{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:39:58Z","timestamp":1788910798367,"version":"build-2803163510"},"reference-count":216,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2016,3,12]],"date-time":"2016-03-12T00:00:00Z","timestamp":1457740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Nutritional supplements are widely used among patients with cancer who perceive them to be anticancer and antitoxicity agents. Depending on the type of malignancy and the gender 30%\u201390% of the cancer patients supplement their diets with antioxidant and immuno-stabilizing micronutrients, such as selenium, vitamin C, and vitamin D, often without the knowledge of the treating physician. From the oncological viewpoint, there are justifiable concerns that dietary supplements decrease the effectiveness of chemotherapy and radiotherapy. Recent studies, however, have provided increasing evidence that treatment is tolerated better\u2014with an increase in patient compliance and a lower rate of treatment discontinuations\u2014when micronutrients, such as selenium, are added as appropriate to the patient\u2019s medication. Nutritional supplementation tailored to an individual\u2019s background diet, genetics, tumor histology, and treatments may yield benefits in subsets of patients. Clinicians should have an open dialogue with patients about nutritional supplements. Supplement advice needs to be individualized and come from a credible source, and it is best communicated by the physician.<\/jats:p>","DOI":"10.3390\/nu8030163","type":"journal-article","created":{"date-parts":[[2016,3,14]],"date-time":"2016-03-14T11:03:45Z","timestamp":1457953425000},"page":"163","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":101,"title":["Micronutrients in Oncological Intervention"],"prefix":"10.3390","volume":"8","author":[{"given":"Uwe","family":"Gr\u00f6ber","sequence":"first","affiliation":[{"name":"Akademie f\u00fcr Mikron\u00e4hrstoffmedizin, Essen, Zweigertstrasse 55, 45130 Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Holzhauer","sequence":"additional","affiliation":[{"name":"Akademie f\u00fcr Mikron\u00e4hrstoffmedizin, Essen, Zweigertstrasse 55, 45130 Essen, Germany"},{"name":"Interdisziplin\u00e4res onkologisches Zentrum (IOZ), M\u00fcnchen, Nu\u00dfbaumstrasse 12, M\u00fcnchen 80336, Germany"},{"name":"Klinik Bad Trissl, Innere Medizin II-Onkologie und Komplement\u00e4rmedizin, Oberaudorf 83080, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Kisters","sequence":"additional","affiliation":[{"name":"Akademie f\u00fcr Mikron\u00e4hrstoffmedizin, Essen, Zweigertstrasse 55, 45130 Essen, Germany"},{"name":"St. Anna Hospital, Medizinische Klinik I, Herne, Hospitalstrasse 19, Herne 44649, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6023-9062","authenticated-orcid":false,"given":"Michael","family":"Holick","sequence":"additional","affiliation":[{"name":"Boston University Medical Center, 85 East Newton Street M-1033, Boston, MA 02118, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7747-7259","authenticated-orcid":false,"given":"Iren\u00e4us","family":"Adamietz","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Strahlentherapie und Radio-Onkologie, Ruhr Universit\u00e4t Bochum (RUB), H\u00f6lkeskampring 40, Herne 44625, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,3,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/S1470-2045(12)70211-5","article-title":"Global cancer transitions according to the Human Development Index (2008\u20132030): A population-based study","volume":"13","author":"Bray","year":"2012","journal-title":"Lancet Oncol."},{"key":"ref_2","unstructured":"American Cancer Society (2015). 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