) injury. However, the strong first-pass metabolism of lycopene influences its bioavailability and impedes its clinic application. In this study, we determined an intravenous (IV) administration dose of lycopene protects against myocardial infarction (MI) in a mouse model, and investigated the effects of acute lycopene administration on reactive oxygen species (ROS) production and related signaling pathways during myocardial I\/R. Methods: In this study, we established both in vitro hypoxia\/reoxygenation (H\/R) cell model and in vivo regional myocardial I\/R mouse model by ligating left anterior artery descending. TTC dual staining was used to assess I\/R induced MI in the absence and presence of acute lycopene administration via tail vein injection. Results: Lycopene treatment (1 \u03bcM) before reoxygenation significantly reduced cardiomyocyte death induced by H\/R. Intravenous administration of lycopene to achieve 1 \u03bcM concentration in circulating blood significantly suppressed MI, ROS production, and JNK phosphorylation in the cardiac tissue of mice during in vivo regional I\/R. Conclusion: Elevating circulating lycopene to 1 \u03bcM via IV injection protects against myocardial I\/R injury through inhibition of ROS accumulation and consequent inflammation in mice.<\/jats:p>","DOI":"10.3390\/nu8030138","type":"journal-article","created":{"date-parts":[[2016,3,3]],"date-time":"2016-03-03T10:30:47Z","timestamp":1457001047000},"page":"138","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Intravenous Administration of Lycopene, a Tomato Extract, Protects against Myocardial Ischemia-Reperfusion Injury"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0828-2674","authenticated-orcid":false,"given":"Chao","family":"Tong","sequence":"first","affiliation":[{"name":"Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Yuzhong District, Chongqing 400016, China"},{"name":"Canada-China-New Zealand Joint Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing 400016, China"},{"name":"Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuan","family":"Peng","sequence":"additional","affiliation":[{"name":"Laboratory of Lipid &amp; Glucose Metabolism, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianlian","family":"Wang","sequence":"additional","affiliation":[{"name":"Canada-China-New Zealand Joint Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Canada-China-New Zealand Joint Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaotao","family":"Yang","sequence":"additional","affiliation":[{"name":"Canada-China-New Zealand Joint Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Xu","sequence":"additional","affiliation":[{"name":"Canada-China-New Zealand Joint Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinjin","family":"Li","sequence":"additional","affiliation":[{"name":"Canada-China-New Zealand Joint Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thibaut","family":"Delplancke","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Yuzhong District, Chongqing 400016, China"},{"name":"Canada-China-New Zealand Joint Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3501-8385","authenticated-orcid":false,"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Yuzhong District, Chongqing 400016, China"},{"name":"Canada-China-New Zealand Joint Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbo","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Yuzhong District, Chongqing 400016, China"},{"name":"Canada-China-New Zealand Joint Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2016,3,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1161\/01.HYP.27.1.7","article-title":"Paracrine systems in the cardioprotective effect of angiotensin-converting enzyme inhibitors on myocardial ischemia reperfusion injury in rats","volume":"27","author":"Liu","year":"1996","journal-title":"Hypertension"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"C460","DOI":"10.1152\/ajpcell.00211.2007","article-title":"Ischemic defects in the electron transport chain increase the production of reactive oxygen species from isolated rat heart mitochondria","volume":"294","author":"Chen","year":"2008","journal-title":"Am. 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