{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T07:10:24Z","timestamp":1770448224637,"version":"3.49.0"},"reference-count":37,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T00:00:00Z","timestamp":1460073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: macronutrient intake has been found to affect sleep parameters including obstructive sleep apnoea (OSA) in experimental studies, but there is uncertainty at the population level in adults. Methods: cross-sectional analysis was conducted of participants in the Men Androgen Inflammation Lifestyle Environment and Stress cohort (n = 784, age 35\u201380 years). Dietary intake was measured by a validated food frequency questionnaire. Self-reported poor sleep quality and daytime sleepiness were measured by questionnaires. Overnight in-home polysomnography (PSG) was conducted among participants with without previously diagnosed OSA. Results: after adjusting for demographic, lifestyle factors, and chronic diseases, the highest quartile of fat intake was positively associated with excessive daytime sleepiness (relative risk ratio (RRR) = 1.78, 95% CI 1.10, 2.89) and apnoea-hypopnoea index (AHI) \u226520, (RRR = 2.98, 95% CI 1.20\u20137.38). Body mass index mediated the association between fat intake and AHI (30%), but not daytime sleepiness. There were no associations between other intake of macronutrient and sleep outcomes. Conclusion: high fat is associated with daytime sleepiness and AHI. Sleep outcomes are generally not assessed in studies investigating the effects of varying macronutrient diets on weight loss. The current result highlights the potential public health significance of doing so.<\/jats:p>","DOI":"10.3390\/nu8040207","type":"journal-article","created":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T21:02:38Z","timestamp":1460149358000},"page":"207","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Associations between Macronutrient Intake and Obstructive Sleep Apnoea as Well as Self-Reported Sleep Symptoms: Results from a Cohort of Community Dwelling Australian Men"],"prefix":"10.3390","volume":"8","author":[{"given":"Yingting","family":"Cao","sequence":"first","affiliation":[{"name":"Population Research and Outcome Studies, the University of Adelaide, SAHMRI, Adelaide, SA 5005, Australia"},{"name":"Freemasons Foundation Centre for Men\u2019s Health, the University of Adelaide, Adelaide, SA 5005, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Wittert","sequence":"additional","affiliation":[{"name":"Freemasons Foundation Centre for Men\u2019s Health, the University of Adelaide, Adelaide, SA 5005, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4422-7974","authenticated-orcid":false,"given":"Anne","family":"Taylor","sequence":"additional","affiliation":[{"name":"Population Research and Outcome Studies, the University of Adelaide, SAHMRI, Adelaide, SA 5005, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Adams","sequence":"additional","affiliation":[{"name":"Health Observatory, Discipline of Medicine, the Queen Elizabeth Hospital Campus, the University of Adelaide, Adelaide, SA 5011, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3099-3299","authenticated-orcid":false,"given":"Zumin","family":"Shi","sequence":"additional","affiliation":[{"name":"Population Research and Outcome Studies, the University of Adelaide, SAHMRI, Adelaide, SA 5005, Australia"},{"name":"Freemasons Foundation Centre for Men\u2019s Health, the University of Adelaide, Adelaide, SA 5005, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2016,4,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1093\/ajcn\/85.2.426","article-title":"High-glycemic-index carbohydrate meals shorten sleep onset","volume":"85","author":"Afaghi","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_2","first-page":"533","article-title":"Effect of low and high glycaemic index drink on sleep pattern in children","volume":"61","author":"Jalilolghadr","year":"2011","journal-title":"J. Pak. Med. Assoc."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"132","DOI":"10.2188\/jea.JE20120101","article-title":"Associations of protein, fat, and carbohydrate intakes with insomnia symptoms among middle-aged Japanese workers","volume":"23","author":"Tanaka","year":"2013","journal-title":"J. Epidemiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s11325-013-0847-y","article-title":"A fatty meal aggravates apnea and increases sleep in patients with obstructive sleep apnea","volume":"18","author":"Trakada","year":"2014","journal-title":"Sleep Breath"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.5664\/jcsm.5384","article-title":"Fiber and saturated fat are associated with sleep arousals and slow wave sleep","volume":"12","author":"Roberts","year":"2016","journal-title":"J. Clin. Sleep Med."},{"key":"ref_6","first-page":"457","article-title":"Relationship of dietary factors and habits with sleep-wake regularity","volume":"22","author":"Yamaguchi","year":"2013","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s11325-012-0658-6","article-title":"Effects of exercise and nutritional intake on sleep architecture in adolescents","volume":"17","author":"Awad","year":"2013","journal-title":"Sleep Breath"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1093\/ije\/dyt064","article-title":"Cohort profile: The men androgen inflammation lifestyle environment and stress (MAOLES) study","volume":"43","author":"Grant","year":"2014","journal-title":"Int. J. Epidemiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1093\/ije\/dyl279","article-title":"Cohort profile: The florey adelaide male ageing study (FAMAS)","volume":"36","author":"Martin","year":"2007","journal-title":"Int. J. Epidemiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1093\/ije\/dyn262","article-title":"Cohort profile: The north west Adelaide health study (NWAHS)","volume":"38","author":"Grant","year":"2009","journal-title":"Int. J. Epidemiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"609","DOI":"10.5664\/jcsm.4768","article-title":"Nocturnal hypoxemia and severe obstructive sleep apnea are associated with incident type 2 diabetes in a population cohort of men","volume":"11","author":"Appleton","year":"2015","journal-title":"J. Clin. Sleep Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1111\/j.1467-842X.2000.tb00520.x","article-title":"The anti cancer council of victoria FFQ: Relative validity of nutrient intakes compared with weighed food records in young to middle-aged women in a study of iron supplementation","volume":"24","author":"Hodge","year":"2000","journal-title":"Aust. N. Z. J. Public Health"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1097\/ALN.0b013e31816d83e4","article-title":"Stop questionnaire: A tool to screen patients for obstructive sleep apnea","volume":"108","author":"Chung","year":"2008","journal-title":"Anesthesiology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0165-1781(89)90047-4","article-title":"The Pittsburgh sleep quality index: A new instrument for psychiatric practice and research","volume":"28","author":"Buysse","year":"1989","journal-title":"Psychiatry Res."