{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T14:32:45Z","timestamp":1777905165939,"version":"3.51.4"},"reference-count":91,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Oxidative stress is a major cause of drug-induced hepatic diseases and several studies have demonstrated that diet supplementation with plants rich in antioxidant compounds provides a variety of health benefits in these circumstances. Genista quadriflora Munby (Gq) and Teucrium polium geyrii Maire (Tp) are known to possess antioxidant and numerous biological properties and these endemic plants are often used for dietary or medicinal applications. Herein, we evaluated the beneficial effect of rich-polyphenol fractions of Gq and Tp to prevent Acetaminophen-induced liver injury and investigated the mechanisms involved in this protective action. Rats were orally administered polyphenolic extracts from Gq or Tp (300 mg\/kg) or N-acetylcysteine (NAC: 200 mg\/kg) once daily for ten days prior to the single oral administration of Acetaminophen (APAP: 1 g\/kg). The results show that preventive administration of polyphenolic extracts from Gq or Tp exerts a hepatoprotective influence during APAP treatment by improving transaminases leakage and liver histology and stimulating antioxidant defenses. Besides, suppression of liver CYP2E1, GSTpi and TNF-\u03b1 mRNA levels, with enhancement of mitochondrial bioenergetics may contribute to the observed hepatoprotection induced by Gq and Tp extracts. The effect of Tp extract is significantly higher (1.5\u20132 fold) than that of Gq extract and NAC regarding the enhancement of mitochondrial functionality. Overall, this study brings the first evidence that pretreatment with these natural extracts display in vivo protective activity against APAP hepatotoxicity through improving mitochondrial bioenergetics, oxidant status, phase I and II enzymes expression and inflammatory processes probably by virtue of their high total polyphenols content.<\/jats:p>","DOI":"10.3390\/nu8040193","type":"journal-article","created":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T10:31:20Z","timestamp":1459506680000},"page":"193","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Protective Activity of Total Polyphenols from Genista quadriflora Munby and Teucrium polium geyrii Maire in Acetaminophen-Induced Hepatotoxicity in Rats"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9368-0241","authenticated-orcid":false,"given":"Nacera","family":"Baali","sequence":"first","affiliation":[{"name":"UMR 866 Dynamique Musculaire et M\u00e9tabolisme, Institut National de la Recherche Agronomique (INRA), Universit\u00e9 de Montpellier, F-34060 Montpellier, France"},{"name":"Facult\u00e9 des Sciences de la Nature et de la Vie, D\u00e9partement de Biologie Animale, Laboratoire de Biologie et Environnement, Universit\u00e9 Constantine 1, 25000 Constantine, Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahia","family":"Belloum","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de recherche (VARENBIOMOL), D\u00e9partement de Chimie, Facult\u00e9 des Sciences Exactes, Universit\u00e9 Constantine 1, 25000 Constantine, Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samiya","family":"Baali","sequence":"additional","affiliation":[{"name":"Facult\u00e9 des Sciences de la Nature et de la Vie, D\u00e9partement de Biologie Animale, Laboratoire de Biologie et Environnement, Universit\u00e9 Constantine 1, 25000 Constantine, Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrice","family":"Chabi","sequence":"additional","affiliation":[{"name":"UMR 866 Dynamique Musculaire et M\u00e9tabolisme, Institut National de la Recherche Agronomique (INRA), Universit\u00e9 de Montpellier, F-34060 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Pessemesse","sequence":"additional","affiliation":[{"name":"UMR 866 Dynamique Musculaire et M\u00e9tabolisme, Institut National de la Recherche Agronomique (INRA), Universit\u00e9 de Montpellier, F-34060 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Fouret","sequence":"additional","affiliation":[{"name":"UMR 866 Dynamique Musculaire et M\u00e9tabolisme, Institut National de la Recherche Agronomique (INRA), Universit\u00e9 de Montpellier, F-34060 Montpellier, 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Constantine, Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Feillet-Coudray","sequence":"additional","affiliation":[{"name":"UMR 866 Dynamique Musculaire et M\u00e9tabolisme, Institut National de la Recherche Agronomique (INRA), Universit\u00e9 de Montpellier, F-34060 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e9rard","family":"Cabello","sequence":"additional","affiliation":[{"name":"UMR 866 Dynamique Musculaire et M\u00e9tabolisme, Institut National de la Recherche Agronomique (INRA), Universit\u00e9 de Montpellier, F-34060 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chantal","family":"Wrutniak-Cabello","sequence":"additional","affiliation":[{"name":"UMR 866 Dynamique Musculaire et M\u00e9tabolisme, Institut National de la Recherche Agronomique (INRA), Universit\u00e9 de Montpellier, F-34060 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2016,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"373S","DOI":"10.1111\/j.1365-2125.1980.tb01825.x","article-title":"Hepatotoxicity of mild analgesics","volume":"10","author":"Prescott","year":"1980","journal-title":"Br. 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