},{"key":"ref_15","unstructured":"Natus Medical Incoportaed-Sleep. Available online: http:\/\/www.embla.com\/index.cfm\/id\/57\/Embletta-X100\/."},{"key":"ref_16","unstructured":"Iber, C., Ancoli-Israel, S., Chesson, A.L., and Quan, S.F. (2007). The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications, American Academy of Sleep Medicine. [1st ed.]."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.nutres.2012.03.009","article-title":"Diet promotes sleep duration and quality","volume":"32","author":"Peuhkuri","year":"2012","journal-title":"Nutr. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/S0140-6736(72)92372-0","article-title":"Tryptophan and sleep","volume":"2","author":"Brezinova","year":"1972","journal-title":"Lancet"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.cmet.2007.09.006","article-title":"High-fat diet disrupts behavioral and molecular circadian rhythms in mice","volume":"6","author":"Kohsaka","year":"2007","journal-title":"Cell Metab."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1079\/BJN19950111","article-title":"Influences of dietary and intraduodenal lipid on alertness, mood, and sustained concentration","volume":"74","author":"Wells","year":"1995","journal-title":"Br. J. Nutr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S0031-9384(96)00519-7","article-title":"Influences of fat and carbohydrate on postprandial sleepiness, mood, and hormones","volume":"61","author":"Wells","year":"1997","journal-title":"Physiol. Behav."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0022-3956(82)90017-6","article-title":"Effects of protein and carbohydrate meals on mood and performance: Interactions with sex and age","volume":"17","author":"Spring","year":"1982","journal-title":"J. Psychiatr. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1212\/01.WNL.0000080365.95436.B8","article-title":"Fatigue in MS is related to sympathetic vasomotor dysfunction","volume":"61","author":"Flachenecker","year":"2003","journal-title":"Neurology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0278-5846(01)00228-7","article-title":"Chronic stimulation of the cat vagus nerve: Effect on sleep and behavior","volume":"26","author":"Martinez","year":"2002","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/0361-9230(85)90032-2","article-title":"Effects of hypnogenic vagal stimulation on thalamic neuronal activity in cats","volume":"15","author":"Juhasz","year":"1985","journal-title":"Brain Res. Bull."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.mehy.2004.04.015","article-title":"Debunking a myth: Neurohormonal and vagal modulation of sleep centers, not redistribution of blood flow, may account for postprandial somnolence","volume":"63","author":"Bazar","year":"2004","journal-title":"Med. Hypotheses"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/edrv.23.1.0454","article-title":"Orexins in the brain-gut axis","volume":"23","author":"Kirchgessner","year":"2002","journal-title":"Endocr. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/BF03179066","article-title":"The effect of high-fat diet on plasma ghrelin and leptin levels in rats","volume":"65","author":"Boyadjieva","year":"2009","journal-title":"J. Physiol. Biochem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.smrv.2004.07.007","article-title":"Roles of orexin\/hypocretin in regulation of sleep\/wakefulness and energy homeostasis","volume":"9","author":"Sakurai","year":"2005","journal-title":"Sleep Med. Rev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.physbeh.2005.10.010","article-title":"Sleep is increased in mice with obesity induced by high-fat food","volume":"87","author":"Jenkins","year":"2006","journal-title":"Physiol. Behav."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"4510","DOI":"10.1210\/jc.2005-0035","article-title":"Excessive daytime sleepiness in a general population sample: The role of sleep apnea, age, obesity, diabetes, and depression","volume":"90","author":"Bixler","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"163","DOI":"10.5664\/jcsm.26511","article-title":"Cross-sectional relationship of reported fatigue to obesity, diet, and physical activity: Results from the third national health and nutrition examination survey","volume":"2","author":"Resnick","year":"2006","journal-title":"J. Clin. Sleep Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1038\/oby.2007.169","article-title":"Sleep apnea is induced by a high-fat diet and reversed and prevented by metformin in non-obese rats","volume":"15","author":"Ramadan","year":"2007","journal-title":"Obesity"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.2337\/dc08-1776","article-title":"Obstructive sleep apnea among obese patients with type 2 diabetes","volume":"32","author":"Foster","year":"2009","journal-title":"Diabetes Care"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1097\/ACI.0b013e32831d8184","article-title":"Risk factors and treatment for obstructive sleep apnea amongst obese children and adults","volume":"9","author":"Kohler","year":"2009","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1093\/ije\/dyh181","article-title":"Adjusting for energy intake\u2014What measure to use in nutritional epidemiological studies?","volume":"33","author":"Jakes","year":"2004","journal-title":"Int. J. Epidemiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3389\/fnins.2013.00185","article-title":"Circadian adaptations to meal timing: Neuroendocrine mechanisms","volume":"7","author":"Patton","year":"2013","journal-title":"Front. Neurosci."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/8\/4\/207\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:21:57Z","timestamp":1760210517000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/8\/4\/207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,8]]},"references-count":37,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,4]]}},"alternative-id":["nu8040207"],"URL":"https:\/\/doi.org\/10.3390\/nu8040207","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,8]]}}}